The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 524 28,032 SH   SOLE   28,032 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 3,314 188,719 SH   SOLE   188,719 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 2,845 538,744 SH   SOLE   538,744 0 0
AFFIMED N V COM N01045108 1,719 202,190 SH   SOLE   202,190 0 0
AKERO THERAPEUTICS INC COM 00973Y108 819 33,028 SH   SOLE   33,028 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 2,179 192,345 SH   SOLE   192,345 0 0
AMRYT PHARMA PLC SPONSORED ADS 03217L106 5,538 456,537 SH   SOLE   456,537 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 443 7,009 SH   SOLE   7,009 0 0
ARCUS BIOSCIENCES INC COM 03969F109 1,659 60,400 SH Put SOLE   60,400 0 0
ARDELYX INC COM 039697107 752 99,237 SH   SOLE   99,237 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 1,403 20,577 SH   SOLE   20,577 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 737 5,599 SH   SOLE   5,599 0 0
ATHIRA PHARMA INC COM 04746L104 1,208 117,980 SH   SOLE   117,980 0 0
AYALA PHARMACEUTICALS INC COM 05465V108 238 23,364 SH   SOLE   23,364 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 653 209,933 SH   SOLE   209,933 0 0
BENITEC BIOPHARMA INC COM 08205P100 1,986 467,256 SH   SOLE   467,256 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 5,497 56,626 SH   SOLE   56,626 0 0
BIOMX INC COM 09090D103 78 14,207 SH   SOLE   14,207 0 0
CALITHERA BIOSCIENCES INC COM 13089P101 66 31,382 SH   SOLE   31,382 0 0
CATABASIS PHARMACEUTICALS IN COM NEW 14875P206 398 188,777 SH   SOLE   188,777 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 2,926 9,921 SH   SOLE   9,921 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 1,659 15,000 SH   SOLE   15,000 0 0
CERUS CORP COM 157085101 528 18,691 SH   SOLE   18,691 0 0
CHARDAN HEALTHCR ACQSTN 2 CO *W EXP 03/05/202 15957T115 85 104,828 SH   SOLE   104,828 0 0
CHEMOCENTRYX INC COM 16383L106 1,339 100,000 SH Put SOLE   100,000 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 12,782 14,158 SH   SOLE   14,158 0 0
COGENT BIOSCIENCES INC COM 19240Q201 1,608 198,245 SH   SOLE   198,245 0 0
COMPUGEN LTD ORD M25722105 1,731 209,113 SH   SOLE   209,113 0 0
CULLINAN ONCOLOGY INC COM 230031106 1,950 75,732 SH   SOLE   75,732 0 0
CURIS INC COM NEW 231269200 2,094 259,539 SH   SOLE   259,539 0 0
CYCLACEL PHARMACEUTICALS INC COM 23254L603 1,527 257,958 SH   SOLE   257,958 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 1,364 37,257 SH   SOLE   37,257 0 0
DELCATH SYS INC COM NEW 24661P807 1,251 99,189 SH   SOLE   99,189 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 8,580 229,892 SH   SOLE   229,892 0 0
ELOXX PHARMACEUTICALS INC COM 29014R103 3,756 1,887,539 SH   SOLE   1,887,539 0 0
ETON PHARMACEUTICALS INC COM 29772L108 115 18,691 SH   SOLE   18,691 0 0
EVOGENE LTD SHS M4119S104 1,235 361,254 SH   SOLE   361,254 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 2,178 242,309 SH   SOLE   242,309 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 241 9,679 SH   SOLE   9,679 0 0
GUARDANT HEALTH INC COM 40131M109 580 4,673 SH   SOLE   4,673 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 3,028 66,673 SH   SOLE   66,673 0 0
HELIX ACQUISITION CORP COM CL A G4444C102 2,422 234,020 SH   SOLE   234,020 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 4,685 50,035 SH   SOLE   50,035 0 0
IMMATICS N.V SHS N44445109 3,360 289,408 SH   SOLE   289,408 0 0
IMMUNOGEN INC COM 45253H101 5,454 827,587 SH   SOLE   827,587 0 0
INSMED INC COM PAR $.01 457669307 5,050 177,433 SH   SOLE   177,433 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 4,623 113,258 SH   SOLE   113,258 0 0
ITEOS THERAPEUTICS INC COM 46565G104 1,937 75,511 SH   SOLE   75,511 0 0
