The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X Genomics Inc COM 88025U109 188,767 1,042,913 SH   SOLE   900,456 0 142,457
2U Inc COM 90214J101 210,250 5,499,618 SH   SOLE   4,077,116 0 1,422,502
908 Devices Inc COM 65443P102 3,351 69,103 SH   SOLE   0 0 69,103
ANSYS Inc COM 03662Q105 12,846 37,830 SH   SOLE   0 0 37,830
Agora Inc COM 00851L103 68,977 1,372,124 SH   SOLE   0 0 1,372,124
AngloGold Ashanti Ltd COM 035128206 2,805 127,668 SH   SOLE   127,668 0 0
Accolade Inc COM 00437E102 21,863 481,885 SH   SOLE   0 0 481,885
Activision Blizzard Inc COM 00507V109 61,854 665,099 SH   SOLE   0 0 665,099
Adaptive Biotechnologies Corp COM 00650F109 16,056 398,810 SH   SOLE   0 0 398,810
Adobe Inc COM 00724F101 65,725 138,261 SH   SOLE   0 0 138,261
AeroVironment Inc COM 008073108 16,003 137,889 SH   SOLE   0 0 137,889
Agnico Eagle Mines Ltd COM 008474108 2,881 49,844 SH   SOLE   49,844 0 0
Air Products and Chemicals Inc COM 009158106 3,886 13,811 SH   SOLE   13,811 0 0
Alamos Gold Inc COM 011532108 3,711 475,155 SH   SOLE   475,155 0 0
Albemarle Corp COM 012653101 1,187 8,126 SH   SOLE   8,126 0 0
Alphabet Inc COM 02079K107 37,161 17,964 SH   SOLE   0 0 17,964
Amazon.com Inc COM 023135106 93,429 30,196 SH   SOLE   0 0 30,196
Anaplan Inc COM 03272L108 53,082 985,736 SH   SOLE   0 0 985,736
Apple Inc COM 037833100 200,168 1,638,708 SH   SOLE   0 0 1,638,708
Aptiv PLC COM G6095L109 14,284 103,585 SH   SOLE   0 0 103,585
ArcLight Clean Transition Corp COM G04561109 809 45,265 SH   SOLE   45,265 0 0
Archer-Daniels-Midland Co COM 039483102 3,615 63,416 SH   SOLE   63,416 0 0
Arcturus Therapeutics Holdings COM 03969T109 13,043 315,812 SH   SOLE   0 0 315,812
Arrowhead Pharmaceuticals Inc COM 04280A100 12,115 182,704 SH   SOLE   0 0 182,704
Atlas Crest Investment Corp COM 049284102 995 99,051 SH   SOLE   0 0 99,051
Atlassian Corp PLC COM G06242104 47,475 225,256 SH   SOLE   0 0 225,256
Autodesk Inc COM 052769106 9,428 34,019 SH   SOLE   0 0 34,019
Avalara Inc COM 05338G106 40,695 304,992 SH   SOLE   0 0 304,992
B2Gold Corp COM 11777Q209 1,782 413,561 SH   SOLE   413,561 0 0
Alibaba Group Holding Ltd COM 01609W102 202,024 891,033 SH   SOLE   0 0 891,033
Banco Bradesco SA COM 059460303 623 132,533 SH   SOLE   0 0 132,533
BHP Group PLC COM 05545E209 12,983 224,394 SH   SOLE   224,394 0 0
KE Holdings Inc COM 482497104 289,564 5,081,858 SH   SOLE   2,417,486 0 2,664,372
Baidu Inc COM 056752108 375,043 1,723,940 SH   SOLE   1,527,564 0 196,376
Bilibili Inc COM 090040106 54,250 506,725 SH   SOLE   0 0 506,725
Burning Rock Biotech Ltd COM 12233L107 23,241 863,343 SH   SOLE   0 0 863,343
