The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 8,779 966,349 SH   DFND 1,2,3,4,5,6 966,349 0 0
AC IMMUNE SA SHS H00263105 7,930 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ACCELERON PHARMA INC COM 00434H108 175,686 1,400,000 SH   DFND 1,2,3,4,5,6 1,400,000 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 22,080 2,255,375 SH   DFND 1,2,3,4,5,6 2,255,375 0 0
ADAGENE INC ADS 005329107 13,560 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 10,500 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 7,273 1,045,000 SH   DFND 1,2,3,4,5,6 1,045,000 0 0
AGENUS INC COM NEW 00847G705 32,940 6,000,000 SH   DFND 1,2,3,4,5,6 6,000,000 0 0
AGILON HEALTH INC COM 00857U107 12,171 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
ALBIREO PHARMA INC COM 01345P106 21,108 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 4,893 431,894 SH   DFND 1,2,3,4,5,6 431,894 0 0
ALLOVIR INC COM 019818103 45,863 2,323,371 SH   DFND 1,2,3,4,5,6 2,323,371 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 127,140 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 5,337 593,030 SH   DFND 1,2,3,4,5,6 593,030 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 27,340 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
AMBRX BIOPHARMA INC SPONSORED ADS 02290A102 16,660 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 36,150 3,750,000 SH   DFND 1,2,3,4,5,6 3,750,000 0 0
APPLIED THERAPEUTICS INC COM 03828A101 8,312 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
APTINYX INC COM 03836N103 17,310 6,116,493 SH   DFND 1,2,3,4,5,6 6,116,493 0 0
ARAVIVE INC COM 03890D108 7,842 1,311,291 SH   DFND 1,2,3,4,5,6 1,311,291 0 0
ARGENX SE SPONSORED ADR 04016X101 150,535 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 23,325 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 12,960 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 3,521 142,500 SH   DFND 1,2,3,4,5,6 142,500 0 0
AVIS BUDGET GROUP COM 053774105 23,367 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
AXCELLA HEALTH INC COM 05454B105 2,857 712,500 SH   DFND 1,2,3,4,5,6 712,500 0 0
BEIGENE LTD SPONSORED ADR 07725L102 291,712 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 14,773 4,750,000 SH   DFND 1,2,3,4,5,6 4,750,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 38,832 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 20,071 1,646,517 SH   DFND 1,2,3,4,5,6 1,646,517 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 8,796 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 16,764 275,000 SH   DFND 1,2,3,4,5,6 275,000 0 0
BRIGHT HEALTH GROUP INC COM 10920V107 5,243 305,555 SH   DFND 1,2,3,4,5,6 305,555 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 66,820 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
CARDIFF ONCOLOGY INC COM 14147L108 4,988 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
CEREVEL THERAPEUTICS HLDNG I *W EXP 06/09/202 15678U102 1,145 79,600 SH   DFND 1,2,3,4,5,6 79,600 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 51,240 2,000,000 SH   DFND 1,2,3,4,5,6 2,000,000 0 0
CHIASMA INC COM 16706W102 1,797 380,000 SH   DFND 1,2,3,4,5,6 380,000 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 2,549 180,500 SH   DFND 1,2,3,4,5,6 180,500 0 0
CIDARA THERAPEUTICS INC COM 171757107 454 224,675 SH   DFND 1,2,3,4,5,6 224,675 0 0
CITIGROUP INC COM NEW 172967424 194,563 2,750,000 SH Call DFND 1,2,3,4,5,6 2,750,000 0 0
CODIAK BIOSCIENCES INC COM 192010106 3,706 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
CONTRAFECT CORP COM NEW 212326300 6,600 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
CULLINAN ONCOLOGY INC COM 230031106 2,575 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
CURIS INC COM NEW 231269200 10,491 1,300,000 SH   DFND 1,2,3,4,5,6 1,300,000 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 10,795 2,768,069 SH   DFND 1,2,3,4,5,6 2,768,069 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 43 11,053 SH   DFND 1,2,3,4 11,053 0 0
CYTOKINETICS INC COM NEW 23282W605 9,895 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 7,322 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