JOUNCE THERAPEUTICS INC COM 481116101 1,704 250,644 SH   SOLE   250,644 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 357 14,882 SH   SOLE   14,882 0 0
KURA ONCOLOGY INC COM 50127T109 1,722 82,573 SH   SOLE   82,573 0 0
MACROGENICS INC COM 556099109 4,752 176,915 SH   SOLE   176,915 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 242 2,480 SH   SOLE   2,480 0 0
MEDICENNA THERAPEUTICS CORP COM 58490H107 333 110,515 SH   SOLE   110,515 0 0
MEDICUS SCIENCES ACQUISITION *W EXP 02/12/202 G5960S124 50 49,990 SH   SOLE   49,990 0 0
MEDICUS SCIENCES ACQUISITION CL A SHS G5960S108 3,602 373,275 SH   SOLE   373,275 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 1,287 405,871 SH   SOLE   405,871 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1,699 125,123 SH   SOLE   125,123 0 0
MERUS N V COM N5749R100 6,760 320,815 SH   SOLE   320,815 0 0
MIRATI THERAPEUTICS INC COM 60468T105 6,098 37,753 SH   SOLE   37,753 0 0
MORPHIC HLDG INC COM 61775R105 5,960 103,858 SH   SOLE   103,858 0 0
NEXTCURE INC COM 65343E108 2,293 285,498 SH   SOLE   285,498 0 0
ODONATE THERAPEUTICS INC COM 676079106 652 186,680 SH   SOLE   186,680 0 0
OTONOMY INC COM 68906L105 2,126 953,434 SH   SOLE   953,434 0 0
POLYPID LTD SHS M8001Q118 1,400 154,566 SH   SOLE   154,566 0 0
RAPT THERAPEUTICS INC COM 75382E109 1,500 47,194 SH   SOLE   47,194 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 1,323 9,346 SH   SOLE   9,346 0 0
RELMADA THERAPEUTICS INC COM 75955J402 1,496 46,729 SH   SOLE   46,729 0 0
RENALYTIX PLC ADS 75973T101 3,893 126,145 SH   SOLE   126,145 0 0
RESEARCH ALLIANCE CORP II COM CL A 760873109 5,028 495,855 SH   SOLE   495,855 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 456 10,293 SH   SOLE   10,293 0 0
SAGE THERAPEUTICS INC COM 78667J108 528 9,300 SH Call SOLE   9,300 0 0
SALARIUS PHARMACEUTICALS INC COM NEW 79400X107 500 471,885 SH   SOLE   471,885 0 0
SEAGEN INC COM 81181C104 905 5,732 SH   SOLE   5,732 0 0
SERES THERAPEUTICS INC COM 81750R102 2,926 122,700 SH Call SOLE   122,700 0 0
SERES THERAPEUTICS INC COM 81750R102 1,524 63,915 SH   SOLE   63,915 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 2,712 139,305 SH   SOLE   139,305 0 0
SOCIAL CAP SUVRETTA HLD CRPI CLASS A ORD SHS G8253W109 2,528 250,000 SH   SOLE   250,000 0 0
SOCIAL CAP SUVRETTA HLDS CP CLASS A ORD SHS G8253Y105 2,525 250,000 SH   SOLE   250,000 0 0
SOCIAL CAP SUVRETTA HLDS CRP CLASS A ORD SHS G8253T106 2,528 250,000 SH   SOLE   250,000 0 0
SOCIAL CAP SUVRETTA HLDS CRP CLASS A ORD SHS G8253U103 2,530 250,000 SH   SOLE   250,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 12,782 94,400 SH Call SOLE   94,400 0 0
STEREOTAXIS INC COM NEW 85916J409 2,954 306,404 SH   SOLE   306,404 0 0
SURFACE ONCOLOGY INC COM 86877M209 705 94,539 SH   SOLE   94,539 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 596 34,727 SH   SOLE   34,727 0 0
TCR2 THERAPEUTICS INC COM 87808K106 3,087 188,142 SH   SOLE   188,142 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 923 95,190 SH   SOLE   95,190 0 0
UNIQURE NV SHS N90064101 288 9,346 SH   SOLE   9,346 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 2,743 15,289 SH   SOLE   15,289 0 0
VERACYTE INC COM 92337F107 6,031 150,861 SH   SOLE   150,861 0 0
VERASTEM INC COM 92337C104 4,271 1,049,357 SH   SOLE   1,049,357 0 0
VIEWRAY INC COM 92672L107 623 94,388 SH   SOLE   94,388 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 519 28,399 SH   SOLE   28,399 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 1,939 615,547 SH   SOLE   615,547 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 826 123,972 SH   SOLE   123,972 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 1,847 34,725 SH   SOLE   34,725 0 0