The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aerovate Therapeutics, Inc. COMM 008064107 44,315 3,758,686 SH   SOLE   3,758,686 0 0
Akouos, Inc. COMM 00973J101 12,878 1,515,074 SH   SOLE   1,515,074 0 0
Ascendis Pharma A/S ADR 04351P101 67,241 499,824 SH   SOLE   499,824 0 0
Bolt Biotherapeutics, Inc. COMM 097702104 13,497 2,754,437 SH   SOLE   2,754,437 0 0
Checkmate Pharmaceuticals Inc COMM 162818108 10,351 3,606,707 SH   SOLE   3,606,707 0 0
Fusion Pharmaceuticals Inc COMM 36118A100 326 78,066 SH   SOLE   78,066 0 0
Galera Therapeutics, Inc COMM 36338D108 14,154 3,083,712 SH   SOLE   3,083,712 0 0
Inozyme Pharma, Inc. COMM 45790W108 13,833 2,028,308 SH   SOLE   2,028,308 0 0
Karuna Therapeutics, Inc. COMM 48576A100 255,770 1,952,441 SH   SOLE   1,952,441 0 0
Natera Inc COMM 632307104 289,561 3,100,560 SH   SOLE   3,100,560 0 0
Nextcure, Inc COMM 65343E108 16,031 2,671,856 SH   SOLE   2,671,856 0 0
Nucana Plc ADR 67022C106 13,328 5,599,999 SH   SOLE   5,599,999 0 0
Nucana Plc Ordinary Shares GB00BYWYV 5,712 2,400,000 SH   SOLE   2,400,000 0 0
ObsEva SA COMM H5861P103 9,452 4,749,623 SH   SOLE   4,749,623 0 0
PDS Biotechnology Corporation COMM 70465T107 1,155 142,635 SH   SOLE   142,635 0 0
Synlogic Inc. COMM 87166L100 1,391 574,972 SH   SOLE   574,972 0 0
Vera Therapeutics, Inc. CL A 92337R101 77,883 2,914,776 SH   SOLE   2,914,776 0 0
Y-mAbs Therapeutics, Inc COMM 984241109 35,569 2,194,278 SH   SOLE   2,194,278 0 0
Abbvie Inc COMM 00287Y109 42,247 312,018 SH   SOLE   312,018 0 0
Adicet Bio Inc COMM 007002108 5,439 310,988 SH   SOLE   310,988 0 0
Agenus Inc COMM 00847G705 6,315 1,961,032 SH   SOLE   1,961,032 0 0
Align Technology Inc COMM 016255101 25,077 38,159 SH   SOLE   38,159 0 0
Aligos Therapeutics Inc COMM 01626L105 1,517 127,791 SH   SOLE   127,791 0 0
Axsome Therapeutics Inc COMM 05464T104 3,778 100,000 SH Put SOLE   100,000 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 20,920 1,510,473 SH   SOLE   1,510,473 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 7,715 87,322 SH   SOLE   87,322 0 0
Blueprint Medicines Corp COMM 09627Y109 26,261 245,182 SH   SOLE   245,182 0 0
Celldex Therapeutics Inc COMM 15117B202 10,492 271,533 SH   SOLE   271,533 0 0
ChemoCentryx Inc COMM 16383L106 26,624 731,222 SH   SOLE   731,222 0 0
Cyteir Therapeutics Inc COMM 23284P103 2,040 179,450 SH   SOLE   179,450 0 0
Cytokinetics Inc COMM 23282W605 21,166 464,366 SH   SOLE   464,366 0 0
Dexcom Inc COMM 252131107 17,399 32,404 SH   SOLE   32,404 0 0
Edwards Lifesciences Corp COMM 28176E108 182 1,406 SH   SOLE   1,406 0 0
Fulcrum Therapeutics Inc COMM 359616109 10,927 617,670 SH   SOLE   617,670 0 0
Guardant Health Inc COMM 40131M109 23,261 232,563 SH   SOLE   232,563 0 0