DENALI THERAPEUTICS INC COM 24823R105 39,220 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
DESIGN THERAPEUTICS INC COM 25056L103 7,956 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 29,856 800,000 SH   DFND 1,2,3,4,5,6 800,000 0 0
DLOCAL LTD CLASS A COM G29018101 15,496 295,000 SH   DFND 1,2,3,4,5,6 295,000 0 0
DYNAMICS SPECIAL PURPOSE COR CLASS A COM 268010105 4,970 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
DYNE THERAPEUTICS INC COM 26818M108 11,046 525,000 SH   DFND 1,2,3,4,5,6 525,000 0 0
EVELO BIOSCIENCES INC COM 299734103 13,740 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
FATE THERAPEUTICS INC COM 31189P102 117,167 1,350,000 SH   DFND 1,2,3,4,5,6 1,350,000 0 0
FOGHORN THERAPEUTICS INC COM 344174107 18,360 1,720,720 SH   DFND 1,2,3,4,5,6 1,720,720 0 0
FORD MTR CO DEL COM 345370860 52,010 3,500,000 SH Call DFND 1,2,3,4,5,6 3,500,000 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 24,890 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
FREEPORT-MCMORAN INC CL B 35671D857 27,833 750,000 SH Call DFND 1,2,3,4,5,6 750,000 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 6,060 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
GENERAL MTRS CO COM 37045V100 118,340 2,000,000 SH Call DFND 1,2,3,4,5,6 2,000,000 0 0
GENERATION BIO CO COM 37148K100 75,702 2,814,191 SH   DFND 1,2,3,4,5,6 2,814,191 0 0
GOSSAMER BIO INC COM 38341P102 19,155 2,358,968 SH   DFND 1,2,3,4,5,6 2,358,968 0 0
GRAPHITE BIO INC COM 38870X104 21,511 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
HARPOON THERAPEUTICS INC COM 41358P106 13,870 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
HOOKIPA PHARMA INC COM 43906K100 5,492 599,616 SH   DFND 1,2,3,4,5,6 599,616 0 0
IGM BIOSCIENCES INC COM 449585108 91,520 1,100,000 SH   DFND 1,2,3,4,5,6 1,100,000 0 0
IKENA ONCOLOGY INC COM 45175G108 21,755 1,549,513 SH   DFND 1,2,3,4,5,6 1,549,513 0 0
I MAB SPONSORED ADS 44975P103 62,963 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
IMMUNIC INC COM 4525EP101 8,582 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 7,810 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
IMMUTEP LTD SPONSORED ADS 45257L108 3,870 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
INSTIL BIO INC COM 45783C101 8,694 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
INTEL CORP COM 458140100 72,982 1,300,000 SH Call DFND 1,2,3,4,5,6 1,300,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 40,478 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
IQIYI INC SPONSORED ADS 46267X108 15,580 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,423 110,532 SH   DFND 1,2,3,4 110,532 0 0
ITEOS THERAPEUTICS INC COM 46565G104 25,497 994,047 SH   DFND 1,2,3,4,5,6 994,047 0 0
KALEIDO BIOSCIENCES INC COM 483347100 3,724 500,500 SH   DFND 1,2,3,4,5,6 500,500 0 0
KINNATE BIOPHARMA INC COM 49705R105 2,910 125,000 SH   DFND 1,2,3,4,5,6 125,000 0 0
KRONOS BIO INC COM 50107A104 31,565 1,317,954 SH   DFND 1,2,3,4,5,6 1,317,954 0 0
KRYSTAL BIOTECH INC COM 501147102 34,000 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
KURA ONCOLOGY INC COM 50127T109 12,510 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
KYMERA THERAPEUTICS INC COM 501575104 12,125 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
LAVA THERAPEUTICS NV SHS N51517105 2,176 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
LEAP THERAPEUTICS INC COM 52187K101 4,920 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 16,139 3,516,214 SH   DFND 1,2,3,4,5,6 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 310,569 67,662,150 SH   DFND 1,2,3,4 67,662,150 0 0
LIFESTANCE HEALTH GROUP INC COM 53228F101 13,930 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
LUFAX HOLDING LTD ADS REP SHS CL A 54975P102 565 50,000 SH   DFND 1,2,3,4,5,6 50,000 0 0
LYELL IMMUNOPHARMA INC COM 55083R104 11,368 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200 17,940 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
MEI PHARMA INC COM NEW 55279B202 2,850 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 4,755 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106 16,296 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
