The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X Genomics Inc Class A CL A COM 88025U109 369,475 1,886,809 SH   DFND 1 1,886,809 0 0
10X Genomics Inc Class A CL A COM 88025U109 362,881 1,853,135 SH   DFND 2 1,736,494 0 116,641
10X Genomics Inc Class A CL A COM 88025U109 136,468 696,907 SH   DFND 3 563,687 0 133,220
10X Genomics Inc Class A CL A COM 88025U109 116,345 594,145 SH   SOLE 0 594,145 0 0
1Life Healthcare COM 68269G107 15 445 SH   DFND 3 445 0 0
2U COM 90214J101 11 273 SH   DFND 3 273 0 0
8x8 Inc COM 282914100 70 2,518 SH   DFND 3 2,518 0 0
908 Devices COM 65443P102 10 249 SH   DFND 3 249 0 0
ACM Research COM 00108J109 22 220 SH   DFND 3 220 0 0
AJ Gallagher & Co COM 363576109 153,238 1,093,931 SH   DFND 1 1,093,931 0 0
AJ Gallagher & Co COM 363576109 510,355 3,643,310 SH   DFND 2 3,413,020 0 230,290
AJ Gallagher & Co COM 363576109 98,696 704,566 SH   DFND 3 327,576 0 376,990
AJ Gallagher & Co COM 363576109 381,489 2,723,366 SH   SOLE 0 2,349,868 0 373,498
Abcellera Biologics Inc COM 00288U106 28,272 1,285,091 SH   DFND 1 1,285,091 0 0
Abcellera Biologics Inc COM 00288U106 7,657 348,046 SH   DFND 2 108,995 0 239,051
Abcellera Biologics Inc COM 00288U106 21,167 962,153 SH   DFND 3 712,000 0 250,153
Abcellera Biologics Inc COM 00288U106 2,858 129,907 SH   SOLE 0 129,907 0 0
Abiomed COM 003654100 340,299 1,090,317 SH   DFND 1 1,090,317 0 0
Abiomed COM 003654100 482,629 1,546,343 SH   DFND 2 1,422,235 0 124,108
Abiomed COM 003654100 124,728 399,628 SH   DFND 3 280,068 0 119,560
Abiomed COM 003654100 186,368 597,124 SH   SOLE 0 533,174 0 63,950
Acadia Pharmaceuticals Inc COM 004225108 13 544 SH   DFND 3 544 0 0
Accelerate Diagnostics COM 00430H102 3 418 SH   DFND 3 418 0 0
Accenture 'A' COM G1151C101 14 48 SH   DFND 3 48 0 0
Acutus Medical COM 005111109 7 424 SH   DFND 3 424 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 22,011 5,166,864 SH   DFND 1 5,166,864 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 11,322 2,657,843 SH   DFND 2 885,574 0 1,772,269
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 4,947 1,161,350 SH   DFND 3 1,161,350 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 11,548 2,710,862 SH   SOLE 0 2,710,862 0 0
Adicet Bio Inc COM 007002108 962 93,449 SH   DFND 1 93,449 0 0
Adicet Bio Inc COM 007002108 907 88,177 SH   SOLE 0 88,177 0 0
Advanced Micro Devices Inc COM 007903107 48 513 SH   DFND 3 513 0 0
Aerovironment COM 008073108 35,104 350,517 SH   DFND 1 350,517 0 0
Aerovironment COM 008073108 24,006 239,702 SH   DFND 2 79,958 0 159,744
Aerovironment COM 008073108 10,822 108,061 SH   DFND 3 108,061 0 0
Aerovironment COM 008073108 22,090 220,567 SH   SOLE 0 220,567 0 0
Affirm Holdings Inc Class A COM CL A 00827B106 141,423 2,099,829 SH   DFND 1 2,099,829 0 0
Affirm Holdings Inc Class A COM CL A 00827B106 189,946 2,820,283 SH   DFND 2 2,695,762 0 124,521
Affirm Holdings Inc Class A COM CL A 00827B106 12,304 182,685 SH   DFND 3 164,727 0 17,958
Affirm Holdings Inc Class A COM CL A 00827B106 83,376 1,237,949 SH   SOLE 0 1,237,949 0 0
Affirm Holdings Inc Class A - converted at IPO COM CL A 00827B106 133,869 1,987,660 SH   SOLE 0 1,987,660 0 0
Affirm Holdings Inc Class B - converted at IPO COM CL A 00827B106 167,336 2,484,575 SH   SOLE 0 2,484,575 0 0
Agios Pharmaceuticals Inc COM 00847X104 10 186 SH   DFND 3 186 0 0
Agora Inc ADR ADS 00851L103 20,531 489,288 SH   DFND 1 489,288 0 0
Agora Inc ADR ADS 00851L103 10,700 255,012 SH   SOLE 0 255,012 0 0
Albemarle Corp COM 012653101 116,350 690,670 SH   DFND 1 690,670 0 0
Albemarle Corp COM 012653101 342,475 2,032,975 SH   DFND 2 1,900,605 0 132,370
Albemarle Corp COM 012653101 58,416 346,767 SH   DFND 3 191,850 0 154,917
Albemarle Corp COM 012653101 261,741 1,553,728 SH   SOLE 0 1,336,845 0 216,883
Alector Inc COM 014442107 1,067 51,229 SH   DFND 1 51,229 0 0
Alector Inc COM 014442107 2,549 122,375 SH   DFND 2 122,375 0 0
Alector Inc COM 014442107 2,650 127,224 SH   DFND 3 127,224 0 0
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 486,413 2,144,869 SH   DFND 1 2,144,869 0 0
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 2,958,490 13,045,637 SH   DFND 2 6,453,964 0 6,591,673
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 366,251 1,615,007 SH   DFND 3 1,165,685 0 449,322
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 2,024,370 8,926,579 SH   SOLE 0 7,365,689 0 1,560,890
Align Technology Inc COM 016255101 16,713 27,354 SH   DFND 2 27,354 0 0
Alkermes Plc COM G01767105 5 192 SH   DFND 3 192 0 0
Allscripts Healthcare Solution COM 01988P108 14 744 SH   DFND 3 744 0 0
Alnylam Pharmaceuticals COM 02043Q107 465,295 2,744,777 SH   DFND 1 2,744,777 0 0
Alnylam Pharmaceuticals COM 02043Q107 691,933 4,081,717 SH   DFND 2 3,430,727 0 650,990
Alnylam Pharmaceuticals COM 02043Q107 205,800 1,214,017 SH   DFND 3 886,620 0 327,397
Alnylam Pharmaceuticals COM 02043Q107 370,291 2,184,348 SH   SOLE 0 1,965,217 0 219,131
Alphabet Inc Class A CAP STK CL A 02079K305 16,543 6,775 SH   DFND 1 6,775 0 0
Alphabet Inc Class A CAP STK CL A 02079K305 33,601 13,761 SH   DFND 2 13,761 0 0
Alphabet Inc Class A CAP STK CL A 02079K305 7,213 2,954 SH   DFND 3 1,987 0 967
Alphabet Inc Class A CAP STK CL A 02079K305 90,754 37,167 SH   SOLE 0 37,167 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 221,378 88,328 SH   DFND 1 88,328 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 830,655 331,424 SH   DFND 2 310,054 0 21,370
Alphabet Inc Class C CAP STK CL C 02079K107 156,139 62,298 SH   DFND 3 29,304 0 32,994
Alphabet Inc Class C CAP STK CL C 02079K107 501,695 200,172 SH   SOLE 0 165,615 0 34,557
Alteryx Inc COM 02156B103 29 336 SH   DFND 3 336 0 0
Amazon.Com COM 023135106 1,172,579 340,850 SH   DFND 1 340,850 0 0
Amazon.Com COM 023135106 4,765,688 1,385,310 SH   DFND 2 876,608 0 508,702
Amazon.Com COM 023135106 499,140 145,092 SH   DFND 3 107,693 0 37,399
Amazon.Com COM 023135106 2,211,851 642,950 SH   SOLE 0 517,429 0 125,521
Ambarella SHS G037AX101 31,051 291,200 SH   DFND 1 291,200 0 0
Ambarella SHS G037AX101 13,999 131,284 SH   DFND 2 43,285 0 87,999
Ambarella SHS G037AX101 5,880 55,146 SH   DFND 3 55,146 0 0
Ambarella SHS G037AX101 10,408 97,605 SH   SOLE 0 97,605 0 0
Amdocs COM G02602103 31 400 SH   DFND 3 400 0 0
Ameren COM 023608102 46,413 579,868 SH   DFND 1 579,868 0 0
Ameren COM 023608102 96 1,204 SH   DFND 2 1,204 0 0
Ameren COM 023608102 2,518 31,463 SH   DFND 3 31,463 0 0
American Electric Power COM 025537101 53,089 627,600 SH   DFND 1 627,600 0 0
American Electric Power COM 025537101 102 1,202 SH   DFND 2 1,202 0 0
American Electric Power COM 025537101 2,848 33,666 SH   DFND 3 33,666 0 0
American Superconductor Corp COM 030111207 8,893 511,400 SH   DFND 1 511,400 0 0
American Superconductor Corp COM 030111207 13,356 768,000 SH   SOLE 0 768,000 0 0
American Well Corp Class A COM 03044L105 963 76,582 SH   DFND 1 76,582 0 0
American Well Corp Class A COM 03044L105 2,366 188,085 SH   DFND 2 188,085 0 0
American Well Corp Class A COM 03044L105 2,422 192,493 SH   DFND 3 192,493 0 0
Amicus Therapeutics Inc COM 03152W109 5 538 SH   DFND 3 538 0 0
Amkor Technology COM 031652100 52 2,205 SH   DFND 3 2,205 0 0
Amneal Pharmaceuticals Inc COM 03168L105 2 452 SH   DFND 3 452 0 0
Analog Devices COM 032654105 30,347 176,270 SH   DFND 1 176,270 0 0
Analog Devices COM 032654105 680 3,948 SH   DFND 2 0 0 3,948
Analog Devices COM 032654105 372 2,163 SH   DFND 3 2,163 0 0
Analog Devices COM 032654105 29,400 170,773 SH   SOLE 0 170,773 0 0
Anaplan Inc Common COM 03272L108 16 306 SH   DFND 3 306 0 0
Annaly Capital Man. COM 035710409 66 7,446 SH   DFND 1 7,446 0 0
Anterix COM 03676C100 10 162 SH   DFND 3 162 0 0
Anthem Inc COM 036752103 192,350 503,799 SH   DFND 1 503,799 0 0
Anthem Inc COM 036752103 698,846 1,830,399 SH   DFND 2 1,712,094 0 118,305
Anthem Inc COM 036752103 135,418 354,684 SH   DFND 3 166,841 0 187,843
Anthem Inc COM 036752103 512,166 1,341,452 SH   SOLE 0 1,148,980 0 192,472
AppFolio COM 03783C100 37 261 SH   DFND 3 261 0 0
Appian Corp CL A 03782L101 309,278 2,245,215 SH   DFND 1 2,245,215 0 0
Appian Corp CL A 03782L101 386,144 2,803,224 SH   DFND 2 2,392,057 0 411,167
Appian Corp CL A 03782L101 42,702 309,995 SH   DFND 3 309,995 0 0
Appian Corp CL A 03782L101 127,093 922,636 SH   SOLE 0 922,636 0 0
Apple COM 037833100 29,118 212,600 SH   DFND 1 212,600 0 0
Apple COM 037833100 655 4,782 SH   DFND 2 0 0 4,782
Apple COM 037833100 360 2,629 SH   DFND 3 2,629 0 0
Apple COM 037833100 28,447 207,704 SH   SOLE 0 207,704 0 0
Applied Optoelectronics COM 03823U102 2 260 SH   DFND 3 260 0 0
Aptiv COM G6095L109 23 149 SH   DFND 3 149 0 0
Ares Capital Corp COM 04010L103 102,926 5,254,000 SH   DFND 1 5,254,000 0 0
Ares Capital Corp COM 04010L103 210 10,700 SH   DFND 2 10,700 0 0
Ares Capital Corp COM 04010L103 5,686 290,270 SH   DFND 3 290,270 0 0
Argan COM 04010E109 5 103 SH   DFND 3 103 0 0
Ascendis Pharma Adr 1:1 SPON ADR 04351P101 1,679 12,760 SH   DFND 1 12,760 0 0
Ascendis Pharma Adr 1:1 SPON ADR 04351P101 3,954 30,060 SH   DFND 2 30,060 0 0
Ascendis Pharma Adr 1:1 SPON ADR 04351P101 4,174 31,732 SH   DFND 3 31,732 0 0
Asensus Surgical Inc COM 04367G103 17 5,338 SH   DFND 3 5,338 0 0
Atlassian Corp Plc CL A G06242104 128,221 499,188 SH   DFND 1 499,188 0 0
Atlassian Corp Plc CL A G06242104 1,008,243 3,925,262 SH   DFND 2 1,319,429 0 2,605,833
Atlassian Corp Plc CL A G06242104 118,381 460,877 SH   DFND 3 383,475 0 77,402
Atlassian Corp Plc CL A G06242104 272,152 1,059,533 SH   SOLE 0 490,690 0 568,843
Atrion COM 049904105 6 9 SH   DFND 3 9 0 0
Autohome Inc - ADR SP ADR RP CL A 05278C107 23,868 373,164 SH   DFND 1 373,164 0 0
Autohome Inc - ADR SP ADR RP CL A 05278C107 85,753 1,340,728 SH   DFND 2 1,251,194 0 89,534
Autohome Inc - ADR SP ADR RP CL A 05278C107 17,112 267,546 SH   DFND 3 121,668 0 145,878
Autohome Inc - ADR SP ADR RP CL A 05278C107 65,758 1,028,107 SH   SOLE 0 878,251 0 149,856
Avangrid COM 05351W103 74,397 1,446,574 SH   DFND 1 1,446,574 0 0
Avangrid COM 05351W103 145 2,828 SH   DFND 2 2,828 0 0
Avangrid COM 05351W103 3,463 67,337 SH   DFND 3 67,337 0 0
Avery Dennison Corporation COM 053611109 23 110 SH   DFND 3 110 0 0
Axogen Inc COM 05463X106 9,506 439,900 SH   DFND 1 439,900 0 0
Axogen Inc COM 05463X106 8,334 385,640 SH   DFND 2 131,065 0 254,575
Axogen Inc COM 05463X106 3,697 171,097 SH   DFND 3 171,097 0 0
