The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
908 DEVICES INC COM 65443P102 12,814 495,332 SH   SOLE   466,703 0 28,629
ABSCI CORPORATION COM 00091E109 2,442 297,823 SH   SOLE   297,823 0 0
AC IMMUNE SA SHS H00263105 5,259 1,062,462 SH   SOLE   1,062,462 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 3,211 114,418 SH   SOLE   114,418 0 0
ALBIREO PHARMA INC COM 01345P106 7,352 315,662 SH   SOLE   315,662 0 0
ALECTOR INC COM 014442107 1,350 65,380 SH   SOLE   65,380 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 127,548 1,073,727 SH   SOLE   947,892 0 125,835
ALLY FINL INC COM 02005N100 30,716 645,162 SH   SOLE   645,162 0 0
ALPHA TEKNOVA INC COM 02080L102 3,466 169,237 SH   SOLE   169,237 0 0
ALPHABET INC CAP STK CL A 02079K305 28,072 9,690 SH   SOLE   9,690 0 0
ALPHABET INC CAP STK CL C 02079K107 68,517 23,679 SH   SOLE   23,679 0 0
AMBARELLA INC SHS G037AX101 374 1,842 SH   SOLE   1,842 0 0
AMERISOURCEBERGEN CORP COM 03073E105 87 657 SH   SOLE   657 0 0
AMGEN INC COM 031162100 91 403 SH   SOLE   403 0 0
ANALOG DEVICES INC COM 032654105 3,189 18,145 SH   SOLE   18,145 0 0
APPLE INC COM 037833100 1,488 8,378 SH   SOLE   8,378 0 0
ARCUS BIOSCIENCES INC COM 03969F109 2,500 61,780 SH   SOLE   61,780 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 993 886,867 SH   SOLE   886,867 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 4,449 1,909,498 SH   SOLE   1,909,498 0 0
AT&T INC COM 00206R102 143 5,810 SH   SOLE   5,810 0 0
ATRECA INC CL A COM 04965G109 1,208 398,541 SH   SOLE   398,541 0 0
AZIYO BIOLOGICS INC COM CL A 05479K106 1,234 195,809 SH   SOLE   195,809 0 0
BARRICK GOLD CORP COM 067901108 135,620 7,137,871 SH   SOLE   5,676,094 0 1,461,777
BIO RAD LABS INC CL A 090572207 4,900 6,485 SH   SOLE   6,485 0 0
BIOATLA INC COM 09077B104 1,791 91,262 SH   SOLE   91,262 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 3,071 221,699 SH   SOLE   221,699 0 0
BIONTECH SE SPONSORED ADS 09075V102 1,931 7,492 SH   SOLE   7,492 0 0
BLOCK INC CL A 852234103 13,242 81,988 SH   SOLE   81,988 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 2,905 27,121 SH   SOLE   27,121 0 0
BOOKING HOLDINGS INC COM 09857L108 91,531 38,150 SH   SOLE   31,012 0 7,138
BTRS HOLDINGS INC COM CL 1 11778X104 17,853 2,282,941 SH   SOLE   2,282,941 0 0
CAMPBELL SOUP CO COM 134429109 89 2,043 SH   SOLE   2,043 0 0
CARVANA CO CL A 146869102 1,714 7,396 SH   SOLE   7,396 0 0
CENTOGENE N V COM N1976T109 11,906 2,277,150 SH   SOLE   2,277,150 0 0
CERENCE INC COM 156727109 6,693 87,329 SH   SOLE   87,329 0 0
CIENA CORP COM NEW 171779309 104,089 1,352,330 SH   SOLE   1,223,502 0 128,828
CIGNA CORP NEW COM 125523100 96 418 SH   SOLE   418 0 0
CISCO SYS INC COM 17275R102 2,262 35,700 SH   SOLE   35,700 0 0
CLEVELAND-CLIFFS INC NEW COM 185899101 2,821 129,562 SH   SOLE   129,562 0 0
COGENT BIOSCIENCES INC COM 19240Q201 9,015 1,050,699 SH   SOLE   1,025,866 0 24,833
COGNYTE SOFTWARE LTD ORD SHS M25133105 447 28,506 SH   SOLE   28,506 0 0
COHERUS BIOSCIENCES INC COM 19249H103 8,540 535,108 SH   SOLE   535,108 0 0
COTERRA ENERGY INC COM 127097103 147 7,742 SH   SOLE   7,742 0 0
CREDICORP LTD COM G2519Y108 40 326 SH   SOLE   326 0 0
CVS HEALTH CORP COM 126650100 135 1,311 SH   SOLE   1,311 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 4,244 980,085 SH   SOLE   980,085 0 0
DENALI THERAPEUTICS INC COM 24823R105 2,273 50,971 SH   SOLE   50,971 0 0
DISH NETWORK CORPORATION CL A 25470M109 517 15,940 SH   SOLE   15,940 0 0
EBAY INC. COM 278642103 1,508 22,679 SH   SOLE   22,679 0 0
EPIZYME INC COM 29428V104 7,057 2,822,936 SH   SOLE   2,822,936 0 0
