The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 5,962 966,349 SH   DFND 1,2,3,4,5,6 966,349 0 0
AC IMMUNE SA SHS H00263105 6,710 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ACCELERON PHARMA INC COM 00434H108 172,100 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 17,569 2,255,375 SH   DFND 1,2,3,4,5,6 2,255,375 0 0
ADAGENE INC ADS 005329107 14,365 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 6,510 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 8,308 1,045,000 SH   DFND 1,2,3,4,5,6 1,045,000 0 0
AGENUS INC COM NEW 00847G705 28,875 5,500,000 SH   DFND 1,2,3,4,5,6 5,500,000 0 0
ALBIREO PHARMA INC COM 01345P106 18,720 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 14,805 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
ALLOVIR INC COM 019818103 58,224 2,323,371 SH   DFND 1,2,3,4,5,6 2,323,371 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 132,167 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 6,328 593,030 SH   DFND 1,2,3,4,5,6 593,030 0 0
ALTICE USA INC CL A 02156K103 559 27,000 SH   DFND 1,2,3,4,5,6 27,000 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 36,930 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
AMBRX BIOPHARMA INC SPONSORED ADS 02290A102 11,475 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 63,956 6,696,955 SH   DFND 1,2,3,4,5,6 6,696,955 0 0
AMRYT PHARMA PLC SPONSORED ADS 03217L106 1,813 150,480 SH   DFND 1,2,3,4,5,6 150,480 0 0
APPLIED THERAPEUTICS INC COM 03828A101 6,640 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
APTINYX INC COM 03836N103 14,313 6,116,493 SH   DFND 1,2,3,4,5,6 6,116,493 0 0
ARAVIVE INC COM 03890D108 4,878 1,311,291 SH   DFND 1,2,3,4,5,6 1,311,291 0 0
ARGENX SE SPONSORED ADR 04016X101 174,347 577,308 SH   DFND 1,2,3,4,5,6 577,308 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 295 33,333 SH   DFND 1,2,3,4,5,6 33,333 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 26,850 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 22,130 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AVANTOR INC COM 05352A100 2,045 50,000 SH   DFND 1,2,3,4,5,6 50,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 3,510 142,500 SH   DFND 1,2,3,4,5,6 142,500 0 0
AXCELLA HEALTH INC COM 05454B105 2,123 712,500 SH   DFND 1,2,3,4,5,6 712,500 0 0
BEIGENE LTD SPONSORED ADR 07725L102 235,950 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 32,235 5,250,000 SH   DFND 1,2,3,4,5,6 5,250,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 13,930 1,646,517 SH   DFND 1,2,3,4,5,6 1,646,517 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 10,281 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 11,718 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 59,170 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
CARDIFF ONCOLOGY INC COM 14147L108 4,995 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
CARIBOU BIOSCIENCES INC COM 142038108 9,676 405,347 SH   DFND 1,2,3,4,5,6 405,347 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 53,100 1,800,000 SH   DFND 1,2,3,4,5,6 1,800,000 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 2,303 180,500 SH   DFND 1,2,3,4,5,6 180,500 0 0
CIDARA THERAPEUTICS INC COM 171757107 503 224,675 SH   DFND 1,2,3,4,5,6 224,675 0 0
CITIGROUP INC COM NEW 172967424 140,360 2,000,000 SH Call DFND 1,2,3,4,5,6 2,000,000 0 0
CODIAK BIOSCIENCES INC COM 192010106 3,266 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
CONTRAFECT CORP COM NEW 212326300 6,075 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 2,420 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
CULLINAN ONCOLOGY INC COM 230031106 2,257 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
CURIS INC COM NEW 231269200 10,179 1,300,000 SH   DFND 1,2,3,4,5,6 1,300,000 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 8,498 2,768,069 SH   DFND 1,2,3,4,5,6 2,768,069 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 34 11,053 SH   DFND 1,2,3,4 11,053 0 0
CYTOKINETICS INC COM NEW 23282W605 46,462 1,300,000 SH   DFND 1,2,3,4,5,6 1,300,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 3,398 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
DENALI THERAPEUTICS INC COM 24823R105 25,225 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
