The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACLARIS THERAPEUTICS INC COM 00461U105 11,632 800,000 SH   DFND 1,2 800,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 4,324 910,251 SH   DFND 1,2 910,251 0 0
ANAPTYSBIO INC COM 032724106 20,581 592,250 SH   DFND 1,2 592,250 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 2,602 668,907 SH   DFND 1,2 668,907 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 49,320 530,670 SH   DFND 1,2 530,670 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 11,885 500,000 SH   DFND 1,2 500,000 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 12,174 200,000 SH   DFND 1,2 200,000 0 0
BIOATLA INC COM 09077B104 16,966 864,300 SH   DFND 1,2 864,300 0 0
CABALETTA BIO INC COM 12674W109 1,791 472,433 SH   DFND 1,2 472,433 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 6,362 390,041 SH   DFND 1,2 390,041 0 0
CYTOKINETICS INC COM NEW 23282W605 15,953 350,000 SH   DFND 1,2 350,000 0 0
DYNE THERAPEUTICS INC COM 26818M108 10,047 845,000 SH   DFND 1,2 845,000 0 0
EXELIXIS INC COM 30161Q104 31,990 1,750,000 SH   DFND 1,2 1,750,000 0 0
GALAPAGOS NV SPON ADR 36315X101 16,539 300,000 SH   DFND 1,2 300,000 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 5,450 411,937 SH   DFND 1,2 411,937 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 6,317 536,738 SH   DFND 1,2 536,738 0 0
MACROGENICS INC COM 556099109 16,050 1,000,000 SH   DFND 1,2 1,000,000 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 5,183 1,170,000 SH   DFND 1,2 1,170,000 0 0
NEKTAR THERAPEUTICS COM 640268108 2,755 203,900 SH Call DFND 1,2 203,900 0 0
PASSAGE BIO INC COM 702712100 9,640 1,518,095 SH   DFND 1,2 1,518,095 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 5,859 1,550,000 SH   DFND 1,2 1,550,000 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 1,067 190,520 SH   DFND 1,2 190,520 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 8,980 1,121,122 SH   DFND 1,2 1,121,122 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101 4,388 400,000 SH   DFND 1,2 400,000 0 0
RAFAEL HLDGS INC COM CL B 75062E106 1,457 285,714 SH   DFND 1,2 285,714 0 0
RELMADA THERAPEUTICS INC COM 75955J402 16,161 717,320 SH   DFND 1,2 717,320 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 13,250 5,000,000 SH   DFND 1,2 5,000,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 10,926 500,526 SH   DFND 1,2 500,526 0 0
SAREPTA THERAPEUTICS INC COM 803607100 13,094 145,405 SH   DFND 1,2 145,405 0 0
SILENCE THERAPEUTICS PLC ADS 82686Q101 10,618 444,443 SH   DFND 1,2 444,443 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 24,832 800,000 SH   DFND 1,2 800,000 0 0
TRICIDA INC COM 89610F101 13,384 1,400,000 SH   DFND 1,2 1,400,000 0 0
UROGEN PHARMA LTD COM M96088105 8,306 873,424 SH   DFND 1,2 873,424 0 0
VAXCYTE INC COM 92243G108 11,895 500,000 SH   DFND 1,2 500,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 18,666 85,000 SH   DFND 1,2 85,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 29,678 950,000 SH   DFND 1,2 950,000 0 0