The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AERIE PHARMACEUTICALS INC COM 00771V108 3,897 555,186 SH   SOLE   555,186 0 0
AKOUOS INC COM 00973J101 9,027 1,061,990 SH   SOLE   1,061,990 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 59,493 500,827 SH   SOLE   500,827 0 0
ALIGOS THERAPEUTICS INC COM 01626L105 31,035 2,614,563 SH   SOLE   2,614,563 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 4,240 25,000 SH   SOLE   25,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 29,570 2,560,211 SH   SOLE   2,560,211 0 0
APPLE INC COM 037833100 163,165 918,879 SH   SOLE   918,879 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 21,101 197,000 SH   SOLE   197,000 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 22,070 4,503,991 SH   SOLE   4,503,991 0 0
BOSTON SCIENTIFIC CORP COM 101137107 147,133 3,463,577 SH   SOLE   3,463,577 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 176,380 2,921,171 SH   SOLE   2,921,171 0 0
CABLE ONE INC COM 12685J105 27,991 15,873 SH   SOLE   15,873 0 0
CHECKMATE PHARMACEUTICALS IN COM 162818108 6,228 2,170,100 SH   SOLE   2,170,100 0 0
CYTEIR THERAPEUTICS INC COM 23284P103 55,035 4,840,413 SH   SOLE   4,840,413 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 85,373 5,587,207 SH   SOLE   5,587,207 0 0
EXSCIENTIA PLC ADS 30223G102 258,591 13,086,600 SH   SOLE   13,086,600 0 0
FREELINE THERAPEUTICS HLDGS SPONSORED ADS 35655L107 3,518 1,776,613 SH   SOLE   1,776,613 0 0
GALECTO INC COM 36322Q107 7,568 2,497,791 SH   SOLE   2,497,791 0 0
GALERA THERAPEUTICS INC COM 36338D108 11,287 2,459,021 SH   SOLE   2,459,021 0 0
INARI MED INC COM 45332Y109 6,591 72,212 SH   SOLE   72,212 0 0
INOGEN INC COM 45780L104 36,473 1,072,735 SH   SOLE   1,072,735 0 0
INSMED INC COM PAR $.01 457669307 18,955 695,840 SH   SOLE   695,840 0 0
INSPIRE MED SYS INC COM 457730109 8,167 35,500 SH   SOLE   35,500 0 0
IO BIOTECH INC COM 449778109 20,979 3,277,932 SH   SOLE   3,277,932 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 15,969 836,518 SH   SOLE   836,518 0 0
KINNATE BIOPHARMA INC COM 49705R105 9,801 553,128 SH   SOLE   553,128 0 0
LAVA THERAPEUTICS NV SHS N51517105 18,300 3,327,312 SH   SOLE   3,327,312 0 0
MARQETA INC CLASS A COM 57142B104 7,582 441,558 SH   SOLE   441,558 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 16,575 2,530,585 SH   SOLE   2,530,585 0 0
MINERVA SURGICAL INC COM 60343F106 10,574 2,057,132 SH   SOLE   2,057,132 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 39,000 2,445,147 SH   SOLE   2,445,147 0 0
MORPHIC HLDG INC COM 61775R105 97,150 2,050,446 SH   SOLE   2,050,446 0 0
NKARTA INC COM 65487U108 42,886 2,793,864 SH   SOLE   2,793,864 0 0
PHARVARIS N V COM N69605108 7,430 516,321 SH   SOLE   516,321 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 4,925 250,000 SH   SOLE   250,000 0 0
PULMONX CORP COM 745848101 7,923 247,047 SH   SOLE   247,047 0 0
RENEO PHARMACEUTICALS INC COM 75974E103 29,330 3,430,377 SH   SOLE   3,430,377 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 13,378 612,822 SH   SOLE   612,822 0 0
SEASPINE HLDGS CORP COM 81255T108 11,696 858,752 SH   SOLE   858,752 0 0
SILK RD MED INC COM 82710M100 6,287 147,557 SH   SOLE   147,557 0 0
SPERO THERAPEUTICS INC COM 84833T103 7,507 468,902 SH   SOLE   468,902 0 0
SPRUCE BIOSCIENCES INC COM 85209E109 20,134 4,514,336 SH   SOLE   4,514,336 0 0
TREACE MED CONCEPTS INC COM 89455T109 9,328 500,421 SH   SOLE   500,421 0 0
VANGUARD INDEX FDS TOTAL STK MKT 922908769 466,921 1,933,900 SH   SOLE   1,933,900 0 0
VECTIVBIO HLDG AG ORD SHS H9060V101 17,293 3,522,019 SH   SOLE   3,522,019 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 5,115 761,205 SH   SOLE   761,205 0 0
VERVE THERAPEUTICS INC COM 92539P101 25,809 700,000 SH   SOLE   700,000 0 0
ZOGENIX INC COM NEW 98978L204 7,191 442,550 SH   SOLE   442,550 0 0