The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 646 4,334 SH   SOLE   4,334 0 0
3M CO COM 88579Y101 37,150 209,143 SH   SOLE   209,143 0 0
3M CO COM 88579Y101 1 5 SH   OTR 1 0 0 5
89BIO INC COM 282559103 6,381 488,197 SH   SOLE   488,197 0 0
ABBOTT LABS COM 002824100 110,574 785,664 SH   SOLE   785,664 0 0
ABBOTT LABS COM 002824100 5 34 SH   OTR 1 0 0 34
ABBVIE INC COM 00287Y109 46,421 342,845 SH   SOLE   342,845 0 0
ABBVIE INC COM 00287Y109 2 12 SH   OTR 1 0 0 12
ACADIA PHARMACEUTICALS INC COM 004225108 6,432 275,560 SH   SOLE   275,560 0 0
ACTIVISION BLIZZARD INC COM 00507V109 20,421 306,944 SH   SOLE   306,944 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 4 7 SH   OTR 1 0 0 7
ADOBE SYSTEMS INCORPORATED COM 00724F101 130,746 230,569 SH   SOLE   230,569 0 0
ADVANCED DRAIN SYS INC DEL COM 00790R104 57,602 423,140 SH   SOLE   423,140 0 0
ADVANCED DRAIN SYS INC DEL COM 00790R104 5 38 SH   OTR 1 0 0 38
ADVANCED MICRO DEVICES INC COM 007903107 102,205 710,253 SH   SOLE   710,253 0 0
ADVANCED MICRO DEVICES INC COM 007903107 1 9 SH   OTR 1 0 0 9
AERIE PHARMACEUTICALS INC COM 00771V108 1,060 151,000 SH   SOLE   151,000 0 0
AFLAC INC COM 001055102 5 89 SH   OTR 1 0 0 89
AFLAC INC COM 001055102 34,173 585,259 SH   SOLE   585,259 0 0
AGCO CORP COM 001084102 7,480 64,471 SH   SOLE   64,471 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 102,260 640,524 SH   SOLE   640,524 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 6 36 SH   OTR 1 0 0 36
AGNICO EAGLE MINES LTD COM 008474108 692 13,017 SH   SOLE   13,017 0 0
AIR PRODS & CHEMS INC COM 009158106 6 20 SH   OTR 1 0 0 20
AIR PRODS & CHEMS INC COM 009158106 78,298 257,340 SH   SOLE   257,340 0 0
AIRBNB INC COM CL A 009066101 5,360 32,194 SH   SOLE   32,194 0 0
AKAMAI TECHNOLOGIES INC COM 00971T101 3,728 31,854 SH   SOLE   31,854 0 0
AKAMAI TECHNOLOGIES INC NOTE 0.375% 9/0 00971TAL5 10,600 9,000 PRN   SOLE   9,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 1,880 88,876 SH   SOLE   88,876 0 0
AKOYA BIOSCIENCES INC COM 00974H104 770 50,300 SH   SOLE   50,300 0 0
ALBEMARLE CORP COM 012653101 1,694 7,245 SH   SOLE   7,245 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 560 140,000 SH   SOLE   140,000 0 0
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 1,898 8,512 SH   SOLE   8,512 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 3,068 25,823 SH   SOLE   25,823 0 0
ALIGN TECHNOLOGY INC COM 016255101 21,992 33,464 SH   SOLE   33,464 0 0
ALLEGHANY CORP MD COM 017175100 17,299 25,912 SH   SOLE   25,912 0 0
ALLSTATE CORP COM 020002101 3,392 28,829 SH   SOLE   28,829 0 0
ALLY FINL INC COM 02005N100 19,625 412,204 SH   SOLE   412,204 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 40,796 240,571 SH   SOLE   240,571 0 0
ALPHABET INC CAP STK CL A 02079K305 12 4 SH   OTR 1 0 0 4
ALPHABET INC CAP STK CL A 02079K305 560,928 193,621 SH   SOLE   193,621 0 0
ALPHABET INC CAP STK CL C 02079K107 153,736 53,130 SH   SOLE   53,130 0 0
ALTERYX INC COM CL A 02156B103 1,020 16,854 SH   SOLE   16,854 0 0
AMAZON COM INC COM 023135106 3 1 SH   OTR 1 0 0 1
AMAZON COM INC COM 023135106 168,641 50,577 SH   SOLE   50,577 0 0
AMBARELLA INC SHS G037AX101 40,598 200,097 SH   SOLE   200,097 0 0
AMEDISYS INC COM 023436108 2,266 14,000 SH   SOLE   14,000 0 0
AMEDISYS INC COM 023436108 3,687 3,750 PRN   SOLE   3,750 0 0
AMERCO COM 023586100 521 718 SH   SOLE   718 0 0
AMERESCO INC CL A 02361E108 23,337 286,552 SH   SOLE   286,552 0 0
AMERESCO INC CL A 02361E108 2 30 SH   OTR 1 0 0 30
AMERICAN CAMPUS CMNTYS INC COM 024835100 3,091 53,960 SH   SOLE   53,960 0 0
AMERICAN EXPRESS CO COM 025816109 39,855 243,615 SH   SOLE   243,615 0 0
AMERICAN EXPRESS CO COM 025816109 3 16 SH   OTR 1 0 0 16
AMERICAN INTL GROUP INC COM NEW 026874784 3,260 57,337 SH   SOLE   57,337 0 0
AMERICAN TOWER CORP NEW COM 03027X100 12,557 42,931 SH   SOLE   42,931 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 67,046 355,004 SH   SOLE   355,004 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 5 24 SH   OTR 1 0 0 24
AMERIPRISE FINL INC COM 03076C106 2 8 SH   OTR 1 0 0 8
AMERIPRISE FINL INC COM 03076C106 3,735 12,380 SH   SOLE   12,380 0 0
AMERISOURCEBERGEN CORP COM 03073E105 1,263 9,506 SH   SOLE   9,506 0 0
AMETEK INC COM 031100100 2,412 16,407 SH   SOLE   16,407 0 0
AMGEN INC COM 031162100 260,308 1,157,077 SH   SOLE   1,157,077 0 0
AMGEN INC COM 031162100 8 36 SH   OTR 1 0 0 36
AMPHENOL CORP NEW CL A 032095101 2,338 26,731 SH   SOLE   26,731 0 0
ANALOG DEVICES INC COM 032654105 52,636 299,461 SH   SOLE   299,461 0 0
ANDERSONS INC COM 034164103 271 7,000 SH   SOLE   7,000 0 0
ANNALY CAPITAL MANAGEMENT IN COM 035710409 779 99,643 SH   SOLE   99,643 0 0
ANSYS INC COM 03662Q105 61,766 153,983 SH   SOLE   153,983 0 0
ANSYS INC COM 03662Q105 2 6 SH   OTR 1 0 0 6
ANTHEM INC COM 036752103 25,282 54,542 SH   SOLE   54,542 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 32,832 694,425 SH   SOLE   694,425 0 0
APPLE INC COM 037833100 537,303 3,025,865 SH   SOLE   3,025,865 0 0
APPLE INC COM 037833100 19 107 SH   OTR 1 0 0 107
APPLIED MATLS INC COM 038222105 2 11 SH   OTR 1 0 0 11
APPLIED MATLS INC COM 038222105 101,922 647,701 SH   SOLE   647,701 0 0
ARCH CAP GROUP LTD ORD G0450A105 689 15,491 SH   SOLE   15,491 0 0
ARCHER DANIELS MIDLAND CO COM 039483102 2 28 SH   OTR 1 0 0 28
ARCHER DANIELS MIDLAND CO COM 039483102 1,716 25,390 SH   SOLE   25,390 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 30,120 324,079 SH   SOLE   324,079 0 0
ARISTA NETWORKS INC COM 040413106 1,554 10,810 SH   SOLE   10,810 0 0
ARK ETF TR FINTECH INNOVA 00214Q708 1,645 40,276 SH   SOLE   40,276 0 0
ARK ETF TR INNOVATION ETF 00214Q104 1,680 17,760 SH   SOLE   17,760 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 3,924 59,187 SH   SOLE   59,187 0 0
ARVINAS INC COM 04335A105 2 23 SH   OTR 1 0 0 23
ARVINAS INC COM 04335A105 42,900 522,283 SH   SOLE   522,283 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 32,075 238,422 SH   SOLE   238,422 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 4,283 1,838,221 SH   SOLE   1,838,221 0 0
ASSURANT INC COM 04621X108 2 10 SH   OTR 1 0 0 10
ASSURANT INC COM 04621X108 2,484 15,939 SH   SOLE   15,939 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 16 281 SH   OTR 1 0 0 281
ASTRAZENECA PLC SPONSORED ADR 046353108 61,799 1,060,929 SH   SOLE   1,060,929 0 0
AT&T INC COM 00206R102 11,102 451,318 SH   SOLE   451,318 0 0
AT&T INC COM 00206R102 6 255 SH   OTR 1 0 0 255
ATHENE HOLDING LTD CL A G0684D107 15,498 186,230 SH   SOLE   186,230 0 0
ATMOS ENERGY CORP COM 049560105 3,041 29,026 SH   SOLE   29,026 0 0
AUTODESK INC COM 052769106 5 19 SH   OTR 1 0 0 19
AUTODESK INC COM 052769106 130,215 463,086 SH   SOLE   463,086 0 0
AUTOLIV INC COM 052800109 1,264 12,220 SH   SOLE   12,220 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 37,953 153,918 SH   SOLE   153,918 0 0
AUTOZONE INC COM 053332102 2,899 1,383 SH   SOLE   1,383 0 0
AVALONBAY CMNTYS INC COM 053484101 2,920 11,560 SH   SOLE   11,560 0 0
AVANTOR INC COM 05352A100 4,147 98,413 SH   SOLE   98,413 0 0
AVERY DENNISON CORP COM 053611109 5,299 24,466 SH   SOLE   24,466 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 3,803 159,988 SH   SOLE   159,988 0 0
AXSOME THERAPEUTICS INC COM 05464T104 3,565 94,357 SH   SOLE   94,357 0 0
BADGER METER INC COM 056525108 1,587 14,897 SH   SOLE   14,897 0 0
BAIDU INC SPON ADR REP A 056752108 3,547 23,836 SH   SOLE   23,836 0 0
BAKER HUGHES COMPANY CL A 05722G100 1,650 68,588 SH   SOLE   68,588 0 0
BALL CORP COM 058498106 46,412 482,099 SH   SOLE   482,099 0 0
BALL CORP COM 058498106 4 45 SH   OTR 1 0 0 45
BALLARD PWR SYS INC NEW COM 058586108 3,605 286,783 SH   SOLE   286,783 0 0
BANCO BRADESCO S A SP ADR PFD NEW 059460303 457 133,595 SH   SOLE   133,595 0 0
BANCOLOMBIA S A SPON ADR PREF 05968L102 200 6,338 SH   SOLE   6,338 0 0
BANK MONTREAL QUE COM 063671101 14,681 136,170 SH   SOLE   136,170 0 0
BANK NEW YORK MELLON CORP COM 064058100 8,733 150,364 SH   SOLE   150,364 0 0
BANK NEW YORK MELLON CORP COM 064058100 1 23 SH   OTR 1 0 0 23
BANK NOVA SCOTIA B C COM 064149107 16,945 239,020 SH   SOLE   239,020 0 0
BARRICK GOLD CORP COM 067901108 997 52,402 SH   SOLE   52,402 0 0
BATH & BODY WORKS INC COM 070830104 857 12,280 SH   SOLE   12,280 0 0
BAXTER INTL INC COM 071813109 3,798 44,245 SH   SOLE   44,245 0 0
BCE INC COM NEW 05534B760 294 5,644 SH   SOLE   5,644 0 0
BEAM THERAPEUTICS INC COM 07373V105 6,148 77,147 SH   SOLE   77,147 0 0