Axogen Inc COM 05463X106 3,665 169,600 SH   SOLE 0 169,600 0 0
Axon Enterprise Inc COM 05464C101 145,448 822,670 SH   DFND 1 822,670 0 0
Axon Enterprise Inc COM 05464C101 329,886 1,865,871 SH   DFND 2 1,608,128 0 257,743
Axon Enterprise Inc COM 05464C101 77,534 438,538 SH   DFND 3 256,851 0 181,687
Axon Enterprise Inc COM 05464C101 247,884 1,402,061 SH   SOLE 0 1,223,807 0 178,254
Axonics Modulation Technologies COM 05465P101 15 230 SH   DFND 3 230 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 13,795 67,656 SH   DFND 1 67,656 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 733,387 3,596,799 SH   DFND 2 3,287,842 0 308,957
Baidu.com Sponsored ADR SPON ADR REP A 056752108 38,900 190,779 SH   DFND 3 28,799 0 161,980
Baidu.com Sponsored ADR SPON ADR REP A 056752108 1,450 7,113 SH   DFND 4 7,113 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 102 498 SH   SOLE 0 498 0 0
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 25,980 5,064,279 SH   DFND 1 5,064,279 0 0
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 196,497 38,303,566 SH   DFND 2 20,719,757 0 17,583,809
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 8,254 1,608,888 SH   DFND 3 1,608,888 0 0
Bandwidth COM 05988J103 22 161 SH   DFND 2 161 0 0
Bandwidth COM 05988J103 22 161 SH   DFND 3 161 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 20,995 592,408 SH   DFND 1 592,408 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 15,372 433,748 SH   DFND 2 143,553 0 290,195
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 6,857 193,492 SH   DFND 3 193,492 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 10,423 294,100 SH   SOLE 0 294,100 0 0
Beam Therapeutics COM 07373V105 63 487 SH   DFND 3 487 0 0
BeiGene Ltd SPONSORED ADR 07725L102 134,625 392,274 SH   DFND 1 392,274 0 0
BeiGene Ltd SPONSORED ADR 07725L102 1,019,093 2,969,473 SH   DFND 2 1,160,951 0 1,808,522
BeiGene Ltd SPONSORED ADR 07725L102 94,065 274,090 SH   DFND 3 227,321 0 46,769
BeiGene Ltd SPONSORED ADR 07725L102 218,386 636,341 SH   SOLE 0 294,203 0 342,138
Benefitfocus Inc COM 08180D106 4,321 306,448 SH   DFND 1 306,448 0 0
Benefitfocus Inc COM 08180D106 4,141 293,696 SH   DFND 2 86,015 0 207,681
Benefitfocus Inc COM 08180D106 1,662 117,894 SH   DFND 3 117,894 0 0
Benefitfocus Inc COM 08180D106 3,192 226,368 SH   SOLE 0 226,368 0 0
Berkeley Lights Inc COM 084310101 44,189 986,148 SH   DFND 1 986,148 0 0
Berkeley Lights Inc COM 084310101 14,107 314,816 SH   DFND 2 177,799 0 137,017
Berkeley Lights Inc COM 084310101 30,629 683,527 SH   DFND 3 536,305 0 147,222
Berkeley Lights Inc COM 084310101 11,117 248,087 SH   SOLE 0 248,087 0 0
Beyond Meat Inc COM 08862E109 180,930 1,148,834 SH   DFND 1 1,148,834 0 0
Beyond Meat Inc COM 08862E109 773,250 4,909,836 SH   DFND 2 1,640,053 0 3,269,783
Beyond Meat Inc COM 08862E109 156,034 990,756 SH   DFND 3 787,611 0 203,145
Beyond Meat Inc COM 08862E109 210,260 1,335,067 SH   SOLE 0 644,473 0 690,594
Bilibili Inc ADR SPONSORED ADR 090040106 101,197 830,574 SH   DFND 1 830,574 0 0
Bilibili Inc ADR SPONSORED ADR 090040106 471,948 3,873,504 SH   DFND 2 1,239,504 0 2,634,000
Bilibili Inc ADR SPONSORED ADR 090040106 50,660 415,792 SH   DFND 3 338,409 0 77,383
Bilibili Inc ADR SPONSORED ADR 090040106 124,136 1,018,842 SH   SOLE 0 473,087 0 545,755
BioNTech ADR SPONS ADS 09075V102 121,836 544,203 SH   DFND 1 544,203 0 0
BioNTech ADR SPONS ADS 09075V102 953,584 4,259,351 SH   DFND 2 1,428,511 0 2,830,840
BioNTech ADR SPONS ADS 09075V102 106,397 475,240 SH   DFND 3 389,344 0 85,896
BioNTech ADR SPONS ADS 09075V102 257,676 1,150,955 SH   SOLE 0 532,693 0 618,262
Biomarin Pharmaceutical Inc COM 09061G101 7 82 SH   DFND 3 82 0 0
Blackline COM 09239B109 67,534 606,942 SH   DFND 1 606,942 0 0
Blackline COM 09239B109 37,219 334,490 SH   DFND 2 111,916 0 222,574
Blackline COM 09239B109 16,762 150,644 SH   DFND 3 150,644 0 0
Blackline COM 09239B109 31,220 280,576 SH   SOLE 0 280,576 0 0
Blackrock Inc COM 09247X101 18 21 SH   DFND 3 21 0 0
Blink Charging COM 09354A100 16 400 SH   DFND 3 400 0 0
Blue Apron Holdings Inc CL A 09523Q101 636 148,506 SH   DFND 1 148,506 0 0
Bluebird Bio Inc COM 09609G100 28 860 SH   DFND 3 860 0 0
Blueprint Medicines Corp COM 09627Y109 36 404 SH   DFND 3 404 0 0
Booking Holdings Inc COM 09857L108 113,527 51,884 SH   DFND 1 51,884 0 0
Booking Holdings Inc COM 09857L108 329,150 150,428 SH   DFND 2 140,491 0 9,937
Booking Holdings Inc COM 09857L108 68,612 31,357 SH   DFND 3 14,908 0 16,449
Booking Holdings Inc COM 09857L108 249,786 114,157 SH   SOLE 0 97,881 0 16,276
Boston Omaha COM 101044105 17 529 SH   DFND 3 529 0 0
Box Inc COM 10316T104 25 979 SH   DFND 3 979 0 0
Brady Corp COM 104674106 14 245 SH   DFND 3 245 0 0
BridgeBio Pharma Inc COM 10806X102 4,321 70,877 SH   DFND 1 70,877 0 0
BridgeBio Pharma Inc COM 10806X102 10,469 171,742 SH   DFND 2 171,742 0 0
BridgeBio Pharma Inc COM 10806X102 10,807 177,273 SH   DFND 3 177,273 0 0
Bristol Myers Squibb COM 110122108 38 562 SH   DFND 3 562 0 0
British Amer.Tobacco - ADR SPONSORED ADR 110448107 3,907 99,377 SH   DFND 1 99,377 0 0
British Amer.Tobacco - ADR SPONSORED ADR 110448107 102 2,586 SH   DFND 2 0 0 2,586
British Amer.Tobacco - ADR SPONSORED ADR 110448107 46 1,164 SH   DFND 3 1,164 0 0
British Amer.Tobacco - ADR SPONSORED ADR 110448107 4,485 114,090 SH   SOLE 0 114,090 0 0
Broadridge Finl.Sltn. COM 11133T103 80,733 499,801 SH   DFND 1 499,801 0 0
Broadridge Finl.Sltn. COM 11133T103 308,631 1,910,676 SH   DFND 2 1,793,802 0 116,874
Broadridge Finl.Sltn. COM 11133T103 57,779 357,699 SH   DFND 3 164,651 0 193,048
Broadridge Finl.Sltn. COM 11133T103 217,768 1,348,158 SH   SOLE 0 1,153,685 0 194,473
Brookfield Renewable COM 11284V105 43,829 1,045,031 SH   DFND 1 1,045,031 0 0
Brookfield Renewable COM 11284V105 136 3,252 SH   DFND 2 3,252 0 0
Brookfield Renewable COM 11284V105 3,138 74,817 SH   DFND 3 74,817 0 0
Bumble Inc COM CL A 12047B105 23,040 400,000 SH   SOLE 0 400,000 0 0
Burford Capital ORD SHS G17977110 8,126 790,620 SH   DFND 1 790,620 0 0
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 58,230 1,976,579 SH   DFND 1 1,976,579 0 0
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 181,229 6,151,700 SH   DFND 2 4,687,353 0 1,464,347
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 5,962 202,371 SH   DFND 3 24,659 0 177,712
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 3,882 131,772 SH   SOLE 0 131,772 0 0
Butterfly Network Inc COM CL A 124155102 3,025 208,933 SH   DFND 1 208,933 0 0
Butterfly Network Inc COM CL A 124155102 4,993 344,820 SH   DFND 2 344,820 0 0
Butterfly Network Inc COM CL A 124155102 7,567 522,573 SH   DFND 3 522,573 0 0
Butterfly Network Inc COM CL A 124155102 12,546 866,410 SH   SOLE 0 866,410 0 0
C3.ai CL A 12468P104 7 117 SH   DFND 3 117 0 0
CEVA Inc COM 157210105 8,452 178,680 SH   DFND 1 178,680 0 0
CEVA Inc COM 157210105 7,407 156,598 SH   DFND 2 51,077 0 105,521
CEVA Inc COM 157210105 2,997 63,354 SH   DFND 3 63,354 0 0
CEVA Inc COM 157210105 3,902 82,500 SH   SOLE 0 82,500 0 0
CH Robinson Worldwide COM NEW 12541W209 27,704 295,762 SH   DFND 1 295,762 0 0
CH Robinson Worldwide COM NEW 12541W209 630 6,729 SH   DFND 2 0 0 6,729
CH Robinson Worldwide COM NEW 12541W209 341 3,639 SH   DFND 3 3,639 0 0
CH Robinson Worldwide COM NEW 12541W209 27,292 291,358 SH   SOLE 0 291,358 0 0
Calavo Growers Inc COM 128246105 7 113 SH   DFND 3 113 0 0
Cardlytics Inc COM 14161W105 20,613 162,400 SH   DFND 1 162,400 0 0
Cardlytics Inc COM 14161W105 18,504 145,784 SH   DFND 2 48,579 0 97,205
Cardlytics Inc COM 14161W105 8,274 65,184 SH   DFND 3 65,184 0 0
Cardlytics Inc COM 14161W105 15,041 118,500 SH   SOLE 0 118,500 0 0
Cargurus Inc COM 141788109 11 429 SH   DFND 2 429 0 0
Cargurus Inc COM 141788109 11 431 SH   DFND 3 431 0 0
Carvana COM 146869102 393,753 1,304,597 SH   DFND 1 1,304,597 0 0
Carvana COM 146869102 1,177,910 3,902,690 SH   DFND 2 2,488,617 0 1,414,073
Carvana COM 146869102 126,949 420,613 SH   DFND 3 306,439 0 114,174
Carvana COM 146869102 657,563 2,178,661 SH   SOLE 0 1,817,030 0 361,631
Castle Biosciences COM 14843C105 15 200 SH   DFND 3 200 0 0
Cbre Group Inc CL A 12504L109 144,399 1,684,342 SH   DFND 1 1,684,342 0 0
Cbre Group Inc CL A 12504L109 428,007 4,992,495 SH   DFND 2 4,678,940 0 313,555
Cbre Group Inc CL A 12504L109 84,126 981,287 SH   DFND 3 467,385 0 513,902
Cbre Group Inc CL A 12504L109 307,371 3,585,337 SH   SOLE 0 3,068,955 0 516,382
Cellectis ADR SPONS ADS 15117K103 11,241 726,605 SH   DFND 1 726,605 0 0
Cellectis ADR SPONS ADS 15117K103 1,961 126,767 SH   DFND 2 126,767 0 0
Cellectis ADR SPONS ADS 15117K103 2,792 180,500 SH   SOLE 0 180,500 0 0
Celsius Holdings COM 15118V207 20 260 SH   DFND 3 260 0 0
Cemex ADR SPON ADR NEW 151290889 41,149 4,898,635 SH   DFND 1 4,898,635 0 0
Cemex ADR SPON ADR NEW 151290889 219,326 26,110,207 SH   DFND 2 10,691,375 0 15,418,832
Cemex ADR SPON ADR NEW 151290889 72,441 8,623,883 SH   DFND 3 1,204,490 0 7,419,393
Cemex ADR SPON ADR NEW 151290889 2,973 353,925 SH   DFND 4 353,925 0 0
Certara COM 15687V109 22,309 787,464 SH   SOLE 0 787,464 0 0
Cerus COM 157085101 7 1,143 SH   DFND 3 1,143 0 0
ChargePoint Holdings Inc COM CL A 15961R105 138,960 4,000,000 SH   SOLE 0 4,000,000 0 0
Chegg COM 163092109 486,081 5,848,651 SH   DFND 1 5,848,651 0 0
Chegg COM 163092109 680,876 8,192,471 SH   DFND 2 7,288,277 0 904,194
Chegg COM 163092109 102,446 1,232,661 SH   DFND 3 922,222 0 310,439
Chegg COM 163092109 276,460 3,326,438 SH   SOLE 0 3,055,533 0 270,905
Chewy Inc CL A 16679L109 233,830 2,933,509 SH   DFND 1 2,933,509 0 0
Chewy Inc CL A 16679L109 325,528 4,083,900 SH   DFND 2 3,897,893 0 186,007
Chewy Inc CL A 16679L109 14,827 186,013 SH   DFND 3 186,013 0 0
Chewy Inc CL A 16679L109 53,820 675,202 SH   SOLE 0 675,202 0 0
Chinook Therapeutics COM 16961L106 5,594 396,187 SH   DFND 1 396,187 0 0
Chinook Therapeutics COM 16961L106 3,187 225,682 SH   DFND 2 79,619 0 146,063
Chinook Therapeutics COM 16961L106 1,418 100,453 SH   DFND 3 100,453 0 0
Chinook Therapeutics COM 16961L106 1,653 117,058 SH   SOLE 0 117,058 0 0
Church & Dwight Co Inc COM 171340102 15 179 SH   DFND 3 179 0 0
Cimpress COM g2143t103 9 84 SH   DFND 3 84 0 0
Cisco Systems COM 17275R102 18,094 341,404 SH   DFND 1 341,404 0 0
Cisco Systems COM 17275R102 412 7,765 SH   DFND 2 0 0 7,765
