The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 13,086 | 900,000 | SH | DFND | 1 | 900,000 | 0 | 0 | |
| ADICET BIO INC | COM | 007002108 | 13,118 | 750,000 | SH | DFND | 1 | 750,000 | 0 | 0 | |
| AEROVATE THERAPEUTICS INC | COM | 008064107 | 21,584 | 1,830,691 | SH | DFND | 1 | 1,830,691 | 0 | 0 | |
| AKERO THERAPEUTICS INC | COM | 00973Y108 | 8,540 | 403,787 | SH | DFND | 1 | 403,787 | 0 | 0 | |
| AKOUOS INC | COM | 00973J101 | 3,353 | 394,500 | SH | DFND | 1 | 394,500 | 0 | 0 | |
| ALIGOS THERAPEUTICS INC | COM | 01626L105 | 6,187 | 521,257 | SH | DFND | 1 | 521,257 | 0 | 0 | |
| ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 16,377 | 762,079 | SH | DFND | 1 | 762,079 | 0 | 0 | |
| AMBRX BIOPHARMA INC | SPONSORED ADS | 02290A102 | 22,452 | 2,486,386 | SH | DFND | 1 | 2,486,386 | 0 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 3,475 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 29,550 | 625,000 | SH | DFND | 1 | 625,000 | 0 | 0 | |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 | 6,726 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| ASTRIA THERAPEUTICS INC | COM | 04635X102 | 2,980 | 552,903 | SH | DFND | 1 | 552,903 | 0 | 0 | |
| ATEA PHARMACEUTICALS INC | COM | 04683R106 | 15,014 | 1,679,442 | SH | DFND | 1 | 1,679,442 | 0 | 0 | |
| ATRECA INC | CL A COM | 04965G109 | 829 | 273,500 | SH | DFND | 1 | 273,500 | 0 | 0 | |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 2,035 | 392,167 | SH | DFND | 1 | 392,167 | 0 | 0 | |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 | 47,828 | 2,012,115 | SH | DFND | 1 | 2,012,115 | 0 | 0 | |
| AXONICS INC | COM | 05465P101 | 18,045 | 322,240 | SH | DFND | 1 | 322,240 | 0 | 0 | |
| BEAM THERAPEUTICS INC | COM | 07373V105 | 39,845 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| BIOATLA INC | COM | 09077B104 | 33,000 | 1,681,115 | SH | DFND | 1 | 1,681,115 | 0 | 0 | |
| BIOMEA FUSION INC | COM | 09077A106 | 23,623 | 3,170,872 | SH | DFND | 1 | 3,170,872 | 0 | 0 | |
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 27,837 | 1,668,909 | SH | DFND | 1 | 1,668,909 | 0 | 0 | |
| CABALETTA BIO INC | COM | 12674W109 | 4,375 | 1,154,424 | SH | DFND | 1 | 1,154,424 | 0 | 0 | |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 3,864 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 28,036 | 2,489,894 | SH | DFND | 1 | 2,489,894 | 0 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 14,564 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| CONNECT BIOPHARMA HLDGS LTD | ADS | 207523101 | 1,030 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 31,906 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| DESIGN THERAPEUTICS INC | COM | 25056L103 | 116,480 | 5,440,453 | SH | DFND | 1 | 5,440,453 | 0 | 0 | |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 54,487 | 3,565,901 | SH | DFND | 1 | 3,565,901 | 0 | 0 | |
| ELEDON PHARMACEUTICALS INC | COM | 28617K101 | 5,755 | 1,305,095 | SH | DFND | 1 | 1,305,095 | 0 | 0 | |
| ELEVATION ONCOLOGY INC | COM | 28623U101 | 11,939 | 1,983,165 | SH | DFND | 1 | 1,983,165 | 0 | 0 | |
| ERASCA INC | COM | 29479A108 | 163,676 | 10,505,550 | SH | DFND | 1 | 10,505,550 | 0 | 0 | |
| FORMA THERAPEUTICS HLDGS INC | SHS | 34633R104 | 65,981 | 4,639,995 | SH | DFND | 1 | 4,639,995 | 0 | 0 | |
| GALECTO INC | COM | 36322Q107 | 3,091 | 1,020,238 | SH | DFND | 1 | 1,020,238 | 0 | 0 | |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 14,188 | 608,123 | SH | DFND | 1 | 608,123 | 0 | 0 | |
| GOSSAMER BIO INC | COM | 38341P102 | 2,244 | 198,382 | SH | DFND | 1 | 198,382 | 0 | 0 | |
| GRAPHITE BIO INC | COM | 38870X104 | 2,525 | 203,153 | SH | DFND | 1 | 203,153 | 0 | 0 | |
| HARPOON THERAPEUTICS INC | COM | 41358P106 | 4,082 | 540,600 | SH | DFND | 1 | 540,600 | 0 | 0 | |
| HELIX ACQUISITION CORP | COM CL A | G4444C102 | 4,253 | 430,000 | SH | DFND | 1 | 430,000 | 0 | 0 | |