BECTON DICKINSON & CO COM 075887109 15,984 63,560 SH   SOLE   63,560 0 0
BEIGENE LTD SPONSORED ADR 07725L102 1 3 SH   OTR 1 0 0 3
BEIGENE LTD SPONSORED ADR 07725L102 900 3,321 SH   SOLE   3,321 0 0
BERKLEY W R CORP COM 084423102 3,250 39,441 SH   SOLE   39,441 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 34,624 115,801 SH   SOLE   115,801 0 0
BEST BUY INC COM 086516101 16,356 160,985 SH   SOLE   160,985 0 0
BEYOND MEAT INC COM 08862E109 822 800 PRN   SOLE   800 0 0
BIO RAD LABS INC CL A 090572207 44,606 59,036 SH   SOLE   59,036 0 0
BIO RAD LABS INC CL A 090572207 2 2 SH   OTR 1 0 0 2
BIOATLA INC COM 09077B104 0 16 SH   OTR 1 0 0 16
BIOATLA INC COM 09077B104 7,943 404,620 SH   SOLE   404,620 0 0
BIOGEN INC COM 09062X103 52,273 217,877 SH   SOLE   217,877 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 24,226 274,207 SH   SOLE   274,207 0 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4 842 800 PRN   SOLE   800 0 0
BIONTECH SE SPONSORED ADS 09075V102 61,566 240,902 SH   SOLE   240,902 0 0
BIO-TECHNE CORP COM 09073M104 2 3 SH   OTR 1 0 0 3
BIO-TECHNE CORP COM 09073M104 35,416 68,458 SH   SOLE   68,458 0 0
BK OF AMERICA CORP COM 060505104 119,281 2,681,073 SH   SOLE   2,681,073 0 0
BK OF AMERICA CORP COM 060505104 11 242 SH   OTR 1 0 0 242
BLACKBAUD INC COM 09227Q100 1,267 16,045 SH   SOLE   16,045 0 0
BLACKBERRY LTD COM 09228F103 193 20,650 SH   SOLE   20,650 0 0
BLACKROCK INC COM 09247X101 9,009 9,840 SH   SOLE   9,840 0 0
BLACKSTONE INC COM 09260D107 4,407 34,063 SH   SOLE   34,063 0 0
BLOCK INC CL A 852234103 4,043 25,033 SH   SOLE   25,033 0 0
BLOCK INC NOTE 5/0 852234AJ2 777 750 PRN   SOLE   750 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 37,727 352,230 SH   SOLE   352,230 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 1 13 SH   OTR 1 0 0 13
BOOKING HOLDINGS INC COM 09857L108 55,715 23,222 SH   SOLE   23,222 0 0
BOOKING HOLDINGS INC COM 09857L108 2 1 SH   OTR 1 0 0 1
BOOKING HOLDINGS INC NOTE 0.750% 5/0 09857LAN8 2,066 1,400 PRN   SOLE   1,400 0 0
BOSTON PROPERTIES INC COM 101121101 604 5,245 SH   SOLE   5,245 0 0
BOSTON SCIENTIFIC CORP COM 101137107 3,159 74,371 SH   SOLE   74,371 0 0
BOTTOMLINE TECH DEL INC COM 101388106 5,793 102,580 SH   SOLE   102,580 0 0
BRIDGEBIO PHARMA INC COM 10806X102 6,704 401,912 SH   SOLE   401,912 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 19,241 308,591 SH   SOLE   308,591 0 0
BROADCOM INC COM 11135F101 45,865 68,927 SH   SOLE   68,927 0 0
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 951 5,204 SH   SOLE   5,204 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 1,863 30,801 SH   SOLE   30,801 0 0
BROWN FORMAN CORP CL B 115637209 1,554 21,335 SH   SOLE   21,335 0 0
BRUKER CORP COM 116794108 4,961 59,128 SH   SOLE   59,128 0 0
BRUNSWICK CORP COM 117043109 4,446 44,142 SH   SOLE   44,142 0 0
BRUNSWICK CORP COM 117043109 921 1,000 PRN   SOLE   1,000 0 0
BUNGE LIMITED COM G16962105 747 8,005 SH   SOLE   8,005 0 0
BURLINGTON STORES INC COM 122017106 1,054 3,614 SH   SOLE   3,614 0 0
CABLE ONE INC COM 12685J105 205 116 SH   SOLE   116 0 0
CADENCE DESIGN SYSTEM INC COM 127387108 3 17 SH   OTR 1 0 0 17
CADENCE DESIGN SYSTEM INC COM 127387108 26,071 139,902 SH   SOLE   139,902 0 0
CAESARS ENTERTAINMENT INC NE COM 12769G100 1,044 11,162 SH   SOLE   11,162 0 0
CAMPBELL SOUP CO COM 134429109 853 19,626 SH   SOLE   19,626 0 0
CANADIAN IMP BK COMM COM 136069101 1,202 10,298 SH   SOLE   10,298 0 0
CANADIAN NAT RES LTD COM 136385101 827 19,554 SH   SOLE   19,554 0 0
CANADIAN NATL RY CO COM 136375102 4,281 34,807 SH   SOLE   34,807 0 0
CANADIAN PAC RY LTD COM 13645T100 1,891 26,259 SH   SOLE   26,259 0 0
CAPITAL ONE FINL CORP COM 14040H105 6,006 41,396 SH   SOLE   41,396 0 0
CARDINAL HEALTH INC COM 14149Y108 1,009 19,598 SH   SOLE   19,598 0 0
CARDINAL HEALTH INC COM 14149Y108 2 40 SH   OTR 1 0 0 40
CARLISLE COS INC COM 142339100 330 1,328 SH   SOLE   1,328 0 0
CARMAX INC COM 143130102 989 7,593 SH   SOLE   7,593 0 0
CARNIVAL CORP COMMON STOCK 143658300 1,035 51,422 SH   SOLE   51,422 0 0
CARRIER GLOBAL CORPORATION COM 14448C104 2,883 53,152 SH   SOLE   53,152 0 0
CATALENT INC COM 148806102 991 1,000 PRN   SOLE   1,000 0 0
CATALENT INC COM 148806102 1,232 9,626 SH   SOLE   9,626 0 0
CATERPILLAR INC COM 149123101 11,317 54,741 SH   SOLE   54,741 0 0
CBOE GLOBAL MKTS INC COM 12503M108 789 6,053 SH   SOLE   6,053 0 0
CBRE GROUP INC CL A 12504L109 5,282 48,676 SH   SOLE   48,676 0 0
CDW CORP COM 12514G108 5,622 27,454 SH   SOLE   27,454 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 14,962 387,221 SH   SOLE   387,221 0 0
CENOVUS ENERGY INC COM 15135U109 134 10,908 SH   SOLE   10,908 0 0
CENTENE CORP DEL COM 15135B101 2,801 33,990 SH   SOLE   33,990 0 0
CENTERPOINT ENERGY INC COM 15189T107 1,914 68,570 SH   SOLE   68,570 0 0
CERENCE INC COM 156727109 21,540 281,048 SH   SOLE   281,048 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 3,424 105,599 SH   SOLE   105,599 0 0
CERIDIAN HCM HLDG INC COM 15677J108 636 6,087 SH   SOLE   6,087 0 0
CERNER CORP COM 156782104 1 16 SH   OTR 1 0 0 16
CERNER CORP COM 156782104 10,713 115,353 SH   SOLE   115,353 0 0
CEVA INC COM 157210105 15,829 366,080 SH   SOLE   366,080 0 0
CF INDS HLDGS INC COM 125269100 799 11,288 SH   SOLE   11,288 0 0
CGI INC CL A SUB VTG 12532H104 293 3,311 SH   SOLE   3,311 0 0
CHARLES RIV LABS INTL INC COM 159864107 3 7 SH   OTR 1 0 0 7
CHARLES RIV LABS INTL INC COM 159864107 49,133 130,402 SH   SOLE   130,402 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 8,071 12,380 SH   SOLE   12,380 0 0
CHENIERE ENERGY INC COM NEW 16411R208 2,000 19,722 SH   SOLE   19,722 0 0
CHEVRON CORP NEW COM 166764100 4,117 35,084 SH   SOLE   35,084 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 18,021 1,104,902 SH   SOLE   1,104,902 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 22,194 12,695 SH   SOLE   12,695 0 0
CHUNGHWA TELECOM CO LTD SPON ADR NEW11 17133Q502 400 9,483 SH   SOLE   9,483 0 0
CHURCH & DWIGHT CO INC COM 171340102 1,753 17,105 SH   SOLE   17,105 0 0
CHURCH & DWIGHT CO INC COM 171340102 4 36 SH   OTR 1 0 0 36
CIA ENERGETICA DE MINAS GERA SP ADR N-V PFD 204409601 149 61,369 SH   SOLE   61,369 0 0
CIGNA CORP NEW COM 125523100 3 11 SH   OTR 1 0 0 11
CIGNA CORP NEW COM 125523100 13,050 56,830 SH   SOLE   56,830 0 0
CINCINNATI FINL CORP COM 172062101 810 7,113 SH   SOLE   7,113 0 0
CINTAS CORP COM 172908105 9,333 21,059 SH   SOLE   21,059 0 0
CISCO SYS INC COM 17275R102 5 77 SH   OTR 1 0 0 77
CISCO SYS INC COM 17275R102 86,145 1,359,395 SH   SOLE   1,359,395 0 0
CIT GROUP INC COM NEW 125581801 3,451 67,220 SH   SOLE   67,220 0 0
CITIGROUP INC COM NEW 172967424 4 74 SH   OTR 1 0 0 74
CITIGROUP INC COM NEW 172967424 93,119 1,541,960 SH   SOLE   1,541,960 0 0
CITIZENS FINL GROUP INC COM 174610105 2,732 57,818 SH   SOLE   57,818 0 0
CITRIX SYS INC COM 177376100 388 4,099 SH   SOLE   4,099 0 0
CLOROX CO DEL COM 189054109 2,643 15,156 SH   SOLE   15,156 0 0
CMC MATERIALS INC COM 12571T100 3,061 15,968 SH   SOLE   15,968 0 0
CME GROUP INC COM 12572Q105 5,266 23,049 SH   SOLE   23,049 0 0
COCA COLA CO COM 191216100 59,143 998,874 SH   SOLE   998,874 0 0
COCA COLA CO COM 191216100 2 29 SH   OTR 1 0 0 29
COGENT BIOSCIENCES INC COM 19240Q201 1 119 SH   OTR 1 0 0 119
COGENT BIOSCIENCES INC COM 19240Q201 16,007 1,865,653 SH   SOLE   1,865,653 0 0
COGNEX CORP COM 192422103 739 9,505 SH   SOLE   9,505 0 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 2,564 28,903 SH   SOLE   28,903 0 0
COHERENT INC COM 192479103 12,198 45,763 SH   SOLE   45,763 0 0
COLGATE PALMOLIVE CO COM 194162103 2 19 SH   OTR 1 0 0 19
COLGATE PALMOLIVE CO COM 194162103 23,966 280,829 SH   SOLE   280,829 0 0
COMCAST CORP NEW CL A 20030N101 5 107 SH   OTR 1 0 0 107
COMCAST CORP NEW CL A 20030N101 44,823 890,579 SH   SOLE   890,579 0 0
COMERICA INC COM 200340107 758 8,711 SH   SOLE   8,711 0 0
CONAGRA BRANDS INC COM 205887102 1,821 53,338 SH   SOLE   53,338 0 0
CONOCOPHILLIPS COM 20825C104 5,703 79,016 SH   SOLE   79,016 0 0
CONSOLIDATED EDISON INC COM 209115104 4,390 51,459 SH   SOLE   51,459 0 0
CONSTELLATION BRANDS INC CL A 21036P108 2,704 10,775 SH   SOLE   10,775 0 0
COOPER COS INC COM NEW 216648402 3,800 9,071 SH   SOLE   9,071 0 0
COPART INC COM 217204106 6,129 40,421 SH   SOLE   40,421 0 0
COREPOINT LODGING INC COM 21872L104 1,379 1,300 PRN   SOLE   1,300 0 0
COREPOINT LODGING INC COM 21872L104 9,086 578,705 SH   SOLE   578,705 0 0
