The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 3,382 966,349 SH   DFND 1,2,3,4,5,6 966,349 0 0
23ANDME HOLDING CO CLASS A COM 90138Q108 4,402 661,009 SH   DFND 1,2,3,4,5,6 661,009 0 0
AC IMMUNE SA SHS H00263105 4,950 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 11,299 2,255,375 SH   DFND 1,2,3,4,5,6 2,255,375 0 0
ADAGENE INC ADS 005329107 8,068 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 5,280 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 4,964 1,045,000 SH   DFND 1,2,3,4,5,6 1,045,000 0 0
AGENUS INC COM NEW 00847G705 20,930 6,500,000 SH   DFND 1,2,3,4,5,6 6,500,000 0 0
ALBIREO PHARMA INC COM 01345P106 13,974 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
ALLOVIR INC COM 019818103 30,064 2,323,371 SH   DFND 1,2,3,4,5,6 2,323,371 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 110,227 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 8,213 593,030 SH   DFND 1,2,3,4,5,6 593,030 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 10,745 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
AMBRX BIOPHARMA INC SPONSORED ADS 02290A102 19,435 2,152,291 SH   DFND 1,2,3,4,5,6 2,152,291 0 0
AMICUS THERAPEUTICS INC COM 03152W109 69,300 6,000,000 SH   DFND 1,2,3,4,5,6 6,000,000 0 0
AMRYT PHARMA PLC SPONSORED ADS 03217L106 1,625 150,480 SH   DFND 1,2,3,4,5,6 150,480 0 0
APPLIED THERAPEUTICS INC COM 03828A101 3,580 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
APTINYX INC COM 03836N103 16,331 6,116,493 SH   DFND 1,2,3,4,5,6 6,116,493 0 0
ARAVIVE INC COM 03890D108 2,872 1,311,291 SH   DFND 1,2,3,4,5,6 1,311,291 0 0
ARGENX SE SPONSORED ADR 04016X101 175,095 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 180 33,333 SH   DFND 1,2,3,4,5,6 33,333 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 23,640 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 22,870 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 5,943 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
AXCELLA HEALTH INC COM 05454B105 1,489 712,500 SH   DFND 1,2,3,4,5,6 712,500 0 0
BEIGENE LTD SPONSORED ADR 07725L102 182,878 675,000 SH   DFND 1,2,3,4,5,6 675,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 68,425 8,500,000 SH   DFND 1,2,3,4,5,6 8,500,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 8,776 1,646,517 SH   DFND 1,2,3,4,5,6 1,646,517 0 0
BRIDGEBIO PHARMA INC COM 10806X102 4,170 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 62,350 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
CARDIFF ONCOLOGY INC COM 14147L108 4,508 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
CARIBOU BIOSCIENCES INC COM 142038108 6,117 405,347 SH   DFND 1,2,3,4,5,6 405,347 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 48,630 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 2,944 180,500 SH   DFND 1,2,3,4,5,6 180,500 0 0
CIDARA THERAPEUTICS INC COM 171757107 285 224,675 SH   DFND 1,2,3,4,5,6 224,675 0 0
CITIGROUP INC COM NEW 172967424 60,390 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
CODIAK BIOSCIENCES INC COM 192010106 2,228 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
CONTRAFECT CORP COM NEW 212326300 3,945 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 1,205 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
CULLINAN ONCOLOGY INC COM 230031106 3,858 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
CURIS INC COM NEW 231269200 6,188 1,300,000 SH   DFND 1,2,3,4,5,6 1,300,000 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 4,761 2,768,069 SH   DFND 1,2,3,4,5,6 2,768,069 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 19 11,053 SH   DFND 1,2,3,4 11,053 0 0
CYTOKINETICS INC COM NEW 23282W605 45,580 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 977 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
DENALI THERAPEUTICS INC COM 24823R105 26,760 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
DESIGN THERAPEUTICS INC COM 25056L103 8,564 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
DLOCAL LTD CLASS A COM G29018101 714 20,000 SH   DFND 1,2,3,4,5,6 20,000 0 0
DYNAMICS SPECIAL PURPOSE COR CLASS A COM 268010105 4,930 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
DYNE THERAPEUTICS INC COM 26818M108 6,242 525,000 SH   DFND 1,2,3,4,5,6 525,000 0 0
EQRX INC COM 26886C107 27,280 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
