The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
5 01 ACQUISITION CORP COM CL A 33836P105 3,988 400,000 SH   DFND 1 400,000 0 0
908 DEVICES INC COM 65443P102 21,131 545,320 SH   DFND 1 545,320 0 0
ACCELERON PHARMA INC COM 00434H108 21,961 175,000 SH   DFND 1 175,000 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 35,120 2,000,000 SH   DFND 1 2,000,000 0 0
AEROVATE THERAPEUTICS INC COM 008064107 44,613 2,030,691 SH   DFND 1 2,030,691 0 0
AGENUS INC COM NEW 00847G705 26,393 4,807,557 SH   DFND 1 4,807,557 0 0
AKERO THERAPEUTICS INC COM 00973Y108 14,886 600,000 SH   DFND 1 600,000 0 0
AKOUOS INC COM 00973J101 4,951 394,500 SH   DFND 1 394,500 0 0
ALIGOS THERAPEUTICS INC COM 01626L105 18,458 905,467 SH   DFND 1 905,467 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 48,635 889,454 SH   DFND 1 889,454 0 0
AMBRX BIOPHARMA INC SPONSORED ADS 02290A102 47,032 2,486,386 SH   DFND 1 2,486,386 0 0
ANAPTYSBIO INC COM 032724106 9,985 385,081 SH   DFND 1 385,081 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 53,720 850,000 SH   DFND 1 850,000 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 12,640 3,807,200 SH   DFND 1 3,807,200 0 0
ARK ETF TR INNOVATION ETF 00214Q104 65,390 500,000 SH Put DFND 1 500,000 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302 69,375 750,000 SH Put DFND 1 750,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 9,866 75,000 SH   DFND 1 75,000 0 0
ATEA PHARMACEUTICALS INC COM 04683R106 137,716 6,411,355 SH   DFND 1 6,411,355 0 0
ATRECA INC CL A COM 04965G109 2,330 273,500 SH   DFND 1 273,500 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 2,604 392,167 SH   DFND 1 392,167 0 0
AVEO PHARMACEUTICALS INC COM NEW 053588307 5,888 893,500 SH   DFND 1 893,500 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 55,070 2,228,667 SH   DFND 1 2,228,667 0 0
AXONICS INC COM 05465P101 20,433 322,240 SH   DFND 1 322,240 0 0
BCTG ACQUISITION CORP COM 05492W103 9,096 800,000 SH   DFND 1 800,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 12,871 100,000 SH   DFND 1 100,000 0 0
BIOATLA INC COM 09077B104 82,714 1,951,718 SH   DFND 1 1,951,718 0 0
BIOMEA FUSION INC COM 09077A106 48,434 3,170,872 SH   DFND 1 3,170,872 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 20,895 237,546 SH   DFND 1 237,546 0 0
BRIDGEBIO PHARMA INC COM 10806X102 114,665 1,880,980 SH   DFND 1 1,880,980 0 0
C4 THERAPEUTICS INC COM STK 12529R107 13,414 354,495 SH   DFND 1 354,495 0 0
CABALETTA BIO INC COM 12674W109 13,860 1,611,623 SH   DFND 1 1,611,623 0 0
CARDIFF ONCOLOGY INC COM 14147L108 637 95,720 SH   DFND 1 95,720 0 0
CATABASIS PHARMACEUTICALS IN COM NEW 14875P206 7,490 3,550,000 SH   DFND 1 3,550,000 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100 31,054 1,427,273 SH   DFND 1 1,427,273 0 0
CEREVEL THERAPEUTICS HLDNG I *W EXP 06/09/202 15678U102 278 19,316 SH   DFND 1 19,316 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 12,694 650,000 SH   DFND 1 650,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 5,288 144,439 SH   DFND 1 144,439 0 0
DERMTECH INC COM 24984K105 18,706 450,000 SH   DFND 1 450,000 0 0
DESIGN THERAPEUTICS INC COM 25056L103 105,965 5,414,850 SH   DFND 1 5,414,850 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 66,530 3,140,914 SH   DFND 1 3,140,914 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 2,428 284,988 SH   DFND 1 284,988 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101 11,197 1,415,500 SH   DFND 1 1,415,500 0 0
ELEVATION ONCOLOGY INC COM 28623U101 25,566 1,983,165 SH   DFND 1 1,983,165 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 117,520 4,721,589 SH   DFND 1 4,721,589 0 0
GALECTO INC COM 36322Q107 8,874 1,753,839 SH   DFND 1 1,753,839 0 0
GENETRON HLDGS LTD ADS 37186H100 2,676 132,867 SH   DFND 1 132,867 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 12,554 608,123 SH   DFND 1 608,123 0 0
GOSSAMER BIO INC COM 38341P102 1,611 198,382 SH   DFND 1 198,382 0 0
GRAPHITE BIO INC COM 38870X104 5,931 203,153 SH   DFND 1 203,153 0 0
HARPOON THERAPEUTICS INC COM 41358P106 7,498 540,600 SH   DFND 1 540,600 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 2,448 240,000 SH   DFND 1 240,000 0 0