| ICOSAVAX INC | COM | 45114M109 | 9,756 | 426,393 | SH | DFND | 1 | 426,393 | 0 | 0 | |
| IGM BIOSCIENCES INC | COM | 449585108 | 14,665 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| IMMUNEERING CORP | CLASS A COM | 45254E107 | 37,233 | 2,302,626 | SH | DFND | 1 | 2,302,626 | 0 | 0 | |
| IMV INC | COM | 44974L103 | 289 | 234,374 | SH | DFND | 1 | 234,374 | 0 | 0 | |
| ITEOS THERAPEUTICS INC | COM | 46565G104 | 6,984 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| KEROS THERAPEUTICS INC | COM | 492327101 | 8,776 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| LONGBOARD PHARMACEUTICALS IN | COM | 54300N103 | 11,069 | 2,273,221 | SH | DFND | 1 | 2,273,221 | 0 | 0 | |
| MEIRAGTX HLDGS PLC | COM | G59665102 | 3,561 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| MERUS N V | COM | N5749R100 | 3,180 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 11,002 | 75,000 | SH | DFND | 1 | 75,000 | 0 | 0 | |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 61,305 | 3,002,199 | SH | DFND | 1 | 3,002,199 | 0 | 0 | |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 20,310 | 2,169,871 | SH | DFND | 1 | 2,169,871 | 0 | 0 | |
| ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 339 | 256,649 | SH | DFND | 1 | 256,649 | 0 | 0 | |
| OUTLOOK THERAPEUTICS INC | *W EXP 02/18/202 | 69012T115 | 32 | 270,698 | SH | DFND | 1 | 270,698 | 0 | 0 | |
| PHARVARIS N V | COM | N69605108 | 9,925 | 689,731 | SH | DFND | 1 | 689,731 | 0 | 0 | |
| PLIANT THERAPEUTICS INC | COM | 729139105 | 6,513 | 482,413 | SH | DFND | 1 | 482,413 | 0 | 0 | |
| PRAXIS PRECISION MEDICINES I | COM | 74006W108 | 14,822 | 752,406 | SH | DFND | 1 | 752,406 | 0 | 0 | |
| PRECISION BIOSCIENCES INC | COM | 74019P108 | 2,564 | 346,524 | SH | DFND | 1 | 346,524 | 0 | 0 | |
| PROMETHEUS BIOSCIENCES INC | COM | 74349U108 | 73,071 | 1,848,024 | SH | DFND | 1 | 1,848,024 | 0 | 0 | |
| PYXIS ONCOLOGY INC | COMMON STOCK | 747324101 | 7,117 | 668,854 | SH | DFND | 1 | 668,854 | 0 | 0 | |
| RAIN THERAPEUTICS INC | COM | 75082Q105 | 29,967 | 2,326,660 | SH | DFND | 1 | 2,326,660 | 0 | 0 | |
| RENOVACOR INC | COM | 75989E106 | 3,850 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| REVOLUTION MEDICINES INC | COM | 76155X100 | 61,210 | 2,431,852 | SH | DFND | 1 | 2,431,852 | 0 | 0 | |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 18,960 | 868,550 | SH | DFND | 1 | 868,550 | 0 | 0 | |
| SONENDO INC | COM | 835431107 | 859 | 149,200 | SH | DFND | 1 | 149,200 | 0 | 0 | |
| STOKE THERAPEUTICS INC | COM | 86150R107 | 28,365 | 1,182,362 | SH | DFND | 1 | 1,182,362 | 0 | 0 | |
| TALARIS THERAPEUTICS INC | COM | 87410C104 | 18,081 | 1,182,545 | SH | DFND | 1 | 1,182,545 | 0 | 0 | |
| TANGO THERAPEUTICS INC | COM | 87583X109 | 53,149 | 4,899,185 | SH | DFND | 1 | 4,899,185 | 0 | 0 | |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 | 31,575 | 1,403,331 | SH | DFND | 1 | 1,403,331 | 0 | 0 | |
| TURNING POINT THERAPEUTICS I | COM | 90041T108 | 144,292 | 3,025,000 | SH | DFND | 1 | 3,025,000 | 0 | 0 | |
| TYRA BIOSCIENCES INC | COM | 90240B106 | 11,605 | 839,932 | SH | DFND | 1 | 839,932 | 0 | 0 | |
| UNIQURE NV | SHS | N90064101 | 1,037 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| VECTIVBIO HLDG AG | ORD SHS | H9060V101 | 10,884 | 2,216,763 | SH | DFND | 1 | 2,216,763 | 0 | 0 | |
| VENTYX BIOSCIENCES INC | COM | 92332V107 | 15,128 | 785,303 | SH | DFND | 1 | 785,303 | 0 | 0 | |
| VERVE THERAPEUTICS INC | COM | 92539P101 | 40,897 | 1,109,224 | SH | DFND | 1 | 1,109,224 | 0 | 0 | |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 5,931 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| X4 PHARMACEUTICALS INC | COM | 98420X103 | 238 | 103,980 | SH | DFND | 1 | 103,980 | 0 | 0 | |
| Y-MABS THERAPEUTICS INC | COM | 984241109 | 4,863 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| ZYMEWORKS INC | COM | 98985W102 | 9,834 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |