The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 178,977 549,820 SH   SOLE 0 549,820 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 38,832 2,337,877 SH   SOLE 0 2,337,877 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 1,412 160,800 SH   SOLE 0 160,800 0 0
ALIGN TECHNOLOGY INC COM 016255101 36,868 55,405 SH   SOLE 0 55,405 0 0
ALIMERA SCIENCES INC COM NEW 016259202 848 200,919 SH   SOLE 0 200,919 0 0
ALKERMES PLC SHS G01767105 18,193 589,900 SH   SOLE 0 589,900 0 0
AMICUS THERAPEUTICS INC COM 03152W109 96,589 10,114,043 SH   SOLE 0 10,114,043 0 0
ANAPTYSBIO INC COM 032724106 11,840 436,592 SH   SOLE 0 436,592 0 0
ASTRAZENECA PLC-SPONS ADR SPONSORED ADR 046353108 12,101 201,489 SH   SOLE 0 201,489 0 0
ATHENEX INC COM 04685N103 958 318,200 SH   SOLE 0 318,200 0 0
BIOGEN INC COM 09062X103 102,329 361,600 SH   SOLE 0 361,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 171,039 2,212,950 SH   SOLE 0 2,212,950 0 0
CLOVIS ONCOLOGY INC COM 189464100 20,000 4,484,411 SH   SOLE 0 4,484,411 0 0
CYTOKINETICS INC COM NEW 23282W605 4,421 123,686 SH   SOLE 0 123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 17,251 855,713 SH   SOLE 0 855,713 0 0
EHEALTH INC COM 28238P109 46,408 1,145,870 SH   SOLE 0 1,145,870 0 0
EPIZYME INC COM 29428V104 35,105 6,856,513 SH   SOLE 0 6,856,513 0 0
GOSSAMER BIO INC COM 38341P102 22,286 1,772,950 SH   SOLE 0 1,772,950 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 25,448 2,356,282 SH   SOLE 0 2,356,282 0 0
IDERA PHARMACEUTICALS INC COM PAR 45168K405 79 77,044 SH   SOLE 0 77,044 0 0
INSMED INC COM PAR $.01 457669307 165,766 6,019,106 SH   SOLE 0 6,019,106 0 0
KALEIDO BIOSCIENCES INC COM 483347100 4,294 786,400 SH   SOLE 0 786,400 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 31,329 5,383,052 SH   SOLE 0 5,383,052 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 5,670 656,200 SH   SOLE 0 656,200 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 3,147 432,300 SH   SOLE 0 432,300 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200 357 31,330 SH   SOLE 0 31,330 0 0
MINERVA NEUROSCIENCES INC COM 603380106 63 36,319 SH   SOLE 0 36,319 0 0
PROTHENA CORP PLC SHS G72800108 120,043 1,685,282 SH   SOLE 0 1,685,282 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 9,765 1,392,997 SH   SOLE 0 1,392,997 0 0
REVANCE THERAPEUTICS INC COM 761330109 89,204 3,201,866 SH   SOLE 0 3,201,866 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 2,368 652,395 SH   SOLE 0 652,395 0 0
SAGE THERAPEUTICS INC COM 78667J108 27,380 617,930 SH   SOLE 0 617,930 0 0
STAAR SURGICAL CO COM PAR $.01 852312305 146,590 1,140,511 SH   SOLE 0 1,140,511 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 8,502 444,900 SH   SOLE 0 444,900 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 360 80,600 SH   SOLE 0 80,600 0 0
TACTILE SYSTEMS TECHNOLOGY I COM 87357P100 1,205 27,100 SH   SOLE 0 27,100 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 4,027 166,069 SH   SOLE 0 166,069 0 0
UNITED THERAPEUTICS CORP COM 91307C102 126,844 687,206 SH   SOLE 0 687,206 0 0
UROGEN PHARMA LTD COM M96088105 412 24,500 SH   SOLE 0 24,500 0 0
VANDA PHARMACEUTICALS INC COM 921659108 64,992 3,791,805 SH   SOLE 0 3,791,805 0 0
VIRACTA THERAPEUTICS INC COM 92765F108 266 33,212 SH   SOLE 0 33,212 0 0
ZOGENIX INC COM NEW 98978L204 3,261 214,700 SH   SOLE 0 214,700 0 0