EQUIFAX INC COM 294429105 53,576 182,984 SH   SOLE   182,984 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 13,566 2,713,176 SH   SOLE   2,442,860 0 270,316
EXAGEN INC COM 30068X103 4,652 400,000 SH   SOLE   344,533 0 55,467
EXSCIENTIA PLC ADS 30223G102 32,568 1,648,154 SH   SOLE   1,611,997 0 36,157
F45 TRAINING HLDGS INC COM 30322L101 10,571 970,744 SH   SOLE   970,744 0 0
FEDEX CORP COM 31428X106 24,384 94,276 SH   SOLE   94,276 0 0
FOX CORP CL A COM 35137L105 38 1,027 SH   SOLE   1,027 0 0
FREEPORT-MCMORAN INC CL B 35671D857 53,596 1,284,358 SH   SOLE   1,064,064 0 220,294
FULL TRUCK ALLIANCE CO LTD SPONSORED ADS 35969L108 1,188 141,924 SH   SOLE   141,924 0 0
GENERAL ELECTRIC CO COM NEW 369604301 88,808 940,067 SH   SOLE   690,121 0 249,946
GENETRON HLDGS LTD ADS 37186H100 8,032 1,316,642 SH   SOLE   1,316,642 0 0
GILEAD SCIENCES INC COM 375558103 81,347 1,120,332 SH   SOLE   863,593 0 256,739
HCA HEALTHCARE INC COM 40412C101 93 362 SH   SOLE   362 0 0
HELLO GROUP INC ADS 423403104 56 6,286 SH   SOLE   6,286 0 0
HERBALIFE NUTRITION LTD COM SHS G4412G101 84 2,048 SH   SOLE   2,048 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 56,737 1,519,462 SH   SOLE   1,519,462 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103 6,706 191,156 SH   SOLE   191,156 0 0
ICOSAVAX INC COM 45114M109 18,678 816,366 SH   SOLE   774,642 0 41,724
IDEAYA BIOSCIENCES INC COM 45166A102 20,829 881,085 SH   SOLE   776,150 0 104,935
IHS MARKIT LTD SHS G47567105 1,906 14,338 SH   SOLE   14,338 0 0
IMMATICS N.V SHS N44445109 4,467 332,356 SH   SOLE   332,356 0 0
IMMUNOVANT INC COM 45258J102 5,247 615,900 SH   SOLE   615,900 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 1,227 545,508 SH   SOLE   545,508 0 0
INHIBRX INC COM 45720L107 3,796 86,929 SH   SOLE   86,929 0 0
INTEL CORP COM 458140100 811 15,750 SH   SOLE   15,750 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 101,315 740,770 SH   SOLE   671,926 0 68,844
INTERNATIONAL BUSINESS MACHS COM 459200101 191 1,426 SH   SOLE   1,426 0 0
IRIS ENERGY LTD ORDINARY SHARES Q4982L109 43,937 2,717,193 SH   SOLE   2,352,065 0 365,128
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 26 6,912 SH   SOLE   6,912 0 0
JD.COM INC SPON ADR CL A 47215P106 36,593 522,239 SH   SOLE   522,239 0 0
JUST EAT TAKEAWAY COM N V SPONSORED ADS 48214T305 3,435 319,228 SH   SOLE   319,228 0 0
KYNDRYL HLDGS INC COMMON STOCK 50155Q100 4 241 SH   SOLE   241 0 0
LAM RESEARCH CORP COM 512807108 96,331 133,951 SH   SOLE   119,555 0 14,396
LAMB WESTON HLDGS INC COM 513272104 22,289 351,679 SH   SOLE   351,679 0 0
LEAP THERAPEUTICS INC COM 52187K101 4,303 1,327,952 SH   SOLE   1,327,952 0 0
LIBERTY GLOBAL PLC SHS CL A G5480U104 411 14,800 SH   SOLE   14,800 0 0
LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854 980 15,500 SH   SOLE   15,500 0 0
LOGICBIO THERAPEUTICS INC COM 54142F102 740 320,273 SH   SOLE   320,273 0 0
LUMEN TECHNOLOGIES INC COM 550241103 764 60,907 SH   SOLE   60,907 0 0
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 78 1,669 SH   SOLE   1,669 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 1,421 320,698 SH   SOLE   320,698 0 0
MELCO RESORTS AND ENTMNT LTD ADR 585464100 21,035 2,066,285 SH   SOLE   2,066,285 0 0
MERSANA THERAPEUTICS INC COM 59045L106 3,082 495,481 SH   SOLE   495,481 0 0
MERUS N V COM N5749R100 5,613 176,509 SH   SOLE   176,509 0 0
META PLATFORMS INC CL A 30303M102 66,400 197,414 SH   SOLE   197,414 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 344,378 3,955,641 SH   SOLE   3,530,169 0 425,472
MICRON TECHNOLOGY INC COM 595112103 327,269 3,513,350 SH   SOLE   3,121,530 0 391,820