Cisco Systems COM 17275R102 224 4,234 SH   DFND 3 4,234 0 0
Cisco Systems COM 17275R102 17,541 330,966 SH   SOLE 0 330,966 0 0
Clear Secure Inc COM 18467V109 32,000 1,000,000 SH   SOLE 0 1,000,000 0 0
Cloudera Inc COM 18914U100 57,839 3,646,828 SH   DFND 1 3,646,828 0 0
Cloudera Inc COM 18914U100 25,255 1,592,367 SH   DFND 2 531,046 0 1,061,321
Cloudera Inc COM 18914U100 11,162 703,788 SH   DFND 3 703,788 0 0
Cloudera Inc COM 18914U100 30,491 1,922,490 SH   SOLE 0 1,922,490 0 0
Cloudflare Inc CL A COM 18915M107 524,558 4,956,140 SH   DFND 1 4,956,140 0 0
Cloudflare Inc CL A COM 18915M107 1,809,037 17,092,191 SH   DFND 2 10,255,512 0 6,836,679
Cloudflare Inc CL A COM 18915M107 219,580 2,074,640 SH   DFND 3 1,471,096 0 603,544
Cloudflare Inc CL A COM 18915M107 650,304 6,144,213 SH   SOLE 0 4,329,014 0 1,815,199
Clover Health Investments Corp COM CL A 18914F103 68,494 5,142,177 SH   SOLE 0 5,142,177 0 0
Clovis Oncology COM 189464100 1 92 SH   DFND 3 92 0 0
CoStar Group COM 22160N109 281,672 3,401,020 SH   DFND 1 3,401,020 0 0
CoStar Group COM 22160N109 492,784 5,950,060 SH   DFND 2 5,652,120 0 297,940
CoStar Group COM 22160N109 46,610 562,790 SH   DFND 3 364,080 0 198,710
CoStar Group COM 22160N109 172,787 2,086,300 SH   SOLE 0 1,887,180 0 199,120
Coca Cola COM 191216100 26,012 480,730 SH   DFND 1 480,730 0 0
Coca Cola COM 191216100 604 11,165 SH   DFND 2 0 0 11,165
Coca Cola COM 191216100 316 5,846 SH   DFND 3 5,846 0 0
Coca Cola COM 191216100 26,131 482,925 SH   SOLE 0 482,925 0 0
Codexis COM 192005106 53,586 2,364,796 SH   DFND 1 2,364,796 0 0
Codexis COM 192005106 44,779 1,976,109 SH   DFND 2 734,915 0 1,241,194
Codexis COM 192005106 21,856 964,531 SH   DFND 3 914,964 0 49,567
Codexis COM 192005106 30,594 1,350,139 SH   SOLE 0 1,350,139 0 0
Cognyte Software ORD SHS M25133105 7 303 SH   DFND 3 303 0 0
Cohen & Steers Inc COM 19247A100 29 356 SH   DFND 3 356 0 0
Coherus BioSciences COM 19249H103 25 1,807 SH   DFND 3 1,807 0 0
Columbia Sportswear Co COM 198516106 9 95 SH   DFND 3 95 0 0
Commscope Holding Co Inc COM 20337X109 33 1,543 SH   DFND 3 1,543 0 0
Consolidated Edison COM 209115104 53,354 743,914 SH   DFND 1 743,914 0 0
Consolidated Edison COM 209115104 96 1,335 SH   DFND 2 1,335 0 0
Consolidated Edison COM 209115104 2,339 32,608 SH   DFND 3 32,608 0 0
Cooper Cos Inc/The COM 216648402 13,117 33,102 SH   DFND 2 33,102 0 0
Copa Holdings S A CL A P31076105 29,292 388,851 SH   DFND 1 388,851 0 0
Copa Holdings S A CL A P31076105 263,117 3,492,853 SH   DFND 2 2,302,369 0 1,190,484
Copa Holdings S A CL A P31076105 57,030 757,075 SH   DFND 3 96,877 0 660,198
Copa Holdings S A CL A P31076105 2,118 28,117 SH   DFND 4 28,117 0 0
Cornerstone Ondemand Inc COM 21925Y103 50 971 SH   DFND 3 971 0 0
Costco Wholesale Corporation COM 22160K105 31 79 SH   DFND 3 79 0 0
Coupa Software Inc COM 22266L106 94 360 SH   DFND 3 360 0 0
Coupang CL A 22266T109 118,711 2,838,622 SH   DFND 1 2,838,622 0 0
Coupang CL A 22266T109 1,034,539 24,737,910 SH   DFND 2 10,415,360 0 14,322,550
Coupang CL A 22266T109 118,708 2,838,551 SH   DFND 3 2,080,804 0 757,747
Coupang CL A 22266T109 776 18,547 SH   DFND 4 18,547 0 0
Coupang CL A 22266T109 226,215 5,409,251 SH   SOLE 0 2,508,299 0 2,900,952
Coursera Inc COM 22266M104 135,467 3,424,348 SH   DFND 1 3,424,348 0 0
Coursera Inc COM 22266M104 144,960 3,664,320 SH   DFND 2 3,329,921 0 334,399
Coursera Inc COM 22266M104 35,668 901,609 SH   DFND 3 708,898 0 192,711
Coursera Inc COM 22266M104 27,676 699,598 SH   SOLE 0 699,598 0 0
Credicorp COM G2519Y108 9,842 81,265 SH   DFND 1 81,265 0 0
Credicorp COM G2519Y108 162,909 1,345,132 SH   DFND 2 896,641 0 448,491
Credicorp COM G2519Y108 34,493 284,805 SH   DFND 3 39,086 0 245,719
Credicorp COM G2519Y108 1,472 12,158 SH   DFND 4 12,158 0 0
CrowdStrike Holdings COM 22788C105 35 138 SH   DFND 3 138 0 0
Cullen/Frost Bankers COM 229899109 13,493 120,472 SH   DFND 1 120,472 0 0
Cullen/Frost Bankers COM 229899109 297 2,654 SH   DFND 2 0 0 2,654
Cullen/Frost Bankers COM 229899109 168 1,503 SH   DFND 3 1,503 0 0
Cullen/Frost Bankers COM 229899109 13,389 119,544 SH   SOLE 0 119,544 0 0
CureVac N.V. - Converted at IPO COM N2451R105 137,408 1,870,009 SH   DFND 2 1,870,009 0 0
CureVac N.V. - Converted at IPO COM N2451R105 114,507 1,558,341 SH   SOLE 0 1,558,341 0 0
Curevac N.V. COM N2451R105 153,346 2,086,912 SH   DFND 2 1,617,130 0 469,782
CyberArk Software Ltd SHS M2682V108 33,099 254,077 SH   DFND 1 254,077 0 0
CyberArk Software Ltd SHS M2682V108 27,776 213,220 SH   DFND 2 71,325 0 141,895
CyberArk Software Ltd SHS M2682V108 12,226 93,855 SH   DFND 3 93,855 0 0
CyberArk Software Ltd SHS M2682V108 14,996 115,118 SH   SOLE 0 115,118 0 0
DTE Energy Co COM 233331107 59,448 458,700 SH   DFND 1 458,700 0 0
DTE Energy Co COM 233331107 114 877 SH   DFND 2 877 0 0
DTE Energy Co COM 233331107 3,112 24,012 SH   DFND 3 24,012 0 0
Dada Nexus Ltd ADR ADS 23344D108 89,401 3,081,716 SH   DFND 1 3,081,716 0 0
Dada Nexus Ltd ADR ADS 23344D108 108,197 3,729,655 SH   DFND 2 2,401,562 0 1,328,093
Dada Nexus Ltd ADR ADS 23344D108 1,100 37,901 SH   DFND 3 37,901 0 0
Dada Nexus Ltd ADR ADS 23344D108 26,310 906,943 SH   SOLE 0 906,943 0 0
Darden Restaurants COM 237194105 12 82 SH   DFND 3 82 0 0
Datadog COM 23804L103 168,536 1,619,295 SH   DFND 1 1,619,295 0 0
Datadog COM 23804L103 339,554 3,262,431 SH   DFND 2 3,087,258 0 175,173
Datadog COM 23804L103 40,496 389,083 SH   DFND 3 220,237 0 168,846
Datadog COM 23804L103 154,485 1,484,294 SH   SOLE 0 1,311,630 0 172,664
Deere & Co COM 244199105 95,359 270,362 SH   DFND 1 270,362 0 0
Deere & Co COM 244199105 26,405 74,862 SH   DFND 2 23,683 0 51,179
Deere & Co COM 244199105 76,787 217,707 SH   DFND 3 161,860 0 55,847
Deere & Co COM 244199105 9,910 28,098 SH   SOLE 0 28,098 0 0
Denali Therapeutics COM 24823R105 244,551 3,117,676 SH   DFND 1 3,117,676 0 0
Denali Therapeutics COM 24823R105 335,239 4,273,833 SH   DFND 2 4,092,485 0 181,348
Denali Therapeutics COM 24823R105 32,640 416,115 SH   DFND 3 377,495 0 38,620
Denali Therapeutics COM 24823R105 575,749 7,339,989 SH   SOLE 0 7,339,989 0 0
DermTech COM 24984K105 12 286 SH   DFND 3 286 0 0
Dexcom Inc COM 252131107 305,393 715,205 SH   DFND 1 715,205 0 0
Dexcom Inc COM 252131107 1,295,277 3,033,435 SH   DFND 2 1,023,029 0 2,010,406
Dexcom Inc COM 252131107 274,505 642,869 SH   DFND 3 515,119 0 127,750
Dexcom Inc COM 252131107 352,323 825,112 SH   SOLE 0 401,135 0 423,977
Digimarc COM 25381B101 8,792 262,445 SH   DFND 1 262,445 0 0
Digimarc COM 25381B101 9,756 291,233 SH   DFND 2 96,360 0 194,873
Digimarc COM 25381B101 4,290 128,056 SH   DFND 3 128,056 0 0
Digimarc COM 25381B101 5,183 154,711 SH   SOLE 0 154,711 0 0
Docebo COM 25609L105 6,732 113,635 SH   DFND 2 113,635 0 0
Docebo COM 25609L105 18 300 SH   DFND 3 300 0 0
Dolby Laboratories 'A' COM 25659T107 14,985 152,454 SH   DFND 1 152,454 0 0
Dolby Laboratories 'A' COM 25659T107 339 3,452 SH   DFND 2 0 0 3,452
Dolby Laboratories 'A' COM 25659T107 187 1,903 SH   DFND 3 1,903 0 0
Dolby Laboratories 'A' COM 25659T107 14,659 149,143 SH   SOLE 0 149,143 0 0
Domo COM 257554105 33 407 SH   DFND 3 407 0 0
Doordash Inc COM 25809K105 154,678 867,367 SH   DFND 1 867,367 0 0
Doordash Inc COM 25809K105 354,353 1,987,062 SH   DFND 2 1,870,500 0 116,562
Doordash Inc COM 25809K105 52,285 293,192 SH   DFND 3 153,926 0 139,266
Doordash Inc COM 25809K105 359,919 2,018,275 SH   SOLE 0 1,879,924 0 138,351
Dropbox CL A 26210C104 27 881 SH   DFND 3 881 0 0
Duck Creek Technologies SHS 264120106 15 355 SH   DFND 3 355 0 0
Duke Realty Corporation REIT COM 264411505 66,986 1,414,700 SH   DFND 1 1,414,700 0 0
Duke Realty Corporation REIT COM 264411505 161 3,392 SH   DFND 2 3,392 0 0
Duke Realty Corporation REIT COM 264411505 3,168 66,900 SH   DFND 3 66,900 0 0
EOG Resources COM 26875P101 42,069 504,178 SH   DFND 1 504,178 0 0
EOG Resources COM 26875P101 153,614 1,841,014 SH   DFND 2 1,720,322 0 120,692
EOG Resources COM 26875P101 22,311 267,387 SH   DFND 3 139,044 0 128,343
EOG Resources COM 26875P101 110,712 1,326,842 SH   SOLE 0 1,093,999 0 232,843
Eargo COM 270087109 10 263 SH   DFND 3 263 0 0
Ecolab COM 278865100 66,458 322,661 SH   DFND 1 322,661 0 0
Ecolab COM 278865100 29,225 141,892 SH   DFND 2 81,315 0 60,577
Ecolab COM 278865100 52,994 257,291 SH   DFND 3 191,442 0 65,849
Ecolab COM 278865100 6,302 30,597 SH   SOLE 0 30,597 0 0
Edwards Lifesciences Corp COM 28176E108 4,629 44,696 SH   DFND 1 44,696 0 0
Edwards Lifesciences Corp COM 28176E108 25,613 247,299 SH   DFND 2 247,299 0 0
Edwards Lifesciences Corp COM 28176E108 11,578 111,792 SH   DFND 3 111,792 0 0
Emergent Biosolutions Inc COM 29089Q105 27 423 SH   DFND 3 423 0 0
Estee Lauder 'A' COM 518439104 117,536 369,517 SH   DFND 1 369,517 0 0
Estee Lauder 'A' COM 518439104 463,009 1,455,637 SH   DFND 2 1,370,407 0 85,230
Estee Lauder 'A' COM 518439104 84,206 264,732 SH   DFND 3 123,840 0 140,892
Estee Lauder 'A' COM 518439104 315,004 990,331 SH   SOLE 0 847,886 0 142,445
EverQuote Inc COM CL A 30041R108 23,496 718,967 SH   DFND 1 718,967 0 0
EverQuote Inc COM CL A 30041R108 9,053 277,009 SH   DFND 2 91,887 0 185,122
EverQuote Inc COM CL A 30041R108 3,989 122,057 SH   DFND 3 122,057 0 0
EverQuote Inc COM CL A 30041R108 7,567 231,550 SH   SOLE 0 231,550 0 0
Everbridge Inc COM 29978A104 45,013 330,786 SH   DFND 1 330,786 0 0
Everbridge Inc COM 29978A104 28,792 211,578 SH   DFND 2 70,702 0 140,876
Everbridge Inc COM 29978A104 12,723 93,496 SH   DFND 3 93,496 0 0
Everbridge Inc COM 29978A104 20,201 148,446 SH   SOLE 0 148,446 0 0
Eversource Energy COM 30040W108 43,466 541,700 SH   DFND 1 541,700 0 0
Eversource Energy COM 30040W108 91 1,128 SH   DFND 2 1,128 0 0
Eversource Energy COM 30040W108 2,250 28,046 SH   DFND 3 28,046 0 0
Exact Sciences COM 30063P105 135,114 1,086,915 SH   DFND 1 1,086,915 0 0
Exact Sciences COM 30063P105 207,681 1,670,670 SH   DFND 2 1,348,618 0 322,052
Exact Sciences COM 30063P105 63,304 509,244 SH   DFND 3 361,910 0 147,334
Exact Sciences COM 30063P105 149,085 1,199,298 SH   SOLE 0 1,068,777 0 130,521
Exelon Corporation COM 30161N101 987 22,268 SH   DFND 1 22,268 0 0
Expeditors Intl COM 302130109 16 126 SH   DFND 3 126 0 0
Exponent COM 30214U102 22 242 SH   DFND 3 242 0 0
Facebook Cl.A CL A 30303M102 272,165 782,736 SH   DFND 1 782,736 0 0