HELIX ACQUISITION CORP COM CL A G4444C102 4,450 430,000 SH   DFND 1 430,000 0 0
HUMANIGEN INC COM NEW 444863203 10,428 600,000 SH   DFND 1 600,000 0 0
IGM BIOSCIENCES INC COM 449585108 20,800 250,000 SH   DFND 1 250,000 0 0
IMV INC COM 44974L103 507 234,374 SH   DFND 1 234,374 0 0
INSMED INC COM PAR $.01 457669307 7,115 250,000 SH   DFND 1 250,000 0 0
INSPIRE MED SYS INC COM 457730109 9,302 48,132 SH   DFND 1 48,132 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 229,370 1,000,000 SH Put DFND 1 1,000,000 0 0
ITEOS THERAPEUTICS INC COM 46565G104 7,396 288,330 SH   DFND 1 288,330 0 0
LONGBOARD PHARMACEUTICALS IN COM 54300N103 20,869 2,321,403 SH   DFND 1 2,321,403 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 4,677 478,200 SH   DFND 1 478,200 0 0
MERUS N V COM N5749R100 6,007 285,096 SH   DFND 1 285,096 0 0
MINERVA NEUROSCIENCES INC COM 603380106 570 245,744 SH   DFND 1 245,744 0 0
MIRATI THERAPEUTICS INC COM 60468T105 28,268 175,000 SH   DFND 1 175,000 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102 69,550 3,193,973 SH   DFND 1 3,193,973 0 0
MORPHIC HLDG INC COM 61775R105 10,891 189,774 SH   DFND 1 189,774 0 0
MYOVANT SCIENCES LTD COM G637AM102 12,353 542,499 SH   DFND 1 542,499 0 0
NUVATION BIO INC *W EXP 07/07/202 67080N119 217 83,332 SH   DFND 1 83,332 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 85,996 3,073,485 SH   DFND 1 3,073,485 0 0
OMEROS CORP COM 682143102 17,808 1,200,000 SH   DFND 1 1,200,000 0 0
OMEROS CORP COM 682143102 14,840 1,000,000 SH Call DFND 1 1,000,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 1,127 256,649 SH   DFND 1 256,649 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 130 416,666 SH   DFND 1 416,666 0 0
PHARVARIS N V COM N69605108 13,634 744,863 SH   DFND 1 744,863 0 0
PLIANT THERAPEUTICS INC COM 729139105 14,048 482,413 SH   DFND 1 482,413 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 18,721 1,024,145 SH   DFND 1 1,024,145 0 0
PRECISION BIOSCIENCES INC COM 74019P108 4,338 346,524 SH   DFND 1 346,524 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 44,480 1,848,024 SH   DFND 1 1,848,024 0 0
QUOTIENT LTD SHS G73268107 4,380 1,203,328 SH   DFND 1 1,203,328 0 0
RAIN THERAPEUTICS INC COM 75082Q105 39,734 2,626,660 SH   DFND 1 2,626,660 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 23,798 168,150 SH   DFND 1 168,150 0 0
REPARE THERAPEUTICS INC COM 760273102 11,342 363,766 SH   DFND 1 363,766 0 0
REVOLUTION MEDICINES INC COM 76155X100 105,953 3,338,166 SH   DFND 1 3,338,166 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 42,897 968,550 SH   DFND 1 968,550 0 0
SILVERBACK THERAPEUTICS INC COM 82835W108 7,386 239,099 SH   DFND 1 239,099 0 0
SORRENTO THERAPEUTICS INC COM NEW 83587F202 4,845 500,000 SH   DFND 1 500,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 1,236 15,000 SH   DFND 1 15,000 0 0
STOKE THERAPEUTICS INC COM 86150R107 43,027 1,278,276 SH   DFND 1 1,278,276 0 0
TALARIS THERAPEUTICS INC COM 87410C104 17,264 1,215,847 SH   DFND 1 1,215,847 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 43,884 1,514,269 SH   DFND 1 1,514,269 0 0
TCR2 THERAPEUTICS INC COM 87808K106 7,869 479,506 SH   DFND 1 479,506 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 4,356 300,000 SH   DFND 1 300,000 0 0
TRICIDA INC COM 89610F101 1,849 427,975 SH   DFND 1 427,975 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 236,950 3,037,042 SH   DFND 1 3,037,042 0 0
TWIST BIOSCIENCE CORP COM 90184D100 24,651 185,000 SH   DFND 1 185,000 0 0
UNIQURE NV SHS N90064101 7,378 239,548 SH   DFND 1 239,548 0 0
VECTIVBIO HLDG AG ORD SHS H9060V101 25,531 2,226,128 SH   DFND 1 2,226,128 0 0
VERU INC COM 92536C103 6,456 800,000 SH   DFND 1 800,000 0 0
VERVE THERAPEUTICS INC COM 92539P101 40,594 709,224 SH   DFND 1 709,224 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 6,273 342,962 SH   DFND 1 342,962 0 0
X4 PHARMACEUTICALS INC COM 98420X103 676 103,980 SH   DFND 1 103,980 0 0
Y-MABS THERAPEUTICS INC COM 984241109 27,040 800,000 SH   DFND 1 800,000 0 0
ZAI LAB LTD ADR 98887Q104 9,461 53,455 SH   DFND 1 53,455 0 0
ZYMEWORKS INC COM 98985W102 45,858 1,321,936 SH   DFND 1 1,321,936 0 0