The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AC IMMUNE SA SHS H00263105 759 153,380 SH   SOLE   153,380 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 1,308 348,716 SH   SOLE   348,716 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 3,102 19,431 SH   SOLE   19,431 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 11,911 70,240 SH   SOLE   70,240 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 35,632 10,573,302 SH   SOLE   10,573,302 0 0
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 30,850 6,440,572 SH   SOLE   6,440,572 0 0
ANAPTYSBIO INC COM 032724106 6,346 182,612 SH   SOLE   182,612 0 0
ANTHEM INC COM 036752103 15,897 34,294 SH   SOLE   34,294 0 0
ARGENX SE SPONSORED ADR 04016X101 7,528 21,496 SH   SOLE   21,496 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302 40,693 664,484 SH   SOLE   664,484 0 0
ARK ETF TR INNOVATION ETF 00214Q104 11,267 119,118 SH   SOLE   119,118 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 54,307 403,678 SH   SOLE   403,678 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 722 310,000 SH   SOLE   310,000 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 55,292 949,224 SH   SOLE   949,224 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 4,606 201,384 SH   SOLE   201,384 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 2,084 401,540 SH   SOLE   401,540 0 0
AVANTOR INC COM 05352A100 47,427 1,125,465 SH   SOLE   1,125,465 0 0
AVROBIO INC COM 05455M100 1,174 304,989 SH   SOLE   304,989 0 0
BIOGEN INC COM 09062X103 7,927 33,041 SH   SOLE   33,041 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 43,428 315,129 SH   SOLE   315,129 0 0
BROOKDALE SR LIVING INC COM 112463104 408 79,146 SH   SOLE   79,146 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 22,893 592,478 SH   SOLE   592,478 0 0
CENTENE CORP DEL COM 15135B101 18,508 224,613 SH   SOLE   224,613 0 0
CERNER CORP COM 156782104 7,222 77,543 SH   SOLE   77,543 0 0
COMMUNITY HEALTH SYS INC NEW COM 203668108 85,045 6,389,538 SH   SOLE   6,389,538 0 0
CUREVAC N V COM N2451R105 2,917 85,017 SH   SOLE   85,017 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 640 371,955 SH   SOLE   371,955 0 0
DANAHER CORPORATION COM 235851102 55,984 170,053 SH   SOLE   170,053 0 0
DEXCOM INC COM 252131107 3,437 6,401 SH   SOLE   6,401 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101 503 114,008 SH   SOLE   114,008 0 0
ENSIGN GROUP INC COM 29358P101 874 10,397 SH   SOLE   10,397 0 0
ENVISTA HOLDINGS CORPORATION COM 29415F104 38,269 849,298 SH   SOLE   849,298 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 1,699 25,137 SH   SOLE   25,137 0 0
EXELIXIS INC COM 30161Q104 9,793 535,700 SH   SOLE   535,700 0 0
F-STAR THERAPEUTICS INC COM 30315R107 251 49,933 SH   SOLE   49,933 0 0
FATE THERAPEUTICS INC COM 31189P102 14,908 254,790 SH   SOLE   254,790 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 25,039 567,205 SH   SOLE   567,205 0 0
GLYCOMIMETICS INC COM 38000Q102 144 100,000 SH   SOLE   100,000 0 0
GOSSAMER BIO INC COM 38341P102 451 39,910 SH   SOLE   39,910 0 0
GRITSTONE BIO INC COM 39868T105 2,188 170,125 SH   SOLE   170,125 0 0
GUARDANT HEALTH INC COM 40131M109 10,035 100,334 SH   SOLE   100,334 0 0
HCA HEALTHCARE INC COM 40412C101 12,613 49,094 SH   SOLE   49,094 0 0
HEALTHEQUITY INC COM 42226A107 14,747 333,352 SH   SOLE   333,352 0 0
HESKA CORP COM RESTRC NEW 42805E306 826 4,525 SH   SOLE   4,525 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 89,845 833,750 SH   SOLE   833,750 0 0
HUMANA INC COM 444859102 12,720 27,382 SH   SOLE   27,382 0 0
ICON PLC SHS G4705A100 16,063 51,867 SH   SOLE   51,867 0 0
INSULET CORP COM 45784P101 8,028 30,172 SH   SOLE   30,172 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 12,132 231,787 SH   SOLE   231,787 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 3,530 9,825 SH   SOLE   9,825 0 0
IONIS PHARMACEUTICALS INC COM 462222100 11,709 384,789 SH   SOLE   384,789 0 0
