The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADAPTIMMUNE THERAPEUTICS PLC ADR 00653A107 72,772 17,082,611 SH   DFND   17,082,611 0 0
ADDEX THERAPEUTICS LTD SPONSORED ADS 00654J107 17,208 180,000 SH   DFND   180,000 0 0
AFFIMED NV COM N01045108 37,625 4,426,488 SH   DFND   4,426,488 0 0
AKARI THERAPEUTICS PLC ADR 00972G108 782 452,167 SH   DFND   452,167 0 0
AKOUOS INC COM 00973J101 53,946 4,298,488 SH   DFND   4,298,488 0 0
ALLAKOS INC COM 01671P100 184,801 2,164,704 SH   DFND   2,164,704 0 0
ANNEXON INC COM 03589W102 56,222 2,497,661 SH   DFND   2,497,661 0 0
ARDELYX INC COM 039697107 103,343 13,633,582 SH   DFND   13,633,582 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 67,038 5,172,683 SH   DFND   5,172,683 0 0
AVEO PHARMACEUTICALS INC COM 053588307 26,050 3,952,958 SH   DFND   3,952,958 0 0
BILL COM HLDGS INC COM 090043100 102,723 560,774 SH   DFND   560,774 0 0
BLACK DIAMOND THERAPEUTICS INC COM 09203E105 42,054 3,449,845 SH   DFND   3,449,845 0 0
BLOOM ENERGY CORP COM CL A 093712107 35,827 1,333,333 SH   DFND   1,333,333 0 0
BRIGHT HEALTH GROUP INC COM 10920V107 3,744,520 218,212,128 SH   DFND   218,212,128 0 0
CASPER SLEEP INC COM 147626105 51,303 6,226,130 SH   DFND   6,226,130 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307 17,617 1,713,720 SH   DFND   1,713,720 0 0
CLOUDFLARE INC CL A COM 18915M107 292,498 2,763,583 SH   DFND   2,763,583 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 257,405 1,590,002 SH   DFND   1,590,002 0 0
CTI BIOPHARMA CORP COM NEW 12648L601 17,851 7,140,450 SH   DFND   7,140,450 0 0
COURSERA INC COM 22266M104 656,817 16,603,063 SH   DFND   16,603,063 0 0
CVRX INC COM 126638105 66,384 2,370,858 SH   DFND   2,370,858 0 0
DESKTOP METAL INC COM CL A 25058X105 223,222 19,410,631 SH   DFND   19,410,631 0 0
EARGO INC COM 270087109 180,420 4,520,670 SH   DFND   4,520,670 0 0
ERYTECH PHARMA SA ADR 29604W108 3,019 625,000 SH   DFND   625,000 0 0
GALERA THERAPEUTICS INC COM 36338D108 42,888 4,362,986 SH   DFND   4,362,986 0 0
GENOCEA BIOSCIENCES INC COM 372427401 24,282 10,376,936 SH   DFND   10,376,936 0 0
GERON CORP COM 374163103 18,981 13,461,538 SH   DFND   13,461,538 0 0
GLYCOMIMETICS INC COM 38000Q102 21,087 9,089,041 SH   DFND   9,089,041 0 0
IMARA INC COM 45249V107 31,736 4,017,170 SH   DFND   4,017,170 0 0
INOZYME PHARMA INC COM 45790W108 41,652 2,444,379 SH   DFND   2,444,379 0 0
INVENTIVA SA ADS 46124U107 14,208 1,041,666 SH   DFND   1,041,666 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 10,935 2,382,286 SH   DFND   2,382,286 0 0
LIQUIDIA TECHNOLOGIES INC COM 53635D202 7,110 2,486,062 SH   DFND   2,486,062 0 0
LUMOS PHARMA INC COM 55028X109 5,267 526,663 SH   DFND   526,663 0 0
MARKER THERAPEUTICS INC COM 57055L107 29,893 10,714,285 SH   DFND   10,714,285 0 0
MEI PHARMA INC COM NEW 55279B202 24,319 8,533,072 SH   DFND   8,533,072 0 0
METACRINE INC COM 59101E103 11,639 3,062,977 SH   DFND   3,062,977 0 0
METROMILE INC COM 591697107 85,866 9,384,295 SH   DFND   9,384,295 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 72,407 4,187,801 SH   DFND   4,187,801 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102 174,863 7,703,205 SH   DFND   7,703,205 0 0
NKARTA INC COM 65487U108 92,059 2,904,974 SH   DFND   2,904,974 0 0
OBSEVA SA COM H5861P103 13,897 4,586,563 SH   DFND   4,586,563 0 0
OPENDOOR TECHNOLOGIES INC COM 683712103 59,090 3,333,276 SH   DFND   3,333,276 0 0
OYSTER PT PHARMA INC COM 69242L106 101,856 5,925,287 SH   DFND   5,925,287 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 24,715 6,643,704 SH   DFND   6,643,704 0 0
REGULUS THERAPEUTICS INC COM NEW 75915K200 5,225 6,451,056 SH   DFND   6,451,056 0 0
RENEO PHARMACEUTICALS INC COM 75974E103 44,662 4,786,921 SH   DFND   4,786,921 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 96,183 4,912,306 SH   DFND   4,912,306 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 22,158 3,142,958 SH   DFND   3,142,958 0 0
SAVARA INC COM 805111101 41,034 24,137,931 SH   DFND   24,137,931 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 12,300 4,141,308 SH   DFND   4,141,308 0 0
SYNLOGIC INC COM 87166L100 16,452 4,229,410 SH   DFND   4,229,410 0 0
TEMPEST THERAPEUTICS INC COM 87978U108 1,317 117,785 SH   DFND   117,785 0 0
TRACON PHARMACEUTICALS INC COM 89237H209 2,250 346,718 SH   DFND   346,718 0 0
TREVENA INC COM 89532E109 6,442 3,811,691 SH   DFND   3,811,691 0 0
TREVI THERAPEUTICS INC COM 89532M101 13,367 5,940,796 SH   DFND   5,940,796 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 55,643 5,736,363 SH   DFND   5,736,363 0 0
UPSTART HLDGS INC COM 91680M107 35,858 287,092 SH   DFND   287,092 0 0
VECTIVBIO HLDG AG ORD SHS H9060V101 782 67,069 SH   DFND   67,069 0 0
VERONA PHARMA PLC ADS 925050106 33,410 5,108,563 SH   DFND   5,108,563 0 0
VIRACTA THERAPEUTICS INC COM 92765F108 421 37,093 SH   DFND   37,093 0 0
VISTAGEN THERAPEUTICS INC COM 92840H202 51,353 16,302,596 SH   DFND   16,302,596 0 0
XENON PHARMACEUTICALS INC COM 98420N105 18,473 992,107 SH   DFND   992,107 0 0