The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100 8,676 200,000 SH   DFND 1 200,000 0 0
5 01 ACQUISITION CORP COM CL A 33836P105 4,988 500,000 SH   DFND 1 500,000 0 0
908 DEVICES INC COM 65443P102 25,919 545,322 SH   DFND 1 545,322 0 0
ACCELERON PHARMA INC COM 00434H108 37,293 275,000 SH   DFND 1 275,000 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 50,400 2,000,000 SH   DFND 1 2,000,000 0 0
AGENUS INC COM NEW 00847G705 21,080 7,750,000 SH   DFND 1 7,750,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 21,541 742,549 SH   DFND 1 742,549 0 0
AKOUOS INC COM 00973J101 6,935 499,989 SH   DFND 1 499,989 0 0
ALBIREO PHARMA INC COM 01345P106 17,625 500,000 SH   DFND 1 500,000 0 0
ALIGOS THERAPEUTICS INC COM 01626L105 28,815 1,267,167 SH   DFND 1 1,267,167 0 0
ALLAKOS INC COM 01671P100 2,870 25,000 SH   DFND 1 25,000 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 65,022 881,770 SH   DFND 1 881,770 0 0
ANAPTYSBIO INC COM 032724106 14,008 650,000 SH   DFND 1 650,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 80,075 1,866,108 SH   DFND 1 1,866,108 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 23,900 4,000,000 SH   DFND 1 4,000,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 1,388 20,000 SH   DFND 1 20,000 0 0
ARGENX SE SPONSORED ADR 04016X101 8,262 30,000 SH   DFND 1 30,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 12,888 100,000 SH   DFND 1 100,000 0 0
ATEA PHARMACEUTICALS INC COM 04683R106 395,901 6,411,355 SH   DFND 1 6,411,355 0 0
ATRECA INC CL A COM 04965G109 4,499 293,500 SH   DFND 1 293,500 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 2,419 422,167 SH   DFND 1 422,167 0 0
AVEO PHARMACEUTICALS INC COM NEW 053588307 10,980 1,500,000 SH   DFND 1 1,500,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 53,752 2,464,545 SH   DFND 1 2,464,545 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 41,504 693,000 SH   DFND 1 693,000 0 0
AXSOME THERAPEUTICS INC COM 05464T104 11,324 200,000 SH   DFND 1 200,000 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 5,285 500,000 SH   DFND 1 500,000 0 0
BCTG ACQUISITION CORP COM 05492W103 8,896 800,000 SH   DFND 1 800,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 13,749 171,775 SH   DFND 1 171,775 0 0
BIOATLA INC COM 09077B104 109,927 2,192,060 SH   DFND 1 2,192,060 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 13,670 200,000 SH   DFND 1 200,000 0 0
BIONTECH SE SPONSORED ADS 09075V102 10,919 100,000 SH   DFND 1 100,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 24,035 247,200 SH   DFND 1 247,200 0 0
BRIDGEBIO PHARMA INC COM 10806X102 133,605 2,168,909 SH   DFND 1 2,168,909 0 0
C4 THERAPEUTICS INC COM STK 12529R107 92,107 2,490,065 SH   DFND 1 2,490,065 0 0
CABALETTA BIO INC COM 12674W109 21,139 1,904,424 SH   DFND 1 1,904,424 0 0
CARDIFF ONCOLOGY INC COM 14147L108 1,389 150,000 SH   DFND 1 150,000 0 0
CEREVEL THERAPEUTICS HLDNG I *W EXP 06/09/202 15678U102 563 133,331 SH   DFND 1 133,331 0 0
CHEMOCENTRYX INC COM 16383L106 43,554 850,000 SH   DFND 1 850,000 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 18,500 1,000,000 SH   DFND 1 1,000,000 0 0
CULLINAN ONCOLOGY INC COM 230031106 6,250 150,000 SH   DFND 1 150,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 8,968 200,000 SH   DFND 1 200,000 0 0
DERMTECH INC COM 24984K105 40,632 800,000 SH   DFND 1 800,000 0 0
DESIGN THERAPEUTICS INC COM 25056L103 146,409 5,114,850 SH   DFND 1 5,114,850 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 74,307 2,340,914 SH   DFND 1 2,340,914 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 3,540 400,000 SH   DFND 1 400,000 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101 15,146 1,415,500 SH   DFND 1 1,415,500 0 0
FATE THERAPEUTICS INC COM 31189P102 824 10,000 SH   DFND 1 10,000 0 0
FOGHORN THERAPEUTICS INC COM 344174107 13,180 1,000,000 SH   DFND 1 1,000,000 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 132,254 4,720,000 SH   DFND 1 4,720,000 0 0
GALECTO INC COM 36322Q107 13,066 2,150,732 SH   DFND 1 2,150,732 0 0
GEMINI THERAPEUTICS INC COM 36870G105 6,436 475,000 SH   DFND 1 475,000 0 0
GENETRON HLDGS LTD ADS 37186H100 6,438 300,000 SH   DFND 1 300,000 0 0
GOSSAMER BIO INC COM 38341P102 7,848 848,382 SH   DFND 1 848,382 0 0
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103 1,925 125,000 SH   DFND 1 125,000 0 0
HARPOON THERAPEUTICS INC COM 41358P106 11,937 570,600 SH   DFND 1 570,600 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 8,984 800,000 SH   DFND 1 800,000 0 0
HELIX ACQUISITION CORP COM CL A G4444C102 4,386 430,000 SH   DFND 1 430,000 0 0
HUMANIGEN INC COM NEW 444863203 19,100 1,000,000 SH   DFND 1 1,000,000 0 0
IGM BIOSCIENCES INC COM 449585108 38,021 495,769 SH   DFND 1 495,769 0 0
IMMUNOVANT INC COM 45258J102 5,406 337,048 SH   DFND 1 337,048 0 0