BP PLC COM 055622104 4,136 169,870 SH   SOLE   169,870 0 0
Baker Hughes Co COM 05722G100 2,399 111,004 SH   SOLE   111,004 0 0
Barrick Gold Corp COM 067901108 4,975 251,253 SH   SOLE   251,253 0 0
Beam Therapeutics Inc COM 07373V105 18,361 229,401 SH   SOLE   0 0 229,401
Berkeley Lights Inc COM 084310101 3,871 77,065 SH   SOLE   0 0 77,065
Bill.com Holdings Inc COM 090043100 12,024 82,639 SH   SOLE   0 0 82,639
Boeing Co/The COM 097023105 4,982 19,558 SH   SOLE   0 0 19,558
Bristol-Myers Squibb Co COM 110122108 16,951 268,503 SH   SOLE   0 0 268,503
Bunge Ltd COM G16962105 2,063 26,020 SH   SOLE   26,020 0 0
CF Industries Holdings Inc COM 125269100 2,128 46,900 SH   SOLE   46,900 0 0
Cellectis SA COM 15117K103 17,997 890,511 SH   SOLE   0 0 890,511
CRISPR Therapeutics AG COM H17182108 445,955 3,659,865 SH   SOLE   3,095,812 0 564,053
Cabot Oil & Gas Corp COM 127097103 2,361 125,706 SH   SOLE   125,706 0 0
Cactus Inc COM 127203107 749 24,466 SH   SOLE   24,466 0 0
Canadian Natural Resources Ltd COM 136385101 2,659 86,128 SH   SOLE   86,128 0 0
CareDx Inc COM 14167L103 55,617 816,812 SH   SOLE   0 0 816,812
Caterpillar Inc COM 149123101 20,502 88,422 SH   SOLE   0 0 88,422
Calyxt Inc COM 13173L107 15,762 2,618,287 SH   SOLE   0 0 2,618,287
Cerus Corp COM 157085101 80,499 13,394,255 SH   SOLE   10,874,440 0 2,519,815
ChampionX Corp COM 15872M104 1,139 52,421 SH   SOLE   52,421 0 0
Charles Schwab Corp/The COM 808513105 78,070 1,197,762 SH   SOLE   0 0 1,197,762
Chevron Corp COM 166764100 10,423 99,461 SH   SOLE   99,461 0 0
Cloudflare Inc COM 18915M107 52,899 752,900 SH   SOLE   0 0 752,900
Codexis Inc COM 192005106 22,150 967,672 SH   SOLE   0 0 967,672
Compugen Ltd COM M25722105 61,525 7,162,406 SH   SOLE   5,851,942 0 1,310,464
ConocoPhillips COM 20825C104 4,043 76,325 SH   SOLE   76,325 0 0
Corteva Inc COM 22052L104 19,886 426,559 SH   SOLE   149,059 0 277,500
Coupa Software Inc COM 22266L106 44,536 175,007 SH   SOLE   0 0 175,007
Crowdstrike Holdings Inc COM 22788C105 45,858 251,265 SH   SOLE   0 0 251,265
Darling Ingredients Inc COM 237266101 1,447 19,666 SH   SOLE   19,666 0 0
Datadog Inc COM 23804L103 70,017 840,131 SH   SOLE   0 0 840,131
Deere & Co COM 244199105 37,051 99,029 SH   SOLE   0 0 99,029
DocuSign Inc COM 256163106 351,542 1,736,441 SH   SOLE   622,108 0 1,114,333
Domino's Pizza Inc COM 25754A201 13,177 35,828 SH   SOLE   0 0 35,828
DraftKings Inc COM 26142R104 208,802 3,404,559 SH   SOLE   815,404 0 2,589,155
EOG Resources Inc COM 26875P101 2,383 32,852 SH   SOLE   32,852 0 0
Editas Medicine Inc COM 28106W103 178,817 4,257,556 SH   SOLE   3,445,529 0 812,027
Elastic NV COM N14506104 62,297 560,223 SH   SOLE   0 0 560,223
