The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADAPTIMMUNE THERAPEUTICS PLC | ADR | 00653A107 | 64,060 | 17,082,611 | SH | DFND | 17,082,611 | 0 | 0 | ||
| ADDEX THERAPEUTICS LTD | SPONSORED ADS | 00654J107 | 205 | 180,000 | SH | DFND | 180,000 | 0 | 0 | ||
| AFFIMED NV | COM | N01045108 | 24,434 | 4,426,488 | SH | DFND | 4,426,488 | 0 | 0 | ||
| AIRSPAN NETWORKS HOLDINGS INC | COM | 00951K104 | 5,814 | 1,534,140 | SH | DFND | 1,534,140 | 0 | 0 | ||
| AKARI THERAPEUTICS PLC | ADR | 00972G108 | 678 | 452,167 | SH | DFND | 452,167 | 0 | 0 | ||
| AKOUOS INC | COM | 00973J101 | 36,537 | 4,298,488 | SH | DFND | 4,298,488 | 0 | 0 | ||
| ALLAKOS INC | COM | 01671P100 | 21,192 | 2,164,704 | SH | DFND | 2,164,704 | 0 | 0 | ||
| ANNEXON INC | COM | 03589W102 | 10,359 | 901,537 | SH | DFND | 901,537 | 0 | 0 | ||
| AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 70,207 | 3,069,834 | SH | DFND | 3,069,834 | 0 | 0 | ||
| AVEO PHARMACEUTICALS INC | COM | 053588307 | 18,539 | 3,952,958 | SH | DFND | 3,952,958 | 0 | 0 | ||
| BERKSHIRE GREY INC | COM CL A | 084656107 | 210,246 | 38,226,621 | SH | DFND | 38,226,621 | 0 | 0 | ||
| BILL COM HLDGS INC | COM | 090043100 | 16,461 | 66,070 | SH | DFND | 66,070 | 0 | 0 | ||
| BLACK DIAMOND THERAPEUTICS INC | COM | 09203E105 | 18,388 | 3,449,845 | SH | DFND | 3,449,845 | 0 | 0 | ||
| BRIGHT HEALTH GROUP INC | COM | 10920V107 | 750,650 | 218,212,128 | SH | DFND | 218,212,128 | 0 | 0 | ||
| BUZZFEED INC | CL A COM | 12430A102 | 81,730 | 15,333,892 | SH | DFND | 15,333,892 | 0 | 0 | ||
| CASPER SLEEP INC | COM | 147626105 | 41,591 | 6,226,130 | SH | DFND | 6,226,130 | 0 | 0 | ||
| CHAMPIONS ONCOLOGY INC | COM NEW | 15870P307 | 14,327 | 1,713,720 | SH | DFND | 1,713,720 | 0 | 0 | ||
| CLOUDFLARE INC | CL A COM | 18915M107 | 246,892 | 1,877,510 | SH | DFND | 1,877,510 | 0 | 0 | ||
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 120,490 | 1,590,002 | SH | DFND | 1,590,002 | 0 | 0 | ||
| CTI BIOPHARMA CORP | COM NEW | 12648L601 | 17,708 | 7,140,450 | SH | DFND | 7,140,450 | 0 | 0 | ||
| COURSERA INC | COM | 22266M104 | 387,808 | 15,867,769 | SH | DFND | 15,867,769 | 0 | 0 | ||
| CVRX INC | COM | 126638105 | 28,996 | 2,370,858 | SH | DFND | 2,370,858 | 0 | 0 | ||
| DESKTOP METAL INC | COM CL A | 25058X105 | 71,318 | 14,407,594 | SH | DFND | 14,407,594 | 0 | 0 | ||
| EARGO INC | COM | 270087109 | 23,055 | 4,520,670 | SH | DFND | 4,520,670 | 0 | 0 | ||
| GENOCEA BIOSCIENCES INC | COM | 372427401 | 12,037 | 10,376,936 | SH | DFND | 10,376,936 | 0 | 0 | ||
| GERON CORP | COM | 374163103 | 16,423 | 13,461,538 | SH | DFND | 13,461,538 | 0 | 0 | ||
| GLYCOMIMETICS INC | COM | 38000Q102 | 13,088 | 9,089,041 | SH | DFND | 9,089,041 | 0 | 0 | ||
| IMARA INC | COM | 45249V107 | 8,069 | 3,586,371 | SH | DFND | 3,586,371 | 0 | 0 | ||
| INOZYME PHARMA INC | COM | 45790W108 | 16,671 | 2,444,379 | SH | DFND | 2,444,379 | 0 | 0 | ||
