The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABCELLERA BIOLOGICS INC COM 00288U106 9,292 422,382 SH   SOLE   422,382 0 0
ACUTUS MED INC COM 005111109 4,330 255,000 SH   SOLE   255,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 8,889 555,186 SH   SOLE   555,186 0 0
AKOUOS INC COM 00973J101 5,764 459,290 SH   SOLE   459,290 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 57,312 214,827 SH   SOLE   214,827 0 0
ALIGOS THERAPEUTICS INC COM 01626L105 53,311 2,614,563 SH   SOLE   2,614,563 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 5,879 34,679 SH   SOLE   34,679 0 0
AMICUS THERAPEUTICS INC COM 03152W109 19,260 1,997,880 SH   SOLE   1,997,880 0 0
APPLE INC COM 037833100 142,083 1,037,404 SH   SOLE   1,037,404 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 5,174 53,300 SH   SOLE   53,300 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 17,328 197,000 SH   SOLE   197,000 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 69,632 4,503,991 SH   SOLE   4,503,991 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 156,768 3,075,079 SH   SOLE   3,075,079 0 0
BROOKFIELD ASSET MGMT REINS CL A EXCH LT VTG G16169107 1,102 21,179 SH   SOLE   21,179 0 0
CABLE ONE INC COM 12685J105 49,538 25,898 SH   SOLE   25,898 0 0
CHECKMATE PHARMACEUTICALS IN COM 162818108 12,934 2,170,100 SH   SOLE   2,170,100 0 0
CYTEIR THERAPEUTICS INC COM 23284P103 103,585 4,840,413 SH   SOLE   4,840,413 0 0
EARGO INC COM 270087109 9,462 237,071 SH   SOLE   237,071 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 119,175 5,587,207 SH   SOLE   5,587,207 0 0
F-STAR THERAPEUTICS INC COM 30315R107 23 2,703 SH   SOLE   2,703 0 0
FLEXION THERAPEUTICS INC COM 33938J106 11,550 1,403,370 SH   SOLE   1,403,370 0 0
FREELINE THERAPEUTICS HLDGS SPONSORED ADS 35655L107 19,244 2,361,229 SH   SOLE   2,361,229 0 0
GALECTO INC COM 36322Q107 12,639 2,497,791 SH   SOLE   2,497,791 0 0
GALERA THERAPEUTICS INC COM 36338D108 24,172 2,459,021 SH   SOLE   2,459,021 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 40,170 1,422,953 SH   SOLE   1,422,953 0 0
INARI MED INC COM 45332Y109 6,736 72,212 SH   SOLE   72,212 0 0
INOGEN INC COM 45780L104 135,509 2,079,320 SH   SOLE   2,079,320 0 0
INSMED INC COM PAR $.01 457669307 19,804 695,840 SH   SOLE   695,840 0 0
INSPIRE MED SYS INC COM 457730109 8,919 46,151 SH   SOLE   46,151 0 0
INTERSECT ENT INC COM 46071F103 8,697 508,922 SH   SOLE   508,922 0 0
INOZYME PHARMA INC COM 45790W108 31,826 1,867,706 SH   SOLE   1,867,706 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 17,568 675,160 SH   SOLE   675,160 0 0
KINNATE BIOPHARMA INC COM 49705R105 6,984 300,000 SH   SOLE   300,000 0 0
LAVA THERAPEUTICS NV SHS N51517105 36,201 3,327,312 SH   SOLE   3,327,312 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 11,481 279,676 SH   SOLE   279,676 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 13,918 2,530,585 SH   SOLE   2,530,585 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 42,277 2,445,147 SH   SOLE   2,445,147 0 0
MORPHIC HLDG INC COM 61775R105 151,822 2,645,446 SH   SOLE   2,645,446 0 0
NKARTA INC COM 65487U108 88,538 2,793,864 SH   SOLE   2,793,864 0 0
PHARVARIS N V COM N69605108 2,071 111,144 SH   SOLE   111,144 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 16,643 910,450 SH   SOLE   910,450 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 26,928 600,010 SH   SOLE   600,010 0 0
PULMONX CORP COM 745848101 8,253 187,047 SH   SOLE   187,047 0 0
RENEO PHARMACEUTICALS INC COM 75974E103 32,005 3,430,377 SH   SOLE   3,430,377 0 0
SEASPINE HLDGS CORP COM 81255T108 22,845 1,113,846 SH   SOLE   1,113,846 0 0
SILK RD MED INC COM 82710M100 7,062 147,557 SH   SOLE   147,557 0 0
SPERO THERAPEUTICS INC COM 84833T103 6,546 468,902 SH   SOLE   468,902 0 0
SPRUCE BIOSCIENCES INC COM 85209E109 50,606 4,514,336 SH   SOLE   4,514,336 0 0
TREACE MED CONCEPTS INC COM 89455T109 10,097 323,000 SH   SOLE   323,000 0 0
VANGUARD INDEX FDS TOTAL STK MKT 922908769 430,912 1,933,900 SH   SOLE   1,933,900 0 0
VECTIVBIO HLDG AG ORD SHS H9060V101 41,067 3,522,019 SH   SOLE   3,522,019 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 4,978 761,205 SH   SOLE   761,205 0 0
VERVE THERAPEUTICS INC COM 92539P101 47,794 793,265 SH   SOLE   793,265 0 0
ZOGENIX INC COM NEW 98978L204 7,647 442,550 SH   SOLE   442,550 0 0