ERASCA INC COM 29479A108 49,423 3,172,221 SH   DFND 1,2,3,4,5,6 3,172,221 0 0
EVELO BIOSCIENCES INC COM 299734103 6,070 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
EVOTEC AG SPONSORED ADS 30050E105 27,299 1,149,425 SH   DFND 1,2,3,4,5,6 1,149,425 0 0
EXSCIENTIA PLC ADS 30223G102 10,868 550,000 SH   DFND 1,2,3,4,5,6 550,000 0 0
FATE THERAPEUTICS INC COM 31189P102 105,318 1,800,000 SH   DFND 1,2,3,4,5,6 1,800,000 0 0
FOGHORN THERAPEUTICS INC COM 344174107 39,353 1,720,720 SH   DFND 1,2,3,4,5,6 1,720,720 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 14,220 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 3,128 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
GDS HLDGS LTD SPONSORED ADS 36165L108 4,716 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
GENERATION BIO CO COM 37148K100 19,924 2,814,191 SH   DFND 1,2,3,4,5,6 2,814,191 0 0
GOSSAMER BIO INC COM 38341P102 26,680 2,358,968 SH   DFND 1,2,3,4,5,6 2,358,968 0 0
GRAPHITE BIO INC COM 38870X104 8,701 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
GRITSTONE BIO INC COM 39868T105 9,645 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
HARPOON THERAPEUTICS INC COM 41358P106 7,550 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
HIPPO HLDGS INC COMMON STOCK 433539103 1,698 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
HOOKIPA PHARMA INC COM 43906K100 1,397 599,616 SH   DFND 1,2,3,4,5,6 599,616 0 0
IGM BIOSCIENCES INC COM 449585108 43,995 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
IKENA ONCOLOGY INC COM 45175G108 19,431 1,549,513 SH   DFND 1,2,3,4,5,6 1,549,513 0 0
I MAB SPONSORED ADS 44975P103 40,282 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
IMMUNIC INC COM 4525EP101 6,699 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 6,848 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
IMMUTEP LTD SPONSORED ADS 45257L108 3,280 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
INSTIL BIO INC COM 45783C101 7,700 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
INTEL CORP COM 458140100 15,450 300,000 SH Call DFND 1,2,3,4,5,6 300,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 32,516 275,000 SH   DFND 1,2,3,4,5,6 275,000 0 0
IQIYI INC SPONSORED ADS 46267X108 4,560 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,289 110,532 SH   DFND 1,2,3,4 110,532 0 0
ITEOS THERAPEUTICS INC COM 46565G104 25,331 544,047 SH   DFND 1,2,3,4,5,6 544,047 0 0
KALEIDO BIOSCIENCES INC COM 483347100 1,196 500,500 SH   DFND 1,2,3,4,5,6 500,500 0 0
KINNATE BIOPHARMA INC COM 49705R105 2,215 125,000 SH   DFND 1,2,3,4,5,6 125,000 0 0
KRONOS BIO INC COM 50107A104 20,969 1,542,954 SH   DFND 1,2,3,4,5,6 1,542,954 0 0
KRYSTAL BIOTECH INC COM 501147102 48,965 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
KURA ONCOLOGY INC COM 50127T109 14,700 1,050,000 SH   DFND 1,2,3,4,5,6 1,050,000 0 0
KYMERA THERAPEUTICS INC COM 501575104 63,490 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
LAVA THERAPEUTICS NV SHS N51517105 1,100 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
LEAP THERAPEUTICS INC COM 52187K101 12,960 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 13,854 3,516,214 SH   DFND 1,2,3,4,5,6 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 266,589 67,662,150 SH   DFND 1,2,3,4 67,662,150 0 0
LYELL IMMUNOPHARMA INC COM 55083R104 5,418 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200 11,880 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
MARRONE BIO INNOVATIONS INC COM 57165B106 755 1,048,679 SH   DFND 1,2,3,4,5,6 1,048,679 0 0
MEI PHARMA INC COM NEW 55279B202 2,670 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 2,400 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106 7,464 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
METACRINE INC COM 59101E103 624 924,898 SH   DFND 1,2,3,4,5,6 924,898 0 0
MINK THERAPEUTICS INC COM 603693102 1,292 289,588 SH   DFND 1,2,3,4,5,6 289,588 0 0
MIRATI THERAPEUTICS INC COM 60468T105 205,366 1,400,000 SH   DFND 1,2,3,4,5,6 1,400,000 0 0
MIRION TECHNOLOGIES INC COM CL A 60471A101 5,235 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
MORPHIC HLDG INC COM 61775R105 75,100 1,585,049 SH   DFND 1,2,3,4,5,6 1,585,049 0 0
NANOBIOTIX SA SPONSORED ADS 63009J107 8,100 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
NEXIMMUNE INC COM 65344D109 5,532 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