| INVENTIVA SA | ADS | 46124U107 | 17,740 | 1,298,700 | SH | DFND | 1,298,700 | 0 | 0 | ||
| IONQ INC | COM | 46222L108 | 488,135 | 29,229,659 | SH | DFND | 29,229,659 | 0 | 0 | ||
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 9,386 | 2,382,286 | SH | DFND | 2,382,286 | 0 | 0 | ||
| LUMOS PHARMA INC | COM | 55028X109 | 2,612 | 376,916 | SH | DFND | 376,916 | 0 | 0 | ||
| MARKER THERAPEUTICS INC | COM | 57055L107 | 10,179 | 10,714,285 | SH | DFND | 10,714,285 | 0 | 0 | ||
| MEI PHARMA INC | COM NEW | 55279B202 | 22,783 | 8,533,072 | SH | DFND | 8,533,072 | 0 | 0 | ||
| METROMILE INC | COM | 591697107 | 20,552 | 9,384,285 | SH | DFND | 9,384,285 | 0 | 0 | ||
| MINERVA SURGICAL INC | COM | 60343F106 | 51,396 | 9,999,125 | SH | DFND | 9,999,125 | 0 | 0 | ||
| MIRUM PHARMACEUTICALS INC | COM | 604749101 | 66,795 | 4,187,801 | SH | DFND | 4,187,801 | 0 | 0 | ||
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 157,299 | 7,703,205 | SH | DFND | 7,703,205 | 0 | 0 | ||
| NEXTNAV INC | COM | 65345N106 | 71,737 | 8,189,156 | SH | DFND | 8,189,156 | 0 | 0 | ||
| NKARTA INC | COM | 65487U108 | 44,591 | 2,904,974 | SH | DFND | 2,904,974 | 0 | 0 | ||
| OBSEVA SA | COM | H5861P103 | 9,127 | 4,586,563 | SH | DFND | 4,586,563 | 0 | 0 | ||
| OYSTER PT PHARMA INC | COM | 69242L106 | 108,196 | 5,925,287 | SH | DFND | 5,925,287 | 0 | 0 | ||
| PHASEBIO PHARMACEUTICALS INC | COM | 717224109 | 17,340 | 6,643,704 | SH | DFND | 6,643,704 | 0 | 0 | ||
| REGULUS THERAPEUTICS INC | COM NEW | 75915K200 | 2,064 | 6,451,056 | SH | DFND | 6,451,056 | 0 | 0 | ||
| RENEO PHARMACEUTICALS INC | COM | 75974E103 | 40,928 | 4,786,921 | SH | DFND | 4,786,921 | 0 | 0 | ||
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 49,025 | 4,912,306 | SH | DFND | 4,912,306 | 0 | 0 | ||
| ROBINHOOD MKTS INC | COM CL A | 770700102 | 1,269,285 | 71,468,726 | SH | DFND | 71,468,726 | 0 | 0 | ||
| SATSUMA PHARMACEUTICALS INC | COM | 80405P107 | 14,143 | 3,142,958 | SH | DFND | 3,142,958 | 0 | 0 | ||
| SAVARA INC | COM | 805111101 | 29,931 | 24,137,931 | SH | DFND | 24,137,931 | 0 | 0 | ||
| SYNLOGIC INC | COM | 87166L100 | 10,235 | 4,229,410 | SH | DFND | 4,229,410 | 0 | 0 | ||
| TEMPEST THERAPEUTICS INC | COM | 87978U108 | 622 | 117,785 | SH | DFND | 117,785 | 0 | 0 | ||
| TRACON PHARMACEUTICALS INC | COM | 89237H209 | 960 | 346,718 | SH | DFND | 346,718 | 0 | 0 | ||
| TREVI THERAPEUTICS INC | COM | 89532M101 | 4,634 | 5,940,796 | SH | DFND | 5,940,796 | 0 | 0 | ||
| VERONA PHARMA PLC | ADS | 925050106 | 34,330 | 5,108,563 | SH | DFND | 5,108,563 | 0 | 0 | ||
| VISTAGEN THERAPEUTICS INC | COM | 92840H202 | 31,790 | 16,302,596 | SH | DFND | 16,302,596 | 0 | 0 | ||
| WHEELS UP EXPERIENCE INC | COM CL A | 96328L106 | 4,924 | 1,061,259 | SH | DFND | 1,061,259 | 0 | 0 | ||
| XERIS BIOPHARMA HOLDINGS INC | COM | 98422E103 | 9,523 | 3,250,000 | SH | DFND | 3,250,000 | 0 | 0 | ||