CORNING INC COM 219350105 2,151 57,789 SH   SOLE   57,789 0 0
COSTAR GROUP INC COM 22160N109 1,551 19,623 SH   SOLE   19,623 0 0
COSTCO WHSL CORP NEW COM 22160K105 62,676 110,403 SH   SOLE   110,403 0 0
COUCHBASE INC COM 22207T101 21,417 858,038 SH   SOLE   858,038 0 0
COUPA SOFTWARE INC COM 22266L106 995 6,295 SH   SOLE   6,295 0 0
COUPA SOFTWARE INC NOTE 0.375% 6/1 22266LAF3 758 800 PRN   SOLE   800 0 0
CREDICORP LTD COM G2519Y108 6,055 49,600 SH   SOLE   49,600 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 22,700 110,867 SH   SOLE   110,867 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 39,941 191,344 SH   SOLE   191,344 0 0
CROWN HLDGS INC COM 228368106 2 18 SH   OTR 1 0 0 18
CROWN HLDGS INC COM 228368106 3,407 30,802 SH   SOLE   30,802 0 0
CSX CORP COM 126408103 5,465 145,346 SH   SOLE   145,346 0 0
CSX CORP COM 126408103 3 71 SH   OTR 1 0 0 71
CUMMINS INC COM 231021106 4,100 18,793 SH   SOLE   18,793 0 0
CURIS INC COM NEW 231269200 1 152 SH   OTR 1 0 0 152
CURIS INC COM NEW 231269200 19,301 4,054,768 SH   SOLE   4,054,768 0 0
CVS HEALTH CORP COM 126650100 34,759 336,939 SH   SOLE   336,939 0 0
CVS HEALTH CORP COM 126650100 5 45 SH   OTR 1 0 0 45
CYRUSONE INC COM 23283R100 11,809 131,624 SH   SOLE   131,624 0 0
CYRUSONE INC COM 23283R100 1,062 1,000 PRN   SOLE   1,000 0 0
CYTOKINETICS INC COM NEW 23282W605 23,398 513,344 SH   SOLE   513,344 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 7,624 1,760,812 SH   SOLE   1,760,812 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 0 110 SH   OTR 1 0 0 110
D R HORTON INC COM 23331A109 3,934 36,274 SH   SOLE   36,274 0 0
DANAHER CORPORATION COM 235851102 297,037 902,820 SH   SOLE   902,820 0 0
DANAHER CORPORATION COM 235851102 17 53 SH   OTR 1 0 0 53
DARDEN RESTAURANTS INC COM 237194105 1,656 10,994 SH   SOLE   10,994 0 0
DARLING INGREDIENTS INC COM 237266101 41,875 604,347 SH   SOLE   604,347 0 0
DARLING INGREDIENTS INC COM 237266101 3 43 SH   OTR 1 0 0 43
DATADOG INC CL A COM 23804L103 8,342 46,839 SH   SOLE   46,839 0 0
DATADOG INC NOTE 0.125% 6/1 23804LAB9 1,005 500 PRN   SOLE   500 0 0
DAVITA INC COM 23918K108 440 3,872 SH   SOLE   3,872 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 0 25 SH   OTR 1 0 0 25
DECIPHERA PHARMACEUTICALS IN COM 24344T101 5,905 604,354 SH   SOLE   604,354 0 0
DEERE & CO COM 244199105 10,482 30,570 SH   SOLE   30,570 0 0
DELL TECHNOLOGIES INC CL C 24703L202 1 26 SH   OTR 1 0 0 26
DELL TECHNOLOGIES INC CL C 24703L202 5,496 97,838 SH   SOLE   97,838 0 0
DENALI THERAPEUTICS INC COM 24823R105 6,311 141,507 SH   SOLE   141,507 0 0
DENTSPLY SIRONA INC COM 24906P109 2,148 38,504 SH   SOLE   38,504 0 0
DEVON ENERGY CORP NEW COM 25179M103 1,808 41,036 SH   SOLE   41,036 0 0
DEXCOM INC COM 252131107 14,629 27,244 SH   SOLE   27,244 0 0
DEXCOM INC NOTE 0.250%11/1 252131AK3 831 700 PRN   SOLE   700 0 0
DIAGEO PLC SPON ADR NEW 25243Q205 3,969 18,029 SH   SOLE   18,029 0 0
DIAGEO PLC SPON ADR NEW 25243Q205 4 17 SH   OTR 1 0 0 17
DIGITAL RLTY TR INC COM 253868103 2,584 14,611 SH   SOLE   14,611 0 0
DIGITAL TURBINE INC COM NEW 25400W102 305 5,000 SH   SOLE   5,000 0 0
DILLARDS INC CL A 254067101 228 931 SH   SOLE   931 0 0
DISCOVER FINL SVCS COM 254709108 5,022 43,462 SH   SOLE   43,462 0 0
DISCOVERY INC COM SER C 25470F302 782 34,157 SH   SOLE   34,157 0 0
DISH NETWORK CORPORATION NOTE 12/1 25470MAF6 1,998 2,000 PRN   SOLE   2,000 0 0
DISNEY WALT CO COM 254687106 102,732 663,259 SH   SOLE   663,259 0 0
DISNEY WALT CO COM 254687106 7 48 SH   OTR 1 0 0 48
DLOCAL LTD CLASS A COM G29018101 8,230 230,600 SH   SOLE   230,600 0 0
DOCUSIGN INC COM 256163106 11,600 76,159 SH   SOLE   76,159 0 0
DOLLAR GEN CORP NEW COM 256677105 10,928 46,338 SH   SOLE   46,338 0 0
DOLLAR TREE INC COM 256746108 1,593 11,336 SH   SOLE   11,336 0 0
DOMINION ENERGY INC COM 25746U109 4,241 53,980 SH   SOLE   53,980 0 0
DOMINOS PIZZA INC COM 25754A201 2,637 4,673 SH   SOLE   4,673 0 0
DONNELLEY R R & SONS CO COM 257867200 5,790 514,221 SH   SOLE   514,221 0 0
DOVER CORP COM 260003108 3 14 SH   OTR 1 0 0 14
DOVER CORP COM 260003108 3,027 16,667 SH   SOLE   16,667 0 0
DOW INC COM 260557103 5,063 89,263 SH   SOLE   89,263 0 0
DROPBOX INC CL A 26210C104 5,747 234,184 SH   SOLE   234,184 0 0
DUPONT DE NEMOURS INC COM 26614N102 14,418 178,489 SH   SOLE   178,489 0 0
DYNE THERAPEUTICS INC COM 26818M108 3,845 323,393 SH   SOLE   323,393 0 0
EBAY INC. COM 278642103 3,616 54,375 SH   SOLE   54,375 0 0
ECOLAB INC COM 278865100 14,663 62,506 SH   SOLE   62,506 0 0
EDISON INTL COM 281020107 2,860 41,901 SH   SOLE   41,901 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 19,891 153,540 SH   SOLE   153,540 0 0
ELANCO ANIMAL HEALTH INC COM 28414H103 638 22,491 SH   SOLE   22,491 0 0
ELECTRONIC ARTS INC COM 285512109 34,881 264,447 SH   SOLE   264,447 0 0
EMCOR GROUP INC COM 29084Q100 6,249 49,052 SH   SOLE   49,052 0 0
EMERSON ELEC CO COM 291011104 62,435 671,563 SH   SOLE   671,563 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 12,066 161,358 SH   SOLE   161,358 0 0
ENBRIDGE INC COM 29250N105 1,470 37,584 SH   SOLE   37,584 0 0
ENPHASE ENERGY INC COM 29355A107 24,686 134,943 SH   SOLE   134,943 0 0
ENPHASE ENERGY INC COM 29355A107 2 10 SH   OTR 1 0 0 10
ENTERGY CORP NEW COM 29364G103 989 8,779 SH   SOLE   8,779 0 0
ENTERGY CORP NEW COM 29364G103 1,361 1,400 PRN   SOLE   1,400 0 0
EOG RES INC COM 26875P101 2,636 29,670 SH   SOLE   29,670 0 0
EPAM SYS INC COM 29414B104 1,883 2,817 SH   SOLE   2,817 0 0
EQUIFAX INC COM 294429105 2,100 7,174 SH   SOLE   7,174 0 0
EQUINIX INC COM 29444U700 3 4 SH   OTR 1 0 0 4
EQUINIX INC COM 29444U700 46,496 54,970 SH   SOLE   54,970 0 0
EQUITY RESIDENTIAL SH BEN INT 29476L107 17,946 198,303 SH   SOLE   198,303 0 0
ERICSSON ADR B SEK 10 294821608 4,314 396,862 SH   SOLE   396,862 0 0
ESSA PHARMA INC COM NEW 29668H708 0 35 SH   OTR 1 0 0 35
ESSA PHARMA INC COM NEW 29668H708 8,893 626,241 SH   SOLE   626,241 0 0
ESSENTIAL UTILS INC COM 29670G102 1,692 31,521 SH   SOLE   31,521 0 0
ESSEX PPTY TR INC COM 297178105 3,603 10,228 SH   SOLE   10,228 0 0
ETSY INC COM 29786A106 13,596 62,097 SH   SOLE   62,097 0 0
EVEREST RE GROUP LTD COM G3223R108 1,614 5,891 SH   SOLE   5,891 0 0
EVERSOURCE ENERGY COM 30040W108 3,427 37,666 SH   SOLE   37,666 0 0
EXACT SCIENCES CORP COM 30063P105 18,432 236,819 SH   SOLE   236,819 0 0
EXACT SCIENCES CORP COM 30063P105 1 14 SH   OTR 1 0 0 14
EXACT SCIENCES CORP NOTE 0.375% 3/0 30063PAC9 1,950 2,000 PRN   SOLE   2,000 0 0
EXELIXIS INC COM 30161Q104 5,773 5,000 PRN   SOLE   5,000 0 0
EXELIXIS INC COM 30161Q104 2 123 SH   OTR 1 0 0 123
EXELIXIS INC COM 30161Q104 48,491 2,652,691 SH   SOLE   2,652,691 0 0
EXELON CORP COM 30161N101 5,541 95,924 SH   SOLE   95,924 0 0
EXPEDIA GROUP INC COM NEW 30212P303 1,367 7,566 SH   SOLE   7,566 0 0
EXPEDITORS INTL WASH INC COM 302130109 1,635 12,174 SH   SOLE   12,174 0 0
EXPEDITORS INTL WASH INC COM 302130109 3 25 SH   OTR 1 0 0 25
EXTRA SPACE STORAGE INC COM 30225T102 1,321 5,827 SH   SOLE   5,827 0 0
EXXON MOBIL CORP COM 30231G102 22,036 360,127 SH   SOLE   360,127 0 0
FAIR ISAAC CORP COM 303250104 895 2,064 SH   SOLE   2,064 0 0
FASTENAL CO COM 311900104 2 32 SH   OTR 1 0 0 32
FASTENAL CO COM 311900104 3,381 52,776 SH   SOLE   52,776 0 0
FATE THERAPEUTICS INC COM 31189P102 0 8 SH   OTR 1 0 0 8
FATE THERAPEUTICS INC COM 31189P102 14,670 250,729 SH   SOLE   250,729 0 0
FEDEX CORP COM 31428X106 3,588 13,871 SH   SOLE   13,871 0 0
FERRO CORP COM 315405100 4,786 219,249 SH   SOLE   219,249 0 0
FIDELITY NATIONAL FINANCIAL FNF GROUP COM 31620R303 597 11,448 SH   SOLE   11,448 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 3,151 2,800 PRN   SOLE   2,800 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 5,255 48,144 SH   SOLE   48,144 0 0
FIFTH THIRD BANCORP COM 316773100 3,287 75,468 SH   SOLE   75,468 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 10,507 50,879 SH   SOLE   50,879 0 0
FISERV INC COM 337738108 4,316 41,584 SH   SOLE   41,584 0 0
FIVE BELOW INC COM 33829M101 337 1,629 SH   SOLE   1,629 0 0
FLAGSTAR BANCORP INC COM PAR .001 337930705 529 11,041 SH   SOLE   11,041 0 0
FLEETCOR TECHNOLOGIES INC COM 339041105 963 4,304 SH   SOLE   4,304 0 0
FMC CORP COM NEW 302491303 1,095 9,967 SH   SOLE   9,967 0 0
FOMENTO ECONOMICO MEXICANO S SPON ADR UNITS 344419106 232 2,984 SH   SOLE   2,984 0 0
FOOT LOCKER INC COM 344849104 3,167 2,300 PRN   SOLE   2,300 0 0
FOOT LOCKER INC COM 344849104 5,708 130,836 SH   SOLE   130,836 0 0
