The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 1,891 144,653 SH   SOLE 144,653 0 0
ACCURAY INC COM 004397105 4,492 941,800 SH   SOLE 941,800 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 511 136,266 SH   SOLE 136,266 0 0
ADICET BIO INC COM 007002108 12,823 733,172 SH   SOLE 733,172 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 2,029 289,040 SH   SOLE 289,040 0 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 1,243 1,500,000 PRN   SOLE 1,500,000 0 0
AFFIMED N V COM N01045108 3,153 571,282 SH   SOLE 571,282 0 0
ALECTOR INC COM 014442107 3,206 155,247 SH   SOLE 155,247 0 0
ANNEXON INC COM 03589W102 354 30,796 SH   SOLE 30,796 0 0
ARCUS BIOSCIENCES INC COM 03969F109 4,743 117,200 SH   SOLE 117,200 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 11,117 119,615 SH   SOLE 119,615 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 1,480 11,000 SH   SOLE 11,000 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 820 732,500 SH   SOLE 732,500 0 0
ATHIRA PHARMA INC COM 04746L104 2,098 160,983 SH   SOLE 160,983 0 0
ATRICURE INC COM 04963C209 5,008 72,029 SH   SOLE 72,029 0 0
AXOGEN INC COM 05463X106 3,112 332,103 SH   SOLE 332,103 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 8,007 58,100 SH   SOLE 58,100 0 0
BIOMEA FUSION INC COM 09077A106 2,339 313,923 SH   SOLE 313,923 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 1,099 206,100 SH   SOLE 206,100 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 22,162 206,911 SH   SOLE 206,911 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 490 100,000 SH   SOLE 100,000 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106 1,540 200,000 SH   SOLE 200,000 0 0
CARDIOVASCULAR SYS INC COM 141619106 5,390 286,988 SH   SOLE 286,988 0 0
CENTURY THERAPEUTICS INC COM 15673T100 1,588 100,135 SH   SOLE 100,135 0 0
COGENT BIOSCIENCES INC COM 19240Q201 1,918 223,554 SH   SOLE 223,554 0 0
COMPASS THERAPEUTICS INC COM 20454B104 622 196,091 SH   SOLE 196,091 0 0
COMPUGEN LTD ORD M25722105 866 201,502 SH   SOLE 201,502 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 6,042 1,787,569 SH   SOLE 1,787,569 0 0
CYTOKINETICS INC COM NEW 23282W605 6,112 134,094 SH   SOLE 134,094 0 0
DEXCOM INC COM 252131107 9,739 18,138 SH   SOLE 18,138 0 0
FATE THERAPEUTICS INC COM 31189P102 21,775 372,160 SH   SOLE 372,160 0 0
FIELD TRIP HEALTH LTD COM 31656R102 839 340,900 SH   SOLE 340,900 0 0
F-STAR THERAPEUTICS INC COM 30315R107 3,483 693,785 SH   SOLE 693,785 0 0
GALAPAGOS NV SPON ADR 36315X101 2,353 42,675 SH   SOLE 42,675 0 0
GENFIT S A ADS 372279109 302 60,448 SH   SOLE 60,448 0 0
HARPOON THERAPEUTICS INC COM 41358P106 794 105,163 SH   SOLE 105,163 0 0
HOOKIPA PHARMA INC COM 43906K100 747 320,444 SH   SOLE 320,444 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 10,876 460,061 SH   SOLE 460,061 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 531 236,160 SH   SOLE 236,160 0 0
INOGEN INC COM 45780L104 510 15,000 SH   SOLE 15,000 0 0
ISHARES TR NASDAQ BIOTECH ETF 464287556 6,242 40,900 SH   SOLE 40,900 0 0
ITEOS THERAPEUTICS INC COM 46565G104 2,518 54,090 SH   SOLE 54,090 0 0
IVERIC BIO INC COM 46583P102 4,614 275,976 SH   SOLE 275,976 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 2,522 190,663 SH   SOLE 190,663 0 0