Heron Therapeutics Inc COMM 427746102 26,781 2,933,351 SH   SOLE   2,933,351 0 0
Horizon Therapeutics PLC COMM G46188101 23,900 221,792 SH   SOLE   221,792 0 0
Immatics NV COMM N44445109 13,798 1,026,623 SH   SOLE   1,026,623 0 0
ImmunoGen Inc COMM 45253H101 12,984 1,749,882 SH   SOLE   1,749,882 0 0
Inflarx NV COMM N44821101 5,530 1,161,736 SH   SOLE   1,161,736 0 0
Inhibrx Inc COMM 45720L107 16,100 368,679 SH   SOLE   368,679 0 0
Insmed Inc COMM 457669307 12,034 441,773 SH   SOLE   441,773 0 0
Insulet Corp COMM 45784P101 284 1,066 SH   SOLE   1,066 0 0
Intercept Pharmaceuticals Inc COMM 45845P108 2,450 150,400 SH Call SOLE   150,400 0 0
Intra-Cellular Therapies Inc COMM 46116X101 2,979 56,915 SH   SOLE   56,915 0 0
Invesco QQQ Trust Series 1 COMM 46090E103 39,785 100,000 SH Put SOLE   100,000 0 0
Iveric Bio Inc COMM 46583P102 13,356 798,789 SH   SOLE   798,789 0 0
Jounce Therapeutics Inc COMM 481116101 13,216 1,582,777 SH   SOLE   1,582,777 0 0
Karuna Therapeutics Inc COMM 48576A100 83 636 SH   SOLE   636 0 0
Kura Oncology Inc COMM 50127T109 5,168 369,173 SH   SOLE   369,173 0 0
Kura Oncology Inc COMM 50127T109 2,450 175,000 SH Call SOLE   175,000 0 0
Marinus Pharmaceuticals Inc COMM 56854Q200 2,035 171,338 SH   SOLE   171,338 0 0
Mink Therapeutics Inc COMM 603693102 1,541 345,499 SH   SOLE   345,499 0 0
Natera Inc COMM 632307104 224 2,400 SH   SOLE   2,400 0 0
Novocure Ltd COMM G6674U108 3,754 50,000 SH Call SOLE   50,000 0 0
PTC Therapeutics Inc COMM 69366J200 5,275 132,448 SH   SOLE   132,448 0 0
Protagonist Therapeutics Inc COMM 74366E102 10,281 300,600 SH Call SOLE   300,600 0 0
Protagonist Therapeutics Inc COMM 74366E102 16,493 482,257 SH   SOLE   482,257 0 0
Regenxbio Inc COMM 75901B107 32,964 1,008,081 SH   SOLE   1,008,081 0 0
Roche Holding AG ADR 771195104 70,764 1,369,011 SH   SOLE   1,369,011 0 0
SPDR S&P 500 ETF Trust COMM 78462F103 47,496 100,000 SH Put SOLE   100,000 0 0
Sarepta Therapeutics Inc COMM 803607100 10,872 120,732 SH   SOLE   120,732 0 0
Sierra Oncology Inc COMM 82640U404 4,615 212,281 SH   SOLE   212,281 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 20,822 951,226 SH   SOLE   951,226 0 0
Travere Therapeutics Inc COMM 89422G107 32,308 1,040,858 SH   SOLE   1,040,858 0 0
Uniqure NV COMM N90064101 10,267 495,025 SH   SOLE   495,025 0 0
United Therapeutics Corp COMM 91307C102 28,037 129,754 SH   SOLE   129,754 0 0
Vir Biotechnology Inc COMM 92764N102 8,374 200,000 SH Put SOLE   200,000 0 0
Xencor Inc COMM 98401F105 21,546 537,030 SH   SOLE   537,030 0 0
Zymeworks Inc COMM 98985W102 6,437 392,712 SH   SOLE   392,712 0 0
iRhythm Technologies Inc COMM 450056106 19,876 168,882 SH   SOLE   168,882 0 0
iShares Russell 2000 ETF COMM 464287655 33,368 150,000 SH Put SOLE   150,000 0 0