FORD MTR CO DEL COM 345370860 6,607 318,089 SH   SOLE   318,089 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 4,162 292,692 SH   SOLE   292,692 0 0
FORTERRA INC COM 34960W106 17,476 734,897 SH   SOLE   734,897 0 0
FORTINET INC COM 34959E109 24,340 67,723 SH   SOLE   67,723 0 0
FORTIS INC COM 349553107 616 12,749 SH   SOLE   12,749 0 0
FORTIVE CORP COM 34959J108 1,885 24,707 SH   SOLE   24,707 0 0
FORTIVE CORP NOTE 0.875% 2/1 34959JAK4 14,059 14,000 PRN   SOLE   14,000 0 0
FOX CORP CL A COM 35137L105 414 11,209 SH   SOLE   11,209 0 0
FOX CORP CL B COM 35137L204 974 28,435 SH   SOLE   28,435 0 0
FRANCO NEV CORP COM 351858105 687 4,963 SH   SOLE   4,963 0 0
FRANKLIN RESOURCES INC COM 354613101 1,319 39,383 SH   SOLE   39,383 0 0
FREEPORT-MCMORAN INC CL B 35671D857 1,002 24,000 SH   SOLE   24,000 0 0
FRESHPET INC COM 358039105 954 10,009 SH   SOLE   10,009 0 0
GALLAGHER ARTHUR J & CO COM 363576109 1,518 8,949 SH   SOLE   8,949 0 0
GARTNER INC COM 366651107 3,563 10,657 SH   SOLE   10,657 0 0
GATX CORP COM 361448103 735 7,051 SH   SOLE   7,051 0 0
GENERAC HLDGS INC COM 368736104 1,966 5,586 SH   SOLE   5,586 0 0
GENERAL ELECTRIC CO COM NEW 369604301 7,958 84,241 SH   SOLE   84,241 0 0
GENERAL MLS INC COM 370334104 4,829 71,673 SH   SOLE   71,673 0 0
GENERAL MTRS CO COM 37045V100 5,782 98,616 SH   SOLE   98,616 0 0
GENMAB A/S SPONSORED ADS 372303206 5,473 138,354 SH   SOLE   138,354 0 0
GENMAB A/S SPONSORED ADS 372303206 5 134 SH   OTR 1 0 0 134
GENUINE PARTS CO COM 372460105 1,477 10,537 SH   SOLE   10,537 0 0
GILDAN ACTIVEWEAR INC COM 375916103 1,669 39,320 SH   SOLE   39,320 0 0
GILEAD SCIENCES INC COM 375558103 2 22 SH   OTR 1 0 0 22
GILEAD SCIENCES INC COM 375558103 115,210 1,586,691 SH   SOLE   1,586,691 0 0
GLADSTONE COMMERCIAL CORP COM 376536108 258 10,000 SH   SOLE   10,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 18,977 648,339 SH   SOLE   648,339 0 0
GLOBAL PMTS INC COM 37940X102 2,131 15,766 SH   SOLE   15,766 0 0
GLOBUS MED INC CL A 379577208 4,260 59,000 SH   SOLE   59,000 0 0
GODADDY INC CL A 380237107 1,092 12,867 SH   SOLE   12,867 0 0
GOLD FIELDS LTD SPONSORED ADR 38059T106 319 29,021 SH   SOLE   29,021 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 984 2,573 SH   SOLE   2,573 0 0
GOODYEAR TIRE & RUBR CO COM 382550101 278 13,031 SH   SOLE   13,031 0 0
GRAINGER W W INC COM 384802104 1,834 3,538 SH   SOLE   3,538 0 0
GREAT WESTERN BANCORP INC COM 391416104 13,323 392,323 SH   SOLE   392,323 0 0
GREENSKY INC CL A 39572G100 8,808 775,396 SH   SOLE   775,396 0 0
GUARDANT HEALTH INC COM 40131M109 14,731 147,281 SH   SOLE   147,281 0 0
GUARDANT HEALTH INC COM 40131M109 1 8 SH   OTR 1 0 0 8
GUARDANT HEALTH INC NOTE 11/1 40131MAB5 807 800 PRN   SOLE   800 0 0
HALLIBURTON CO COM 406216101 2,675 116,979 SH   SOLE   116,979 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 1 18 SH   OTR 1 0 0 18
HALOZYME THERAPEUTICS INC COM 40637H109 28,351 705,061 SH   SOLE   705,061 0 0
HANNON ARMSTRONG SUST INFR C COM 41068X100 2 45 SH   OTR 1 0 0 45
HANNON ARMSTRONG SUST INFR C COM 41068X100 22,721 427,724 SH   SOLE   427,724 0 0
HARPOON THERAPEUTICS INC COM 41358P106 0 51 SH   OTR 1 0 0 51
HARPOON THERAPEUTICS INC COM 41358P106 6,112 809,517 SH   SOLE   809,517 0 0
HARTFORD FINL SVCS GROUP INC COM 416515104 2,296 33,254 SH   SOLE   33,254 0 0
HASBRO INC COM 418056107 9,206 90,454 SH   SOLE   90,454 0 0
HCA HEALTHCARE INC COM 40412C101 31,270 121,710 SH   SOLE   121,710 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 2,374 36,490 SH   SOLE   36,490 0 0
HEADHUNTER GROUP PLC SPONSORED ADS 42207L106 7,807 152,800 SH   SOLE   152,800 0 0
HEALTHPEAK PROPERTIES INC COM 42250P103 1,174 32,527 SH   SOLE   32,527 0 0
HEICO CORP NEW CL A 422806208 1,043 8,115 SH   SOLE   8,115 0 0
HENRY JACK & ASSOC INC COM 426281101 6,636 39,740 SH   SOLE   39,740 0 0
HERON THERAPEUTICS INC COM 427746102 493 53,993 SH   SOLE   53,993 0 0
HERSHEY CO COM 427866108 4 22 SH   OTR 1 0 0 22
HERSHEY CO COM 427866108 5,617 29,032 SH   SOLE   29,032 0 0
HESS CORP COM 42809H107 1,204 16,265 SH   SOLE   16,265 0 0
HEWLETT PACKARD ENTERPRISE C COM 42824C109 2,045 129,690 SH   SOLE   129,690 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A203 22,469 144,041 SH   SOLE   144,041 0 0
HOLOGIC INC COM 436440101 87,210 1,139,108 SH   SOLE   1,139,108 0 0
HOLOGIC INC COM 436440101 5 66 SH   OTR 1 0 0 66
HOME DEPOT INC COM 437076102 7 17 SH   OTR 1 0 0 17
HOME DEPOT INC COM 437076102 102,810 247,729 SH   SOLE   247,729 0 0
HONEYWELL INTL INC COM 438516106 2,446 11,730 SH   SOLE   11,730 0 0
HORMEL FOODS CORP COM 440452100 1,821 37,313 SH   SOLE   37,313 0 0
HOST HOTELS & RESORTS INC COM 44107P104 20,583 1,183,611 SH   SOLE   1,183,611 0 0
HOWMET AEROSPACE INC COM 443201108 920 28,908 SH   SOLE   28,908 0 0
HP INC COM 40434L105 2 55 SH   OTR 1 0 0 55
HP INC COM 40434L105 24,026 637,789 SH   SOLE   637,789 0 0
HUAZHU GROUP LTD NOTE 0.375%11/0 16949NAC3 623 600 PRN   SOLE   600 0 0
HUBSPOT INC COM 443573100 1,838 2,788 SH   SOLE   2,788 0 0
HUMANA INC COM 444859102 11,061 23,845 SH   SOLE   23,845 0 0
HUNTINGTON BANCSHARES INC COM 446150104 1,788 115,962 SH   SOLE   115,962 0 0
HUNTINGTON INGALLS INDS INC COM 446413106 363 1,943 SH   SOLE   1,943 0 0
IAC INTERACTIVECORP NEW COM NEW 44891N208 866 6,624 SH   SOLE   6,624 0 0
ICICI BANK LIMITED ADR 45104G104 2,795 141,250 SH   SOLE   141,250 0 0
IDEX CORP COM 45167R104 1,987 8,408 SH   SOLE   8,408 0 0
IDEX CORP COM 45167R104 4 17 SH   OTR 1 0 0 17
IDEXX LABS INC COM 45168D104 35,323 53,645 SH   SOLE   53,645 0 0
IHS MARKIT LTD SHS G47567105 36,420 274,002 SH   SOLE   274,002 0 0
IHS MARKIT LTD SHS G47567105 1 9 SH   OTR 1 0 0 9
ILLINOIS TOOL WKS INC COM 452308109 19,388 78,558 SH   SOLE   78,558 0 0
ILLUMINA INC COM 452327109 91,513 240,546 SH   SOLE   240,546 0 0
ILLUMINA INC COM 452327109 1 3 SH   OTR 1 0 0 3
ILLUMINA INC NOTE 8/1 452327AK5 7,138 6,200 PRN   SOLE   6,200 0 0
INCYTE CORP COM 45337C102 56,843 774,421 SH   SOLE   774,421 0 0
INCYTE CORP COM 45337C102 2 21 SH   OTR 1 0 0 21
INFOSYS LTD SPONSORED ADR 456788108 6,976 275,633 SH   SOLE   275,633 0 0
INGERSOLL RAND INC COM 45687V106 1,805 29,178 SH   SOLE   29,178 0 0
INGREDION INC COM 457187102 291 3,011 SH   SOLE   3,011 0 0
INHIBRX INC COM 45720L107 16,390 375,326 SH   SOLE   375,326 0 0
INSMED INC COM PAR $.01 457669307 26,307 965,755 SH   SOLE   965,755 0 0
INSMED INC NOTE 1.750% 1/1 457669AA7 519 500 PRN   SOLE   500 0 0
INSULET CORP COM 45784P101 4,104 15,423 SH   SOLE   15,423 0 0
INTEL CORP COM 458140100 35,938 697,830 SH   SOLE   697,830 0 0
INTEL CORP COM 458140100 5 89 SH   OTR 1 0 0 89
INTELLIA THERAPEUTICS INC COM 45826J105 11,957 101,127 SH   SOLE   101,127 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 9,574 70,000 SH   SOLE   70,000 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 12,538 93,802 SH   SOLE   93,802 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 5 39 SH   OTR 1 0 0 39
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 3,781 25,101 SH   SOLE   25,101 0 0
INTERNATIONAL PAPER CO COM 460146103 1,137 24,210 SH   SOLE   24,210 0 0
INTERPUBLIC GROUP COS INC COM 460690100 35,514 948,304 SH   SOLE   948,304 0 0
INTERSECT ENT INC COM 46071F103 5,455 199,744 SH   SOLE   199,744 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 6,156 117,617 SH   SOLE   117,617 0 0
INTUIT COM 461202103 61,350 95,379 SH   SOLE   95,379 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 50,771 141,305 SH   SOLE   141,305 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 1,591 4,000 SH   SOLE   4,000 0 0
INVITATION HOMES INC COM 46187W107 32,719 721,641 SH   SOLE   721,641 0 0
IONIS PHARMACEUTICALS INC COM 462222100 28,502 936,635 SH   SOLE   936,635 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 17,111 896,330 SH   SOLE   896,330 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 1 34 SH   OTR 1 0 0 34
IQVIA HLDGS INC COM 46266C105 3 9 SH   OTR 1 0 0 9
IQVIA HLDGS INC COM 46266C105 50,919 180,476 SH   SOLE   180,476 0 0
IRON MTN INC NEW COM 46284V101 767 14,653 SH   SOLE   14,653 0 0
ISHARES INC MSCI CDA ETF 464286509 4,355 113,314 SH   SOLE   113,314 0 0
ISHARES TR GL CLEAN ENE ETF 464288224 214 10,100 SH   SOLE   10,100 0 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 503 134,240 SH   SOLE   134,240 0 0
ITEOS THERAPEUTICS INC COM 46565G104 35,260 757,296 SH   SOLE   757,296 0 0
ITEOS THERAPEUTICS INC COM 46565G104 1 31 SH   OTR 1 0 0 31
IVERIC BIO INC COM 46583P102 20,319 1,215,272 SH   SOLE   1,215,272 0 0