Elbit Systems Ltd COM M3760D101 8,431 58,955 SH   SOLE   0 0 58,955
Etsy Inc COM 29786A106 61,098 302,962 SH   SOLE   0 0 302,962
ExOne Co/The COM 302104104 46,284 1,475,897 SH   SOLE   1,457,036 0 18,861
Exact Sciences Corp COM 30063P105 289,670 2,198,130 SH   SOLE   2,043,635 0 154,495
Experience Investment Corp COM 30217C109 9,621 934,956 SH   SOLE   0 0 934,956
Exxon Mobil Corp COM 30231G102 9,944 178,116 SH   SOLE   178,116 0 0
Facebook Inc COM 30303M102 305,581 1,037,521 SH   SOLE   0 0 1,037,521
Fastly Inc COM 31188V100 113,474 1,686,586 SH   SOLE   0 0 1,686,586
Fate Therapeutics Inc COM 31189P102 46,304 561,595 SH   SOLE   0 0 561,595
Freeport-McMoRan Inc COM 35671D857 10,280 312,172 SH   SOLE   312,172 0 0
Garmin Ltd COM H2906T109 12,589 95,481 SH   SOLE   0 0 95,481
Southern Copper Corp COM 84265V105 1,963 28,921 SH   SOLE   28,921 0 0
Guardant Health Inc COM 40131M109 22,686 148,614 SH   SOLE   0 0 148,614
Guidewire Software Inc COM 40171V100 60,500 595,298 SH   SOLE   0 0 595,298
HDFC Bank Ltd COM 40415F101 55,156 709,950 SH   SOLE   0 0 709,950
HEICO Corp COM 422806109 1,595 12,681 SH   SOLE   0 0 12,681
HUYA Inc COM 44852D108 51,784 2,658,338 SH   SOLE   1,388,575 0 1,269,763
Halliburton Co COM 406216101 1,273 59,316 SH   SOLE   59,316 0 0
Helmerich & Payne Inc COM 423452101 794 29,468 SH   SOLE   29,468 0 0
Hess Corp COM 42809H107 1,865 26,363 SH   SOLE   26,363 0 0
Honeywell International Inc COM 438516106 1,553 7,154 SH   SOLE   0 0 7,154
HubSpot Inc COM 443573100 94,030 207,018 SH   SOLE   0 0 207,018
Huntsman Corp COM 447011107 1,863 64,615 SH   SOLE   64,615 0 0
Incyte Corp COM 45337C102 17,395 214,040 SH   SOLE   0 0 214,040
Intellia Therapeutics Inc COM 45826J105 388,697 4,843,270 SH   SOLE   3,558,439 0 1,284,831
Intercontinental Exchange Inc COM 45866F104 339,862 3,043,173 SH   SOLE   1,149,839 0 1,893,334
International Paper Co COM 460146103 5,698 105,387 SH   SOLE   105,387 0 0
Intuit Inc COM 461202103 78,807 205,729 SH   SOLE   0 0 205,729
Invitae Corp COM 46185L103 521,993 13,661,155 SH   SOLE   11,402,890 0 2,258,265
Ionis Pharmaceuticals Inc COM 462222100 22,402 498,256 SH   SOLE   0 0 498,256
Iovance Biotherapeutics Inc COM 462260100 169,250 5,345,861 SH   SOLE   4,230,295 0 1,115,566
Iridium Communications Inc COM 46269C102 111,017 2,691,329 SH   SOLE   2,513,341 0 177,988
JD.com Inc COM 47215P106 247,958 2,940,326 SH   SOLE   0 0 2,940,326
Kratos Defense & Security Solu COM 50077B207 36,307 1,330,906 SH   SOLE   0 0 1,330,906
L3Harris Technologies Inc COM 502431109 6,963 34,354 SH   SOLE   0 0 34,354
LendingClub Corp COM 52603A208 75,679 4,581,060 SH   SOLE   2,812,360 0 1,768,700