KARUNA THERAPEUTICS INC COM 48576A100 9,487 72,423 SH   SOLE 72,423 0 0
KINNATE BIOPHARMA INC COM 49705R105 1,886 106,453 SH   SOLE 106,453 0 0
KURA ONCOLOGY INC COM 50127T109 1,552 110,829 SH   SOLE 110,829 0 0
LARIMAR THERAPEUTICS INC COM 517125100 757 70,177 SH   SOLE 70,177 0 0
LAVA THERAPEUTICS NV SHS N51517105 766 139,332 SH   SOLE 139,332 0 0
LINEAGE CELL THERAPEUTICS IN COM 53566P109 196 80,000 SH   SOLE 80,000 0 0
MACROGENICS INC COM 556099109 1,445 90,000 SH   SOLE 90,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 475 5,600 SH   SOLE 5,600 0 0
MASIMO CORP COM 574795100 878 3,000 SH   SOLE 3,000 0 0
MEI PHARMA INC COM NEW 55279B202 4,712 1,764,846 SH   SOLE 1,764,846 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 1,803 1,126,613 SH   SOLE 1,126,613 0 0
MERSANA THERAPEUTICS INC COM 59045L106 872 140,263 SH   SOLE 140,263 0 0
MERUS N V COM N5749R100 7,190 226,089 SH   SOLE 226,089 0 0
MORPHIC HLDG INC COM 61775R105 8,598 181,467 SH   SOLE 181,467 0 0
NATUS MED INC COM 639050103 4,524 190,635 SH   SOLE 190,635 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 7,125 83,655 SH   SOLE 83,655 0 0
NEURONETICS INC COM 64131A105 1,399 313,717 SH   SOLE 313,717 0 0
NEXTCURE INC COM 65343E108 1,126 187,696 SH   SOLE 187,696 0 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 1,425 80,485 SH   SOLE 80,485 0 0
NURIX THERAPEUTICS INC COM 67080M103 8,868 306,320 SH   SOLE 306,320 0 0
OTONOMY INC COM 68906L105 4,577 2,200,297 SH   SOLE 2,200,297 0 0
PARDES BIOSCIENCES INC COM 69945Q105 3,822 233,500 SH   SOLE 233,500 0 0
PHARVARIS N V COM N69605108 528 36,720 SH   SOLE 36,720 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 988 378,611 SH   SOLE 378,611 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109 685 85,476 SH   SOLE 85,476 0 0
RADIUS HEALTH INC COM NEW 750469207 1,328 191,978 SH   SOLE 191,978 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 3,860 4,000,000 PRN   SOLE 4,000,000 0 0
REGULUS THERAPEUTICS INC COM NEW 75915K200 1,750 5,555,555 SH   SOLE 5,555,555 0 0
REVOLUTION MEDICINES INC COM 76155X100 5,342 212,231 SH   SOLE 212,231 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 2,329 879,000 SH   SOLE 879,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 7,670 180,306 SH   SOLE 180,306 0 0
SCYNEXIS INC COM NEW 811292200 740 121,242 SH   SOLE 121,242 0 0
STEREOTAXIS INC COM NEW 85916J409 84,819 13,680,554 SH   SOLE 13,680,554 0 0
SURFACE ONCOLOGY INC COM 86877M209 1,506 315,000 SH   SOLE 315,000 0 0
SURGALIGN HOLDINGS INC COM 86882C105 415 579,710 SH   SOLE 579,710 0 0
SUTRO BIOPHARMA INC COM 869367102 670 45,000 SH   SOLE 45,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 6,491 296,535 SH   SOLE 296,535 0 0
THESEUS PHARMACEUTICALS INC COM 88369M101 1,236 97,500 SH   SOLE 97,500 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 2,216 46,452 SH   SOLE 46,452 0 0
VENUS CONCEPT INC COM 92332W105 1,659 975,687 SH   SOLE 975,687 0 0
VIKING THERAPEUTICS INC COM 92686J106 2,058 447,400 SH   SOLE 447,400 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 1,225 390,161 SH   SOLE 390,161 0 0
XENON PHARMACEUTICALS INC COM 98420N105 12,579 402,667 SH   SOLE 402,667 0 0