JAZZ INVESTMENTS I LTD NOTE 1.500% 8/1 472145AD3 3,019 3,000 PRN   SOLE   3,000 0 0
JD.COM INC SPON ADR CL A 47215P106 814 11,620 SH   SOLE   11,620 0 0
JEFFERIES FINL GROUP INC COM 47233W109 560 14,436 SH   SOLE   14,436 0 0
JOHNSON & JOHNSON COM 478160104 10 60 SH   OTR 1 0 0 60
JOHNSON & JOHNSON COM 478160104 149,728 875,246 SH   SOLE   875,246 0 0
JOUNCE THERAPEUTICS INC COM 481116101 2,817 337,382 SH   SOLE   337,382 0 0
JOUNCE THERAPEUTICS INC COM 481116101 0 16 SH   OTR 1 0 0 16
JPMORGAN CHASE & CO COM 46625H100 43,768 276,400 SH   SOLE   276,400 0 0
KARUNA THERAPEUTICS INC COM 48576A100 2,496 19,056 SH   SOLE   19,056 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 0 44 SH   OTR 1 0 0 44
KARYOPHARM THERAPEUTICS INC COM 48576U106 5,643 877,624 SH   SOLE   877,624 0 0
KELLOGG CO COM 487836108 2 29 SH   OTR 1 0 0 29
KELLOGG CO COM 487836108 1,910 29,655 SH   SOLE   29,655 0 0
KEROS THERAPEUTICS INC COM 492327101 14,098 240,946 SH   SOLE   240,946 0 0
KEURIG DR PEPPER INC COM 49271V100 1,897 51,460 SH   SOLE   51,460 0 0
KEURIG DR PEPPER INC COM 49271V100 1 33 SH   OTR 1 0 0 33
KEYCORP COM 493267108 8,846 382,468 SH   SOLE   382,468 0 0
KEYSIGHT TECHNOLOGIES INC COM 49338L103 41,595 201,419 SH   SOLE   201,419 0 0
KIMBERLY-CLARK CORP COM 494368103 1 8 SH   OTR 1 0 0 8
KIMBERLY-CLARK CORP COM 494368103 3,753 26,260 SH   SOLE   26,260 0 0
KINDER MORGAN INC DEL COM 49456B101 3,527 222,356 SH   SOLE   222,356 0 0
KINROSS GOLD CORP COM 496902404 464 79,926 SH   SOLE   79,926 0 0
KKR & CO INC COM 48251W104 1,773 23,799 SH   SOLE   23,799 0 0
KLA CORP COM NEW 482480100 20,875 48,533 SH   SOLE   48,533 0 0
KODIAK SCIENCES INC COM 50015M109 2,814 33,186 SH   SOLE   33,186 0 0
KRAFT HEINZ CO COM 500754106 2,349 65,439 SH   SOLE   65,439 0 0
KRATON CORP COM 50077C106 4,475 96,608 SH   SOLE   96,608 0 0
KROGER CO COM 501044101 4 82 SH   OTR 1 0 0 82
KROGER CO COM 501044101 10,042 221,876 SH   SOLE   221,876 0 0
KURA ONCOLOGY INC COM 50127T109 1 36 SH   OTR 1 0 0 36
KURA ONCOLOGY INC COM 50127T109 12,704 907,397 SH   SOLE   907,397 0 0
KYMERA THERAPEUTICS INC COM 501575104 1 17 SH   OTR 1 0 0 17
KYMERA THERAPEUTICS INC COM 501575104 25,574 402,802 SH   SOLE   402,802 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 17,440 55,504 SH   SOLE   55,504 0 0
LAM RESEARCH CORP COM 512807108 11,857 16,487 SH   SOLE   16,487 0 0
LAS VEGAS SANDS CORP COM 517834107 834 22,146 SH   SOLE   22,146 0 0
LAUDER ESTEE COS INC CL A 518439104 2 5 SH   OTR 1 0 0 5
LAUDER ESTEE COS INC CL A 518439104 74,077 200,101 SH   SOLE   200,101 0 0
LENNAR CORP CL A 526057104 1,398 12,038 SH   SOLE   12,038 0 0
LENNOX INTL INC COM 526107107 3,339 10,293 SH   SOLE   10,293 0 0
LIBERTY BROADBAND CORP COM SER C 530307305 1,420 8,816 SH   SOLE   8,816 0 0
LILLY ELI & CO COM 532457108 144,235 522,174 SH   SOLE   522,174 0 0
LILLY ELI & CO COM 532457108 3 12 SH   OTR 1 0 0 12
LINCOLN NATL CORP IND COM 534187109 880 12,886 SH   SOLE   12,886 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 1,218 10,179 SH   SOLE   10,179 0 0
LKQ CORP COM 501889208 2,301 38,334 SH   SOLE   38,334 0 0
LOEWS CORP COM 540424108 2,802 48,510 SH   SOLE   48,510 0 0
LOUISIANA PAC CORP COM 546347105 12,829 163,735 SH   SOLE   163,735 0 0
LOWES COS INC COM 548661107 60,348 233,474 SH   SOLE   233,474 0 0
LULULEMON ATHLETICA INC COM 550021109 19,315 49,342 SH   SOLE   49,342 0 0
LUMEN TECHNOLOGIES INC COM 550241103 861 68,566 SH   SOLE   68,566 0 0
LUMENTUM HLDGS INC NOTE 0.500%12/1 55024UAD1 748 600 PRN   SOLE   600 0 0
LYFT INC CL A COM 55087P104 7,115 166,509 SH   SOLE   166,509 0 0
LYFT INC CL A COM 55087P104 1,440 1,000 PRN   SOLE   1,000 0 0
M & T BK CORP COM 55261F104 1,475 9,605 SH   SOLE   9,605 0 0
MACROGENICS INC COM 556099109 8,791 547,705 SH   SOLE   547,705 0 0
MACROGENICS INC COM 556099109 0 24 SH   OTR 1 0 0 24
MACYS INC COM 55616P104 5,630 215,064 SH   SOLE   215,064 0 0
MAGELLAN HEALTH INC COM NEW 559079207 18,411 193,817 SH   SOLE   193,817 0 0
MAGNA INTL INC COM 559222401 751 9,269 SH   SOLE   9,269 0 0
MANPOWERGROUP INC WIS COM 56418H100 5,332 54,787 SH   SOLE   54,787 0 0
MANULIFE FINL CORP COM 56501R106 1,238 64,854 SH   SOLE   64,854 0 0
MARATHON OIL CORP COM 565849106 1,204 73,309 SH   SOLE   73,309 0 0
MARATHON PETE CORP COM 56585A102 2,309 36,084 SH   SOLE   36,084 0 0
MARKETAXESS HLDGS INC COM 57060D108 1,335 3,246 SH   SOLE   3,246 0 0
MARRIOTT INTL INC NEW CL A 571903202 2,746 16,616 SH   SOLE   16,616 0 0
MARSH & MCLENNAN COS INC COM 571748102 1 7 SH   OTR 1 0 0 7
MARSH & MCLENNAN COS INC COM 571748102 16,930 97,401 SH   SOLE   97,401 0 0
MARTIN MARIETTA MATLS INC COM 573284106 5,605 12,724 SH   SOLE   12,724 0 0
MARVELL TECHNOLOGY INC COM 573874104 3,678 42,039 SH   SOLE   42,039 0 0
MASCO CORP COM 574599106 3 36 SH   OTR 1 0 0 36
MASCO CORP COM 574599106 5,043 71,816 SH   SOLE   71,816 0 0
MASIMO CORP COM 574795100 3,320 11,341 SH   SOLE   11,341 0 0
MASTEC INC COM 576323109 3 32 SH   OTR 1 0 0 32
MASTEC INC COM 576323109 27,031 292,928 SH   SOLE   292,928 0 0
MASTERCARD INCORPORATED CL A 57636Q104 80,617 224,360 SH   SOLE   224,360 0 0
MASTERCARD INCORPORATED CL A 57636Q104 4 10 SH   OTR 1 0 0 10
MATCH GROUP INC NEW COM 57667L107 1,866 14,108 SH   SOLE   14,108 0 0
MATERIALISE NV SPONSORED ADS 57667T100 239 10,000 SH   SOLE   10,000 0 0
MATTEL INC COM 577081102 11,535 535,016 SH   SOLE   535,016 0 0
MCAFEE CORP COM CL A 579063108 8,966 347,651 SH   SOLE   347,651 0 0
MCCORMICK & CO INC COM NON VTG 579780206 24,992 258,687 SH   SOLE   258,687 0 0
MCCORMICK & CO INC COM NON VTG 579780206 2 19 SH   OTR 1 0 0 19
MCDONALDS CORP COM 580135101 1 5 SH   OTR 1 0 0 5
MCDONALDS CORP COM 580135101 68,209 254,445 SH   SOLE   254,445 0 0
MCKESSON CORP COM 58155Q103 1,981 7,969 SH   SOLE   7,969 0 0
MERCADOLIBRE INC COM 58733R102 48,564 36,016 SH   SOLE   36,016 0 0
MERCK & CO INC COM 58933Y105 203,304 2,652,710 SH   SOLE   2,652,710 0 0
MERCK & CO INC COM 58933Y105 11 145 SH   OTR 1 0 0 145
MERSANA THERAPEUTICS INC COM 59045L106 0 79 SH   OTR 1 0 0 79
MERSANA THERAPEUTICS INC COM 59045L106 12,582 2,022,816 SH   SOLE   2,022,816 0 0
MESA LABS INC COM 59064R109 2,164 6,597 SH   SOLE   6,597 0 0
META PLATFORMS INC CL A 30303M102 4 11 SH   OTR 1 0 0 11
META PLATFORMS INC CL A 30303M102 158,730 471,918 SH   SOLE   471,918 0 0
METLIFE INC COM 59156R108 3,923 62,778 SH   SOLE   62,778 0 0
METLIFE INC COM 59156R108 3 54 SH   OTR 1 0 0 54
METTLER TOLEDO INTERNATIONAL COM 592688105 31,639 18,642 SH   SOLE   18,642 0 0
MGM RESORTS INTERNATIONAL COM 552953101 867 19,316 SH   SOLE   19,316 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 2,392 27,473 SH   SOLE   27,473 0 0
MICRON TECHNOLOGY INC COM 595112103 2 20 SH   OTR 1 0 0 20
MICRON TECHNOLOGY INC COM 595112103 6,626 71,137 SH   SOLE   71,137 0 0
MICROSOFT CORP COM 594918104 874,540 2,600,322 SH   SOLE   2,600,322 0 0
MICROSOFT CORP COM 594918104 31 93 SH   OTR 1 0 0 93
MID-AMER APT CMNTYS INC COM 59522J103 8,829 38,479 SH   SOLE   38,479 0 0
MIRATI THERAPEUTICS INC COM 60468T105 72,239 492,463 SH   SOLE   492,463 0 0
MIRATI THERAPEUTICS INC COM 60468T105 3 20 SH   OTR 1 0 0 20
MODERNA INC COM 60770K107 42,990 169,264 SH   SOLE   169,264 0 0
MOLINA HEALTHCARE INC COM 60855R100 847 2,662 SH   SOLE   2,662 0 0
MOLSON COORS BEVERAGE CO CL B 60871R209 655 14,134 SH   SOLE   14,134 0 0
MONDELEZ INTL INC CL A 609207105 2 25 SH   OTR 1 0 0 25
MONDELEZ INTL INC CL A 609207105 36,245 546,602 SH   SOLE   546,602 0 0
MONGODB INC CL A 60937P106 2,195 4,147 SH   SOLE   4,147 0 0
MONOLITHIC PWR SYS INC COM 609839105 893 1,811 SH   SOLE   1,811 0 0
MONSTER BEVERAGE CORP NEW COM 61174X109 2,839 29,560 SH   SOLE   29,560 0 0
MOODYS CORP COM 615369105 11,838 30,310 SH   SOLE   30,310 0 0
MORGAN STANLEY COM NEW 617446448 63,079 642,616 SH   SOLE   642,616 0 0
MORGAN STANLEY COM NEW 617446448 6 63 SH   OTR 1 0 0 63
MORPHOSYS AG SPONSORED ADS 617760202 1 57 SH   OTR 1 0 0 57
MORPHOSYS AG SPONSORED ADS 617760202 5,172 5,000 PRN   SOLE   5,000 0 0
MORPHOSYS AG SPONSORED ADS 617760202 2,532 268,778 SH   SOLE   268,778 0 0
MOSAIC CO NEW COM 61945C103 2,453 62,430 SH   SOLE   62,430 0 0
MOTOROLA SOLUTIONS INC COM NEW 620076307 22,084 81,280 SH   SOLE   81,280 0 0
MSCI INC COM 55354G100 2,616 4,269 SH   SOLE   4,269 0 0
NASDAQ INC COM 631103108 235 1,117 SH   SOLE   1,117 0 0
NATERA INC COM 632307104 894 9,572 SH   SOLE   9,572 0 0
NATIONAL FUEL GAS CO COM 636180101 658 10,284 SH   SOLE   10,284 0 0