NOVAGOLD RES INC COM NEW 66987E206 17,836 2,600,000 SH   DFND 1,2,3,4,5,6 2,600,000 0 0
OATLY GROUP AB SPONSORED ADS 67421J108 11,940 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 2,438 260,500 SH   DFND 1,2,3,4,5,6 260,500 0 0
OMEGA ALPHA SPAC CL A G6749V107 7,328 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
OMEGA THERAPEUTICS INC COMMON STOCK 68217N105 25,759 2,273,530 SH   DFND 1,2,3,4,5,6 2,273,530 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 2,381 1,803,858 SH   DFND 1,2,3,4,5,6 1,803,858 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 5,880 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
OVID THERAPEUTICS INC COM 690469101 8,025 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 3,934 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
PORTAGE FINTECH ACQUISITN CO CLASS A ORD SHS G7185D106 3,781 380,000 SH   DFND 1,2,3,4,5,6 380,000 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 23,640 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 42,750 1,250,000 SH   DFND 1,2,3,4,5,6 1,250,000 0 0
RECURSION PHARMACEUTICALS IN CL A 75629V104 3,426 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
RELAY THERAPEUTICS INC COM 75943R102 23,033 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
REPARE THERAPEUTICS INC COM 760273102 14,763 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
REPLIMUNE GROUP INC COM 76029N106 24,390 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 851 321,100 SH   DFND 1,2,3,4,5,6 321,100 0 0
RIVIAN AUTOMOTIVE INC COM CL A 76954A103 726 7,000 SH   DFND 1,2,3,4,5,6 7,000 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 35,831 3,701,580 SH   DFND 1,2,3,4,5,6 3,701,580 0 0
SAGE THERAPEUTICS INC COM 78667J108 42,540 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 10,635 250,000 SH Call DFND 1,2,3,4,5,6 250,000 0 0
SANA BIOTECHNOLOGY INC COM 799566104 6,192 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 60,858 2,450,000 SH   DFND 1,2,3,4,5,6 2,450,000 0 0
SCHRODINGER INC COM 80810D103 24,381 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
SEAGEN INC COM 81181C104 77,300 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
SEER INC COM CL A 81578P106 108,348 4,750,000 SH   DFND 1,2,3,4,5,6 4,750,000 0 0
SELECTA BIOSCIENCES INC COM 816212104 13,040 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
SIGILON THERAPEUTICS INC COM 82657L107 762 276,000 SH   DFND 1,2,3,4,5,6 276,000 0 0
SOLID BIOSCIENCES INC COM 83422E105 5,250 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 111,960 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 8,005 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 52,683 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
SQZ BIOTECHNOLOGIES CO COM 78472W104 14,344 1,606,309 SH   DFND 1,2,3,4,5,6 1,606,309 0 0
STOKE THERAPEUTICS INC COM 86150R107 5,998 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
SURFACE ONCOLOGY INC COM 86877M209 478 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 9,780 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
TALARIS THERAPEUTICS INC COM 87410C104 31,563 2,064,262 SH   DFND 1,2,3,4,5,6 2,064,262 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 12,126 1,040,882 SH   DFND 1,2,3,4,5,6 1,040,882 0 0
TCR2 THERAPEUTICS INC COM 87808K106 3,495 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
TG THERAPEUTICS INC COM 88322Q108 15,200 800,000 SH   DFND 1,2,3,4,5,6 800,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 11,925 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 21,960 100,000 SH Call DFND 1,2,3,4,5,6 100,000 0 0
VERVE THERAPEUTICS INC COM 92539P101 14,748 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
VOR BIOPHARMA INC COM 929033108 6,391 550,000 SH   DFND 1,2,3,4,5,6 550,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 3,140 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
WW INTL INC COM 98262P101 239,019 14,818,300 SH   DFND 1,2,3,4,7 14,818,300 0 0
XILIO THERAPEUTICS INC COM 98422T100 7,200 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
Y-MABS THERAPEUTICS INC COM 984241109 6,484 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
YUMANITY THERAPEUTICS INC COM 98872L102 643 217,391 SH   DFND 1,2,3,4,5,6 217,391 0 0
ZYMEWORKS INC COM 98985W102 7,376 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0