METACRINE INC COM 59101E103 3,515 924,898 SH   DFND 1,2,3,4,5,6 924,898 0 0
MIRATI THERAPEUTICS INC COM 60468T105 137,301 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
MOLECULAR PARTNERS AG ADS 60853G106 2,049 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
MORPHIC HLDG INC COM 61775R105 104,403 1,819,186 SH   DFND 1,2,3,4,5,6 1,819,186 0 0
NANOBIOTIX SA SPONSORED ADS 63009J107 13,780 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
NEXIMMUNE INC COM 65344D109 19,584 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
NOVAGOLD RES INC COM NEW 66987E206 20,826 2,600,000 SH   DFND 1,2,3,4,5,6 2,600,000 0 0
OATLY GROUP AB SPONSORED ADS 67421J108 36,690 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 7,289 260,500 SH   DFND 1,2,3,4,5,6 260,500 0 0
OMEGA ALPHA SPAC CL A G6749V107 7,463 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 7,919 1,803,858 SH   DFND 1,2,3,4,5,6 1,803,858 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 7,076 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
OVID THERAPEUTICS INC COM 690469101 9,775 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 21,936 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
RECURSION PHARMACEUTICALS IN CL A 75629V104 7,300 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
RELAY THERAPEUTICS INC COM 75943R102 14,636 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
REPARE THERAPEUTICS INC COM 760273102 17,149 550,000 SH   DFND 1,2,3,4,5,6 550,000 0 0
REPLIMUNE GROUP INC COM 76029N106 34,578 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 1,394 321,100 SH   DFND 1,2,3,4,5,6 321,100 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 113,111 4,633,791 SH   DFND 1,2,3,4,5,6 4,633,791 0 0
SAGE THERAPEUTICS INC COM 78667J108 56,810 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
SANA BIOTECHNOLOGY INC COM 799566104 7,864 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 57,800 2,000,000 SH   DFND 1,2,3,4,5,6 2,000,000 0 0
SCHRODINGER INC COM 80810D103 60,295 797,445 SH   DFND 1,2,3,4,5,6 797,445 0 0
SEER INC COM CL A 81578P106 183,187 5,588,366 SH   DFND 1,2,3,4,5,6 5,588,366 0 0
SELECTA BIOSCIENCES INC COM 816212104 16,720 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
SERES THERAPEUTICS INC COM 81750R102 4,770 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
SIGILON THERAPEUTICS INC COM 82657L107 2,961 276,000 SH   DFND 1,2,3,4,5,6 276,000 0 0
SOLID BIOSCIENCES INC COM 83422E105 8,235 2,250,000 SH   DFND 1,2,3,4,5,6 2,250,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 6,980 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 41,205 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
SQZ BIOTECHNOLOGIES CO COM 78472W104 23,211 1,606,309 SH   DFND 1,2,3,4,5,6 1,606,309 0 0
STOKE THERAPEUTICS INC COM 86150R107 8,415 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
SURFACE ONCOLOGY INC COM 86877M209 746 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 9,265 1,700,000 SH   DFND 1,2,3,4,5,6 1,700,000 0 0
TALARIS THERAPEUTICS INC COM 87410C104 30,324 2,064,262 SH   DFND 1,2,3,4,5,6 2,064,262 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 22,067 1,040,882 SH   DFND 1,2,3,4,5,6 1,040,882 0 0
TCR2 THERAPEUTICS INC COM 87808K106 12,308 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
TG THERAPEUTICS INC COM 88322Q108 31,032 800,000 SH   DFND 1,2,3,4,5,6 800,000 0 0
TRANSLATE BIO INC COM 89374L104 13,770 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 24,250 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 27,307 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
VERVE THERAPEUTICS INC COM 92539P101 30,125 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
VIACOMCBS INC CL B 92556H206 3,390 75,000 SH   DFND 1,2,3,4,5,6 75,000 0 0
VOR BIOPHARMA INC COM 929033108 10,258 550,000 SH   DFND 1,2,3,4,5,6 550,000 0 0
WW INTL INC COM 98262P101 535,533 14,818,300 SH   DFND 1,2,3,4,7 14,818,300 0 0
Y-MABS THERAPEUTICS INC COM 984241109 13,520 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
YUMANITY THERAPEUTICS INC COM 98872L102 2,533 217,391 SH   DFND 1,2,3,4,5,6 217,391 0 0
ZYMEWORKS INC COM 98985W102 15,611 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0