NATIONAL HEALTH INVS INC COM 63633D104 575 10,000 SH   SOLE   10,000 0 0
NATURA &CO HLDG S A ADS 63884N108 95 10,298 SH   SOLE   10,298 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 803 155,000 SH   SOLE   155,000 0 0
NEOGENOMICS INC COM NEW 64049M209 9,150 268,178 SH   SOLE   268,178 0 0
NEOGENOMICS INC COM NEW 64049M209 1 16 SH   OTR 1 0 0 16
NEOLEUKIN THERAPEUTICS INC COM 64049K104 4,136 858,118 SH   SOLE   858,118 0 0
NEOLEUKIN THERAPEUTICS INC COM 64049K104 0 55 SH   OTR 1 0 0 55
NETAPP INC COM 64110D104 1,185 12,887 SH   SOLE   12,887 0 0
NETFLIX INC COM 64110L106 20,470 33,978 SH   SOLE   33,978 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 26,395 309,913 SH   SOLE   309,913 0 0
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 36 17,150 SH   SOLE   17,150 0 0
NEWELL BRANDS INC COM 651229106 1,823 83,487 SH   SOLE   83,487 0 0
NEWMONT CORP COM 651639106 15,585 251,294 SH   SOLE   251,294 0 0
NEWMONT CORP COM 651639106 1 19 SH   OTR 1 0 0 19
NEXTERA ENERGY INC COM 65339F101 1 16 SH   OTR 1 0 0 16
NEXTERA ENERGY INC COM 65339F101 21,578 231,124 SH   SOLE   231,124 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 42,061 498,357 SH   SOLE   498,357 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 4 47 SH   OTR 1 0 0 47
NIKE INC CL B 654106103 82,257 493,532 SH   SOLE   493,532 0 0
NIKE INC CL B 654106103 3 17 SH   OTR 1 0 0 17
NIO INC SPON ADS 62914V106 3,445 108,747 SH   SOLE   108,747 0 0
NKARTA INC COM 65487U108 1,044 67,992 SH   SOLE   67,992 0 0
NKARTA INC COM 65487U108 0 4 SH   OTR 1 0 0 4
NOMAD FOODS LTD USD ORD SHS G6564A105 6,650 261,925 SH   SOLE   261,925 0 0
NORDSON CORP COM 655663102 2,576 10,093 SH   SOLE   10,093 0 0
NORFOLK SOUTHN CORP COM 655844108 6,023 20,231 SH   SOLE   20,231 0 0
NORTHERN TR CORP COM 665859104 4,553 38,062 SH   SOLE   38,062 0 0
NORTONLIFELOCK INC COM 668771108 2,977 114,569 SH   SOLE   114,569 0 0
NOVAVAX INC COM NEW 670002401 10,435 72,935 SH   SOLE   72,935 0 0
NU SKIN ENTERPRISES INC CL A 67018T105 3,054 60,171 SH   SOLE   60,171 0 0
NUANCE COMMUNICATIONS INC COM 67020Y100 26,230 474,152 SH   SOLE   474,152 0 0
NUCOR CORP COM 670346105 20,504 179,626 SH   SOLE   179,626 0 0
NUCOR CORP COM 670346105 441 500 PRN   SOLE   500 0 0
NURIX THERAPEUTICS INC COM 67080M103 22,988 794,073 SH   SOLE   794,073 0 0
NURIX THERAPEUTICS INC COM 67080M103 1 30 SH   OTR 1 0 0 30
NUTRIEN LTD COM 67077M108 831 11,046 SH   SOLE   11,046 0 0
NUVATION BIO INC COM CL A 67080N101 0 20 SH   OTR 1 0 0 20
NUVATION BIO INC COM CL A 67080N101 2,515 295,915 SH   SOLE   295,915 0 0
NVIDIA CORPORATION COM 67066G104 181,555 617,304 SH   SOLE   617,304 0 0
NVR INC COM 62944T105 3,244 549 SH   SOLE   549 0 0
OCCIDENTAL PETE CORP COM 674599105 1,407 48,522 SH   SOLE   48,522 0 0
OKTA INC CL A 679295105 6,323 28,206 SH   SOLE   28,206 0 0
OKTA INC NOTE 0.375% 6/1 679295AF2 1,553 1,300 PRN   SOLE   1,300 0 0
OLD DOMINION FREIGHT LINE IN COM 679580100 5,622 15,687 SH   SOLE   15,687 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 3,113 332,551 SH   SOLE   332,551 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 0 21 SH   OTR 1 0 0 21
OMNICOM GROUP INC COM 681919106 1,608 21,941 SH   SOLE   21,941 0 0
ON SEMICONDUCTOR CORP COM 682189105 5 67 SH   OTR 1 0 0 67
ON SEMICONDUCTOR CORP COM 682189105 117,136 1,724,615 SH   SOLE   1,724,615 0 0
ONEOK INC NEW COM 682680103 2,051 34,903 SH   SOLE   34,903 0 0
ONESPAN INC COM 68287N100 1,906 1,300 PRN   SOLE   1,300 0 0
ORACLE CORP COM 68389X105 12,841 147,245 SH   SOLE   147,245 0 0
OREILLY AUTOMOTIVE INC COM 67103H107 2,203 3,119 SH   SOLE   3,119 0 0
ORTHOPEDIATRICS CORP COM 68752L100 5,648 94,352 SH   SOLE   94,352 0 0
OTIS WORLDWIDE CORP COM 68902V107 40,781 468,368 SH   SOLE   468,368 0 0
OTIS WORLDWIDE CORP COM 68902V107 3 34 SH   OTR 1 0 0 34
OUTSET MED INC COM 690145107 5,464 118,555 SH   SOLE   118,555 0 0
OWENS CORNING NEW COM 690742101 3 32 SH   OTR 1 0 0 32
OWENS CORNING NEW COM 690742101 51,781 572,162 SH   SOLE   572,162 0 0
PACCAR INC COM 693718108 450 350 PRN   SOLE   350 0 0
PACCAR INC COM 693718108 3,619 41,007 SH   SOLE   41,007 0 0
PACIRA BIOSCIENCES INC COM 695127100 13,844 230,081 SH   SOLE   230,081 0 0
PACKAGING CORP AMER COM 695156109 681 4,999 SH   SOLE   4,999 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 324 12,350 SH   SOLE   12,350 0 0
PALO ALTO NETWORKS INC COM 697435105 2 4 SH   OTR 1 0 0 4
PALO ALTO NETWORKS INC COM 697435105 113,491 203,842 SH   SOLE   203,842 0 0
PALO ALTO NETWORKS INC NOTE 0.375% 6/0 697435AF2 2,104 1,108,000 PRN   SOLE   1,108,000 0 0
PARKER-HANNIFIN CORP COM 701094104 9,396 29,537 SH   SOLE   29,537 0 0
PAYCHEX INC COM 704326107 1 10 SH   OTR 1 0 0 10
PAYCHEX INC COM 704326107 5,812 42,582 SH   SOLE   42,582 0 0
PAYCOM SOFTWARE INC COM 70432V102 1,092 2,630 SH   SOLE   2,630 0 0
PAYPAL HLDGS INC COM 70450Y103 127,867 678,053 SH   SOLE   678,053 0 0
PAYPAL HLDGS INC COM 70450Y103 3 16 SH   OTR 1 0 0 16
PELOTON INTERACTIVE INC CL A COM 70614W100 777 21,734 SH   SOLE   21,734 0 0
PEMBINA PIPELINE CORP COM 706327103 552 18,183 SH   SOLE   18,183 0 0
PEPSICO INC COM 713448108 28,311 162,979 SH   SOLE   162,979 0 0
PEPSICO INC COM 713448108 5 29 SH   OTR 1 0 0 29
PERKINELMER INC COM 714046109 1,235 6,143 SH   SOLE   6,143 0 0
PERSONALIS INC COM 71535D106 0 21 SH   OTR 1 0 0 21
PERSONALIS INC COM 71535D106 5,030 352,479 SH   SOLE   352,479 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 865 78,778 SH   SOLE   78,778 0 0
PFIZER INC COM 717081103 26,164 443,077 SH   SOLE   443,077 0 0
PHILLIPS 66 COM 718546104 2,727 37,639 SH   SOLE   37,639 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 4,014 1,061,834 SH   SOLE   1,061,834 0 0
PINDUODUO INC NOTE 12/0 722304AC6 6,409 6,154,910 PRN   SOLE   6,154,910 0 0
PINDUODUO INC SPONSORED ADS 722304102 1,163 19,944 SH   SOLE   19,944 0 0
PINTEREST INC CL A 72352L106 1,319 36,294 SH   SOLE   36,294 0 0
PIONEER NAT RES CO COM 723787107 2,157 11,858 SH   SOLE   11,858 0 0
PLANET FITNESS INC CL A 72703H101 5,355 59,115 SH   SOLE   59,115 0 0
PLUG POWER INC COM NEW 72919P202 961 34,038 SH   SOLE   34,038 0 0
PNC FINL SVCS GROUP INC COM 693475105 24,942 124,385 SH   SOLE   124,385 0 0
POOL CORP COM 73278L105 246 434 SH   SOLE   434 0 0
POWER INTEGRATIONS INC COM 739276103 28,149 303,034 SH   SOLE   303,034 0 0
POWER INTEGRATIONS INC COM 739276103 3 30 SH   OTR 1 0 0 30
PPG INDS INC COM 693506107 3,138 18,197 SH   SOLE   18,197 0 0
PRECISION BIOSCIENCES INC COM 74019P108 4,685 633,162 SH   SOLE   633,162 0 0
PRICE T ROWE GROUP INC COM 74144T108 3,195 16,246 SH   SOLE   16,246 0 0
PRINCIPAL FINANCIAL GROUP IN COM 74251V102 1,610 22,256 SH   SOLE   22,256 0 0
PROCTER AND GAMBLE CO COM 742718109 7 44 SH   OTR 1 0 0 44
PROCTER AND GAMBLE CO COM 742718109 162,749 994,921 SH   SOLE   994,921 0 0
PROGRESSIVE CORP COM 743315103 3,659 35,650 SH   SOLE   35,650 0 0
PROLOGIS INC. COM 74340W103 40,795 242,306 SH   SOLE   242,306 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 2,861 83,646 SH   SOLE   83,646 0 0
PRUDENTIAL FINL INC COM 744320102 4 37 SH   OTR 1 0 0 37
PRUDENTIAL FINL INC COM 744320102 5,110 47,213 SH   SOLE   47,213 0 0
PTC INC COM 69370C100 53,993 445,671 SH   SOLE   445,671 0 0
PTC THERAPEUTICS INC COM 69366J200 10,888 273,374 SH   SOLE   273,374 0 0
PUBLIC STORAGE COM 74460D109 4,251 11,350 SH   SOLE   11,350 0 0
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 4,355 65,259 SH   SOLE   65,259 0 0
PULTE GROUP INC COM 745867101 2,411 42,172 SH   SOLE   42,172 0 0
QORVO INC COM 74736K101 516 3,298 SH   SOLE   3,298 0 0
QUALCOMM INC COM 747525103 83,294 455,480 SH   SOLE   455,480 0 0
QUEST DIAGNOSTICS INC COM 74834L100 6,756 39,047 SH   SOLE   39,047 0 0
RADNET INC COM 750491102 10,438 346,655 SH   SOLE   346,655 0 0
RADNET INC COM 750491102 1 20 SH   OTR 1 0 0 20
RAYMOND JAMES FINL INC COM 754730109 3,768 37,530 SH   SOLE   37,530 0 0
REALTY INCOME CORP COM 756109104 2,309 32,252 SH   SOLE   32,252 0 0
REDFIN CORP NOTE 10/1 75737FAC2 449 500 PRN   SOLE   500 0 0
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 184 71,267 SH   SOLE   71,267 0 0
REGENCY CTRS CORP COM 758849103 4,529 60,110 SH   SOLE   60,110 0 0
REGENERON PHARMACEUTICALS COM 75886F107 6 10 SH   OTR 1 0 0 10
REGENERON PHARMACEUTICALS COM 75886F107 230,237 364,576 SH   SOLE   364,576 0 0
REGIONS FINANCIAL CORP NEW COM 7591EP100 3,509 160,963 SH   SOLE   160,963 0 0