Facebook Cl.A CL A 30303M102 1,623,092 4,667,947 SH   DFND 2 2,354,708 0 2,313,239
Facebook Cl.A CL A 30303M102 230,762 663,663 SH   DFND 3 460,056 0 203,607
Facebook Cl.A CL A 30303M102 654,908 1,883,488 SH   SOLE 0 1,258,815 0 624,673
Farfetch ORD SHS CL A 30744W107 90,580 1,798,653 SH   DFND 1 1,798,653 0 0
Farfetch ORD SHS CL A 30744W107 286,887 5,696,728 SH   DFND 2 5,321,031 0 375,697
Farfetch ORD SHS CL A 30744W107 64,093 1,272,688 SH   DFND 3 662,765 0 609,923
Farfetch ORD SHS CL A 30744W107 274,836 5,457,418 SH   SOLE 0 4,445,576 0 1,011,842
Fastenal COM 311900104 53,230 1,023,649 SH   DFND 1 1,023,649 0 0
Fastenal COM 311900104 21,080 405,394 SH   DFND 2 386,614 0 18,780
Fastenal COM 311900104 4,819 92,666 SH   DFND 3 65,466 0 27,200
Fastenal COM 311900104 42,245 812,401 SH   SOLE 0 812,401 0 0
Fastly CL A 31188V100 12 205 SH   DFND 3 205 0 0
Ferrari NV COM N3167Y103 1,835,582 8,895,628 SH   DFND 2 7,249,923 0 1,645,705
Ferrari NV COM N3167Y103 280,615 1,359,921 SH   SOLE 0 1,359,921 0 0
Fibrogen Inc COM 31572Q808 12 467 SH   DFND 3 467 0 0
First Industrial REIT COM 32054K103 66,645 1,276,000 SH   DFND 1 1,276,000 0 0
First Industrial REIT COM 32054K103 159 3,053 SH   DFND 2 3,053 0 0
First Industrial REIT COM 32054K103 3,148 60,268 SH   DFND 3 60,268 0 0
First Majestic Silver COM 32076V103 128 8,100 SH   DFND 2 8,100 0 0
First Republic Bank COM 33616C100 342,790 1,831,435 SH   DFND 1 1,831,435 0 0
First Republic Bank COM 33616C100 486,945 2,601,617 SH   DFND 2 2,497,180 0 104,437
First Republic Bank COM 33616C100 30,322 162,001 SH   DFND 3 144,584 0 17,417
First Republic Bank COM 33616C100 74,559 398,351 SH   SOLE 0 398,351 0 0
FirstCash COM 33767D105 23,393 306,030 SH   DFND 1 306,030 0 0
FirstCash COM 33767D105 1,143 14,953 SH   DFND 3 14,953 0 0
Fiverr Intl ORD SHS M4R82T106 15 61 SH   DFND 3 61 0 0
Fortis COM 349553107 1,350 30,457 SH   DFND 1 30,457 0 0
Fortive Corp COM 34959J108 7,606 109,062 SH   DFND 2 109,062 0 0
Fox COM 35137L105 13 359 SH   DFND 3 359 0 0
Freshpet Inc COM 358039105 18 112 SH   DFND 2 112 0 0
Full Truck Alliance - converted at IPO SPONS ADS 35969L108 127,559 125,181,008 SH   SOLE 0 125,181,008 0 0
Full Truck Alliance Co Ltd ADR SPONS ADS 35969L108 328,534 16,120,424 SH   DFND 2 15,939,604 0 180,820
GAN COM G3728V109 9 572 SH   DFND 3 572 0 0
Gentex Corp COM 371901109 17 516 SH   DFND 3 516 0 0
Glaukos Corp COM 377322102 187,008 2,204,498 SH   DFND 1 2,204,498 0 0
Glaukos Corp COM 377322102 213,526 2,517,102 SH   DFND 2 2,342,872 0 174,230
Glaukos Corp COM 377322102 41,729 491,913 SH   DFND 3 408,541 0 83,372
Glaukos Corp COM 377322102 32,930 388,183 SH   SOLE 0 388,183 0 0
Global Blood Therapeutics Inc COM 37890U108 33 954 SH   DFND 3 954 0 0
Graco COM 384109104 27 363 SH   DFND 3 363 0 0
Grifols ADR SP ADR REP B NVT 398438408 51,148 2,948,016 SH   DFND 2 2,318,271 0 629,745
HDFC Bank ADR ADR REPS 3 SHS 40415F101 4,511 61,687 SH   DFND 1 61,687 0 0
HDFC Bank ADR ADR REPS 3 SHS 40415F101 62,027 848,289 SH   DFND 2 786,267 0 62,022
HDFC Bank ADR ADR REPS 3 SHS 40415F101 13,646 186,620 SH   DFND 3 100,364 0 86,256
HDFC Bank ADR ADR REPS 3 SHS 40415F101 79,695 1,089,927 SH   SOLE 0 986,635 0 103,292
HEICO COM 422806109 17,172 123,169 SH   DFND 1 123,169 0 0
HEICO COM 422806109 7,832 56,177 SH   SOLE 0 56,177 0 0
HEICO 'A' CL A 422806208 65,433 526,920 SH   DFND 1 526,920 0 0
HEICO 'A' CL A 422806208 124,114 999,465 SH   DFND 2 960,005 0 39,460
HEICO 'A' CL A 422806208 5,100 41,072 SH   DFND 3 41,072 0 0
HEICO 'A' CL A 422806208 10,660 85,844 SH   SOLE 0 85,844 0 0
HUYA ADR ADS REP SHS A 44852D108 54,846 3,107,418 SH   DFND 1 3,107,418 0 0
HUYA ADR ADS REP SHS A 44852D108 77,811 4,408,559 SH   DFND 2 2,483,022 0 1,925,537
HUYA ADR ADS REP SHS A 44852D108 6,977 395,287 SH   DFND 3 27,258 0 368,029
HUYA ADR ADS REP SHS A 44852D108 23,327 1,321,644 SH   SOLE 0 1,321,644 0 0
Halozyme Therapeutics COM 40637H109 44 962 SH   DFND 3 962 0 0
Harris Corp COM 502431109 13 61 SH   DFND 3 61 0 0
Health Catalyst Inc COM 42225T107 2,831 50,999 SH   DFND 1 50,999 0 0
Health Catalyst Inc COM 42225T107 6,762 121,823 SH   DFND 2 121,823 0 0
Health Catalyst Inc COM 42225T107 7,035 126,740 SH   DFND 3 126,740 0 0
Healthcare Services Group Inc COM 421906108 5 157 SH   DFND 3 157 0 0
Hecla Mining Co COM 422704106 124 16,700 SH   DFND 2 16,700 0 0
Heron Therapeutics Inc COM 427746102 5 308 SH   DFND 3 308 0 0
Hillenbrand COM 431571108 7 170 SH   DFND 3 170 0 0
Home Depot COM 437076102 19 61 SH   DFND 3 61 0 0
Homology Medicines COM 438083107 3 481 SH   DFND 3 481 0 0
Hormel Foods Corp COM 440452100 13 264 SH   DFND 3 264 0 0
Howard Hughes COM 44267D107 66,076 677,982 SH   DFND 1 677,982 0 0
Howard Hughes COM 44267D107 141,708 1,454,017 SH   DFND 2 1,358,605 0 95,412
Howard Hughes COM 44267D107 29,309 300,725 SH   DFND 3 146,119 0 154,606
Howard Hughes COM 44267D107 108,564 1,113,937 SH   SOLE 0 955,691 0 158,246
Hubbell COM 443510607 16 87 SH   DFND 3 87 0 0
Hubspot Inc COM 443573100 87 149 SH   DFND 3 149 0 0
Humana COM 444859102 26 58 SH   DFND 3 58 0 0
Hutchison China Meditech SPONSORED ADR 44842L103 4,827 122,917 SH   DFND 1 122,917 0 0
Hutchison China Meditech SPONSORED ADR 44842L103 2,383 60,680 SH   DFND 2 0 0 60,680
Hutchison China Meditech SPONSORED ADR 44842L103 7,212 183,661 SH   DFND 3 72 0 183,589
ICICI Bank ADR ADR 45104G104 146,935 8,592,661 SH   DFND 1 8,592,661 0 0
ICICI Bank ADR ADR 45104G104 159,223 9,311,263 SH   DFND 2 8,624,176 0 687,087
ICICI Bank ADR ADR 45104G104 75,847 4,435,493 SH   DFND 3 2,667,608 0 1,767,885
ICICI Bank ADR ADR 45104G104 7,311 427,538 SH   DFND 4 427,538 0 0
ICICI Bank ADR ADR 45104G104 160,257 9,371,742 SH   SOLE 0 8,193,763 0 1,177,979
IPG Photonics Corp COM 44980X109 25,450 120,747 SH   DFND 1 120,747 0 0
IPG Photonics Corp COM 44980X109 24,205 114,840 SH   DFND 2 38,572 0 76,268
IPG Photonics Corp COM 44980X109 10,684 50,689 SH   DFND 3 50,689 0 0
IPG Photonics Corp COM 44980X109 19,040 90,336 SH   SOLE 0 90,336 0 0
Iac/Interactivecorp COM 44891N208 34,742 225,349 SH   DFND 1 225,349 0 0
Iac/Interactivecorp COM 44891N208 113,820 738,276 SH   DFND 2 685,437 0 52,839
Iac/Interactivecorp COM 44891N208 25,353 164,449 SH   DFND 3 76,365 0 88,084
Iac/Interactivecorp COM 44891N208 93,533 606,686 SH   SOLE 0 520,042 0 86,644
Iclick Interactive Asia G SPON ADR 45113Y104 36,226 3,281,375 SH   DFND 1 3,281,375 0 0
Iclick Interactive Asia G SPON ADR 45113Y104 9,234 836,416 SH   DFND 2 836,416 0 0
Iclick Interactive Asia G SPON ADR 45113Y104 401 36,316 SH   DFND 3 36,316 0 0
Iclick Interactive Asia G SPON ADR 45113Y104 7,634 691,490 SH   SOLE 0 691,490 0 0
Ii-Vi Inc COM 902104108 46 636 SH   DFND 3 636 0 0
Illumina COM 452327109 968,446 2,046,545 SH   DFND 1 2,046,545 0 0
Illumina COM 452327109 5,836,452 12,333,747 SH   DFND 2 8,881,582 0 3,452,165
Illumina COM 452327109 512,873 1,083,817 SH   DFND 3 844,699 0 239,118
Illumina COM 452327109 2,709,004 5,724,740 SH   SOLE 0 5,006,752 0 717,988
InMode SHS M5425M103 35 369 SH   DFND 3 369 0 0
Incyte Corp COM 45337C102 14 165 SH   DFND 3 165 0 0
Infinera COM 45667G103 30 2,941 SH   DFND 3 2,941 0 0
Infosys Ltd ADR SPONSORED ADR 456788108 22,340 1,054,275 SH   DFND 1 1,054,275 0 0
Infosys Ltd ADR SPONSORED ADR 456788108 16,099 759,768 SH   DFND 2 77,844 0 681,924
Infosys Ltd ADR SPONSORED ADR 456788108 14,333 676,402 SH   DFND 3 553,985 0 122,417
Infosys Ltd ADR SPONSORED ADR 456788108 3,241 152,945 SH   DFND 4 152,945 0 0
Inogen Inc COM 45780L104 9 141 SH   DFND 3 141 0 0
Insmed Inc COM 457669307 22 787 SH   DFND 3 787 0 0
Inspire Medical Systems COM 457730109 38 198 SH   DFND 3 198 0 0
Intercept Pharmaceuticals Inc COM 45845P108 2 101 SH   DFND 3 101 0 0
Intersect ENT COM 46071F103 6 361 SH   DFND 3 361 0 0
Intuitive Surgical COM NEW 46120E602 118,087 128,406 SH   DFND 1 128,406 0 0
Intuitive Surgical COM NEW 46120E602 929,764 1,011,009 SH   DFND 2 338,571 0 672,438
Intuitive Surgical COM NEW 46120E602 108,322 117,787 SH   DFND 3 97,803 0 19,984
Intuitive Surgical COM NEW 46120E602 250,385 272,264 SH   SOLE 0 125,896 0 146,368
Invesco Senior Income Trust COM 46131H107 11,404 2,556,949 SH   DFND 1 2,556,949 0 0
Invesco Senior Income Trust COM 46131H107 2,849 638,746 SH   DFND 3 638,746 0 0
Ionis Pharmaceuticals COM 462222100 1,822 45,685 SH   DFND 1 45,685 0 0
Ionis Pharmaceuticals COM 462222100 4,390 110,048 SH   DFND 2 110,048 0 0
Ionis Pharmaceuticals COM 462222100 4,614 115,663 SH   DFND 3 115,663 0 0
Ironwood Pharmaceuticals Inc COM 46333X108 12 935 SH   DFND 3 935 0 0
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 16,251 2,704,041 SH   DFND 1 2,704,041 0 0
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 231,446 38,510,232 SH   DFND 2 25,086,919 0 13,423,313
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 56,024 9,321,827 SH   DFND 3 1,245,074 0 8,076,753
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 2,315 385,212 SH   DFND 4 385,212 0 0
Itron Inc COM 465741106 20 204 SH   DFND 3 204 0 0
J&J Snack Foods Corp COM 466032109 14 83 SH   DFND 3 83 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 113,074 1,416,794 SH   DFND 1 1,416,794 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 5,457 68,377 SH   DFND 2 68,377 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 186 2,331 SH   DFND 3 2,331 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 23,299 291,937 SH   SOLE 0 291,937 0 0
JDS Uniphase Corporation COM 925550105 20 1,142 SH   DFND 3 1,142 0 0
JFrog Ltd ORD SHS M6191J100 23,784 522,500 SH   DFND 1 522,500 0 0
JFrog Ltd ORD SHS M6191J100 13,301 292,206 SH   DFND 2 97,419 0 194,787
JFrog Ltd ORD SHS M6191J100 5,781 127,001 SH   DFND 3 127,001 0 0
JFrog Ltd ORD SHS M6191J100 16,296 358,000 SH   SOLE 0 358,000 0 0
Jack Henry & Associates COM 426281101 12 71 SH   DFND 3 71 0 0
Jaguar Health - US indemnity shares COM 47010C409 0 2,033,592 SH   SOLE 0 2,033,592 0 0
John Wiley & Sons Inc COM 968223206 9 153 SH   DFND 3 153 0 0
Johnson & Johnson COM 478160104 15 89 SH   DFND 3 89 0 0
Jumia Technologies Ag ADR SPONSORED ADS 48138M105 291,757 9,619,417 SH   DFND 2 9,089,040 0 530,377
Jumia Technologies Ag ADR SPONSORED ADS 48138M105 11 374 SH   DFND 3 374 0 0
KE Holdings ADR ADR 482497104 102,896 2,158,045 SH   DFND 1 2,158,045 0 0
KE Holdings ADR ADR 482497104 614,066 12,878,899 SH   DFND 2 6,453,196 0 6,425,703
