The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACLARIS THERAPEUTICS INC COM 00461U105 9,000 500,000 SH   DFND 1,2 500,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 7,155 900,000 SH   DFND 1,2 900,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 2,378 249,000 SH   DFND 1,2 249,000 0 0
ANAPTYSBIO INC COM 032724106 14,904 549,545 SH   DFND 1,2 549,545 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 6,592 200,000 SH Call DFND 1,2 200,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 31,601 530,670 SH   DFND 1,2 530,670 0 0
BIOATLA INC COM 09077B104 24,847 844,002 SH   DFND 1,2 844,002 0 0
BIOGEN INC COM 09062X103 13,442 47,500 SH   DFND 1,2 47,500 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 2,395 121,342 SH   DFND 1,2 121,342 0 0
CYTOKINETICS INC COM NEW 23282W605 13,990 391,429 SH   DFND 1,2 391,429 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 7,635 1,500,000 SH   DFND 1,2 1,500,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 16,128 799,999 SH   DFND 1,2 799,999 0 0
DYNE THERAPEUTICS INC COM 26818M108 12,099 745,000 SH   DFND 1,2 745,000 0 0
EXELIXIS INC COM 30161Q104 32,239 1,525,000 SH   DFND 1,2 1,525,000 0 0
INFLARX NV COM N44821101 1,429 551,918 SH   DFND 1,2 551,918 0 0
KADMON HLDGS INC COM 48283N106 29,396 3,375,000 SH   DFND 1,2 3,375,000 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 5,467 480,000 SH   DFND 1,2 480,000 0 0
MACROGENICS INC COM 556099109 20,940 1,000,000 SH   DFND 1,2 1,000,000 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 8,518 1,170,000 SH   DFND 1,2 1,170,000 0 0
NEKTAR THERAPEUTICS COM 640268108 9,064 504,691 SH   DFND 1,2 504,691 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 9,070 329,086 SH   DFND 1,2 329,086 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 7,090 220,863 SH   DFND 1,2 220,863 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 254 30,336 SH   DFND 1,2 30,336 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 9,113 1,300,000 SH   DFND 1,2 1,300,000 0 0
RAFAEL HLDGS INC COM CL B 75062E106 8,780 285,714 SH   DFND 1,2 285,714 0 0
REPARE THERAPEUTICS INC COM 760273102 2,444 93,137 SH   DFND 1,2 93,137 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 7,187 1,980,000 SH   DFND 1,2 1,980,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 22,866 765,000 SH   DFND 1,2 765,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 11,920 269,010 SH   DFND 1,2 269,010 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 15,156 625,000 SH   DFND 1,2 625,000 0 0
TRICIDA INC COM 89610F101 9,159 1,974,000 SH   DFND 1,2 1,974,000 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 15,997 86,667 SH   DFND 1,2 86,667 0 0
UROGEN PHARMA LTD COM M96088105 12,615 750,000 SH   DFND 1,2 750,000 0 0
VAXCYTE INC COM 92243G108 2,488 98,061 SH   DFND 1,2 98,061 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 15,418 85,000 SH   DFND 1,2 85,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 10,696 700,000 SH   DFND 1,2 700,000 0 0