RELAY THERAPEUTICS INC COM 75943R102 1 20 SH   OTR 1 0 0 20
RELAY THERAPEUTICS INC COM 75943R102 16,272 529,865 SH   SOLE   529,865 0 0
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REPUBLIC SVCS INC COM 760759100 5 39 SH   OTR 1 0 0 39
REPUBLIC SVCS INC COM 760759100 2,846 20,410 SH   SOLE   20,410 0 0
RESMED INC COM 761152107 16,471 63,232 SH   SOLE   63,232 0 0
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RIGEL PHARMACEUTICALS INC COM NEW 766559603 5,887 2,221,696 SH   SOLE   2,221,696 0 0
RINGCENTRAL INC CL A 76680R206 1,460 7,793 SH   SOLE   7,793 0 0
RINGCENTRAL INC NOTE 3/0 76680RAF4 1,410 1,500 PRN   SOLE   1,500 0 0
ROBERT HALF INTL INC COM 770323103 29,412 263,738 SH   SOLE   263,738 0 0
ROCKWELL AUTOMATION INC COM 773903109 4 12 SH   OTR 1 0 0 12
ROCKWELL AUTOMATION INC COM 773903109 87,403 250,546 SH   SOLE   250,546 0 0
ROGERS COMMUNICATIONS INC CL B 775109200 733 15,382 SH   SOLE   15,382 0 0
ROGERS CORP COM 775133101 11,064 40,528 SH   SOLE   40,528 0 0
ROKU INC COM CL A 77543R102 1,618 7,089 SH   SOLE   7,089 0 0
ROPER TECHNOLOGIES INC COM 776696106 3,439 6,991 SH   SOLE   6,991 0 0
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ROYAL BK CDA COM 780087102 4 35 SH   OTR 1 0 0 35
ROYAL CARIBBEAN GROUP NOTE 4.250% 6/1 780153BB7 384 300 PRN   SOLE   300 0 0
RYDER SYS INC COM 783549108 5,593 67,854 SH   SOLE   67,854 0 0
S&P GLOBAL INC COM 78409V104 43,093 91,313 SH   SOLE   91,313 0 0
S&P GLOBAL INC COM 78409V104 2 4 SH   OTR 1 0 0 4
SAILPOINT TECHNOLOGIES HLDGS COM 78781P105 27,560 570,118 SH   SOLE   570,118 0 0
SALESFORCE COM INC COM 79466L302 104,803 412,401 SH   SOLE   412,401 0 0
SALESFORCE COM INC COM 79466L302 3 11 SH   OTR 1 0 0 11
SBA COMMUNICATIONS CORP NEW CL A 78410G104 4,035 10,373 SH   SOLE   10,373 0 0
SCHLUMBERGER LTD COM STK 806857108 4,095 136,715 SH   SOLE   136,715 0 0
SCHWAB CHARLES CORP COM 808513105 3 38 SH   OTR 1 0 0 38
SCHWAB CHARLES CORP COM 808513105 54,583 649,022 SH   SOLE   649,022 0 0
SEA LTD NOTE 0.250% 9/1 81141RAG5 1,568 1,700 PRN   SOLE   1,700 0 0
SEA LTD SPONSORD ADS 81141R100 465 2,077 SH   SOLE   2,077 0 0
SEAGEN INC COM 81181C104 137,380 888,615 SH   SOLE   888,615 0 0
SEAGEN INC COM 81181C104 5 32 SH   OTR 1 0 0 32
SEER INC COM CL A 81578P106 1,141 50,000 SH   SOLE   50,000 0 0
SEMPRA COM 816851109 5,243 39,635 SH   SOLE   39,635 0 0
SERVICENOW INC COM 81762P102 43,761 67,417 SH   SOLE   67,417 0 0
SHAW COMMUNICATIONS INC CL B CONV 82028K200 333 10,956 SH   SOLE   10,956 0 0
SHERWIN WILLIAMS CO COM 824348106 2 5 SH   OTR 1 0 0 5
SHERWIN WILLIAMS CO COM 824348106 5,742 16,305 SH   SOLE   16,305 0 0
SHINHAN FINANCIAL GROUP CO L SPN ADR RESTRD 824596100 331 10,700 SH   SOLE   10,700 0 0
SHOCKWAVE MED INC COM 82489T104 2,568 14,400 SH   SOLE   14,400 0 0
SHOPIFY INC CL A 82509L107 12,050 8,740 SH   SOLE   8,740 0 0
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SILICON LABORATORIES INC COM 826919102 46,350 224,543 SH   SOLE   224,543 0 0
SILICON LABORATORIES INC NOTE 0.625% 6/1 826919AD4 1,053 600 PRN   SOLE   600 0 0
SIMON PPTY GROUP INC NEW COM 828806109 771 750 PRN   SOLE   750 0 0
SIMON PPTY GROUP INC NEW COM 828806109 2,982 18,663 SH   SOLE   18,663 0 0
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SKECHERS U S A INC CL A 830566105 3,163 72,876 SH   SOLE   72,876 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 1,249 8,054 SH   SOLE   8,054 0 0
SLEEP NUMBER CORP COM 83125X103 2,198 28,699 SH   SOLE   28,699 0 0
SLM CORP COM 78442P106 3,073 156,247 SH   SOLE   156,247 0 0
SMITH A O CORP COM 831865209 4,635 53,990 SH   SOLE   53,990 0 0
SMUCKER J M CO COM NEW 832696405 1,588 11,690 SH   SOLE   11,690 0 0
SNAP INC CL A 83304A106 3,825 81,327 SH   SOLE   81,327 0 0
SNAP ON INC COM 833034101 1,456 6,758 SH   SOLE   6,758 0 0
SNOWFLAKE INC CL A 833445109 3,903 11,523 SH   SOLE   11,523 0 0
SOCIEDAD QUIMICA Y MINERA DE SPON ADR SER B 833635105 72,619 1,439,988 SH   SOLE   1,439,988 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 25,793 91,932 SH   SOLE   91,932 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 2 8 SH   OTR 1 0 0 8
SONY GROUP CORPORATION SPONSORED ADR 835699307 6 44 SH   OTR 1 0 0 44
SONY GROUP CORPORATION SPONSORED ADR 835699307 4,318 34,163 SH   SOLE   34,163 0 0
SOUTHERN COPPER CORP COM 84265V105 16,106 261,000 SH   SOLE   261,000 0 0
SOUTHWEST AIRLS CO NOTE 1.250% 5/0 844741BG2 2,677 2,000 PRN   SOLE   2,000 0 0
SPDR INDEX SHS FDS PORTFOLIO EMG MK 78463X509 252 6,072 SH   SOLE   6,072 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 2,236 5,362 SH Put SOLE   5,362 0 0
SPLUNK INC COM 848637104 20,183 174,410 SH   SOLE   174,410 0 0
SPLUNK INC NOTE 0.500% 9/1 848637AC8 2,148 2,000 PRN   SOLE   2,000 0 0
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SPRINGWORKS THERAPEUTICS INC COM 85205L107 1 11 SH   OTR 1 0 0 11
SPRINGWORKS THERAPEUTICS INC COM 85205L107 10,694 172,545 SH   SOLE   172,545 0 0
SPROUTS FMRS MKT INC COM 85208M102 1,110 37,396 SH   SOLE   37,396 0 0
SPX FLOW INC COM 78469X107 2,894 33,463 SH   SOLE   33,463 0 0
STANLEY BLACK & DECKER INC COM 854502101 2 10 SH   OTR 1 0 0 10
STANLEY BLACK & DECKER INC COM 854502101 28,920 153,325 SH   SOLE   153,325 0 0
STARBUCKS CORP COM 855244109 99,868 853,795 SH   SOLE   853,795 0 0
STARBUCKS CORP COM 855244109 3 22 SH   OTR 1 0 0 22
STATE STR CORP COM 857477103 3,813 41,001 SH   SOLE   41,001 0 0
STEEL DYNAMICS INC COM 858119100 1,222 19,682 SH   SOLE   19,682 0 0
STRYKER CORPORATION COM 863667101 58,750 219,691 SH   SOLE   219,691 0 0
STRYKER CORPORATION COM 863667101 3 13 SH   OTR 1 0 0 13
SUN CMNTYS INC COM 866674104 1,092 5,203 SH   SOLE   5,203 0 0
SUN LIFE FINANCIAL INC. COM 866796105 1,022 18,344 SH   SOLE   18,344 0 0
SUNCOR ENERGY INC NEW COM 867224107 972 1,000 PRN   SOLE   1,000 0 0
SUNCOR ENERGY INC NEW COM 867224107 627 25,017 SH   SOLE   25,017 0 0
SUNRUN INC COM 86771W105 592 17,268 SH   SOLE   17,268 0 0
SVB FINANCIAL GROUP COM 78486Q101 2,201 3,245 SH   SOLE   3,245 0 0
SYNCHRONY FINANCIAL COM 87165B103 24,019 517,761 SH   SOLE   517,761 0 0
SYNOPSYS INC COM 871607107 43,075 116,893 SH   SOLE   116,893 0 0
SYNOPSYS INC COM 871607107 4 10 SH   OTR 1 0 0 10
SYROS PHARMACEUTICALS INC COM 87184Q107 1,905 584,272 SH   SOLE   584,272 0 0
SYSCO CORP COM 871829107 3,175 40,424 SH   SOLE   40,424 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 90,382 751,242 SH   SOLE   751,242 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 2 19 SH   OTR 1 0 0 19
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 1,926 10,839 SH   SOLE   10,839 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 115 29,220 SH   SOLE   29,220 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 5,372 35,688 SH   SOLE   35,688 0 0
TARGET CORP COM 87612E106 37,668 162,756 SH   SOLE   162,756 0 0
TARGET CORP COM 87612E106 2 10 SH   OTR 1 0 0 10
TAYLOR MORRISON HOME CORP COM 87724P106 1,622 46,398 SH   SOLE   46,398 0 0
TC ENERGY CORP COM 87807B107 984 21,122 SH   SOLE   21,122 0 0
TECK RESOURCES LTD CL B 878742204 692 23,981 SH   SOLE   23,981 0 0
TELADOC HEALTH INC COM 87918A105 3,631 39,545 SH   SOLE   39,545 0 0
TELADOC HEALTH INC NOTE 1.250% 6/0 87918AAF2 920 1,000 PRN   SOLE   1,000 0 0
TELEDYNE TECHNOLOGIES INC COM 879360105 858 1,964 SH   SOLE   1,964 0 0
TELEFLEX INCORPORATED COM 879369106 968 2,946 SH   SOLE   2,946 0 0
TELEFONICA BRASIL SA NEW ADR 87936R205 99 11,478 SH   SOLE   11,478 0 0
TELUS CORPORATION COM 87971M103 434 18,403 SH   SOLE   18,403 0 0
TERADYNE INC COM 880770102 997 6,098 SH   SOLE   6,098 0 0
TERNIUM SA SPONSORED ADS 880890108 26,459 607,983 SH   SOLE   607,983 0 0
TESLA INC COM 88160R101 144,033 136,294 SH   SOLE   136,294 0 0
TESLA INC COM 88160R101 2 2 SH   OTR 1 0 0 2
TETRA TECH INC NEW COM 88162G103 40,001 235,577 SH   SOLE   235,577 0 0
TETRA TECH INC NEW COM 88162G103 4 25 SH   OTR 1 0 0 25
TEXAS INSTRS INC COM 882508104 2 10 SH   OTR 1 0 0 10
TEXAS INSTRS INC COM 882508104 66,002 350,200 SH   SOLE   350,200 0 0
TG THERAPEUTICS INC COM 88322Q108 6,725 353,969 SH   SOLE   353,969 0 0
TG THERAPEUTICS INC COM 88322Q108 0 14 SH   OTR 1 0 0 14
THERMO FISHER SCIENTIFIC INC COM 883556102 280,757 420,773 SH   SOLE   420,773 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 13 19 SH   OTR 1 0 0 19
THOMSON REUTERS CORP. COM NEW 884903709 8,750 73,066 SH   SOLE   73,066 0 0
TILLYS INC CL A 886885102 1,933 120,000 SH   SOLE   120,000 0 0
TJX COS INC NEW COM 872540109 47,683 628,064 SH   SOLE   628,064 0 0