KE Holdings ADR ADR 482497104 48,110 1,009,008 SH   DFND 3 741,807 0 267,201
KE Holdings ADR ADR 482497104 233,249 4,891,967 SH   SOLE 0 3,721,979 0 1,169,988
Kaleido Biosciences Inc COM 483347100 2,740 368,288 SH   DFND 1 368,288 0 0
Kaleido Biosciences Inc COM 483347100 8 1,070 SH   DFND 2 1,070 0 0
Kaleido Biosciences Inc COM 483347100 2,151 289,103 SH   SOLE 0 289,103 0 0
Keysight Technologies COM 49338L103 24 158 SH   DFND 3 158 0 0
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 67,536 1,990,457 SH   DFND 1 1,990,457 0 0
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 161,311 4,754,228 SH   DFND 2 2,902,627 0 1,851,601
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 10,751 316,868 SH   DFND 3 32,999 0 283,869
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 13,340 393,153 SH   SOLE 0 393,153 0 0
Korea Electric Power ADR SPONSORED ADR 500631106 24 2,224 SH   DFND 2 2,224 0 0
Korea Electric Power ADR SPONSORED ADR 500631106 1,743 161,422 SH   DFND 3 161,422 0 0
Lci Industries COM 50189K103 11 86 SH   DFND 3 86 0 0
Lemonade Inc COM 52567D107 188,464 1,722,551 SH   DFND 1 1,722,551 0 0
Lemonade Inc COM 52567D107 259,267 2,369,685 SH   DFND 2 2,263,749 0 105,936
Lemonade Inc COM 52567D107 11,793 107,787 SH   DFND 3 107,787 0 0
Lemonade Inc COM 52567D107 97,671 892,708 SH   SOLE 0 892,708 0 0
LendingTree COM 52603B107 68,430 322,966 SH   DFND 1 322,966 0 0
LendingTree COM 52603B107 120,207 567,334 SH   DFND 2 409,938 0 157,396
LendingTree COM 52603B107 37,349 176,275 SH   DFND 3 132,298 0 43,977
LendingTree COM 52603B107 79,760 376,441 SH   SOLE 0 338,865 0 37,576
Li Auto ADR SPONS ADS 50202M102 66,114 1,892,209 SH   DFND 1 1,892,209 0 0
Li Auto ADR SPONS ADS 50202M102 229,893 6,579,637 SH   DFND 2 5,884,112 0 695,525
Li Auto ADR SPONS ADS 50202M102 46,639 1,334,840 SH   DFND 3 620,630 0 714,210
Li Auto ADR SPONS ADS 50202M102 175,492 5,022,654 SH   SOLE 0 4,322,892 0 699,762
Liberty Broadband Corp COM 530307305 12 70 SH   DFND 3 70 0 0
Lightspeed POS COM 53227R106 28 335 SH   DFND 3 335 0 0
LivePerson Inc COM 538146101 31,132 492,291 SH   DFND 1 492,291 0 0
LivePerson Inc COM 538146101 24,008 379,637 SH   DFND 2 126,977 0 252,660
LivePerson Inc COM 538146101 10,775 170,377 SH   DFND 3 170,377 0 0
LivePerson Inc COM 538146101 15,676 247,880 SH   SOLE 0 247,880 0 0
Liveramp Holdings Inc COM 53815P108 28,832 615,401 SH   DFND 1 615,401 0 0
Liveramp Holdings Inc COM 53815P108 15,277 326,075 SH   DFND 2 108,829 0 217,246
Liveramp Holdings Inc COM 53815P108 6,752 144,119 SH   DFND 3 144,119 0 0
Liveramp Holdings Inc COM 53815P108 13,824 295,075 SH   SOLE 0 295,075 0 0
Logitech International SA SHS H50430232 32 265 SH   DFND 3 265 0 0
Lowes Cos COM 548661107 13 69 SH   DFND 3 69 0 0
Lufax Holding Ltd COM 54975P102 71,223 6,302,948 SH   DFND 1 6,302,948 0 0
Lufax Holding Ltd COM 54975P102 137,313 12,151,624 SH   DFND 2 7,119,323 0 5,032,301
Lufax Holding Ltd COM 54975P102 967 85,596 SH   DFND 3 85,596 0 0
Lufax Holding Ltd COM 54975P102 9,071 802,735 SH   SOLE 0 802,735 0 0
Lumentum Hdgs COM 55024U109 14 168 SH   DFND 3 168 0 0
Lyell Immunopharma Inc COM 55083R104 705 43,388 SH   DFND 1 43,388 0 0
Lyell Immunopharma Inc COM 55083R104 1,767 108,789 SH   DFND 2 108,789 0 0
Lyell Immunopharma Inc COM 55083R104 1,732 106,646 SH   DFND 3 106,646 0 0
Lyft Inc Class A Common CL A COM 55087P104 129,768 2,145,632 SH   DFND 1 2,145,632 0 0
Lyft Inc Class A Common CL A COM 55087P104 274,418 4,537,337 SH   DFND 2 4,272,223 0 265,114
Lyft Inc Class A Common CL A COM 55087P104 44,997 743,996 SH   DFND 3 388,479 0 355,517
Lyft Inc Class A Common CL A COM 55087P104 160,533 2,654,322 SH   SOLE 0 2,294,339 0 359,983
MakeMyTrip SHS V5633W109 74,239 2,470,515 SH   DFND 2 1,849,145 0 621,370
Marathon Digital Holdings COM 565788106 9 284 SH   DFND 3 284 0 0
Markel Corp COM 570535104 65,624 55,299 SH   DFND 1 55,299 0 0
Markel Corp COM 570535104 227,352 191,582 SH   DFND 2 179,041 0 12,541
Markel Corp COM 570535104 46,508 39,191 SH   DFND 3 18,606 0 20,585
Markel Corp COM 570535104 170,632 143,786 SH   SOLE 0 123,259 0 20,527
MarketAxess Holdings COM 57060D108 277,948 599,555 SH   DFND 1 599,555 0 0
MarketAxess Holdings COM 57060D108 393,848 849,562 SH   DFND 2 708,344 0 141,218
MarketAxess Holdings COM 57060D108 59,390 128,108 SH   DFND 3 119,001 0 9,107
MarketAxess Holdings COM 57060D108 91,515 197,406 SH   SOLE 0 197,406 0 0
Martin Marietta Materials COM 573284106 186,974 531,464 SH   DFND 1 531,464 0 0
Martin Marietta Materials COM 573284106 600,782 1,707,690 SH   DFND 2 1,597,837 0 109,853
Martin Marietta Materials COM 573284106 111,979 318,295 SH   DFND 3 163,025 0 155,270
Martin Marietta Materials COM 573284106 441,955 1,256,231 SH   SOLE 0 1,074,839 0 181,392
Masimo Corp COM 574795100 3,179 13,114 SH   DFND 1 13,114 0 0
Masimo Corp COM 574795100 7,617 31,415 SH   DFND 2 31,415 0 0
Masimo Corp COM 574795100 7,952 32,799 SH   DFND 3 32,799 0 0
Mastercard Inc-Class A CL A 57636Q104 201,207 551,117 SH   DFND 1 551,117 0 0
Mastercard Inc-Class A CL A 57636Q104 716,136 1,961,533 SH   DFND 2 1,839,979 0 121,554
Mastercard Inc-Class A CL A 57636Q104 139,532 382,184 SH   DFND 3 181,646 0 200,538
Mastercard Inc-Class A CL A 57636Q104 495,968 1,358,481 SH   SOLE 0 1,161,122 0 197,359
McDonald's COM 580135101 22,527 97,524 SH   DFND 1 97,524 0 0
McDonald's COM 580135101 509 2,204 SH   DFND 2 0 0 2,204
McDonald's COM 580135101 278 1,203 SH   DFND 3 1,203 0 0
McDonald's COM 580135101 21,829 94,504 SH   SOLE 0 94,504 0 0
Medalllia Inc COM 584021109 18 542 SH   DFND 2 542 0 0
Medifast Inc COM 58470H101 37 129 SH   DFND 3 129 0 0
Medtronic COM G5960L103 18,774 151,246 SH   DFND 1 151,246 0 0
Medtronic COM G5960L103 437 3,518 SH   DFND 2 0 0 3,518
Medtronic COM G5960L103 233 1,878 SH   DFND 3 1,878 0 0
Medtronic COM G5960L103 18,486 148,924 SH   SOLE 0 148,924 0 0
MercadoLibre COM 58733R102 436,295 280,073 SH   DFND 1 280,073 0 0
MercadoLibre COM 58733R102 5,935,523 3,810,220 SH   DFND 2 3,163,864 0 646,356
MercadoLibre COM 58733R102 208,372 133,761 SH   DFND 3 109,027 0 24,734
MercadoLibre COM 58733R102 9,496 6,096 SH   DFND 4 6,096 0 0
MercadoLibre COM 58733R102 580,235 372,473 SH   SOLE 0 372,473 0 0
Mercury Computer Systems COM 589378108 14 205 SH   DFND 3 205 0 0
Meredith Corp COM 589433101 13 293 SH   DFND 3 293 0 0
Mettler-Toledo COM 592688105 116,097 83,804 SH   DFND 1 83,804 0 0
Mettler-Toledo COM 592688105 601,724 434,351 SH   DFND 2 308,547 0 125,804
Mettler-Toledo COM 592688105 4,822 3,481 SH   DFND 3 3,481 0 0
Mettler-Toledo COM 592688105 38,544 27,823 SH   SOLE 0 27,823 0 0
Microsoft COM 594918104 266,294 982,999 SH   DFND 1 982,999 0 0
Microsoft COM 594918104 852,468 3,146,798 SH   DFND 2 2,954,093 0 192,705
Microsoft COM 594918104 158,084 583,551 SH   DFND 3 275,849 0 307,702
Microsoft COM 594918104 624,073 2,303,703 SH   SOLE 0 1,994,585 0 309,118
Mobile Telesystems ADR SPONSORED ADR 607409109 275 29,700 SH   DFND 1 29,700 0 0
Moderna Inc COM 60770K107 1,278,364 5,440,310 SH   DFND 1 5,440,310 0 0
Moderna Inc COM 60770K107 6,283,924 26,742,377 SH   DFND 2 20,720,587 0 6,021,790
Moderna Inc COM 60770K107 640,489 2,725,715 SH   DFND 3 2,079,841 0 645,874
Moderna Inc COM 60770K107 2,578,861 10,974,811 SH   SOLE 0 9,721,551 0 1,253,260
Momentive Global Inc COM 78489X103 23 1,095 SH   DFND 3 1,095 0 0
MongoDB Inc COM 60937P106 86 239 SH   DFND 3 239 0 0
Monolithic Power Systems Inc COM 609839105 31 83 SH   DFND 3 83 0 0
Moody's Corp COM 615369105 251,364 693,666 SH   DFND 1 693,666 0 0
Moody's Corp COM 615369105 913,081 2,519,747 SH   DFND 2 2,358,146 0 161,601
Moody's Corp COM 615369105 178,855 493,570 SH   DFND 3 230,500 0 263,070
Moody's Corp COM 615369105 658,980 1,818,528 SH   SOLE 0 1,553,084 0 265,444
NIO Inc ADR SPON ADS 62914V106 112,296 2,110,818 SH   DFND 1 2,110,818 0 0
NIO Inc ADR SPON ADS 62914V106 3,192,253 60,004,757 SH   DFND 2 46,440,727 0 13,564,030
NIO Inc ADR SPON ADS 62914V106 101,337 1,904,826 SH   DFND 3 1,578,019 0 326,807
NIO Inc ADR SPON ADS 62914V106 1,430,753 26,893,858 SH   SOLE 0 24,512,019 0 2,381,839
NV5 Global COM 62945V109 13 138 SH   DFND 3 138 0 0
NVIDIA COM 67066G104 486,346 607,856 SH   DFND 1 607,856 0 0
NVIDIA COM 67066G104 2,265,137 2,831,067 SH   DFND 2 1,248,474 0 1,582,593
NVIDIA COM 67066G104 248,449 310,523 SH   DFND 3 261,201 0 49,322
NVIDIA COM 67066G104 1,233,335 1,541,476 SH   SOLE 0 1,211,943 0 329,533
Nano Dimension ADR SPONS ADS 63008G203 13 1,600 SH   DFND 3 1,600 0 0
Nanobiotix ADR COM 63009J107 11,725 850,841 SH   DFND 1 850,841 0 0
Nanobiotix ADR COM 63009J107 7,567 549,159 SH   SOLE 0 549,159 0 0
National Instruments Corp COM 636518102 22,272 526,779 SH   DFND 1 526,779 0 0
National Instruments Corp COM 636518102 500 11,822 SH   DFND 2 0 0 11,822
National Instruments Corp COM 636518102 274 6,489 SH   DFND 3 6,489 0 0
National Instruments Corp COM 636518102 21,408 506,350 SH   SOLE 0 506,350 0 0
Nektar Therapeutics COM 640268108 26 1,542 SH   DFND 3 1,542 0 0
NetEase.com ADR SPONSORED ADR 64110W102 102,703 891,129 SH   DFND 1 891,129 0 0
NetEase.com ADR SPONSORED ADR 64110W102 613,095 5,319,700 SH   DFND 2 1,672,880 0 3,646,820
NetEase.com ADR SPONSORED ADR 64110W102 75,050 651,196 SH   DFND 3 541,349 0 109,847
NetEase.com ADR SPONSORED ADR 64110W102 172,358 1,495,510 SH   SOLE 0 690,613 0 804,897
Netflix Inc COM 64110L106 697,741 1,320,953 SH   DFND 1 1,320,953 0 0
Netflix Inc COM 64110L106 2,218,046 4,199,174 SH   DFND 2 2,343,689 0 1,855,485
Netflix Inc COM 64110L106 254,830 482,441 SH   DFND 3 380,110 0 102,331
Netflix Inc COM 64110L106 1,124,368 2,128,638 SH   SOLE 0 1,699,120 0 429,518
Nevro Corp COM 64157F103 26 154 SH   DFND 3 154 0 0
New Relic COM 64829B100 56 840 SH   DFND 3 840 0 0
Newmont Mining COM 651639106 946 14,931 SH   DFND 1 14,931 0 0
NextEra Energy COM 65339F101 54,780 747,548 SH   DFND 1 747,548 0 0
NextEra Energy COM 65339F101 115 1,570 SH   DFND 2 1,570 0 0
NextEra Energy COM 65339F101 3,006 41,015 SH   DFND 3 41,015 0 0
Nike COM 654106103 16 105 SH   DFND 3 105 0 0
Novanta Inc COM 67000B104 16 116 SH   DFND 2 116 0 0
Novocure Ltd ORD SHS G6674U108 565,898 2,551,160 SH   DFND 1 2,551,160 0 0
Novocure Ltd ORD SHS G6674U108 942,469 4,248,799 SH   DFND 2 3,777,486 0 471,313
