The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 8,157 65,000 SH   DFND 1,2,3,4 65,000 0 0
ADICET BIO INC COM 007002108 1,183 115,000 SH   DFND 1,2,3,4 115,000 0 0
ADVANCED MICRO DEVICES INC COM 007903107 23,483 250,000 SH   DFND 1,2,3,4 250,000 0 0
ALLIANCE DATA SYSTEMS CORP COM 018581108 14,066 135,000 SH   DFND 1,2,3,4 135,000 0 0
ALPHABET INC CAP STK CL A 02079K305 12,189 4,992 SH   DFND 1,2,3,4 4,992 0 0
AMAZON COM INC COM 023135106 41,454 12,050 SH   DFND 1,2,3,4 12,050 0 0
API GROUP CORP COM STK 00187Y100 25,855 1,237,656 SH   DFND 1,2,3,4 1,237,656 0 0
ARAMARK COM 03852U106 14,863 399,000 SH   DFND 1,2,3,4 399,000 0 0
ATHENE HOLDING LTD CL A G0684D107 12,960 192,000 SH   DFND 1,2,3,4 192,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 20,518 1,583,208 SH   DFND 1,2,3,4 1,583,208 0 0
BAIDU INC SPON ADR REP A 056752108 17,128 84,000 SH   DFND 1,2,3,4 84,000 0 0
BAKER HUGHES COMPANY CL A 05722G100 9,331 408,000 SH   DFND 1,2,3,4 408,000 0 0
BEYOND AIR INC COM 08862L103 4,505 695,228 SH   DFND 1,2,3,4 695,228 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 38,930 401,006 SH   DFND 1,2,3,4 401,006 0 0
CALIFORNIA RES CORP COM STOCK 13057Q305 880 29,199 SH   DFND 1,2,3,4 29,199 0 0
CARA THERAPEUTICS INC COM 140755109 6,167 432,178 SH   DFND 1,2,3,4 432,178 0 0
CROWN HLDGS INC COM 228368106 22,211 217,312 SH   DFND 1,2,3,4 217,312 0 0
CURIS INC COM NEW 231269200 9,920 1,229,220 SH   DFND 1,2,3,4 1,229,220 0 0
DANAHER CORPORATION COM 235851102 11,568 43,107 SH   DFND 1,2,3,4 43,107 0 0
DARIOHEALTH CORP COM NEW 23725P209 1,388 65,000 SH   DFND 1,2,3,4 65,000 0 0
DISNEY WALT CO COM 254687106 16,856 95,900 SH   DFND 1,2,3,4 95,900 0 0
DUCKHORN PORTFOLIO INC COM 26414D106 2,581 117,000 SH   DFND 1,2,3,4 117,000 0 0
EUCRATES BIOMEDICAL ACQU COR *W EXP 10/23/202 G3141W122 69 66,665 SH   DFND 1,2,3,4 66,665 0 0
EUCRATES BIOMEDICAL ACQU COR SHS G3141W106 1,969 200,000 SH   DFND 1,2,3,4 200,000 0 0
EXICURE INC COM 30205M101 509 339,395 SH   DFND 1,2,3,4 339,395 0 0
FACEBOOK INC CL A 30303M102 40,746 117,183 SH   DFND 1,2,3,4 117,183 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 11,603 81,900 SH   DFND 1,2,3,4 81,900 0 0
FLEXION THERAPEUTICS INC COM 33938J106 7,354 893,580 SH   DFND 1,2,3,4 893,580 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 4,615 1,972,056 SH   DFND 1,2,3,4 1,972,056 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 7,325 19,300 SH   DFND 1,2,3,4 19,300 0 0
GREAT ELM GROUP INC COM NEW 39037G109 2,833 1,259,049 SH   DFND 1,2,3,4 1,259,049 0 0
GTY TECHNOLOGY HOLDINGS INC COM 362409104 8,245 1,159,600 SH   DFND 1,2,3,4 1,159,600 0 0
INFLARX NV COM N44821101 1,188 400,000 SH   DFND 1,2,3,4 400,000 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 63,266 178,500 SH Put DFND 1,2,3,4 178,500 0 0
