The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 52,728 265,460 SH   DFND 1 265,460 0 0
ABBVIE INC COM 00287Y109 4,856 43,113 SH   DFND 1 43,113 0 0
ADMA BIOLOGICS INC COM 000899104 48 30,075 SH   DFND 1 30,075 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108 155 89,815 SH   DFND 1 89,815 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 227 20,020 SH   DFND 1 20,020 0 0
ALIBABA GROUP HOLDING LIMITED SPONSORED ADR 01609W102 247 1,090 SH   DFND 1 1,090 0 0
ALPHABET INC CLASS A CL A 38259P508 442 181 SH   DFND 1 181 0 0
ALPHABET INC CLASS C CL C 38259P706 17,544 7,000 SH   DFND 1 0 0 7,000
ALPINE IMMUNE SCIENCES INC COM 02083G100 94 10,445 SH   DFND 1 10,445 0 0
ALTRIA GROUP INC COM 02209S103 18,287 383,540 SH   DFND 1 383,540 0 0
AMARIN CORP PLC-ADR COM 023111206 66 15,000 SH   DFND 1 15,000 0 0
AMETEK INC COM 031100100 1,594 11,940 SH   DFND 1 11,940 0 0
AMGEN INC COM 031162100 7,951 32,620 SH   DFND 1 32,620 0 0
ANAVEX LIFE SCIENCES CORP COM 032797300 1,956 85,585 SH   DFND 1 85,585 0 0
ANHEUSER-BUSCH INBEV NV COM 03524A108 7,839 108,860 SH   DFND 1 108,860 0 0
BANK OF AMERICA CORPORATION COM 060505104 1,927 46,740 SH   DFND 1 46,740 0 0
BANK OF NEW YORK MELLON CORP COM 064058100 34,635 676,070 SH   DFND 1 676,070 0 0
BECTON DICKINSON & CO COM 075887109 5,829 23,970 SH   DFND 1 23,970 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108 327,765 783 SH   DFND 1 783 0 0
BERKSHIRE HATHAWAY INC CLASS B CL B 084670702 2,054 7,390 SH   DFND 1 7,390 0 0
BHP BILLITON PLC SPONSORED ADR 05545E209 8,798 147,400 SH   DFND 1 147,400 0 0
BIODELIVERY SCIENCES INTERNATIONAL INC COM 09060J106 90 25,000 SH   DFND 1 25,000 0 0
BOEING CO COM 097023105 5,869 24,500 SH   DFND 1 24,500 0 0
BRISTOL-MYERS SQUIBB COMPANY COM 110122108 1,272 19,040 SH   DFND 1 19,040 0 0
BRITISH AMERICAN TOBACCO PLC SPONSORED ADR 110448107 930 23,650 SH   DFND 1 23,650 0 0
CIGNA CORPORATION COM 125509109 5,429 22,899 SH   DFND 1 22,899 0 0
CISCO SYSTEMS INC COM 17275R102 1,882 35,500 SH   DFND 1 35,500 0 0
COCA COLA CO COM 191216100 2,619 48,400 SH   DFND 1 48,400 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 53 19,959 SH   DFND 1 19,959 0 0
DANAHER CORP COM 235851102 50,814 189,350 SH   DFND 1 189,350 0 0
ECOLAB INC COM 278865100 433 2,100 SH   DFND 1 2,100 0 0
EXXON MOBIL CORPORATION COM 30231G102 17,054 270,350 SH   DFND 1 270,350 0 0
FORTIVE CORP COM 34959J108 4,757 68,210 SH   DFND 1 68,210 0 0
GILEAD SCIENCES INC COM 375558103 1,283 18,630 SH   DFND 1 18,630 0 0
HONEYWELL INTERNATIONAL INC COM 438516106 3,553 16,200 SH   DFND 1 16,200 0 0