Novocure Ltd ORD SHS G6674U108 150,590 678,886 SH   DFND 3 501,597 0 177,289
Novocure Ltd ORD SHS G6674U108 404,208 1,822,236 SH   SOLE 0 1,656,061 0 166,175
Nucana Plc ADR SPONSORED ADR 67022C106 6,704 2,420,041 SH   DFND 1 2,420,041 0 0
Nucana Plc ADR SPONSORED ADR 67022C106 3,432 1,238,989 SH   SOLE 0 1,238,989 0 0
Nutanix Inc COM 67059N108 24 621 SH   DFND 3 621 0 0
Oatly Inc. SPONS ADS 67421J108 556,959 22,770,189 SH   DFND 2 19,519,194 0 3,250,995
Oatly Inc. SPONS ADS 67421J108 25,976 1,061,969 SH   SOLE 0 1,061,969 0 0
OneConnect Financial Technology ADR COM 68248T105 24,699 2,054,800 SH   DFND 1 2,054,800 0 0
OneConnect Financial Technology ADR COM 68248T105 7,745 644,368 SH   DFND 2 214,850 0 429,518
OneConnect Financial Technology ADR COM 68248T105 3,378 281,030 SH   DFND 3 281,030 0 0
Opko Health Inc COM 68375N103 30 7,300 SH   DFND 3 7,300 0 0
Oscar Health Inc COM 687793109 28,766 1,337,965 SH   DFND 1 1,337,965 0 0
Oscar Health Inc COM 687793109 99,493 4,627,561 SH   DFND 2 4,076,539 0 551,022
Oscar Health Inc COM 687793109 22,443 1,043,867 SH   DFND 3 536,002 0 507,865
Oscar Health Inc COM 687793109 76,297 3,548,689 SH   SOLE 0 3,065,051 0 483,638
Oscar Health Inc - converted at IPO COM 687793109 25,876 1,203,533 SH   DFND 2 413,947 0 789,586
Oscar Health Inc - converted at IPO COM 687793109 22,860 1,063,253 SH   SOLE 0 1,063,253 0 0
Outset Medical COM 690145107 17 346 SH   DFND 3 346 0 0
Oxford Industries Inc COM 691497309 7 73 SH   DFND 3 73 0 0
Ozon Holdings COM 69269L104 13,788 235,211 SH   DFND 1 235,211 0 0
Ozon Holdings COM 69269L104 102,436 1,747,463 SH   DFND 2 937,322 0 810,141
Ozon Holdings COM 69269L104 440 7,509 SH   DFND 3 7,509 0 0
Pacific Biosciences of California COM 69404D108 20 561 SH   DFND 3 561 0 0
Pacira BioSciences COM 695127100 59,677 983,474 SH   DFND 1 983,474 0 0
Pacira BioSciences COM 695127100 30,660 505,276 SH   DFND 2 219,629 0 285,647
Pacira BioSciences COM 695127100 17,449 287,563 SH   DFND 3 256,388 0 31,175
Pacira BioSciences COM 695127100 19,809 326,446 SH   SOLE 0 326,446 0 0
PagerDuty COM 69553P100 26 615 SH   DFND 3 615 0 0
Pan American Silver Corp COM 697900108 129 4,500 SH   DFND 2 4,500 0 0
Paychex COM 704326107 12 116 SH   DFND 3 116 0 0
Peloton Interactive Inc CL A COM 70614W100 261,369 2,107,475 SH   DFND 1 2,107,475 0 0
Peloton Interactive Inc CL A COM 70614W100 1,581,864 12,754,909 SH   DFND 2 4,270,543 0 8,484,366
Peloton Interactive Inc CL A COM 70614W100 238,305 1,921,504 SH   DFND 3 1,568,693 0 352,811
Peloton Interactive Inc CL A COM 70614W100 430,612 3,472,116 SH   SOLE 0 1,643,146 0 1,828,970
Penumbra Inc COM 70975L107 140,859 513,973 SH   DFND 1 513,973 0 0
Penumbra Inc COM 70975L107 185,609 677,255 SH   DFND 2 646,857 0 30,398
Penumbra Inc COM 70975L107 8,748 31,921 SH   DFND 3 31,921 0 0
Penumbra Inc COM 70975L107 31,790 115,997 SH   SOLE 0 115,997 0 0
Pepsico COM 713448108 33,539 226,355 SH   DFND 1 226,355 0 0
Pepsico COM 713448108 754 5,087 SH   DFND 2 0 0 5,087
Pepsico COM 713448108 411 2,773 SH   DFND 3 2,773 0 0
Pepsico COM 713448108 32,185 217,215 SH   SOLE 0 217,215 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 204,301 16,704,914 SH   DFND 1 16,704,914 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 666,156 54,469,042 SH   DFND 2 25,691,328 0 28,777,714
Petrobras Common ADR SPONSORED ADR 71654V408 207,564 16,971,669 SH   DFND 3 2,469,895 0 14,501,774
Petrobras Common ADR SPONSORED ADR 71654V408 8,635 706,010 SH   DFND 4 706,010 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 15,344 1,254,653 SH   SOLE 0 1,254,653 0 0
Petrobras Pref ADR SP ADR NON VTG 71654V101 22,669 1,919,507 SH   DFND 1 1,919,507 0 0
Petrobras Pref ADR SP ADR NON VTG 71654V101 153,634 13,008,819 SH   DFND 2 7,673,774 0 5,335,045
Petrobras Pref ADR SP ADR NON VTG 71654V101 718 60,782 SH   DFND 3 60,782 0 0
Pinduoduo Inc ADR SPONSORED ADS 722304102 238,337 1,876,376 SH   DFND 1 1,876,376 0 0
Pinduoduo Inc ADR SPONSORED ADS 722304102 2,220,461 17,481,193 SH   DFND 2 8,117,320 0 9,363,873
Pinduoduo Inc ADR SPONSORED ADS 722304102 216,213 1,702,199 SH   DFND 3 1,428,368 0 273,831
Pinduoduo Inc ADR SPONSORED ADS 722304102 812,091 6,393,407 SH   SOLE 0 4,391,821 0 2,001,586
Pinterest COM 72352L106 193,837 2,455,181 SH   DFND 1 2,455,181 0 0
Pinterest COM 72352L106 274,029 3,470,918 SH   DFND 2 3,318,887 0 152,031
Pinterest COM 72352L106 12,413 157,227 SH   DFND 3 157,227 0 0
Pinterest COM 72352L106 46,408 587,819 SH   SOLE 0 587,819 0 0
Plantronics Inc COM 727493108 11 254 SH   DFND 3 254 0 0
Precision BioSciences Inc COM 74019P108 10 826 SH   DFND 2 826 0 0
Procter & Gamble COM 742718109 39,794 294,921 SH   DFND 1 294,921 0 0
Procter & Gamble COM 742718109 901 6,681 SH   DFND 2 0 0 6,681
Procter & Gamble COM 742718109 492 3,647 SH   DFND 3 3,647 0 0
Procter & Gamble COM 742718109 38,853 287,951 SH   SOLE 0 287,951 0 0
Progyny COM 74340E103 23 396 SH   DFND 3 396 0 0
Prologis Inc REIT COM 74340W103 68,431 572,500 SH   DFND 1 572,500 0 0
Prologis Inc REIT COM 74340W103 162 1,357 SH   DFND 2 1,357 0 0
Prologis Inc REIT COM 74340W103 3,245 27,144 SH   DFND 3 27,144 0 0
Proofpoint Inc COM 743424103 25 144 SH   DFND 3 144 0 0
Ptc Therapeutics Inc COM 69366J200 10 246 SH   DFND 3 246 0 0
Puma Biotechnology COM 74587V107 2 252 SH   DFND 3 252 0 0
Pure Storage Inc COM 74624M102 29 1,470 SH   DFND 3 1,470 0 0
Q2 Holdings Inc COM 74736L109 32,656 318,346 SH   DFND 1 318,346 0 0
Q2 Holdings Inc COM 74736L109 19,630 191,364 SH   DFND 2 64,417 0 126,947
Q2 Holdings Inc COM 74736L109 8,840 86,179 SH   DFND 3 86,179 0 0
Q2 Holdings Inc COM 74736L109 12,539 122,235 SH   SOLE 0 122,235 0 0
Quaker Chemical Corp COM 747316107 20 86 SH   DFND 3 86 0 0
Qualcomm COM 747525103 29 200 SH   DFND 3 200 0 0
Quanterix Corp COM 74766Q101 22,944 391,135 SH   DFND 1 391,135 0 0
Quanterix Corp COM 74766Q101 21 359 SH   DFND 2 359 0 0
Quanterix Corp COM 74766Q101 12,300 209,677 SH   SOLE 0 209,677 0 0
QuantumScape Corp COM CL A 74767V109 26,723 913,279 SH   SOLE 0 913,279 0 0
Quest Diagnostics COM 74834L100 21 160 SH   DFND 3 160 0 0
Quidel Corp COM 74838J101 16 128 SH   DFND 3 128 0 0
Rambus Inc COM 750917106 17 699 SH   DFND 3 699 0 0
Recursion Pharmaceuticals - converted at IPO CL A 75629V104 469,258 12,856,385 SH   SOLE 0 12,856,385 0 0
Recursion Pharmaceuticals Inc CL A 75629V104 57,772 1,582,786 SH   DFND 1 1,582,786 0 0
Recursion Pharmaceuticals Inc CL A 75629V104 81,371 2,229,341 SH   DFND 2 2,136,274 0 93,067
Recursion Pharmaceuticals Inc CL A 75629V104 14,155 387,801 SH   DFND 3 387,801 0 0
Recursion Pharmaceuticals Inc CL A 75629V104 53,461 1,464,687 SH   SOLE 0 1,464,687 0 0
Redfin COM 75737F108 258,957 4,083,857 SH   DFND 1 4,083,857 0 0
Redfin COM 75737F108 326,860 5,154,715 SH   DFND 2 4,926,668 0 228,047
Redfin COM 75737F108 23,575 371,789 SH   DFND 3 330,192 0 41,597
Redfin COM 75737F108 52,416 826,616 SH   SOLE 0 826,616 0 0
Regeneron Pharmaceuticals COM 75886F107 35 63 SH   DFND 3 63 0 0
Relay Therapeutics Inc COM 75943R102 1,169 31,955 SH   DFND 1 31,955 0 0
Relay Therapeutics Inc COM 75943R102 2,925 79,950 SH   DFND 2 79,950 0 0
Relay Therapeutics Inc COM 75943R102 2,950 80,616 SH   DFND 3 80,616 0 0
ResMed COM 761152107 101,743 412,718 SH   DFND 1 412,718 0 0
ResMed COM 761152107 350,215 1,420,635 SH   DFND 2 1,330,762 0 89,873
ResMed COM 761152107 80,342 325,906 SH   DFND 3 175,507 0 150,399
ResMed COM 761152107 266,446 1,080,830 SH   SOLE 0 929,884 0 150,946
Research in Motion COM 09228F103 38 3,082 SH   DFND 3 3,082 0 0
Rexford Industrial Realty REIT COM 76169C100 66,597 1,169,400 SH   DFND 1 1,169,400 0 0
Rexford Industrial Realty REIT COM 76169C100 161 2,826 SH   DFND 2 2,826 0 0
Rexford Industrial Realty REIT COM 76169C100 3,145 55,223 SH   DFND 3 55,223 0 0
Ringcentral Inc COM 76680R206 117 403 SH   DFND 3 403 0 0
Ritchie Bros Auctioneers (USA) COM 767744105 102,418 1,727,695 SH   DFND 2 1,611,628 0 116,067
Ritchie Bros. Auctioneers COM 767744105 67,530 1,137,873 SH   DFND 2 611,967 0 525,906
Robert Half International Inc COM 770323103 13 151 SH   DFND 3 151 0 0
Roku COM CL A 77543R102 662,414 1,442,383 SH   DFND 1 1,442,383 0 0
Roku COM CL A 77543R102 894,328 1,947,366 SH   DFND 2 1,861,462 0 85,904
Roku COM CL A 77543R102 42,585 92,727 SH   DFND 3 92,727 0 0
Roku COM CL A 77543R102 146,280 318,520 SH   SOLE 0 318,520 0 0
Rollins Inc COM 775711104 21 605 SH   DFND 3 605 0 0
Royal Caribbean Cruises COM V7780T103 22,451 263,257 SH   DFND 1 263,257 0 0
Royal Caribbean Cruises COM V7780T103 1,104 12,942 SH   DFND 3 12,942 0 0
Rubius Therapeutics Inc COM 78116T103 21,652 887,000 SH   DFND 1 887,000 0 0
Rubius Therapeutics Inc COM 78116T103 3,762 154,127 SH   DFND 2 59,080 0 95,047
Rubius Therapeutics Inc COM 78116T103 1,668 68,336 SH   DFND 3 68,336 0 0
Rubius Therapeutics Inc COM 78116T103 87,523 3,585,559 SH   SOLE 0 3,585,559 0 0
Ryanair ADR SPONSORED ADR NE 783513203 30,771 284,366 SH   DFND 1 284,366 0 0
Ryanair ADR SPONSORED ADR NE 783513203 1,086,828 10,043,692 SH   DFND 2 8,733,476 0 1,310,216
Ryanair ADR SPONSORED ADR NE 783513203 13,585 125,539 SH   DFND 3 50,144 0 75,395
Ryanair ADR SPONSORED ADR NE 783513203 6,465 59,744 SH   SOLE 0 59,744 0 0
S&P Global Inc COM 78409V104 96,122 234,188 SH   DFND 1 234,188 0 0
S&P Global Inc COM 78409V104 357,493 870,978 SH   DFND 2 816,783 0 54,195
S&P Global Inc COM 78409V104 68,616 167,172 SH   DFND 3 78,261 0 88,911
S&P Global Inc COM 78409V104 256,516 624,962 SH   SOLE 0 536,521 0 88,441
SCP Pool Corporation COM 73278L105 40 87 SH   DFND 3 87 0 0
SEA Ltd ADR ADR 81141R100 642,698 2,340,489 SH   DFND 1 2,340,489 0 0
SEA Ltd ADR ADR 81141R100 1,212,723 4,416,324 SH   DFND 2 3,645,732 0 770,592
SEA Ltd ADR ADR 81141R100 163,950 597,049 SH   DFND 3 289,648 0 307,401
SEA Ltd ADR ADR 81141R100 675,264 2,459,081 SH   SOLE 0 2,152,026 0 307,055
Saba Capital Income & Opportunities Fund SH BEN INT 92913A100 2,033 431,655 SH   DFND 1 431,655 0 0
Saba Capital Income & Opportunities Fund SH BEN INT 92913A100 1,920 407,624 SH   DFND 3 407,624 0 0
Sage Therapeutics Inc COM 78667J108 763 13,439 SH   DFND 1 13,439 0 0
Sage Therapeutics Inc COM 78667J108 1,868 32,882 SH   DFND 2 32,882 0 0
Sage Therapeutics Inc COM 78667J108 1,928 33,944 SH   DFND 3 33,944 0 0
Sailpoint Technologies Holding COM 78781P105 20 388 SH   DFND 3 388 0 0
