The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abeona Therapeutics Inc COM 00289Y107 3,203 2,859,767 SH   SOLE   2,859,767 0 0
Advanced Micro Deviced Inc COM 007903107 1,270 12,350 SH   SOLE   12,350 0 0
Aldeyra Therapeutics Inc COM 01438T106 4,999 569,405 SH   SOLE   569,405 0 0
Altimmune Inc COM NEW 02155H200 1,504 132,978 SH   SOLE   132,978 0 0
Altria Group Inc COM 02209S103 1,033 22,700 SH   SOLE   22,700 0 0
Angion BioMedica Corp COM 03476J107 586 60,000 SH   SOLE   60,000 0 0
Anavex Life Sciemves Corp COM NEW 003279730 3,784 210,789 SH   SOLE   210,789 0 0
Annovis COM 03615A108 451 14,210 SH   SOLE   14,210 0 0
Applied genetiv therapies COM 03820J100 301 100,000 SH   SOLE   100,000 0 0
Applied Therapeutics Inc COM 03828A101 17,133 1,032,123 SH   SOLE   1,032,123 0 0
Arista Networks Inc COM 040413106 1,186 3,450 SH   SOLE   3,450 0 0
ASML Holdings N Y REGISTRY SHS N07059210 912 1,280 SH   SOLE   1,280 0 0
Biohaven Pharmactl Hldg Co L COM G11196105 119,024 856,844 SH   SOLE   856,844 0 0
BioXCel Therapeutics Inc COM 09075P105 607 20,000 SH   SOLE   20,000 0 0
Blackstone Group LP COM UNIT LTD 09253U108 2,792 24,000 SH   SOLE   24,000 0 0
Booz Allen Hamilton HLDG COR CL A 099502106 1,032 13,000 SH   SOLE   13,000 0 0
Corbus Pharmaceuticals HLDGS COM 21833P103 5,147 5,045,870 SH   SOLE   5,045,870 0 0
Corning Inc COM 219350105 971 26,600 SH   SOLE   26,600 0 0
CVS Health Corp COM 126650100 1,230 14,500 SH   SOLE   14,500 0 0
Eiger Biopharmaceuticals Inc COM 28249U105 4,637 694,232 SH   SOLE   694,232 0 0
Entera Bio Ltd SHS M40527109 11,701 2,484,275 SH   SOLE   2,484,275 0 0
Exicure COM 30205M101 962 801,922 SH   SOLE   801,922 0 0
Lumen Technologies Inc COM 156700106 1,239 100,000 SH   SOLE   100,000 0 0
Orgenesis, Inc. COM 68619K105 6,516 1,316,364 SH   SOLE   1,316,364 0 0
Soligenix Inc. COM 834223307 835 787,830 SH   SOLE   787,830 0 0
Thermo Fischer Scientific Inc COM 883556102 1,200 2,100 SH   SOLE   2,100 0 0
Visa COM CL A 92826C839 1,080 4,850 SH   SOLE   4,850 0 0
VMWare Inc CL A COM 928563402 1,033 6,950 SH   SOLE   6,950 0 0
FRANCO NEV CORP COM 351858105 487 3,750 SH   SOLE   3,750 0 0
MAVERIX METALS INC COM NEW 57776F405 514 115,000 SH   SOLE   115,000 0 0
AGNICO EAGLE MINES LTD COM 008474108 358 6,900 SH   SOLE   6,900 0 0
KIRKLAND LAKE GOLD LTD COM 49741E100 447 10,750 SH   SOLE   10,750 0 0
EQUINOX GOLD CORP COM 29446Y502 300 45,500 SH   SOLE   45,500 0 0
SEABRIDGE GOLD INC COM 811916105 494 32,000 SH   SOLE   32,000 0 0
OSISKO GOLD ROYALTIES LTD COM 68827L101 357 190,000 SH   SOLE   190,000 0 0
FORTUNA SILVER MINES INC COM 349915108 172 43,700 SH   SOLE   43,700 0 0
MAG SILVER CORP COM 55903Q104 280 17,300 SH   SOLE   17,300 0 0
PAN AMERN SILVER CORP COM 697900108 191 8,200 SH   SOLE   8,200 0 0
SILVERCREST METALS INC COM 828363101 293 42,000 SH   SOLE   42,000 0 0
SILVERCORP METALS INC COM 82835P103 267 70,000 SH   SOLE   70,000 0 0