DESIGN THERAPEUTICS INC COM 25056L103 5,876 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 14,112 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
DYNAMICS SPECIAL PURPOSE COR CLASS A COM 268010105 4,970 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
DYNE THERAPEUTICS INC COM 26818M108 8,526 525,000 SH   DFND 1,2,3,4,5,6 525,000 0 0
EQT CORP COM 26884L109 198 9,678 SH   DFND 1,2,3,4,5,6 9,678 0 0
ERASCA INC COM 29479A108 67,315 3,172,221 SH   DFND 1,2,3,4,5,6 3,172,221 0 0
EVELO BIOSCIENCES INC COM 299734103 7,040 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
FATE THERAPEUTICS INC COM 31189P102 85,942 1,450,000 SH   DFND 1,2,3,4,5,6 1,450,000 0 0
FOGHORN THERAPEUTICS INC COM 344174107 23,970 1,720,720 SH   DFND 1,2,3,4,5,6 1,720,720 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 23,190 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
FREEPORT-MCMORAN INC CL B 35671D857 113,855 3,500,000 SH Call DFND 1,2,3,4,5,6 3,500,000 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 5,940 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
GDS HLDGS LTD SPONSORED ADS 36165L108 5,661 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
GENERATION BIO CO COM 37148K100 70,552 2,814,191 SH   DFND 1,2,3,4,5,6 2,814,191 0 0
GOSSAMER BIO INC COM 38341P102 29,652 2,358,968 SH   DFND 1,2,3,4,5,6 2,358,968 0 0
GRAPHITE BIO INC COM 38870X104 11,473 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
HARPOON THERAPEUTICS INC COM 41358P106 7,900 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
HIPPO HLDGS INC COM 433539103 2,808 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
HOOKIPA PHARMA INC COM 43906K100 3,532 599,616 SH   DFND 1,2,3,4,5,6 599,616 0 0
IGM BIOSCIENCES INC COM 449585108 88,776 1,350,000 SH   DFND 1,2,3,4,5,6 1,350,000 0 0
IKENA ONCOLOGY INC COM 45175G108 19,555 1,549,513 SH   DFND 1,2,3,4,5,6 1,549,513 0 0
I MAB SPONSORED ADS 44975P103 59,804 825,000 SH   DFND 1,2,3,4,5,6 825,000 0 0
IMMUNIC INC COM 4525EP101 6,195 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 7,414 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
IMMUTEP LTD SPONSORED ADS 45257L108 3,870 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
INSTIL BIO INC COM 45783C101 8,044 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
INTEL CORP COM 458140100 15,984 300,000 SH Call DFND 1,2,3,4,5,6 300,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 36,891 275,000 SH   DFND 1,2,3,4,5,6 275,000 0 0
IQIYI INC SPONSORED ADS 46267X108 8,030 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,444 110,532 SH   DFND 1,2,3,4 110,532 0 0
ITEOS THERAPEUTICS INC COM 46565G104 26,839 994,047 SH   DFND 1,2,3,4,5,6 994,047 0 0
KALEIDO BIOSCIENCES INC COM 483347100 2,733 500,500 SH   DFND 1,2,3,4,5,6 500,500 0 0
KINNATE BIOPHARMA INC COM 49705R105 2,878 125,000 SH   DFND 1,2,3,4,5,6 125,000 0 0
KRONOS BIO INC COM 50107A104 27,624 1,317,954 SH   DFND 1,2,3,4,5,6 1,317,954 0 0
KRYSTAL BIOTECH INC COM 501147102 26,105 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
KURA ONCOLOGY INC COM 50127T109 19,667 1,050,000 SH   DFND 1,2,3,4,5,6 1,050,000 0 0
KYMERA THERAPEUTICS INC COM 501575104 23,496 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
LAVA THERAPEUTICS NV SHS N51517105 1,184 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
LEAP THERAPEUTICS INC COM 52187K101 16,040 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 16,913 3,516,214 SH   DFND 1,2,3,4,5,6 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 325,455 67,662,150 SH   DFND 1,2,3,4 67,662,150 0 0
LYELL IMMUNOPHARMA INC COM 55083R104 10,360 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200 11,380 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
MEI PHARMA INC COM NEW 55279B202 2,760 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
MERCK & CO INC COM 58933Y105 37,555 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 3,630 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106 11,316 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
METACRINE INC COM 59101E103 3,172 924,898 SH   DFND 1,2,3,4,5,6 924,898 0 0
MIRATI THERAPEUTICS INC COM 60468T105 212,292 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
MORPHIC HLDG INC COM 61775R105 89,777 1,585,049 SH   DFND 1,2,3,4,5,6 1,585,049 0 0