INTUITIVE SURGICAL INC COM 46120E602 15,974 17,370 SH   DFND 1 17,370 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 2,337 14,290 SH   DFND 1 14,290 0 0
JOHNSON & JOHNSON COM 478160104 55,919 339,440 SH   DFND 1 339,440 0 0
THE KRAFT HEINZ COMPANY COM 500754106 1,054 25,850 SH   DFND 1 25,850 0 0
LINDE PUBLIC LIMITED COMPANY COM G5494J103 45,296 156,680 SH   DFND 1 156,680 0 0
LOCKHEED MARTIN CORP COM 539830109 2,342 6,190 SH   DFND 1 6,190 0 0
MASTERCARD INC CL A 57636Q104 3,651 10,000 SH   DFND 1 10,000 0 0
MEDTRONIC INC COM 585055106 9,814 79,060 SH   DFND 1 79,060 0 0
MERCK & CO INC COM 58933Y105 1,171 15,060 SH   DFND 1 15,060 0 0
METLIFE INC COM 59156R108 633 10,580 SH   DFND 1 10,580 0 0
MOODYS CORPORATION COM 20775CZK3 18,825 51,950 SH   DFND 1 51,950 0 0
NASDAQ INC COM 631103108 5,889 33,500 SH   DFND 1 33,500 0 0
NESTLE SA SPONSORED ADR 641069406 29,580 237,130 SH   DFND 1 237,130 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 9,793 116,900 SH   DFND 1 116,900 0 0
NOVOCURE LIMITED COM G6674U108 377 1,700 SH   DFND 1 1,700 0 0
NUTRIEN LTD COM 67077M108 14,783 243,910 SH   DFND 1 243,910 0 0
PARKER HANNIFIN CORPORATION COM 701094104 691 2,250 SH   DFND 1 2,250 0 0
PHILLIPS 66 COM 718546104 15,218 177,330 SH   DFND 1 177,330 0 0
PRUDENTIAL FINANCIAL INC COM 744320102 651 6,350 SH   DFND 1 6,350 0 0
ROCHE HOLDING AG COM 771195104 10,818 230,220 SH   DFND 1 230,220 0 0
ROPER TECHNOLOGIES INC COM 776696106 34,188 72,710 SH   DFND 1 72,710 0 0
ROYAL DUTCH SHELL PLC CLASS B COM 780259107 11,738 302,280 SH   DFND 1 302,280 0 0
STORE CAPITAL CORPORATION REIT 862121100 1,267 36,700 SH   DFND 1 36,700 0 0
UNION PACIFIC CORP COM 907818108 897 4,080 SH   DFND 1 4,080 0 0
US BANCORP COM 902973304 22,408 393,330 SH   DFND 1 393,330 0 0
VANGUARD FTSE EMERGING MARKETS ETF COM 922042858 3,194 58,810 SH   DFND 1 58,810 0 0
VANGUARD HEALTH CARE ETF ETF 92204A504 568 2,300 SH   DFND 1 2,300 0 0
VANGUARD S&P 500 ETF ETF 922908363 7,556 19,200 SH   DFND 1 19,200 0 0
VEEVA SYSTEMS INC-CLASS A CL A 922475108 622 2,000 SH   DFND 1 2,000 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 527 9,400 SH   DFND 1 9,400 0 0
VISA INC CLASS A CL A 92826C839 35,845 153,300 SH   DFND 1 153,300 0 0
VONTIER CORP COM 928881101 1,565 48,026 SH   DFND 1 48,026 0 0
WABTEC CORPORATION COM 929740108 5,886 71,523 SH   DFND 1 71,523 0 0
WATERS CORPORATION COM 941848103 16,102 46,590 SH   DFND 1 46,590 0 0
WELLS FARGO & CO COM 949746101 34,603 764,040 SH   DFND 1 764,040 0 0
XTRACKERS HARVEST CSI 300 CHINA A-SHARES ETF ETF 233051879 474 11,700 SH   DFND 1 11,700 0 0