The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACLARIS THERAPEUTICS INC COM 00461U105 27,000 1,500,000 SH   DFND 1 1,500,000 0 0
AEROVATE THERAPEUTICS INC COM 008064107 41,962 2,030,691 SH   DFND 1 2,030,691 0 0
AGENUS INC COM NEW 00847G705 25,240 4,807,557 SH   DFND 1 4,807,557 0 0
AKERO THERAPEUTICS INC COM 00973Y108 13,410 600,000 SH   DFND 1 600,000 0 0
AKOUOS INC COM 00973J101 4,580 394,500 SH   DFND 1 394,500 0 0
ALIGOS THERAPEUTICS INC COM 01626L105 10,348 667,167 SH   DFND 1 667,167 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 74,752 1,012,079 SH   DFND 1 1,012,079 0 0
AMBRX BIOPHARMA INC SPONSORED ADS 02290A102 33,097 2,486,386 SH   DFND 1 2,486,386 0 0
ANAPTYSBIO INC COM 032724106 10,443 385,081 SH   DFND 1 385,081 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 30,488 925,000 SH   DFND 1 925,000 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 6,540 3,000,000 SH   DFND 1 3,000,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 27,096 170,000 SH   DFND 1 170,000 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 4,888 552,903 SH   DFND 1 552,903 0 0
ATEA PHARMACEUTICALS INC COM 04683R106 172,802 4,928,756 SH   DFND 1 4,928,756 0 0
ATRECA INC CL A COM 04965G109 1,704 273,500 SH   DFND 1 273,500 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 2,569 392,167 SH   DFND 1 392,167 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 53,253 2,162,115 SH   DFND 1 2,162,115 0 0
AXONICS INC COM 05465P101 20,975 322,240 SH   DFND 1 322,240 0 0
BEAM THERAPEUTICS INC COM 07373V105 8,701 100,000 SH   DFND 1 100,000 0 0
BIOATLA INC COM 09077B104 53,450 1,815,546 SH   DFND 1 1,815,546 0 0
BIOMEA FUSION INC COM 09077A106 37,955 3,170,872 SH   DFND 1 3,170,872 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 15,422 150,000 SH   DFND 1 150,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 82,909 1,768,909 SH   DFND 1 1,768,909 0 0
CABALETTA BIO INC COM 12674W109 19,597 1,611,623 SH   DFND 1 1,611,623 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100 28,724 1,727,273 SH   DFND 1 1,727,273 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 11,950 500,000 SH   DFND 1 500,000 0 0
CYTOKINETICS INC COM NEW 23282W605 35,740 1,000,000 SH   DFND 1 1,000,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 4,908 144,439 SH   DFND 1 144,439 0 0
DERMTECH INC COM 24984K105 9,633 300,000 SH   DFND 1 300,000 0 0
DESIGN THERAPEUTICS INC COM 25056L103 78,810 5,364,850 SH   DFND 1 5,364,850 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 55,957 3,370,914 SH   DFND 1 3,370,914 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101 8,065 1,305,095 SH   DFND 1 1,305,095 0 0
ELEVATION ONCOLOGY INC COM 28623U101 15,140 1,983,165 SH   DFND 1 1,983,165 0 0
ERASCA INC COM 29479A108 216,845 10,505,550 SH   DFND 1 10,505,550 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 109,468 4,720,495 SH   DFND 1 4,720,495 0 0
GALECTO INC COM 36322Q107 4,131 1,150,730 SH   DFND 1 1,150,730 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 13,147 608,123 SH   DFND 1 608,123 0 0
GOSSAMER BIO INC COM 38341P102 2,494 198,382 SH   DFND 1 198,382 0 0
GRAPHITE BIO INC COM 38870X104 3,263 203,153 SH   DFND 1 203,153 0 0
HARPOON THERAPEUTICS INC COM 41358P106 4,271 540,600 SH   DFND 1 540,600 0 0
HELIX ACQUISITION CORP COM CL A G4444C102 4,275 430,000 SH   DFND 1 430,000 0 0
I MAB SPONSORED ADS 44975P103 14,498 200,000 SH   DFND 1 200,000 0 0
ICOSAVAX INC COM 45114M109 12,238 426,393 SH   DFND 1 426,393 0 0