NANOBIOTIX SA SPONSORED ADS 63009J107 11,360 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
NEXIMMUNE INC COM 65344D109 18,168 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
NOVAGOLD RES INC COM NEW 66987E206 17,888 2,600,000 SH   DFND 1,2,3,4,5,6 2,600,000 0 0
OATLY GROUP AB SPONSORED ADS 67421J108 22,680 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
OLAPLEX HLDGS INC COM 679369108 5,513 225,000 SH   DFND 1,2,3,4,5,6 225,000 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 7,179 260,500 SH   DFND 1,2,3,4,5,6 260,500 0 0
OMEGA ALPHA SPAC CL A G6749V107 7,301 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
OMEGA THERAPEUTICS INC COM 68217N105 42,856 2,273,530 SH   DFND 1,2,3,4,5,6 2,273,530 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 4,149 1,803,858 SH   DFND 1,2,3,4,5,6 1,803,858 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 8,364 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
OVID THERAPEUTICS INC COM 690469101 8,400 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
PORTAGE FINTECH ACQUISITN CO CLASS A ORD SHS G7185D106 3,800 380,000 SH   DFND 1,2,3,4,5,6 380,000 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 22,188 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 26,580 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
RECURSION PHARMACEUTICALS IN CL A 75629V104 4,602 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
RELAY THERAPEUTICS INC COM 75943R102 12,612 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
REPARE THERAPEUTICS INC COM 760273102 14,432 550,000 SH   DFND 1,2,3,4,5,6 550,000 0 0
REPLIMUNE GROUP INC COM 76029N106 26,676 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 1,166 321,100 SH   DFND 1,2,3,4,5,6 321,100 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 74,303 4,155,625 SH   DFND 1,2,3,4,5,6 4,155,625 0 0
SAGE THERAPEUTICS INC COM 78667J108 44,310 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
SANA BIOTECHNOLOGY INC COM 799566104 9,008 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 64,389 1,950,000 SH   DFND 1,2,3,4,5,6 1,950,000 0 0
SCHRODINGER INC COM 80810D103 38,276 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
SEAGEN INC COM 81181C104 63,675 375,000 SH   DFND 1,2,3,4,5,6 375,000 0 0
SEER INC COM CL A 81578P106 164,018 4,750,000 SH   DFND 1,2,3,4,5,6 4,750,000 0 0
SELECTA BIOSCIENCES INC COM 816212104 16,640 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
SIGILON THERAPEUTICS INC COM 82657L107 1,559 276,000 SH   DFND 1,2,3,4,5,6 276,000 0 0
SOLID BIOSCIENCES INC COM 83422E105 7,170 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 9,205 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 38,064 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
SQZ BIOTECHNOLOGIES CO COM 78472W104 23,163 1,606,309 SH   DFND 1,2,3,4,5,6 1,606,309 0 0
STOKE THERAPEUTICS INC COM 86150R107 6,360 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
SURFACE ONCOLOGY INC COM 86877M209 757 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 8,940 2,000,000 SH   DFND 1,2,3,4,5,6 2,000,000 0 0
TALARIS THERAPEUTICS INC COM 87410C104 27,991 2,064,262 SH   DFND 1,2,3,4,5,6 2,064,262 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 19,381 1,040,882 SH   DFND 1,2,3,4,5,6 1,040,882 0 0
TCR2 THERAPEUTICS INC COM 87808K106 6,383 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
TG THERAPEUTICS INC COM 88322Q108 26,624 800,000 SH   DFND 1,2,3,4,5,6 800,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 23,251 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 36,278 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
VERVE THERAPEUTICS INC COM 92539P101 18,800 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
VOR BIOPHARMA INC COM 929033108 8,624 550,000 SH   DFND 1,2,3,4,5,6 550,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 4,900 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
WW INTL INC COM 98262P101 270,434 14,818,300 SH   DFND 1,2,3,4,7 14,818,300 0 0
Y-MABS THERAPEUTICS INC COM 984241109 11,416 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
YUMANITY THERAPEUTICS INC COM 98872L102 2,243 217,391 SH   DFND 1,2,3,4,5,6 217,391 0 0
ZYMEWORKS INC COM 98985W102 13,068 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0