LendingTree Inc COM 52603B107 240,470 1,128,965 SH   SOLE   561,883 0 567,082
Liberty Oilfield Services Inc COM 53115L104 695 61,575 SH   SOLE   61,575 0 0
Personalis Inc COM 71535D106 30,090 1,222,678 SH   SOLE   0 0 1,222,678
Linde PLC COM G5494J103 4,971 17,745 SH   SOLE   17,745 0 0
LivePerson Inc COM 538146101 9,843 186,634 SH   SOLE   0 0 186,634
Lockheed Martin Corp COM 539830109 6,242 16,892 SH   SOLE   0 0 16,892
Materialise NV COM 57667T100 94,933 2,640,699 SH   SOLE   2,602,652 0 38,047
Magna International Inc COM 559222401 15,386 174,766 SH   SOLE   0 0 174,766
Marathon Petroleum Corp COM 56585A102 1,747 32,658 SH   SOLE   32,658 0 0
MarketAxess Holdings Inc COM 57060D108 21,305 42,789 SH   SOLE   0 0 42,789
MercadoLibre Inc COM 58733R102 201,253 136,708 SH   SOLE   0 0 136,708
Microsoft Corp COM 594918104 89,830 381,009 SH   SOLE   0 0 381,009
Mimecast Ltd COM G14838109 69,976 1,740,265 SH   SOLE   0 0 1,740,265
MongoDB Inc COM 60937P106 85,263 318,823 SH   SOLE   0 0 318,823
Mosaic Co/The COM 61945C103 1,795 56,786 SH   SOLE   56,786 0 0
Niu Technologies COM 65481N100 16,797 458,313 SH   SOLE   0 0 458,313
NVIDIA Corp COM 67066G104 78,752 147,495 SH   SOLE   0 0 147,495
NXP Semiconductors NV COM N6596X109 31,330 155,605 SH   SOLE   0 0 155,605
NanoString Technologies Inc COM 63009R109 21,120 321,405 SH   SOLE   311,058 0 10,347
Netflix Inc COM 64110L106 160,645 307,950 SH   SOLE   0 0 307,950
Newmont Corp COM 651639106 4,550 75,493 SH   SOLE   75,493 0 0
Nomad Foods Ltd COM G6564A105 1,773 64,579 SH   SOLE   64,579 0 0
Nucor Corp COM 670346105 4,063 50,617 SH   SOLE   50,617 0 0
Nutrien Ltd COM 67077M108 10,120 187,791 SH   SOLE   187,791 0 0
Occidental Petroleum Corp COM 674599105 1,823 68,491 SH   SOLE   68,491 0 0
Oceaneering International Inc COM 675232102 1,073 93,981 SH   SOLE   93,981 0 0
Oil States International Inc COM 678026105 827 137,099 SH   SOLE   137,099 0 0
One COM G7000X105 10,013 863,934 SH   SOLE   0 0 863,934
Opendoor Technologies Inc COM 683712103 129,675 6,119,643 SH   SOLE   0 0 6,119,643
Organovo Holdings Inc COM 68620A203 4,664 483,811 SH   SOLE   371,410 0 112,401
PACCAR Inc COM 693718108 112,840 1,214,381 SH   SOLE   1,202,287 0 12,094
Petroleo Brasileiro SA COM 71654V408 473 55,777 SH   SOLE   55,777 0 0
Pinduoduo Inc COM 722304102 162,919 1,216,903 SH   SOLE   0 0 1,216,903
Pacific Biosciences of Califor COM 69404D108 174,785 5,247,237 SH   SOLE   4,338,089 0 909,148
Packaging Corp of America COM 695156109 2,222 16,523 SH   SOLE   16,523 0 0
PagerDuty Inc COM 69553P100 289,377 7,193,069 SH   SOLE   4,345,317 0 2,847,752