MICROSOFT CORP COM 594918104 9,562 28,431 SH   SOLE   28,431 0 0
MODERNA INC COM 60770K107 4,884 19,230 SH   SOLE   19,230 0 0
MOSAIC CO NEW COM 61945C103 150,198 3,822,804 SH   SOLE   3,442,934 0 379,870
MOTOROLA SOLUTIONS INC COM NEW 620076307 382 1,406 SH   SOLE   1,406 0 0
MYOVANT SCIENCES LTD COM G637AM102 3,039 195,211 SH   SOLE   195,211 0 0
MYT NETHERLANDS PARENT B V ADS 55406W103 427 20,118 SH   SOLE   20,118 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 14,811 350,719 SH   SOLE   319,600 0 31,119
NIELSEN HLDGS PLC SHS EUR G6518L108 349 17,000 SH   SOLE   17,000 0 0
NOAH HLDGS LTD SPON ADS CL A 65487X102 56,768 1,849,717 SH   SOLE   1,849,717 0 0
OMEGA THERAPEUTICS INC COMMON STOCK 68217N105 4,696 414,513 SH   SOLE   387,712 0 26,801
ONECONNECT FINL TECHNOLOGY C SPONSORED ADS 68248T105 2,472 1,000,847 SH   SOLE   1,000,847 0 0
OPENDOOR TECHNOLOGIES INC COM 683712103 552 37,797 SH   SOLE   37,797 0 0
ORACLE CORP COM 68389X105 1,559 17,875 SH   SOLE   17,875 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 1,762 1,335,174 SH   SOLE   1,335,174 0 0
OVID THERAPEUTICS INC COM 690469101 2,462 766,901 SH   SOLE   766,901 0 0
PARDES BIOSCIENCES INC COM 69945Q105 17,795 1,087,070 SH   SOLE   1,087,070 0 0
PAYPAL HLDGS INC COM 70450Y103 1,137 6,029 SH   SOLE   6,029 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 86 7,866 SH   SOLE   7,866 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 3,887 1,028,322 SH   SOLE   1,028,322 0 0
PLANET FITNESS INC CL A 72703H101 9,641 106,440 SH   SOLE   106,440 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 20,621 521,529 SH   SOLE   479,986 0 41,543
PROTHENA CORP PLC SHS G72800108 2,989 60,512 SH   SOLE   60,512 0 0
QUANTERIX CORP COM 74766Q101 23,982 565,610 SH   SOLE   519,637 0 45,973
RECURSION PHARMACEUTICALS IN CL A 75629V104 24,733 1,443,863 SH   SOLE   1,398,569 0 45,294
ROBLOX CORP CL A 771049103 63,809 618,542 SH   SOLE   579,438 0 39,104
ROIVANT SCIENCES LTD SHS G76279101 3,262 323,643 SH   SOLE   323,643 0 0
SANGAMO THERAPEUTICS INC COM 800677106 1,638 218,336 SH   SOLE   218,336 0 0
SILVERCREST METALS INC COM 828363101 22,183 2,804,448 SH   SOLE   2,089,651 0 714,797
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 3,045 263,443 SH   SOLE   263,443 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 52,292 337,061 SH   SOLE   254,531 0 82,530
SPROUTS FMRS MKT INC COM 85208M102 51 1,722 SH   SOLE   1,722 0 0
SUZANO S A SPON ADS 86959K105 13,406 1,241,314 SH   SOLE   1,241,314 0 0
SYNEOS HEALTH INC CL A 87166B102 7,331 71,397 SH   SOLE   71,397 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 11,541 2,936,719 SH   SOLE   2,936,719 0 0
TRIP COM GROUP LTD ADS 89677Q107 277,385 11,266,671 SH   SOLE   10,245,068 0 1,021,603
ULTA BEAUTY INC COM 90384S303 11,693 28,358 SH   SOLE   28,358 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 85 657 SH   SOLE   657 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 92 418 SH   SOLE   418 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 4,195 1,336,105 SH   SOLE   1,336,105 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 2,541 213,381 SH   SOLE   213,381 0 0
WESTERN DIGITAL CORP. COM 958102105 2,516 38,586 SH   SOLE   38,586 0 0
XILINX INC COM 983919101 1,622 7,650 SH   SOLE   7,650 0 0
XP INC CL A G98239109 5 159 SH   SOLE   159 0 0
YUM CHINA HLDGS INC COM 98850P109 5,441 109,179 SH   SOLE   109,179 0 0
ZAI LAB LTD ADR 98887Q104 8,836 140,591 SH   SOLE   140,591 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105 420,636 14,905,595 SH   SOLE   13,410,826 0 1,494,769
ZYMEWORKS INC COM 98985W102 3,857 235,299 SH   SOLE   235,299 0 0