The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 182,251 583,933 SH   SOLE 0 583,933 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 57,021 2,337,877 SH   SOLE 0 2,337,877 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 1,822 160,800 SH   SOLE 0 160,800 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 17,425 94,850 SH   SOLE 0 94,850 0 0
ALIGN TECHNOLOGY INC COM 016255101 33,852 55,405 SH   SOLE 0 55,405 0 0
ALIMERA SCIENCES INC COM NEW 016259202 1,828 200,919 SH   SOLE 0 200,919 0 0
ALKERMES PLC SHS G01767105 11,944 487,100 SH   SOLE 0 487,100 0 0
AMICUS THERAPEUTICS INC COM 03152W109 96,424 10,002,443 SH   SOLE 0 10,002,443 0 0
ANAPTYSBIO INC COM 032724106 11,321 436,592 SH   SOLE 0 436,592 0 0
ATHENEX INC COM 04685N103 1,470 318,200 SH   SOLE 0 318,200 0 0
BIOGEN INC COM 09062X103 125,211 361,600 SH   SOLE 0 361,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 184,649 2,212,950 SH   SOLE 0 2,212,950 0 0
CLOVIS ONCOLOGY INC COM 189464100 26,010 4,484,411 SH   SOLE 0 4,484,411 0 0
CYTOKINETICS INC COM NEW 23282W605 2,448 123,686 SH   SOLE 0 123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 12,417 332,713 SH   SOLE 0 332,713 0 0
EHEALTH INC COM 28238P109 66,919 1,145,870 SH   SOLE 0 1,145,870 0 0
EPIZYME INC COM 29428V104 56,978 6,856,513 SH   SOLE 0 6,856,513 0 0
GOSSAMER BIO INC COM 38341P102 14,396 1,772,950 SH   SOLE 0 1,772,950 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 21,513 2,356,282 SH   SOLE 0 2,356,282 0 0
IDERA PHARMACEUTICALS INC COM PAR 45168K405 92 77,044 SH   SOLE 0 77,044 0 0
INSMED INC COM PAR $.01 457669307 171,304 6,019,106 SH   SOLE 0 6,019,106 0 0
KALEIDO BIOSCIENCES INC COM 483347100 5,851 786,400 SH   SOLE 0 786,400 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 55,553 5,383,052 SH   SOLE 0 5,383,052 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 3,563 656,200 SH   SOLE 0 656,200 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 4,228 432,300 SH   SOLE 0 432,300 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200 562 31,330 SH   SOLE 0 31,330 0 0
MINERVA NEUROSCIENCES INC COM 603380106 84 36,319 SH   SOLE 0 36,319 0 0
PROTHENA CORP PLC SHS G72800108 89,015 1,731,482 SH   SOLE 0 1,731,482 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 12,788 1,392,997 SH   SOLE 0 1,392,997 0 0
REVANCE THERAPEUTICS INC COM 761330109 94,903 3,201,866 SH   SOLE 0 3,201,866 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 2,831 652,395 SH   SOLE 0 652,395 0 0
SAGE THERAPEUTICS INC COM 78667J108 34,114 600,500 SH   SOLE 0 600,500 0 0
STAAR SURGICAL CO COM PAR $.01 852312305 193,341 1,267,811 SH   SOLE 0 1,267,811 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 6,887 401,100 SH   SOLE 0 401,100 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 439 80,600 SH   SOLE 0 80,600 0 0
TACTILE SYSTEMS TECHNOLOGY I COM 87357P100 1,409 27,100 SH   SOLE 0 27,100 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 2,423 166,069 SH   SOLE 0 166,069 0 0
UNITED THERAPEUTICS CORP COM 91307C102 123,292 687,206 SH   SOLE 0 687,206 0 0
UROGEN PHARMA LTD COM M96088105 374 24,500 SH   SOLE 0 24,500 0 0
VANDA PHARMACEUTICALS INC COM 921659108 81,562 3,791,805 SH   SOLE 0 3,791,805 0 0
VIRACTA THERAPEUTICS INC COM 92765F108 377 33,212 SH   SOLE 0 33,212 0 0
ZOGENIX INC COM NEW 98978L204 3,710 214,700 SH   SOLE 0 214,700 0 0