Palantir Technologies Inc COM 69608A108 131,359 5,640,148 SH   SOLE   5,583,944 0 56,204
PayPal Holdings Inc COM 70450Y103 498,931 2,054,567 SH   SOLE   45,777 0 2,008,790
Peloton Interactive Inc COM 70614W100 158,100 1,406,079 SH   SOLE   0 0 1,406,079
Performance Food Group Co COM 71377A103 1,630 28,290 SH   SOLE   28,290 0 0
Phillips 66 COM 718546104 1,617 19,827 SH   SOLE   19,827 0 0
Pinterest Inc COM 72352L106 201,888 2,727,107 SH   SOLE   0 0 2,727,107
Pioneer Natural Resources Co COM 723787107 1,630 10,266 SH   SOLE   10,266 0 0
Pluristem Therapeutics Inc COM 72940R300 576 120,729 SH   SOLE   0 0 120,729
AquaBounty Technologies Inc COM 03842K200 1,448 216,182 SH   SOLE   0 0 216,182
Proto Labs Inc COM 743713109 240,640 1,976,509 SH   SOLE   1,848,920 0 127,589
Pure Storage Inc COM 74624M102 199,541 9,263,745 SH   SOLE   7,794,684 0 1,469,061
Royal Dutch Shell PLC COM 780259206 5,893 150,304 SH   SOLE   150,304 0 0
Rio Tinto PLC COM 767204100 6,543 84,266 SH   SOLE   84,266 0 0
ROBLOX Corp COM 771049103 26,847 414,111 SH   SOLE   0 0 414,111
Raven Industries Inc COM 754212108 16,169 421,835 SH   SOLE   0 0 421,835
Regeneron Pharmaceuticals Inc COM 75886F107 37,670 79,618 SH   SOLE   18,564 0 61,054
Reinvent Technology Partners COM G7483N129 1,008 99,322 SH   SOLE   0 0 99,322
Roku Inc COM 77543R102 708,143 2,173,750 SH   SOLE   1,614,943 0 558,807
Sea Ltd COM 81141R100 610,604 2,735,312 SH   SOLE   919,379 0 1,815,933
China Petroleum & Chemical Cor COM 16941R108 778 14,746 SH   SOLE   14,746 0 0
SSR Mining Inc COM 784730103 2,049 143,453 SH   SOLE   143,453 0 0
Sarepta Therapeutics Inc COM 803607100 14,358 192,650 SH   SOLE   0 0 192,650
Schlumberger NV COM 806857108 2,050 75,392 SH   SOLE   75,392 0 0
Schrodinger Inc/United States COM 80810D103 15,930 208,808 SH   SOLE   0 0 208,808
Seer Inc COM 81578P106 7,668 153,294 SH   SOLE   0 0 153,294
Seres Therapeutics Inc COM 81750R102 123,527 5,999,356 SH   SOLE   4,846,954 0 1,152,402
Shoals Technologies Group Inc COM 82489W107 927 26,656 SH   SOLE   26,656 0 0
Shopify Inc COM 82509L107 609,826 551,131 SH   SOLE   210,190 0 340,941
Smartsheet Inc COM 83200N103 26,906 420,934 SH   SOLE   0 0 420,934
Snap Inc COM 83304A106 274,707 5,253,522 SH   SOLE   0 0 5,253,522
Spirit AeroSystems Holdings In COM 848574109 4,306 88,519 SH   SOLE   0 0 88,519
Spotify Technology SA COM L8681T102 433,024 1,616,064 SH   SOLE   1,127,685 0 488,379
Square Inc COM 852234103 1,285,637 5,662,354 SH   SOLE   2,881,117 0 2,781,237
Steel Dynamics Inc COM 858119100 4,183 82,401 SH   SOLE   82,401 0 0
Stratasys Ltd COM M85548101 112,955 4,361,179 SH   SOLE   4,115,311 0 245,868
