The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 186,421 519,033 SH   SOLE   519,033 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 54,566 2,337,877 SH   SOLE   2,337,877 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 643 160,800 SH   SOLE   160,800 0 0
ALIGN TECHNOLOGY INC COM 016255101 36,411 55,405 SH   SOLE   55,405 0 0
ALIMERA SCIENCES INC COM 016259202 1,031 200,919 SH   SOLE   200,919 0 0
ALKERMES PLC COM G01767105 17,543 754,200 SH   SOLE   754,200 0 0
AMICUS THERAPEUTICS INC COM 03152W109 116,817 10,114,043 SH   SOLE   10,114,043 0 0
ANAPTYSBIO INC COM 032724106 15,172 436,592 SH   SOLE   436,592 0 0
ASTRAZENECA PLC-SPONS ADR COM 046353108 1,704 29,260 SH   SOLE   29,260 0 0
BIOGEN INC COM 09062X103 92,369 385,000 SH   SOLE   385,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 195,514 2,212,950 SH   SOLE   2,212,950 0 0
CLOVIS ONCOLOGY INC COM 189464100 10,834 3,997,826 SH   SOLE   3,997,826 0 0
CYTOKINETICS INC COM 23282W605 5,638 123,686 SH   SOLE   123,686 0 0
EHEALTH INC COM 28238P109 41,197 1,615,570 SH   SOLE   1,615,570 0 0
EPIZYME INC COM 29428V104 13,713 5,485,213 SH   SOLE   5,485,213 0 0
GOSSAMER BIO INC COM 38341P102 20,052 1,772,950 SH   SOLE   1,772,950 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 30,302 2,356,282 SH   SOLE   2,356,282 0 0
INSMED INC COM 457669307 164,140 6,025,706 SH   SOLE   6,025,706 0 0
KALEIDO BIOSCIENCES INC COM 483347100 815 341,030 SH   SOLE   341,030 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 35,175 5,470,452 SH   SOLE   5,470,452 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 10,972 656,200 SH   SOLE   656,200 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 1,915 432,300 SH   SOLE   432,300 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q200 372 31,330 SH   SOLE   31,330 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 1,032 64,700 SH   SOLE   64,700 0 0
NOVAVAX INC COM 670002401 1,788 12,500 SH   SOLE   12,500 0 0
PROTHENA CORP PLC COM G72800108 83,253 1,685,282 SH   SOLE   1,685,282 0 0
REVANCE THERAPEUTICS INC COM 761330109 71,308 4,369,366 SH   SOLE   4,369,366 0 0
RIGEL PHARMACEUTICALS INC COM 766559603 1,729 652,395 SH   SOLE   652,395 0 0
SAGE THERAPEUTICS INC COM 78667J108 33,255 781,730 SH   SOLE   781,730 0 0
STAAR SURGICAL CO COM 852312305 104,129 1,140,511 SH   SOLE   1,140,511 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 13,110 598,900 SH   SOLE   598,900 0 0
TACTILE SYSTEMS TECHNOLOGY I COM 87357P100 516 27,100 SH   SOLE   27,100 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 5,155 166,069 SH   SOLE   166,069 0 0
UNITED THERAPEUTICS CORP COM 91307C102 148,491 687,206 SH   SOLE   687,206 0 0
UROGEN PHARMA LTD COM M96088105 233 24,500 SH   SOLE   24,500 0 0
VANDA PHARMACEUTICALS INC COM 921659108 44,469 2,834,244 SH   SOLE   2,834,244 0 0
ZOGENIX INC COM 98978L204 2,987 183,800 SH   SOLE   183,800 0 0