The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aerovate Therapeutics, Inc. COMM 008064107 78,857 3,758,686 SH   SOLE   3,758,686 0 0
Akouos, Inc. COMM 00973J101 17,590 1,515,074 SH   SOLE   1,515,074 0 0
Amarin Corp ADR 023111206 5,457 1,069,968 SH   SOLE   1,069,968 0 0
Ascendis Pharma A/S ADR 04351P101 79,667 499,824 SH   SOLE   499,824 0 0
Bolt Biotherapeutics, Inc. COMM 097702104 34,844 2,754,437 SH   SOLE   2,754,437 0 0
Checkmate Pharmaceuticals Inc COMM 162818108 14,319 3,606,707 SH   SOLE   3,606,707 0 0
Fusion Pharmaceuticals Inc COMM 36118A100 618 78,066 SH   SOLE   78,066 0 0
Galera Therapeutics, Inc. COMM 36338D108 24,978 3,083,712 SH   SOLE   3,083,712 0 0
Inozyme Pharma, Inc. COMM 45790W108 23,508 2,028,308 SH   SOLE   2,028,308 0 0
Karuna Therapeutics, Inc. COMM 48576A100 238,920 1,953,077 SH   SOLE   1,953,077 0 0
Natera Inc COMM 632307104 345,794 3,102,960 SH   SOLE   3,102,960 0 0
Nextcure, Inc COMM 65343E108 18,008 2,671,856 SH   SOLE   2,671,856 0 0
Nucana Plc ADR 67022C106 14,448 5,599,999 SH   SOLE   5,599,999 0 0
Nucana Plc Ordinary Shares GB00BYWYV 6,192 2,400,000 SH   SOLE   2,400,000 0 0
ObsEva SA COMM H5861P103 14,771 4,749,623 SH   SOLE   4,749,623 0 0
PDS Biotechnology Corporation COMM 70465T107 2,125 142,635 SH   SOLE   142,635 0 0
Synlogic Inc. COMM 87166L100 1,754 574,972 SH   SOLE   574,972 0 0
Vera Therapeutics, Inc. CL A 92337R101 50,571 2,914,776 SH   SOLE   2,914,776 0 0
Y-mAbs Therapeutics, Inc. COMM 984241109 62,625 2,194,278 SH   SOLE   2,194,278 0 0
ALX Oncology Holdings Inc COMM 00166B105 7,919 107,220 SH   SOLE   107,220 0 0
Abbvie Inc COMM 00287Y109 29,405 272,600 SH   SOLE   272,600 0 0
Acceleron Pharma Inc COMM 00434H108 6,813 39,589 SH   SOLE   39,589 0 0
Agenus Inc COMM 00847G705 12,308 2,344,410 SH   SOLE   2,344,410 0 0
Align Technology Inc COMM 016255101 31,275 47,000 SH   SOLE   47,000 0 0
Aligos Therapeutics Inc COMM 01626L105 1,929 124,342 SH   SOLE   124,342 0 0
AstraZeneca PLC ADR 046353108 67,764 1,128,272 SH   SOLE   1,128,272 0 0
Biogen Inc COMM 09062X103 9,401 33,220 SH   SOLE   33,220 0 0
Blueprint Medicines Corp COMM 09627Y109 18,697 181,860 SH   SOLE   181,860 0 0
Bristol-Myers Squibb Co CALL 110122908 23,668 400,000 SH Call SOLE   400,000 0 0
CTI BioPharma Corp COMM 12648L601 6,120 2,074,714 SH   SOLE   2,074,714 0 0
Celldex Therapeutics, Inc. COMM 15117B202 7,398 137,032 SH   SOLE   137,032 0 0
ChemoCentryx Inc COMM 16383L106 8,853 517,708 SH   SOLE   517,708 0 0
ChemoCentryx Inc PUT 16383L956 8,649 505,800 SH Put SOLE   505,800 0 0
Cyteir Therapeutics, Inc. COMM 23284P103 4,323 246,321 SH   SOLE   246,321 0 0