Suncor Energy Inc COM 867224107 3,682 176,196 SH   SOLE   176,196 0 0
Synopsys Inc COM 871607107 108,725 438,797 SH   SOLE   379,156 0 59,641
Syros Pharmaceuticals Inc COM 87184Q107 37,714 5,042,009 SH   SOLE   4,090,307 0 951,702
TOTAL SE COM 89151E109 9,061 194,684 SH   SOLE   194,684 0 0
TPI Composites Inc COM 87266J104 687 12,179 SH   SOLE   12,179 0 0
Taiwan Semiconductor Manufactu COM 874039100 50,544 427,324 SH   SOLE   0 0 427,324
TechnipFMC PLC COM G87110105 1,271 164,625 SH   SOLE   164,625 0 0
Teck Resources Ltd COM 878742204 3,009 156,864 SH   SOLE   156,864 0 0
Teladoc Health Inc COM 87918A105 807,981 4,445,562 SH   SOLE   3,197,499 0 1,248,063
Teledyne Technologies Inc COM 879360105 15,419 37,276 SH   SOLE   0 0 37,276
Teradyne Inc COM 880770102 87,470 718,855 SH   SOLE   510,455 0 208,400
Tesla Inc COM 88160R101 1,065,408 1,595,090 SH   SOLE   1,459,216 0 135,874
Thermo Fisher Scientific Inc COM 883556102 12,417 27,207 SH   SOLE   0 0 27,207
Trimble Inc COM 896239100 72,501 932,012 SH   SOLE   0 0 932,012
Twilio Inc COM 90138F102 563,971 1,655,038 SH   SOLE   744,875 0 910,163
Twist Bioscience Corp COM 90184D100 255,543 2,063,164 SH   SOLE   1,715,418 0 347,746
Twitter Inc COM 90184L102 170,955 2,686,707 SH   SOLE   1,831,761 0 854,946
Union Pacific Corp COM 907818108 1,541 6,993 SH   SOLE   6,993 0 0
United Parcel Service Inc COM 911312106 8,898 52,347 SH   SOLE   0 0 52,347
Unity Software Inc COM 91332U101 325,851 3,248,435 SH   SOLE   2,238,368 0 1,010,067
Univar Solutions Inc COM 91336L107 2,552 118,462 SH   SOLE   118,462 0 0
Vale SA COM 91912E105 6,961 400,538 SH   SOLE   400,538 0 0
Valero Energy Corp COM 91913Y100 1,259 17,579 SH   SOLE   17,579 0 0
Veeva Systems Inc COM 922475108 18,878 72,262 SH   SOLE   0 0 72,262
Veracyte Inc COM 92337F107 176,705 3,287,529 SH   SOLE   2,776,068 0 511,461
Vertex Pharmaceuticals Inc COM 92532F100 26,485 123,247 SH   SOLE   0 0 123,247
Virgin Galactic Holdings Inc COM 92766K106 18,087 590,492 SH   SOLE   0 0 590,492
Weyerhaeuser Co COM 962166104 4,392 123,372 SH   SOLE   123,372 0 0
Walt Disney Co/The COM 254687106 104,521 566,448 SH   SOLE   0 0 566,448
Williams Cos Inc/The COM 969457100 1,544 65,177 SH   SOLE   65,177 0 0
Workday Inc COM 98138H101 106,376 428,195 SH   SOLE   0 0 428,195
Workhorse Group Inc COM 98138J206 10,184 739,614 SH   SOLE   0 0 739,614
Xilinx Inc COM 983919101 12,000 96,850 SH   SOLE   0 0 96,850
Xylem Inc/NY COM 98419M100 1,573 14,951 SH   SOLE   14,951 0 0
Zillow Group Inc COM 98954M200 678,050 5,230,252 SH   SOLE   2,760,592 0 2,469,660
Zoom Video Communications Inc COM 98980L101 401,553 1,249,814 SH   SOLE   882,763 0 367,051