Salesforce.com COM 79466L302 104,640 428,379 SH   DFND 1 428,379 0 0
Salesforce.com COM 79466L302 838,479 3,432,591 SH   DFND 2 1,206,713 0 2,225,878
Salesforce.com COM 79466L302 94,899 388,500 SH   DFND 3 322,135 0 66,365
Salesforce.com COM 79466L302 220,516 902,754 SH   SOLE 0 417,943 0 484,811
Sana Biotechnology Inc COM 799566104 41,655 2,118,779 SH   DFND 1 2,118,779 0 0
Sana Biotechnology Inc COM 799566104 56,113 2,854,148 SH   DFND 2 2,854,148 0 0
Sana Biotechnology Inc COM 799566104 3,570 181,609 SH   DFND 3 181,609 0 0
Sana Biotechnology Inc COM 799566104 19,656 999,816 SH   SOLE 0 999,816 0 0
Sana Biotechnology Inc - converted at IPO COM 799566104 100,020 5,087,499 SH   SOLE 0 5,087,499 0 0
Sarepta Therapeutics Inc COM 803607100 16 205 SH   DFND 3 205 0 0
Schrodinger COM 80810D103 18 242 SH   DFND 3 242 0 0
Schweitzer-Maudit Int. COM 808541106 11 265 SH   DFND 3 265 0 0
Seagen Inc COM 81181C104 20 128 SH   DFND 3 128 0 0
Seer COM CL A 81578P106 7 223 SH   DFND 3 223 0 0
Service Corp.Intl. COM 817565104 77,450 1,445,231 SH   DFND 1 1,445,231 0 0
Service Corp.Intl. COM 817565104 294,625 5,497,767 SH   DFND 2 5,162,646 0 335,121
Service Corp.Intl. COM 817565104 55,636 1,038,185 SH   DFND 3 489,619 0 548,566
Service Corp.Intl. COM 817565104 205,735 3,839,051 SH   SOLE 0 3,280,391 0 558,660
Shake Shack Inc COM 819047101 19 174 SH   DFND 3 174 0 0
Sherwin-Williams Co COM 824348106 12,910 47,386 SH   DFND 2 47,386 0 0
ShockWave Medical Inc COM 82489T104 31,903 168,149 SH   DFND 1 168,149 0 0
ShockWave Medical Inc COM 82489T104 36,815 194,041 SH   DFND 2 110,737 0 83,304
ShockWave Medical Inc COM 82489T104 24,101 127,029 SH   DFND 3 127,029 0 0
ShockWave Medical Inc COM 82489T104 16,296 85,892 SH   SOLE 0 85,892 0 0
Shopify 'A' CL A 82509L107 1,684,986 1,153,326 SH   DFND 1 1,153,326 0 0
Shopify 'A' CL A 82509L107 4,514,912 3,090,331 SH   DFND 2 2,133,433 0 956,898
Shopify 'A' CL A 82509L107 536,324 367,099 SH   DFND 3 265,544 0 101,555
Shopify 'A' CL A 82509L107 1,666,698 1,140,808 SH   SOLE 0 929,951 0 210,857
Silicon Laboratories Inc COM 826919102 19 127 SH   DFND 3 127 0 0
Silicon Motion Technology ADR COM 82706C108 20,799 324,478 SH   DFND 1 324,478 0 0
Silicon Motion Technology ADR COM 82706C108 373 5,822 SH   DFND 2 0 0 5,822
Silicon Motion Technology ADR COM 82706C108 255 3,984 SH   DFND 3 3,984 0 0
Silicon Motion Technology ADR COM 82706C108 20,105 313,651 SH   SOLE 0 313,651 0 0
Silk Road Medical COM 82710M100 11 235 SH   DFND 3 235 0 0
SiteOne Landscape Supply COM 82982L103 80,849 477,663 SH   DFND 1 477,663 0 0
SiteOne Landscape Supply COM 82982L103 282,896 1,671,370 SH   DFND 2 1,562,303 0 109,067
SiteOne Landscape Supply COM 82982L103 58,569 346,028 SH   DFND 3 161,277 0 184,751
SiteOne Landscape Supply COM 82982L103 211,984 1,252,418 SH   SOLE 0 1,072,647 0 179,771
Six Flags Entertainment Corp COM 83001A102 23,496 542,890 SH   DFND 1 542,890 0 0
Six Flags Entertainment Corp COM 83001A102 1,157 26,730 SH   DFND 3 26,730 0 0
Smartsheet COM 83200N103 26 353 SH   DFND 3 353 0 0
Snap Inc CL A 83304A106 134,199 1,969,462 SH   DFND 1 1,969,462 0 0
Snap Inc CL A 83304A106 185,955 2,729,012 SH   DFND 2 2,607,125 0 121,887
Snap Inc CL A 83304A106 8,721 127,980 SH   DFND 3 127,980 0 0
Snap Inc CL A 83304A106 32,104 471,149 SH   SOLE 0 471,149 0 0
Snowflake Inc COM 833445109 188,239 778,490 SH   DFND 1 778,490 0 0
Snowflake Inc COM 833445109 369,913 1,529,831 SH   DFND 2 1,445,267 0 84,564
Snowflake Inc COM 833445109 45,330 187,468 SH   DFND 3 107,088 0 80,380
Snowflake Inc COM 833445109 360,881 1,492,479 SH   SOLE 0 1,411,913 0 80,566
Sohu.com COM 83410S108 3,723 200,140 SH   DFND 3 0 0 200,140
Solaredge Technologies Inc COM 83417M104 53 190 SH   DFND 3 190 0 0
Sorrento Therapeutics COM 83587F202 50 5,152 SH   DFND 3 5,152 0 0
Splunk Inc COM 848637104 14,594 100,940 SH   DFND 1 100,940 0 0
Splunk Inc COM 848637104 20,318 140,533 SH   DFND 2 46,370 0 94,163
Splunk Inc COM 848637104 9,102 62,957 SH   DFND 3 62,957 0 0
Splunk Inc COM 848637104 10,682 73,884 SH   SOLE 0 73,884 0 0
Spotify Technology SA SHS L8681T102 344,697 1,250,762 SH   DFND 1 1,250,762 0 0
Spotify Technology SA SHS L8681T102 4,339,633 15,746,699 SH   DFND 2 11,375,056 0 4,371,643
Spotify Technology SA SHS L8681T102 144,679 524,980 SH   DFND 3 397,919 0 127,061
Spotify Technology SA SHS L8681T102 873,414 3,169,251 SH   SOLE 0 2,655,978 0 513,273
Sprout Social COM 85209W109 28,711 321,078 SH   DFND 1 321,078 0 0
Sprout Social COM 85209W109 16,361 182,969 SH   DFND 2 60,841 0 122,128
Sprout Social COM 85209W109 7,111 79,522 SH   DFND 3 79,522 0 0
Sprout Social COM 85209W109 17,854 199,670 SH   SOLE 0 199,670 0 0
Staar Surgical COM PAR $0.01 852312305 225,648 1,479,661 SH   DFND 1 1,479,661 0 0
Staar Surgical COM PAR $0.01 852312305 302,933 1,986,449 SH   DFND 2 1,515,105 0 471,344
Staar Surgical COM PAR $0.01 852312305 92,385 605,805 SH   DFND 3 435,685 0 170,120
Staar Surgical COM PAR $0.01 852312305 229,347 1,503,917 SH   SOLE 0 1,357,230 0 146,687
Stamps.Com COM NEW 852857200 11 55 SH   DFND 3 55 0 0
Stanley Black & Decker COM 854502101 16 77 SH   DFND 3 77 0 0
Stericycle Inc COM 858912108 43,183 603,539 SH   DFND 1 603,539 0 0
Stericycle Inc COM 858912108 155,287 2,170,333 SH   DFND 2 2,026,994 0 143,339
Stericycle Inc COM 858912108 30,682 428,816 SH   DFND 3 200,476 0 228,340
Stericycle Inc COM 858912108 118,408 1,654,899 SH   SOLE 0 1,414,567 0 240,332
Stitch Fix COM CL A 860897107 136,229 2,259,193 SH   DFND 1 2,259,193 0 0
Stitch Fix COM CL A 860897107 185,154 3,070,553 SH   DFND 2 2,932,411 0 138,142
Stitch Fix COM CL A 860897107 8,773 145,482 SH   DFND 3 145,482 0 0
Stitch Fix COM CL A 860897107 31,514 522,617 SH   SOLE 0 522,617 0 0
StoneCo COM CL A G85158106 1,873 27,931 SH   DFND 1 27,931 0 0
StoneCo COM CL A G85158106 20,844 310,833 SH   DFND 2 217,076 0 93,757
StoneCo COM CL A G85158106 60 900 SH   DFND 3 900 0 0
Stratasys SHS M85548101 5,852 226,300 SH   DFND 1 226,300 0 0
Stratasys SHS M85548101 9,393 363,231 SH   DFND 2 116,181 0 247,050
Stratasys SHS M85548101 3,988 154,221 SH   DFND 3 154,221 0 0
Stratasys SHS M85548101 3,739 144,600 SH   SOLE 0 144,600 0 0
Stryker COM 863667101 14 54 SH   DFND 3 54 0 0
Summit Therapeutics New Listing COM 86627T108 1,601 214,617 SH   DFND 1 214,617 0 0
Summit Therapeutics New Listing COM 86627T108 1,655 221,895 SH   SOLE 0 221,895 0 0
Sumo Logic COM 86646P103 15 726 SH   DFND 3 726 0 0
Sunpower Corp COM 867652406 44 1,508 SH   DFND 3 1,508 0 0
Sutro Biopharma COM 869367102 19,379 1,042,428 SH   DFND 1 1,042,428 0 0
Sutro Biopharma COM 869367102 19 1,019 SH   DFND 2 1,019 0 0
Sutro Biopharma COM 869367102 13,956 750,726 SH   SOLE 0 750,726 0 0
Symantec Corp COM 668771108 13 462 SH   DFND 3 462 0 0
Synopsys COM 871607107 38 137 SH   DFND 3 137 0 0
T. Rowe Price COM 74144T108 19,567 98,837 SH   DFND 1 98,837 0 0
T. Rowe Price COM 74144T108 440 2,221 SH   DFND 2 0 0 2,221
T. Rowe Price COM 74144T108 239 1,209 SH   DFND 3 1,209 0 0
T. Rowe Price COM 74144T108 18,833 95,130 SH   SOLE 0 95,130 0 0
TAL Education Group ADR ADS REPSTG COM 874080104 33,862 1,342,113 SH   DFND 1 1,342,113 0 0
TAL Education Group ADR ADS REPSTG COM 874080104 811,724 32,172,974 SH   DFND 2 24,255,330 0 7,917,644
TAL Education Group ADR ADS REPSTG COM 874080104 30,596 1,212,677 SH   DFND 3 1,006,742 0 205,935
TAL Education Group ADR ADS REPSTG COM 874080104 70,239 2,783,943 SH   SOLE 0 1,286,916 0 1,497,027
TJX Companies COM 872540109 6,416 95,163 SH   DFND 2 95,163 0 0
TSMC ADR SPONSORED ADR 874039100 54,479 453,391 SH   DFND 1 453,391 0 0
TSMC ADR SPONSORED ADR 874039100 715,296 5,952,865 SH   DFND 2 4,566,777 0 1,386,088
TSMC ADR SPONSORED ADR 874039100 2,492 20,743 SH   DFND 3 20,743 0 0
TSMC ADR SPONSORED ADR 874039100 159,013 1,323,341 SH   SOLE 0 1,151,267 0 172,074
Tabula Rasa HealthCare Inc COM 873379101 28,059 561,175 SH   DFND 1 561,175 0 0
Tabula Rasa HealthCare Inc COM 873379101 8,932 178,647 SH   DFND 2 59,156 0 119,491
Tabula Rasa HealthCare Inc COM 873379101 3,916 78,321 SH   DFND 3 78,321 0 0
Tabula Rasa HealthCare Inc COM 873379101 11,929 238,574 SH   SOLE 0 238,574 0 0
Tandem Diabetes Care COM NEW 875372203 19,304 198,192 SH   DFND 1 198,192 0 0
Tandem Diabetes Care COM NEW 875372203 16 168 SH   DFND 2 168 0 0
Tandem Diabetes Care COM NEW 875372203 18 188 SH   DFND 3 188 0 0
Tandem Diabetes Care COM NEW 875372203 14,452 148,377 SH   SOLE 0 148,377 0 0
Tata Motors Ltd ADR COM 876568502 93,183 4,090,544 SH   DFND 1 4,090,544 0 0
Tata Motors Ltd ADR COM 876568502 64,828 2,845,826 SH   DFND 2 2,845,826 0 0
Tata Motors Ltd ADR COM 876568502 1,224 53,741 SH   DFND 3 53,741 0 0
Tata Motors Ltd ADR COM 876568502 38,750 1,701,035 SH   SOLE 0 1,701,035 0 0
Teladoc COM 87918A105 397,238 2,388,828 SH   DFND 1 2,388,828 0 0
Teladoc COM 87918A105 558,916 3,361,090 SH   DFND 2 2,876,552 0 484,538
Teladoc COM 87918A105 169,455 1,019,033 SH   DFND 3 740,883 0 278,150
Teladoc COM 87918A105 274,095 1,648,293 SH   SOLE 0 1,482,423 0 165,870
Telus Corp COM 87971M103 9 397 SH   DFND 3 397 0 0
Tenable Holdings COM 88025T102 13 315 SH   DFND 3 315 0 0
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 64,154 4,144,342 SH   DFND 1 4,144,342 0 0
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 505,615 32,662,475 SH   DFND 2 24,277,126 0 8,385,349
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 28,716 1,855,054 SH   DFND 3 890,778 0 964,276
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 107,049 6,915,338 SH   SOLE 0 5,939,867 0 975,471
Teradyne COM 880770102 112,090 836,740 SH   DFND 1 836,740 0 0
Teradyne COM 880770102 581,071 4,337,647 SH   DFND 2 4,145,851 0 191,796
Teradyne COM 880770102 79,003 589,752 SH   DFND 3 271,417 0 318,335
Teradyne COM 880770102 292,143 2,180,826 SH   SOLE 0 1,865,884 0 314,942
Tesla Inc COM 88160R101 1,378,080 2,027,482 SH   DFND 1 2,027,482 0 0
Tesla Inc COM 88160R101 6,390,872 9,402,490 SH   DFND 2 6,853,793 0 2,548,697
Tesla Inc COM 88160R101 657,186 966,876 SH   DFND 3 737,698 0 229,178
Tesla Inc COM 88160R101 2,345,847 3,451,298 SH   SOLE 0 2,937,244 0 514,054
Texas Roadhouse Inc COM 882681109 13 131 SH   DFND 3 131 0 0
The Trade Desk COM CL A 88339J105 907,358 11,729,033 SH   DFND 1 11,729,033 0 0
The Trade Desk COM CL A 88339J105 2,228,640 28,808,686 SH   DFND 2 19,767,986 0 9,040,700