IGM BIOSCIENCES INC COM 449585108 23,016 350,000 SH   DFND 1 350,000 0 0
IMMUNEERING CORP CLASS A COM 45254E107 58,451 2,252,626 SH   DFND 1 2,252,626 0 0
IMV INC COM 44974L103 385 234,374 SH   DFND 1 234,374 0 0
INSPIRE MED SYS INC COM 457730109 11,209 48,132 SH   DFND 1 48,132 0 0
ITEOS THERAPEUTICS INC COM 46565G104 7,785 288,330 SH   DFND 1 288,330 0 0
LONGBOARD PHARMACEUTICALS IN COM 54300N103 20,155 2,273,221 SH   DFND 1 2,273,221 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 3,481 478,200 SH   DFND 1 478,200 0 0
MERUS N V COM N5749R100 5,500 250,000 SH   DFND 1 250,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 167 95,744 SH   DFND 1 95,744 0 0
MIRATI THERAPEUTICS INC COM 60468T105 21,229 120,000 SH   DFND 1 120,000 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102 67,957 3,102,199 SH   DFND 1 3,102,199 0 0
MORPHIC HLDG INC COM 61775R105 5,664 100,000 SH   DFND 1 100,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 6,732 300,000 SH   DFND 1 300,000 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 84,705 3,073,485 SH   DFND 1 3,073,485 0 0
OMEROS CORP COM 682143102 13,100 950,000 SH   DFND 1 950,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 590 256,649 SH   DFND 1 256,649 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 54 270,698 SH   DFND 1 270,698 0 0
PHARVARIS N V COM N69605108 12,229 689,731 SH   DFND 1 689,731 0 0
PLIANT THERAPEUTICS INC COM 729139105 8,143 482,413 SH   DFND 1 482,413 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 18,937 1,024,161 SH   DFND 1 1,024,161 0 0
PRECISION BIOSCIENCES INC COM 74019P108 3,999 346,524 SH   DFND 1 346,524 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 43,817 1,848,024 SH   DFND 1 1,848,024 0 0
QUOTIENT LTD SHS G73268107 2,340 1,000,000 SH   DFND 1 1,000,000 0 0
RAIN THERAPEUTICS INC COM 75082Q105 34,807 2,326,660 SH   DFND 1 2,326,660 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 10,061 100,000 SH   DFND 1 100,000 0 0
RENOVACOR INC COM 75989E106 4,525 500,000 SH   DFND 1 500,000 0 0
REVOLUTION MEDICINES INC COM 76155X100 86,511 3,144,700 SH   DFND 1 3,144,700 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 28,950 968,550 SH   DFND 1 968,550 0 0
SORRENTO THERAPEUTICS INC COM NEW 83587F202 3,052 400,000 SH   DFND 1 400,000 0 0
STOKE THERAPEUTICS INC COM 86150R107 32,519 1,278,276 SH   DFND 1 1,278,276 0 0
TALARIS THERAPEUTICS INC COM 87410C104 16,349 1,215,847 SH   DFND 1 1,215,847 0 0
TANGO THERAPEUTICS INC COM 87583X109 48,814 3,899,185 SH   DFND 1 3,899,185 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 31,136 1,444,831 SH   DFND 1 1,444,831 0 0
TCR2 THERAPEUTICS INC COM 87808K106 4,081 479,506 SH   DFND 1 479,506 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 8,488 350,000 SH   DFND 1 350,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 188,814 2,842,297 SH   DFND 1 2,842,297 0 0
TYRA BIOSCIENCES INC COM 90240B106 18,154 1,069,932 SH   DFND 1 1,069,932 0 0
UNIQURE NV SHS N90064101 7,668 239,548 SH   DFND 1 239,548 0 0
VECTIVBIO HLDG AG ORD SHS H9060V101 17,197 2,226,128 SH   DFND 1 2,226,128 0 0
VERU INC COM 92536C103 6,824 800,000 SH   DFND 1 800,000 0 0
VERVE THERAPEUTICS INC COM 92539P101 32,667 709,224 SH   DFND 1 709,224 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 5,635 342,562 SH   DFND 1 342,562 0 0
X4 PHARMACEUTICALS INC COM 98420X103 550 103,980 SH   DFND 1 103,980 0 0
Y-MABS THERAPEUTICS INC COM 984241109 14,270 500,000 SH   DFND 1 500,000 0 0
ZYMEWORKS INC COM 98985W102 27,588 950,000 SH   DFND 1 950,000 0 0