Cytokinetics Inc COMM 23282W605 15,248 426,632 SH   SOLE   426,632 0 0
Dexcom Inc COMM 252131107 20,379 37,266 SH   SOLE   37,266 0 0
Exelixis Inc COMM 30161Q104 10,325 488,414 SH   SOLE   488,414 0 0
Fulcrum Therapeutics Inc COMM 359616109 1,439 51,006 SH   SOLE   51,006 0 0
Guardant Health Inc COMM 40131M109 5,000 40,000 SH   SOLE   40,000 0 0
Heron Therapeutics Inc COMM 427746102 24,600 2,301,179 SH   SOLE   2,301,179 0 0
Horizon Therapeutics Pub L SHS G46188101 17,251 157,487 SH   SOLE   157,487 0 0
Immatics N.V COMM N44445109 6,217 478,216 SH   SOLE   478,216 0 0
Insmed Inc COMM 457669307 14,737 535,120 SH   SOLE   535,120 0 0
Insulet Corp COMM 45784P101 303 1,066 SH   SOLE   1,066 0 0
Intercept Pharmaceuticals In CALL 45845P908 2,822 190,000 SH Call SOLE   190,000 0 0
Intra-Cellular Therapies Inc COMM 46116X101 8,478 227,419 SH   SOLE   227,419 0 0
Iveric Bio Inc COMM 46583P102 5,804 357,400 SH   SOLE   357,400 0 0
Iveric Bio Inc PUT 46583P952 4,146 255,300 SH Put SOLE   255,300 0 0
Jounce Therapeutics Inc COMM 481116101 4,735 637,347 SH   SOLE   637,347 0 0
Kadmon Holdings Inc COMM 48283N106 9,113 1,046,312 SH   SOLE   1,046,312 0 0
Kura Oncology Inc COMM 50127T109 14,143 755,121 SH   SOLE   755,121 0 0
Marinus Pharmaceuticals Inc COMM 56854Q200 1,897 166,711 SH   SOLE   166,711 0 0
Merck & Co Inc CALL 58933Y905 45,066 600,000 SH Call SOLE   600,000 0 0
Mirati Therapeutics Inc COMM 60468T105 10,066 56,900 SH   SOLE   56,900 0 0
Novocure Ltd CALL G6674U908 3,485 30,000 SH Call SOLE   30,000 0 0
PTC Therapeutics Inc COMM 69366J200 8,559 230,019 SH   SOLE   230,019 0 0
Protagonist Therapeutics Inc CALL 74366E902 5,316 300,000 SH Call SOLE   300,000 0 0
Protagonist Therapeutics Inc COMM 74366E102 5,275 297,709 SH   SOLE   297,709 0 0
Reata Pharmaceuticals Inc COMM 75615P103 15,845 157,488 SH   SOLE   157,488 0 0
Regeneron Pharmaceuticals PUT 75886F957 18,155 30,000 SH Put SOLE   30,000 0 0
Regenxbio Inc COMM 75901B107 5,349 127,593 SH   SOLE   127,593 0 0
Sarepta Therapeutics, Inc. COMM 803607100 14,545 157,279 SH   SOLE   157,279 0 0
Sierra Oncology, Inc. COMM 82640U404 4,528 206,564 SH   SOLE   206,564 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 7,909 413,841 SH   SOLE   413,841 0 0
Travere Therapeutics Inc COMM 89422G107 10,604 437,280 SH   SOLE   437,280 0 0
Uniqure NV COMM N90064101 2,521 78,742 SH   SOLE   78,742 0 0
United Therapeutics Corp COMM 91307C102 40,994 222,094 SH   SOLE   222,094 0 0
United Therapeutics Corp PUT 91307C952 17,443 94,500 SH Put SOLE   94,500 0 0
Zoetis Inc CL A 98978V103 14,755 76,000 SH   SOLE   76,000 0 0
Zymeworks Inc COMM 98985W102 11,924 410,619 SH   SOLE   410,619 0 0