The Trade Desk COM CL A 88339J105 240,471 3,108,464 SH   DFND 3 2,306,741 0 801,723
The Trade Desk COM CL A 88339J105 687,622 8,888,600 SH   SOLE 0 6,574,174 0 2,314,426
Thermo Fisher Scientific COM 883556102 93,223 184,794 SH   DFND 1 184,794 0 0
Thermo Fisher Scientific COM 883556102 353,732 701,195 SH   DFND 2 658,271 0 42,924
Thermo Fisher Scientific COM 883556102 66,540 131,900 SH   DFND 3 61,635 0 70,265
Thermo Fisher Scientific COM 883556102 245,375 486,401 SH   SOLE 0 416,372 0 70,029
Thor Industries Inc COM 885160101 15 133 SH   DFND 3 133 0 0
Tractor Supply Co COM 892356106 28 151 SH   DFND 3 151 0 0
TransMedics Group COM 89377M109 13 400 SH   DFND 3 400 0 0
Trimble Navigation COM 896239100 29 359 SH   DFND 3 359 0 0
Trip.com Group Sponsored ADR AMERICAN DEP SHS 89677Q107 118,892 3,352,853 SH   DFND 2 2,640,716 0 712,137
Trupanion COM 898202106 22,744 197,600 SH   DFND 1 197,600 0 0
Trupanion COM 898202106 40,314 350,248 SH   DFND 2 116,127 0 234,121
Trupanion COM 898202106 17,802 154,665 SH   DFND 3 154,665 0 0
Trupanion COM 898202106 84,598 735,000 SH   SOLE 0 735,000 0 0
TuSimple Hdgs CL A 90089L108 25 349 SH   DFND 3 349 0 0
Twilio Inc CL A 90138F102 647,903 1,643,756 SH   DFND 1 1,643,756 0 0
Twilio Inc CL A 90138F102 1,125,671 2,855,873 SH   DFND 2 2,711,468 0 144,405
Twilio Inc CL A 90138F102 117,890 299,093 SH   DFND 3 189,050 0 110,043
Twilio Inc CL A 90138F102 404,514 1,026,268 SH   SOLE 0 931,078 0 95,190
Ultragenyx COM 90400D108 11 115 SH   DFND 3 115 0 0
United Parcel Service CL B 911312106 54,968 264,307 SH   DFND 1 264,307 0 0
United Parcel Service CL B 911312106 1,241 5,965 SH   DFND 2 0 0 5,965
United Parcel Service CL B 911312106 677 3,256 SH   DFND 3 3,256 0 0
United Parcel Service CL B 911312106 54,012 259,709 SH   SOLE 0 259,709 0 0
Unity Biotechnology Inc COM 91381U101 1,151 248,000 SH   DFND 1 248,000 0 0
Unity Biotechnology Inc COM 91381U101 9,540 2,056,111 SH   SOLE 0 2,056,111 0 0
Upwork Inc COM 91688F104 144,367 2,476,699 SH   DFND 1 2,476,699 0 0
Upwork Inc COM 91688F104 72,758 1,248,202 SH   DFND 2 541,163 0 707,039
Upwork Inc COM 91688F104 40,949 702,498 SH   DFND 3 627,850 0 74,648
Upwork Inc COM 91688F104 70,725 1,213,324 SH   SOLE 0 1,213,324 0 0
Uxin ADR ADS 91818X108 4,664 1,211,500 SH   DFND 1 1,211,500 0 0
Uxin ADR ADS 91818X108 2,174 564,600 SH   SOLE 0 564,600 0 0
Vale SA ADR ADR 91912E105 50,550 2,216,148 SH   DFND 1 2,216,148 0 0
Vale SA ADR ADR 91912E105 384,804 16,869,970 SH   DFND 2 9,070,614 0 7,799,356
Vale SA ADR ADR 91912E105 1,629 71,402 SH   DFND 3 71,402 0 0
Varonis Systems Inc COM 922280102 17 295 SH   DFND 2 295 0 0
Varonis Systems Inc COM 922280102 37 639 SH   DFND 3 639 0 0
Vedanta Ltd ADR COM 92242Y100 17,125 1,206,000 SH   DFND 1 1,206,000 0 0
Vedanta Ltd ADR COM 92242Y100 20,269 1,427,381 SH   DFND 2 1,427,381 0 0
Vedanta Ltd ADR COM 92242Y100 929 65,399 SH   DFND 3 65,399 0 0
Vedanta Ltd ADR COM 92242Y100 20,472 1,441,655 SH   SOLE 0 1,441,655 0 0
Veeco Instruments COM 922417100 14,108 586,854 SH   DFND 1 586,854 0 0
Veeco Instruments COM 922417100 12,432 517,133 SH   DFND 2 171,553 0 345,580
Veeco Instruments COM 922417100 5,417 225,342 SH   DFND 3 225,342 0 0
Veeva Systems Inc Class A COM 922475108 1,776 5,710 SH   DFND 1 5,710 0 0
Veeva Systems Inc Class A COM 922475108 4,379 14,084 SH   DFND 2 14,084 0 0
Veeva Systems Inc Class A COM 922475108 4,505 14,489 SH   DFND 3 14,489 0 0
Verint Systems Inc COM 92343X100 18 395 SH   DFND 3 395 0 0
Verisk Analytics COM 92345Y106 9,481 54,263 SH   DFND 2 54,263 0 0
Veritone COM 92347M100 11 569 SH   DFND 3 569 0 0
ViewRay COM 92672L107 6 911 SH   DFND 3 911 0 0
Vimeo Inc. COM 92719V100 23,086 471,140 SH   DFND 1 471,140 0 0
Vimeo Inc. COM 92719V100 77,579 1,583,251 SH   DFND 2 1,403,676 0 179,575
Vimeo Inc. COM 92719V100 16,794 342,732 SH   DFND 3 160,115 0 182,617
Vimeo Inc. COM 92719V100 61,349 1,252,018 SH   SOLE 0 1,079,352 0 172,666
Vir Biotechnology Inc COM 92764N102 1,206 25,514 SH   DFND 1 25,514 0 0
Vir Biotechnology Inc COM 92764N102 2,899 61,306 SH   DFND 2 61,306 0 0
Vir Biotechnology Inc COM 92764N102 2,995 63,336 SH   DFND 3 63,336 0 0
Vir Biotechnology Inc COM 92764N102 174,905 3,699,353 SH   SOLE 0 3,699,353 0 0
Visa Inc-Class A Shares COM CL A 92826C839 13,059 55,850 SH   DFND 2 55,850 0 0
Vroom Inc COM 92918V109 177,777 4,246,946 SH   DFND 1 4,246,946 0 0
Vroom Inc COM 92918V109 277,737 6,634,912 SH   DFND 2 6,335,908 0 299,004
Vroom Inc COM 92918V109 11,241 268,544 SH   DFND 3 268,544 0 0
Vroom Inc COM 92918V109 41,127 982,491 SH   SOLE 0 982,491 0 0
Vuzix COM 92921W300 17 924 SH   DFND 3 924 0 0
Vyne Therapeutics Inc COM 92941V209 171 48,706 SH   DFND 1 48,706 0 0
Vyne Therapeutics Inc COM 92941V209 176 50,056 SH   SOLE 0 50,056 0 0
WD-40 Co COM 929236107 15 58 SH   DFND 3 58 0 0
WEC Energy Group COM 92939U106 1,355 15,233 SH   DFND 1 15,233 0 0
Wabtec COM 929740108 38,446 467,142 SH   DFND 1 467,142 0 0
Wabtec COM 929740108 133,043 1,616,559 SH   DFND 2 1,507,034 0 109,525
Wabtec COM 929740108 27,771 337,441 SH   DFND 3 156,675 0 180,766
Wabtec COM 929740108 102,009 1,239,477 SH   SOLE 0 1,058,721 0 180,756
Wal-Mart Stores COM 931142103 14 101 SH   DFND 3 101 0 0
Waters COM 941848103 8,730 25,259 SH   DFND 1 25,259 0 0
Waters COM 941848103 11,234 32,504 SH   DFND 2 32,504 0 0
Waters COM 941848103 3,698 10,700 SH   DFND 3 7,161 0 3,539
Waters COM 941848103 232 672 SH   SOLE 0 672 0 0
Watsco Inc COM 942622200 230,143 802,899 SH   DFND 1 802,899 0 0
Watsco Inc COM 942622200 274,282 956,888 SH   DFND 2 915,827 0 41,061
Watsco Inc COM 942622200 17,504 61,067 SH   DFND 3 55,111 0 5,956
Watsco Inc COM 942622200 71,817 250,549 SH   SOLE 0 250,549 0 0
Wayfair Inc Class A CL A 94419L101 888,181 2,813,282 SH   DFND 1 2,813,282 0 0
Wayfair Inc Class A CL A 94419L101 1,377,148 4,362,067 SH   DFND 2 4,062,962 0 299,105
Wayfair Inc Class A CL A 94419L101 145,693 461,478 SH   DFND 3 331,929 0 129,549
Wayfair Inc Class A CL A 94419L101 780,327 2,471,659 SH   SOLE 0 2,352,402 0 119,257
Wheaton Precious Metals COM 962879102 607 13,764 SH   DFND 1 13,764 0 0
Williams-Sonoma Inc COM 969904101 12 76 SH   DFND 3 76 0 0
Wix Com SHS M98068105 1,001,683 3,450,746 SH   DFND 2 2,079,715 0 1,371,031
Wix Com SHS M98068105 131 451 SH   DFND 3 451 0 0
Workday Inc CL A 98138H101 363,924 1,524,354 SH   DFND 1 1,524,354 0 0
Workday Inc CL A 98138H101 1,353,078 5,667,579 SH   DFND 2 2,730,908 0 2,936,671
Workday Inc CL A 98138H101 148,277 621,081 SH   DFND 3 523,566 0 97,515
Workday Inc CL A 98138H101 531,065 2,224,448 SH   SOLE 0 1,594,901 0 629,547
XPEL COM 98379L100 29 342 SH   DFND 3 342 0 0
Xencor Inc COM 98401F105 16 473 SH   DFND 2 473 0 0
Xencor Inc COM 98401F105 15 431 SH   DFND 3 431 0 0
Xperi Holding Corp COM 98390M103 44 1,960 SH   DFND 3 1,960 0 0
Xylem COM 98419M100 10,621 88,537 SH   SOLE 0 88,537 0 0
Xylem COM 98419M100 82,155 684,857 SH   DFND 3 508,465 0 176,392
Xylem COM 98419M100 28,384 236,615 SH   DFND 2 75,120 0 161,495
Xylem COM 98419M100 102,561 854,957 SH   DFND 1 854,957 0 0
Yatsen Holding Ltd ADR COM 985194109 134 14,267 SH   DFND 3 14,267 0 0
Yatsen Holding Ltd ADR COM 985194109 101,086 10,788,313 SH   DFND 2 8,681,461 0 2,106,852
Yatsen Holding Ltd ADR COM 985194109 12,739 1,359,580 SH   DFND 1 1,359,580 0 0
Yelp COM 985817105 10 262 SH   DFND 3 262 0 0
Zai Lab ADR ADR 98887Q104 60,563 342,185 SH   SOLE 0 342,185 0 0
Zai Lab ADR ADR 98887Q104 61 343 SH   DFND 4 343 0 0
Zai Lab ADR ADR 98887Q104 73,326 414,292 SH   DFND 3 229,910 0 184,382
Zai Lab ADR ADR 98887Q104 249,324 1,408,689 SH   DFND 1 1,408,689 0 0
Zai Lab ADR ADR 98887Q104 331,994 1,875,781 SH   DFND 2 901,682 0 974,099
Zillow Group Inc Class A CL A 98954M101 18,401 150,174 SH   DFND 3 150,174 0 0
Zillow Group Inc Class A CL A 98954M101 247,298 2,018,268 SH   DFND 2 1,836,467 0 181,801
Zillow Group Inc Class A CL A 98954M101 146,197 1,193,155 SH   DFND 1 1,193,155 0 0
Zillow Group Inc Class A CL A 98954M101 42,562 347,357 SH   SOLE 0 347,357 0 0
Zillow Group Inc Class C CL C CAP STK 98954M200 294,777 2,411,857 SH   SOLE 0 2,140,918 0 270,939
Zillow Group Inc Class C CL C CAP STK 98954M200 97,657 799,028 SH   DFND 3 528,717 0 270,311
Zillow Group Inc Class C CL C CAP STK 98954M200 195,171 1,596,884 SH   DFND 1 1,596,884 0 0
Zillow Group Inc Class C CL C CAP STK 98954M200 387,345 3,169,244 SH   DFND 2 2,462,975 0 706,269
Zoom Video Communications Inc CL A 98980L101 150,521 388,914 SH   DFND 3 332,600 0 56,314
Zoom Video Communications Inc CL A 98980L101 1,604,303 4,145,165 SH   DFND 2 2,427,605 0 1,717,560
Zoom Video Communications Inc CL A 98980L101 598,741 1,547,015 SH   DFND 1 1,547,015 0 0
Zoom Video Communications Inc CL A 98980L101 763,628 1,973,047 SH   SOLE 0 1,615,164 0 357,883
Zuora Inc Class A COM CL A 98983V106 13,480 781,436 SH   SOLE 0 781,436 0 0
Zuora Inc Class A COM CL A 98983V106 7,450 431,871 SH   DFND 3 431,871 0 0
Zuora Inc Class A COM CL A 98983V106 30,683 1,778,724 SH   DFND 1 1,778,724 0 0
Zuora Inc Class A COM CL A 98983V106 16,740 970,463 SH   DFND 2 321,151 0 649,312
Zymergen Inc COM 98985X100 32,266 806,451 SH   SOLE 0 806,451 0 0
Zymergen Inc - converted at IPO COM 98985X100 80,640 2,015,505 SH   SOLE 0 2,015,505 0 0
Zynex COM 98986M103 7 437 SH   DFND 3 437 0 0
Zynga Inc COM 98986T108 36 3,427 SH   DFND 3 3,427 0 0
dLocal CL A G29018101 29,087 553,728 SH   DFND 1 553,728 0 0
dLocal CL A G29018101 12,937 246,272 SH   DFND 3 0 0 246,272
iQIYI Inc ADR SPON ADR 46267X108 11,540 740,698 SH   DFND 2 477,924 0 262,774
iQIYI Inc ADR SPON ADR 46267X108 194 12,483 SH   DFND 3 12,483 0 0
iQIYI Inc ADR SPON ADR 46267X108 2,858 183,441 SH   SOLE 0 183,441 0 0
iQIYI Inc ADR SPON ADR 46267X108 25,183 1,616,353 SH   DFND 1 1,616,353 0 0
iRobot COM 462726100 22,203 237,748 SH   DFND 2 96,607 0 141,141
iRobot COM 462726100 11,631 124,542 SH   DFND 3 113,754 0 10,788
iRobot COM 462726100 27,657 296,148 SH   SOLE 0 296,148 0 0
iRobot COM 462726100 19,489 208,682 SH   DFND 1 208,682 0 0
iShares Physical Silver ETC COM 46428Q109 3,038 121,600 SH   DFND 3 121,600 0 0
iShares Physical Silver ETC COM 46428Q109 59,258 2,372,000 SH   DFND 1 2,372,000 0 0
j2 Global COM 48123V102 10 73 SH   DFND 3 73 0 0
nCino COM 63947U107 12 200 SH   DFND 3 200 0 0
nLIGHT COM 65487K100 20 542 SH   DFND 3 542 0 0