The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AKERO THERAPEUTICS INC | COM | 00973Y108 | 78 | 3,470 | SH | DFND | 1,2 | 3,470 | 0 | 0 | |
| ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 3,098 | 41,950 | SH | DFND | 1,2 | 41,950 | 0 | 0 | |
| BEAM THERAPEUTICS INC | COM | 07373V105 | 4,777 | 54,903 | SH | DFND | 1,2 | 54,903 | 0 | 0 | |
| BOLT BIOTHERAPEUTICS INC | COM | 097702104 | 14,762 | 1,166,952 | SH | DFND | 1,2 | 1,166,952 | 0 | 0 | |
| DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | 1,818 | 370,950 | SH | DFND | 1,2 | 370,950 | 0 | 0 | |
| DYNE THERAPEUTICS INC | COM | 26818M108 | 189 | 11,629 | SH | DFND | 1,2 | 11,629 | 0 | 0 | |
| EARGO INC | COM | 270087109 | 19,428 | 2,886,724 | SH | DFND | 1,2 | 2,886,724 | 0 | 0 | |
| EXACT SCIENCES CORP | COM | 30063P105 | 1,667 | 17,464 | SH | DFND | 1,2 | 17,464 | 0 | 0 | |
| EXELIXIS INC | COM | 30161Q104 | 1,357 | 64,200 | SH | DFND | 1,2 | 64,200 | 0 | 0 | |
| FLUENT INC | COM | 34380C102 | 442 | 194,800 | SH | DFND | 1,2 | 194,800 | 0 | 0 | |
| GALERA THERAPEUTICS INC | COM | 36338D108 | 4,967 | 613,223 | SH | DFND | 1,2 | 613,223 | 0 | 0 | |
| HARMONY BIOSCIENCES HLDGS IN | COM | 413197104 | 29,465 | 768,708 | SH | DFND | 1,2 | 768,708 | 0 | 0 | |
| ILLUMINA INC | COM | 452327109 | 52,586 | 129,647 | SH | DFND | 1,2 | 129,647 | 0 | 0 | |
| INVITAE CORP | COM | 46185L103 | 4,113 | 144,667 | SH | DFND | 1,2 | 144,667 | 0 | 0 | |
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 | 1,374 | 78,720 | SH | DFND | 1,2 | 78,720 | 0 | 0 | |
| KARUNA THERAPEUTICS INC | COM | 48576A100 | 28,724 | 234,811 | SH | DFND | 1,2 | 234,811 | 0 | 0 | |
| NEW FRONTIER HEALTH CORP | ORD SHS | G6461G106 | 93,771 | 8,350,000 | SH | DFND | 1,2 | 8,350,000 | 0 | 0 | |
| NEW FRONTIER HEALTH CORP | *W EXP 11/30/202 | G6461G114 | 4,456 | 1,580,000 | SH | DFND | 1,2 | 1,580,000 | 0 | 0 | |
| OTONOMY INC | COM | 68906L105 | 1,634 | 851,000 | SH | DFND | 1,2 | 851,000 | 0 | 0 | |
| RANI THERAPEUTICS HLDGS INC | COM CL A | 753018100 | 8,796 | 493,584 | SH | DFND | 1,2 | 493,584 | 0 | 0 | |
| REATA PHARMACEUTICALS INC | CL A | 75615P103 | 832 | 8,265 | SH | DFND | 1,2 | 8,265 | 0 | 0 | |
| RUBIUS THERAPEUTICS INC | COM | 78116T103 | 1,015 | 56,768 | SH | DFND | 1,2 | 56,768 | 0 | 0 | |
| SATSUMA PHARMACEUTICALS INC | COM | 80405P107 | 666 | 142,900 | SH | DFND | 1,2 | 142,900 | 0 | 0 | |
| SIERRA ONCOLOGY INC | COM NEW | 82640U404 | 1,161 | 52,979 | SH | DFND | 1,2 | 52,979 | 0 | 0 | |
| SOMALOGIC INC | CLASS A COM | 83444K105 | 21,020 | 1,696,558 | SH | DFND | 1,2 | 1,696,558 | 0 | 0 | |
| SYNLOGIC INC | COM | 87166L100 | 209 | 68,634 | SH | DFND | 1,2 | 68,634 | 0 | 0 | |
| VIR BIOTECHNOLOGY INC | COM | 92764N102 | 6,972 | 160,211 | SH | DFND | 1,2 | 160,211 | 0 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 3,024 | 197,880 | SH | DFND | 1,2 | 197,880 | 0 | 0 | |