IQVIA HLDGS INC COM 46266C105 6,946 24,618 SH   SOLE   24,618 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 8,611 73,169 SH   SOLE   73,169 0 0
KARUNA THERAPEUTICS INC COM 48576A100 2,087 15,934 SH   SOLE   15,934 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 14,303 45,522 SH   SOLE   45,522 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 3,143 797,694 SH   SOLE   797,694 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 7,051 1,447,898 SH   SOLE   1,447,898 0 0
LOGICBIO THERAPEUTICS INC COM 54142F102 672 291,101 SH   SOLE   291,101 0 0
MAGELLAN HEALTH INC COM NEW 559079207 9,945 104,700 SH   SOLE   104,700 0 0
MARAVAI LIFESCIENCES HLDGS I COM CL A 56600D107 3,679 87,795 SH   SOLE   87,795 0 0
MCKESSON CORP COM 58155Q103 33,898 136,111 SH   SOLE   136,111 0 0
MERCK & CO INC COM 58933Y105 5,025 19,456 SH   SOLE   19,456 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 415 259,470 SH   SOLE   259,470 0 0
MERUS N V COM N5749R100 604 19,000 SH   SOLE   19,000 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 964 147,165 SH   SOLE   147,165 0 0
MIRATI THERAPEUTICS INC COM 60468T105 2,177 14,840 SH   SOLE   14,840 0 0
MYOMO INC COM NEW 62857J201 1,027 150,000 SH   SOLE   150,000 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 11,220 265,695 SH   SOLE   265,695 0 0
NATERA INC COM 632307104 9,532 102,071 SH   SOLE   102,071 0 0
NEVRO CORP COM 64157F103 5,357 66,074 SH   SOLE   66,074 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 554 419,581 SH   SOLE   419,581 0 0
ORTHO CLINICAL DIAGNOSTICS H ORD SHS G6829J107 18,955 886,140 SH   SOLE   886,140 0 0
PERKINELMER INC COM 714046109 6,207 30,869 SH   SOLE   30,869 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 3,398 1,117,898 SH   SOLE   1,117,898 0 0
QIAGEN NV SHS NEW N72482123 9,034 162,534 SH   SOLE   162,534 0 0
R1 RCM INC COM 749397105 18,688 733,132 SH   SOLE   733,132 0 0
REPLIGEN CORP COM 759916109 1,214 4,584 SH   SOLE   4,584 0 0
SANOFI SPONSORED ADR 80105N105 1,937 38,672 SH   SOLE   38,672 0 0
SI-BONE INC COM 825704109 5,732 258,094 SH   SOLE   258,094 0 0
SONIDA SENIOR LIVING INC COM 140475203 433 15,209 SH   SOLE   15,209 0 0
SURGALIGN HOLDINGS INC COM 86882C105 1,375 1,918,743 SH   SOLE   1,918,743 0 0
SYNEOS HEALTH INC CL A 87166B102 8,791 85,612 SH   SOLE   85,612 0 0
TARO PHARMACEUTICAL INDS LTD SHS M8737E108 9,077 181,151 SH   SOLE   181,151 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 18,435 2,301,498 SH   SOLE   2,301,498 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 84,686 391,920 SH   SOLE   391,920 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 3,847 194,589 SH   SOLE   194,589 0 0
VOCERA COMMUNICATIONS INC COM 92857F107 971 14,970 SH   SOLE   14,970 0 0
XENON PHARMACEUTICALS INC COM 98420N105 6,545 209,519 SH   SOLE   209,519 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 5,309 63,163 SH   SOLE   63,163 0 0
ZOGENIX INC COM NEW 98978L204 8,953 550,966 SH   SOLE   550,966 0 0
ACADIA PHARMACEUTICALS INC CALL 004225908 1,019 846 SH   SOLE   846 0 0
ARK ETF TR CALL 00214Q902 1,356 2,438 SH   SOLE   2,438 0 0
ASTRAZENECA PLC CALL 046353908 16,999 5,723 SH   SOLE   5,723 0 0
COMMUNITY HEALTH SYS INC NEW CALL 203668908 12,454 12,772 SH   SOLE   12,772 0 0
GLAXOSMITHKLINE PLC CALL 37733W905 59,078 15,037 SH   SOLE   15,037 0 0
HORIZON THERAPEUTICS PUB L CALL G46188901 7,522 700 SH   SOLE   700 0 0
ISHARES TR PUT 464287955 7,606 1,250 SH   SOLE   1,250 0 0
ISHARES TR PUT 464287958 3,725 900 SH   SOLE   900 0 0
MERCK & CO INC CALL 58933Y905 2,339 487 SH   SOLE   487 0 0
PROGYNY INC PUT 74340E953 1,067 500 SH   SOLE   500 0 0
INVESCO QQQ TR PUT 46090E953 29,175 2,866 SH   SOLE   2,866 0 0
VERTEX PHARMACEUTICALS INC CALL 92532F900 5,971 941 SH   SOLE   941 0 0
SPDR SER TR CALL 78464A900 1,095 1,138 SH   SOLE   1,138 0 0
TEVA PHARMACEUTICAL INDS LTD CALL 881624909 1,112 9,624 SH   SOLE   9,624 0 0
UNITED THERAPEUTICS CORP DEL CALL 91307C902 1,587 76 SH   SOLE   76 0 0