T-MOBILE US INC COM 872590104 3,630 31,299 SH   SOLE   31,299 0 0
TOPBUILD CORP COM 89055F103 5 17 SH   OTR 1 0 0 17
TOPBUILD CORP COM 89055F103 44,136 159,967 SH   SOLE   159,967 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 8,204 106,860 SH   SOLE   106,860 0 0
TRACTOR SUPPLY CO COM 892356106 4,593 19,249 SH   SOLE   19,249 0 0
TRANSUNION COM 89400J107 3,773 31,821 SH   SOLE   31,821 0 0
TRAVELERS COMPANIES INC COM 89417E109 14,680 93,843 SH   SOLE   93,843 0 0
TRAVELERS COMPANIES INC COM 89417E109 2 10 SH   OTR 1 0 0 10
TREACE MED CONCEPTS INC COM 89455T109 596 32,000 SH   SOLE   32,000 0 0
TREX CO INC COM 89531P105 18,692 138,425 SH   SOLE   138,425 0 0
TREX CO INC COM 89531P105 2 14 SH   OTR 1 0 0 14
TRIMBLE INC COM 896239100 7 81 SH   OTR 1 0 0 81
TRIMBLE INC COM 896239100 119,128 1,366,304 SH   SOLE   1,366,304 0 0
TRINITY INDS INC COM 896522109 2,160 71,531 SH   SOLE   71,531 0 0
TRISTATE CAP HLDGS INC COM 89678F100 6,273 207,290 SH   SOLE   207,290 0 0
TRUIST FINL CORP COM 89832Q109 5,067 86,543 SH   SOLE   86,543 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 27,450 575,463 SH   SOLE   575,463 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 1 25 SH   OTR 1 0 0 25
TWILIO INC CL A 90138F102 9,154 34,761 SH   SOLE   34,761 0 0
TWIST BIOSCIENCE CORP COM 90184D100 5,637 72,841 SH   SOLE   72,841 0 0
TWITTER INC COM 90184L102 2,010 46,509 SH   SOLE   46,509 0 0
TYLER TECHNOLOGIES INC COM 902252105 962 1,789 SH   SOLE   1,789 0 0
UDR INC COM 902653104 16,001 266,730 SH   SOLE   266,730 0 0
UGI CORP NEW COM 902681105 1,721 37,478 SH   SOLE   37,478 0 0
ULTA BEAUTY INC COM 90384S303 2,588 6,277 SH   SOLE   6,277 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 4,161 49,480 SH   SOLE   49,480 0 0
UMPQUA HLDGS CORP COM 904214103 10,831 562,932 SH   SOLE   562,932 0 0
UNDER ARMOUR INC CL A 904311107 1,037 48,933 SH   SOLE   48,933 0 0
UNDER ARMOUR INC CL C 904311206 1,081 59,900 SH   SOLE   59,900 0 0
UNILEVER PLC SPON ADR NEW 904767704 1,578 29,340 SH   SOLE   29,340 0 0
UNILEVER PLC SPON ADR NEW 904767704 3 49 SH   OTR 1 0 0 49
UNION PAC CORP COM 907818108 11,458 45,480 SH   SOLE   45,480 0 0
UNITED NAT FOODS INC COM 911163103 935 19,045 SH   SOLE   19,045 0 0
UNITED PARCEL SERVICE INC CL B 911312106 20,830 97,181 SH   SOLE   97,181 0 0
UNITED RENTALS INC COM 911363109 4,946 14,884 SH   SOLE   14,884 0 0
UNITEDHEALTH GROUP INC COM 91324P102 171,367 341,274 SH   SOLE   341,274 0 0
UNITEDHEALTH GROUP INC COM 91324P102 9 17 SH   OTR 1 0 0 17
UNIVERSAL DISPLAY CORP COM 91347P105 1 6 SH   OTR 1 0 0 6
UNIVERSAL DISPLAY CORP COM 91347P105 35,919 217,651 SH   SOLE   217,651 0 0
US BANCORP DEL COM NEW 902973304 4,674 5,200 PRN   SOLE   5,200 0 0
US BANCORP DEL COM NEW 902973304 4,270 76,021 SH   SOLE   76,021 0 0
V F CORP COM 918204108 1,691 23,089 SH   SOLE   23,089 0 0
VAIL RESORTS INC COM 91879Q109 7,927 24,175 SH   SOLE   24,175 0 0
VAIL RESORTS INC NOTE 1/0 91879QAN9 535 500 PRN   SOLE   500 0 0
VALERO ENERGY CORP COM 91913Y100 2,175 28,963 SH   SOLE   28,963 0 0
VALMONT INDS INC COM 920253101 3,300 13,174 SH   SOLE   13,174 0 0
VARONIS SYS INC COM 922280102 32,474 665,722 SH   SOLE   665,722 0 0
VEEVA SYS INC CL A COM 922475108 5,827 22,808 SH   SOLE   22,808 0 0
VENTAS INC COM 92276F100 1,800 35,203 SH   SOLE   35,203 0 0
VEONEER INC COM 92336X109 6,829 192,470 SH   SOLE   192,470 0 0
VERISIGN INC COM 92343E102 1,984 7,818 SH   SOLE   7,818 0 0
VERISIGN INC COM 92343E102 3 11 SH   OTR 1 0 0 11
VERISK ANALYTICS INC COM 92345Y106 1,955 8,549 SH   SOLE   8,549 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 13,380 257,513 SH   SOLE   257,513 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 5 89 SH   OTR 1 0 0 89
VERTEX PHARMACEUTICALS INC COM 92532F100 2 7 SH   OTR 1 0 0 7
VERTEX PHARMACEUTICALS INC COM 92532F100 141,560 644,625 SH   SOLE   644,625 0 0
VIACOMCBS INC CL B 92556H206 1,060 35,119 SH   SOLE   35,119 0 0
VIATRIS INC COM 92556V106 3,620 267,552 SH   SOLE   267,552 0 0
VIAVI SOLUTIONS INC NOTE 1.000% 3/0 925550AB1 212 150 PRN   SOLE   150 0 0
VIEWRAY INC COM 92672L107 10,192 1,849,771 SH   SOLE   1,849,771 0 0
VIEWRAY INC COM 92672L107 1 108 SH   OTR 1 0 0 108
VISA INC COM CL A 92826C839 8 35 SH   OTR 1 0 0 35
VISA INC COM CL A 92826C839 126,636 584,358 SH   SOLE   584,358 0 0
VMWARE INC CL A COM 928563402 3 27 SH   OTR 1 0 0 27
VMWARE INC CL A COM 928563402 42,118 363,464 SH   SOLE   363,464 0 0
VONAGE HLDGS CORP COM 92886T201 11,931 556,276 SH   SOLE   556,276 0 0
VORNADO RLTY TR SH BEN INT 929042109 983 23,494 SH   SOLE   23,494 0 0
VULCAN MATLS CO COM 929160109 1,839 8,861 SH   SOLE   8,861 0 0
WABTEC COM 929740108 9,000 97,708 SH   SOLE   97,708 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 3,294 63,147 SH   SOLE   63,147 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 1 26 SH   OTR 1 0 0 26
WALMART INC COM 931142103 2,078 14,364 SH   SOLE   14,364 0 0
WASTE CONNECTIONS INC COM 94106B101 50,316 369,238 SH   SOLE   369,238 0 0
WASTE CONNECTIONS INC COM 94106B101 4 32 SH   OTR 1 0 0 32
WASTE MGMT INC DEL COM 94106L109 13 75 SH   OTR 1 0 0 75
WASTE MGMT INC DEL COM 94106L109 134,775 807,520 SH   SOLE   807,520 0 0
WATERS CORP COM 941848103 9,931 26,654 SH   SOLE   26,654 0 0
WAYFAIR INC CL A 94419L101 869 4,573 SH   SOLE   4,573 0 0
WAYFAIR INC NOTE 0.625%10/0 94419LAM3 914 1,000 PRN   SOLE   1,000 0 0
WELLS FARGO CO NEW COM 949746101 13,107 273,166 SH   SOLE   273,166 0 0
WELLTOWER INC COM 95040Q104 2,574 30,005 SH   SOLE   30,005 0 0
WEST PHARMACEUTICAL SVSC INC COM 955306105 28,346 60,439 SH   SOLE   60,439 0 0
WESTERN DIGITAL CORP. COM 958102105 1,030 15,794 SH   SOLE   15,794 0 0
WESTERN DIGITAL CORP. NOTE 1.500% 2/0 958102AP0 10,172 10,000 PRN   SOLE   10,000 0 0
WESTERN UN CO COM 959802109 2 95 SH   OTR 1 0 0 95
WESTERN UN CO COM 959802109 2,547 142,787 SH   SOLE   142,787 0 0
WESTROCK CO COM 96145D105 551 12,422 SH   SOLE   12,422 0 0
WEYERHAEUSER CO MTN BE COM NEW 962166104 1,658 40,263 SH   SOLE   40,263 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 610 14,209 SH   SOLE   14,209 0 0
WHIRLPOOL CORP COM 963320106 746 3,181 SH   SOLE   3,181 0 0
WILEY JOHN & SONS INC CL A 968223206 1,286 22,462 SH   SOLE   22,462 0 0
WILLIAMS COS INC COM 969457100 3,168 121,671 SH   SOLE   121,671 0 0
WORKDAY INC CL A 98138H101 3,040 11,129 SH   SOLE   11,129 0 0
WP CAREY INC COM 92936U109 1,133 13,808 SH   SOLE   13,808 0 0
WP CAREY INC COM 92936U109 2 20 SH   OTR 1 0 0 20
WYNN RESORTS LTD COM 983134107 674 7,920 SH   SOLE   7,920 0 0
XENCOR INC COM 98401F105 33,352 831,311 SH   SOLE   831,311 0 0
XENCOR INC COM 98401F105 1 28 SH   OTR 1 0 0 28
XENON PHARMACEUTICALS INC COM 98420N105 16,573 530,511 SH   SOLE   530,511 0 0
XILINX INC COM 983919101 18,704 88,213 SH   SOLE   88,213 0 0
XP INC CL A G98239109 1,483 51,615 SH   SOLE   51,615 0 0
XYLEM INC COM 98419M100 41,958 349,880 SH   SOLE   349,880 0 0
XYLEM INC COM 98419M100 3 26 SH   OTR 1 0 0 26
YAMANA GOLD INC COM 98462Y100 140 33,100 SH   SOLE   33,100 0 0
YETI HLDGS INC COM 98585X104 3,274 39,526 SH   SOLE   39,526 0 0
Y-MABS THERAPEUTICS INC COM 984241109 0 12 SH   OTR 1 0 0 12
Y-MABS THERAPEUTICS INC COM 984241109 2,977 183,680 SH   SOLE   183,680 0 0
YUM BRANDS INC COM 988498101 3,326 3,000 PRN   SOLE   3,000 0 0
YUM BRANDS INC COM 988498101 2,789 20,088 SH   SOLE   20,088 0 0
YUM CHINA HLDGS INC COM 98850P109 493 9,900 SH   SOLE   9,900 0 0
ZAI LAB LTD ADR 98887Q104 6,759 107,539 SH   SOLE   107,539 0 0
ZAI LAB LTD ADR 98887Q104 0 7 SH   OTR 1 0 0 7
ZEBRA TECHNOLOGIES CORPORATI CL A 989207105 14,710 24,715 SH   SOLE   24,715 0 0
ZENDESK INC COM 98936J101 1,121 10,752 SH   SOLE   10,752 0 0
ZENDESK INC NOTE 0.625% 6/1 98936JAD3 778 650 PRN   SOLE   650 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 11,450 136,217 SH   SOLE   136,217 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 1 9 SH   OTR 1 0 0 9
ZILLOW GROUP INC CL C CAP STK 98954M200 847 13,271 SH   SOLE   13,271 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 10,282 80,937 SH   SOLE   80,937 0 0
ZIONS BANCORPORATION N A COM 989701107 430 6,803 SH   SOLE   6,803 0 0
ZOETIS INC CL A 98978V103 12,120 49,667 SH   SOLE   49,667 0 0
ZOGENIX INC COM NEW 98978L204 7,808 480,497 SH   SOLE   480,497 0 0
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 2,361 12,838 SH   SOLE   12,838 0 0
ZSCALER INC COM 98980G102 10,514 32,719 SH   SOLE   32,719 0 0
ZYNGA INC NOTE 12/1 98986TAD0 738 800 PRN   SOLE   800 0 0