IMV INC COM 44974L103 772 234,374 SH   DFND 1 234,374 0 0
INSMED INC COM PAR $.01 457669307 10,218 300,000 SH   DFND 1 300,000 0 0
INSPIRE MED SYS INC COM 457730109 17,594 85,000 SH   DFND 1 85,000 0 0
INSTIL BIO INC COM 45783C101 3,762 150,000 SH   DFND 1 150,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 24,075 300,000 SH Put DFND 1 300,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 441,880 2,000,000 SH Put DFND 1 2,000,000 0 0
ITEOS THERAPEUTICS INC COM 46565G104 10,254 300,000 SH   DFND 1 300,000 0 0
KADMON HLDGS INC COM 48283N106 2,918 750,000 SH   DFND 1 750,000 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 19,268 750,000 SH   DFND 1 750,000 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 2,406 130,000 SH   DFND 1 130,000 0 0
LONGBOARD PHARMACEUTICALS IN COM 54300N103 37,193 2,356,000 SH   DFND 1 2,356,000 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 7,104 600,000 SH   DFND 1 600,000 0 0
MERUS N V COM N5749R100 7,311 350,000 SH   DFND 1 350,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 584 200,000 SH   DFND 1 200,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 47,108 275,000 SH   DFND 1 275,000 0 0
MORPHIC HLDG INC COM 61775R105 22,148 350,000 SH   DFND 1 350,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 20,580 1,000,000 SH   DFND 1 1,000,000 0 0
NEKTAR THERAPEUTICS COM 640268108 400 20,000 SH   DFND 1 20,000 0 0
NOVAVAX INC COM NEW 670002401 45,328 250,000 SH   DFND 1 250,000 0 0
NUVATION BIO INC COM CL A 67080N101 2,450 234,445 SH   DFND 1 234,445 0 0
NUVATION BIO INC *W EXP 07/07/202 67080N119 222 83,332 SH   DFND 1 83,332 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 105,084 3,195,544 SH   DFND 1 3,195,544 0 0
OMEROS CORP COM 682143102 58,741 3,300,030 SH   DFND 1 3,300,030 0 0
OMEROS CORP COM 682143102 17,800 1,000,000 SH Call DFND 1 1,000,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 1,863 256,649 SH   DFND 1 256,649 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 421 416,666 SH   DFND 1 416,666 0 0
PHARVARIS N V COM N69605108 23,811 864,143 SH   DFND 1 864,143 0 0
PLIANT THERAPEUTICS INC COM 729139105 24,047 611,409 SH   DFND 1 611,409 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 35,189 1,074,145 SH   DFND 1 1,074,145 0 0
PRECISION BIOSCIENCES INC COM 74019P108 3,587 346,524 SH   DFND 1 346,524 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 36,623 2,098,024 SH   DFND 1 2,098,024 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 5,509 350,000 SH   DFND 1 350,000 0 0
QUOTIENT LTD SHS G73268107 5,520 1,500,000 SH   DFND 1 1,500,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 39,880 400,000 SH   DFND 1 400,000 0 0
REPARE THERAPEUTICS INC COM 760273102 14,185 462,205 SH   DFND 1 462,205 0 0
REPLIMUNE GROUP INC COM 76029N106 3,814 125,000 SH   DFND 1 125,000 0 0
REVOLUTION MEDICINES INC COM 76155X100 115,847 2,525,000 SH   DFND 1 2,525,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 60,723 1,368,550 SH   DFND 1 1,368,550 0 0
SAREPTA THERAPEUTICS INC COM 803607100 5,217 70,000 SH   DFND 1 70,000 0 0
SILVERBACK THERAPEUTICS INC COM 82835W108 21,815 500,000 SH   DFND 1 500,000 0 0
SORRENTO THERAPEUTICS INC COM NEW 83587F202 22,742 2,750,000 SH   DFND 1 2,750,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 396,330 1,000,000 SH Put DFND 1 1,000,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 135,650 1,000,000 SH Put DFND 1 1,000,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 9,196 125,000 SH   DFND 1 125,000 0 0
STOKE THERAPEUTICS INC COM 86150R107 55,844 1,437,807 SH   DFND 1 1,437,807 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 55,251 1,714,269 SH   DFND 1 1,714,269 0 0
TCR2 THERAPEUTICS INC COM 87808K106 19,872 900,000 SH   DFND 1 900,000 0 0
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 5,255 500,000 SH   DFND 1 500,000 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 11,226 550,000 SH   DFND 1 550,000 0 0
TRICIDA INC COM 89610F101 2,264 427,975 SH   DFND 1 427,975 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 260,122 2,750,000 SH   DFND 1 2,750,000 0 0
TWIST BIOSCIENCE CORP COM 90184D100 22,914 185,000 SH   DFND 1 185,000 0 0
UNIQURE NV SHS N90064101 8,422 250,000 SH   DFND 1 250,000 0 0
VERU INC COM 92536C103 32,325 3,000,000 SH   DFND 1 3,000,000 0 0
VESPER HEALTHCARE ACQSTN COR UNIT 99/99/9999 92538T203 4,620 400,000 SH   DFND 1 400,000 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 7,672 459,144 SH   DFND 1 459,144 0 0
X4 PHARMACEUTICALS INC COM 98420X103 895 103,980 SH   DFND 1 103,980 0 0
Y-MABS THERAPEUTICS INC COM 984241109 37,195 1,230,000 SH   DFND 1 1,230,000 0 0
ZAI LAB LTD ADR 98887Q104 20,014 150,000 SH   DFND 1 150,000 0 0
ZYMEWORKS INC COM 98985W102 63,160 2,000,000 SH   DFND 1 2,000,000 0 0