The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADDEX THERAPEUTICS LTD SHS 00654J107 478 50,000 SH   DFND   50,000 0 0
ALECTOR INC COM 014442107 7,073 339,569 SH   DFND   339,569 0 0
APTINYX INC COM 03836N103 9,311 3,290,079 SH   DFND   3,290,079 0 0
ARAVIVE INC COM 03890D108 5,660 946,423 SH   DFND   946,423 0 0
ARVINAS INC COM 04335A105 170,382 2,212,748 SH   DFND   2,212,748 0 0
AVROBIO INC COM 05455M100 2,805 315,550 SH   DFND   315,550 0 0
CHIASMA INC COM 16706W102 5,372 1,135,700 SH   DFND   1,135,700 0 0
CHIMERIX INC COM 16934W106 9,797 1,224,600 SH   DFND   1,224,600 0 0
COGENT BIOSCIENCES INC. COM 19240Q201 2,658 501,530 SH   DFND   501,530 0 0
CRINETICS PHARMACEUTICALS INC COM 22663K107 44,282 141,000 SH   DFND   141,000 0 0
DECIPHERA PHARMACEUTICALS INC COM 24344T101 33,140 1,209,571 SH   DFND   1,209,571 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 43,783 1,553,661 SH   DFND   1,553,661 0 0
HARPOON THERAPEUTICS INC COM 41358P106 3,364 3,156,699 SH   DFND   3,156,699 0 0
ITERUM THERAPEUTICS PLC SHS G6333L101 2,729 1,456,303 SH   DFND   1,456,303 0 0
OBSEVA SA COM H5861P103 33,072 900,501 SH   DFND   900,501 0 0
PASSAGE BIO COM 702712100 1,471 2,497,922 SH   DFND   2,497,922 0 0
PDS BIOTECHNOLOGY CORP COM 70465T107 7,975 117,242 SH   DFND   117,242 0 0
SIERRA ONCOLOGY INC COM 82640U107 4,067 409,611 SH   DFND   409,611 0 0
X4 PHARMACEUTICALS INC COM 98420X103 2,178 335,000 SH   DFND   335,000 0 0