ISHARES TR EXPANDED TECH 464287515 19,502 50,000 SH Put DFND 1,2,3,4 50,000 0 0
LITHIA MTRS INC COM 536797103 29,092 84,658 SH   DFND 1,2,3,4 84,658 0 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 1,503 50,000 SH Call DFND 1,2,3,4 50,000 0 0
MEDICUS SCIENCES ACQUISITION *W EXP 02/12/202 G5960S124 34 33,332 SH   DFND 1,2,3,4 33,332 0 0
MEDICUS SCIENCES ACQUISITION CL A SHS G5960S108 2,895 300,000 SH   DFND 1,2,3,4 300,000 0 0
MICROSOFT CORP COM 594918104 13,951 51,500 SH   DFND 1,2,3,4 51,500 0 0
MOLECULAR TEMPLATES INC COM 608550109 7,910 1,011,495 SH   DFND 1,2,3,4 1,011,495 0 0
ON SEMICONDUCTOR CORP COM 682189105 12,181 318,200 SH   DFND 1,2,3,4 318,200 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 10,345 185,000 SH Put DFND 1,2,3,4 185,000 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 13,421 240,000 SH   DFND 1,2,3,4 240,000 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 4,570 250,000 SH   DFND 1,2,3,4 250,000 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 204 8,317 SH   DFND 1,2,3,4 8,317 0 0
RAPT THERAPEUTICS INC COM 75382E109 6,358 200,000 SH Call DFND 1,2,3,4 200,000 0 0
RAPT THERAPEUTICS INC COM 75382E109 24,504 770,821 SH   DFND 1,2,3,4 770,821 0 0
SCYNEXIS INC COM NEW 811292200 4,689 637,048 SH   DFND 1,2,3,4 637,048 0 0
SEA LTD SPONSORD ADS 81141R100 3,158 11,500 SH Put DFND 1,2,3,4 11,500 0 0
SEA LTD SPONSORD ADS 81141R100 7,809 28,436 SH   DFND 1,2,3,4 28,436 0 0
SHIFT4 PMTS INC CL A 82452J109 11,234 119,870 SH   DFND 1,2,3,4 119,870 0 0
SIGNATURE BK NEW YORK N Y COM 82669G104 12,639 51,450 SH   DFND 1,2,3,4 51,450 0 0
SOARING EAGLE ACQUISITION CO CL A SHS G8354H126 4,023 403,900 SH   DFND 1,2,3,4 403,900 0 0
SOL GEL TECHNOLOGIES SHS M8694L103 10,310 832,800 SH   DFND 1,2,3,4 832,800 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 74,911 175,000 SH Put DFND 1,2,3,4 175,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 22,612 167,000 SH Put DFND 1,2,3,4 167,000 0 0
SPDR SER TR S&P OILGAS EXP 78468R556 15,441 159,700 SH   DFND 1,2,3,4 159,700 0 0
TECK RESOURCES LTD CL B 878742204 16,946 735,500 SH   DFND 1,2,3,4 735,500 0 0
TRANSDIGM GROUP INC COM 893641100 8,318 12,850 SH   DFND 1,2,3,4 12,850 0 0
TRILOGY METALS INC NEW COM 89621C105 4,200 1,673,461 SH   DFND 1,2,3,4 1,673,461 0 0
TWILIO INC CL A 90138F102 8,358 21,205 SH   DFND 1,2,3,4 21,205 0 0
UNIQURE NV SHS N90064101 6,160 200,000 SH Call DFND 1,2,3,4 200,000 0 0
VERTIV HOLDINGS CO COM CL A 92537N108 18,270 669,222 SH   DFND 1,2,3,4 669,222 0 0
VINCERX PHARMA INC COM NEW 92731L106 2,642 203,418 SH   DFND 1,2,3,4 203,418 0 0
WILLSCOT MOBIL MINI HLDNG CO COM CL A 971378104 9,773 350,670 SH   DFND 1,2,3,4 350,670 0 0
WNS HLDGS LTD SPON ADR 92932M101 4,153 52,000 SH   DFND 1,2,3,4 52,000 0 0
WORKDAY INC CL A 98138H101 5,014 21,000 SH   DFND 1,2,3,4 21,000 0 0