The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 224,795 2,077,200 SH   SOLE   2,077,200 0 0
ABIOMED INC COM 003654100 42,232 132,500 SH   SOLE   132,500 0 0
ACCELERON PHARMA INC COM 00434H108 43,775 322,800 SH   SOLE   322,800 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 10,561 2,200,200 SH   SOLE   2,200,200 0 0
ADICET BIO INC COM 007002108 29,168 2,230,000 SH   SOLE   2,230,000 0 0
AFFIMED N V COM N01045108 10,251 1,296,000 SH   SOLE   1,296,000 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 30,318 2,552,000 SH   SOLE   2,552,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 60,425 427,969 SH   SOLE   427,969 0 0
ALPHATEC HLDGS INC COM NEW 02081G201 36,854 2,334,000 SH   SOLE   2,334,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 16,017 1,511,000 SH   SOLE   1,511,000 0 0
AMERICAN WELL CORP CL A 03044L105 1,220 70,250 SH   SOLE   70,250 0 0
ANNEXON INC COM 03589W102 1,949 70,000 SH   SOLE   70,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 62,350 898,550 SH   SOLE   898,550 0 0
ARGENX SE SPONSORED ADR 04016X101 5,508 20,000 SH   SOLE   20,000 0 0
ARVINAS INC COM 04335A105 116,356 1,760,300 SH   SOLE   1,760,300 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108 5,236 500,000 SH   SOLE   500,000 0 0
ARYA SCIENCES ACQUISITION CO COM CL A G3166W106 6,890 500,000 SH   SOLE   500,000 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 181,503 3,650,500 SH   SOLE   3,650,500 0 0
ATHIRA PHARMA INC COM 04746L104 30,872 1,677,845 SH   SOLE   1,677,845 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 23,165 1,784,000 SH   SOLE   1,784,000 0 0
AVANTOR INC COM 05352A100 144,219 4,985,100 SH   SOLE   4,985,100 0 0
BAUSCH HEALTH COS INC COM 071734107 60,030 1,891,300 SH   SOLE   1,891,300 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 5,285 500,000 SH   SOLE   500,000 0 0
BCTG ACQUISITION CORP COM 05492W103 3,336 300,000 SH   SOLE   300,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 26,102 6,797,400 SH   SOLE   6,797,400 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 71,754 1,049,800 SH   SOLE   1,049,800 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196905 35,754 523,100 SH Call SOLE   523,100 0 0
BIOVENTUS INC COM CL A 09075A108 19,166 1,254,333 SH   SOLE   1,254,333 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 53,088 546,000 SH   SOLE   546,000 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 21,533 654,294 SH   SOLE   654,294 0 0
BRIDGEBIO PHARMA INC COM 10806X102 50,210 815,100 SH   SOLE   815,100 0 0
CARDIFF ONCOLOGY INC COM 14147L108 22,666 2,447,700 SH   SOLE   2,447,700 0 0
CARDINAL HEALTH INC COM 14149Y108 88,877 1,463,000 SH   SOLE   1,463,000 0 0
CATALENT INC COM 148806102 58,974 560,000 SH   SOLE   560,000 0 0
CHEMOCENTRYX INC COM 16383L106 48,207 940,800 SH   SOLE   940,800 0 0
CHIMERIX INC COM 16934W106 21,497 2,230,000 SH   SOLE   2,230,000 0 0
CIGNA CORP NEW COM 125523100 32,635 135,000 SH   SOLE   135,000 0 0
CM LIFE SCIENCES II INC UNIT 02/25/2028 125842203 4,310 336,700 SH   SOLE   336,700 0 0
CM LIFE SCIENCES INC COM CL A 18978W109 8,190 550,000 SH   SOLE   550,000 0 0
COGENT BIOSCIENCES INC COM 19240Q201 3,667 417,710 SH   SOLE   417,710 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 17,538 740,000 SH   SOLE   740,000 0 0
CULLINAN ONCOLOGY INC COM 230031106 29,476 707,359 SH   SOLE   707,359 0 0
CURIS INC COM NEW 231269200 23,249 2,053,789 SH   SOLE   2,053,789 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 34,405 3,500,000 SH   SOLE   3,500,000 0 0
ESSA PHARMA INC COM NEW 29668H708 82,502 2,840,000 SH   SOLE   2,840,000 0 0
EVELO BIOSCIENCES INC COM 299734103 8,560 800,000 SH   SOLE   800,000 0 0
EXACT SCIENCES CORP COM 30063P105 78,804 598,000 SH   SOLE   598,000 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 2,362 232,504 SH   SOLE   232,504 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 20,011 2,122,064 SH   SOLE   2,122,064 0 0
HARPOON THERAPEUTICS INC COM 41358P106 29,455 1,408,000 SH   SOLE   1,408,000 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 4,476 400,000 SH   SOLE   400,000 0 0
HEALTHCOR CATALIO ACQU CORP CL A SHS G44125105 5,000 500,000 SH   SOLE   500,000 0 0
HELIX ACQUISITION CORP COM CL A G4444C102 4,080 400,000 SH   SOLE   400,000 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 53,475 581,000 SH   SOLE   581,000 0 0
I MAB SPONSORED ADS 44975P103 64,417 1,329,000 SH   SOLE   1,329,000 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 34,592 1,472,000 SH   SOLE   1,472,000 0 0
IGM BIOSCIENCES INC COM 449585108 22,470 293,000 SH   SOLE   293,000 0 0
IMMATICS N.V SHS N44445109 9,916 884,600 SH   SOLE   884,600 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 23,414 550,000 SH   SOLE   550,000 0 0
INOVIO PHARMACEUTICALS INC COM NEW 45773H201 37,161 4,004,391 SH   SOLE   4,004,391 0 0
INSTIL BIO INC COM 45783C101 10,032 400,000 SH   SOLE   400,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 103,008 139,400 SH   SOLE   139,400 0 0
KADMON HLDGS INC COM 48283N106 37,127 9,544,200 SH   SOLE   9,544,200 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 11,366 1,907,081 SH   SOLE   1,907,081 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 24,631 1,330,700 SH   SOLE   1,330,700 0 0
LIFESCI ACQUISITION II CORP COM 53229E103 4,056 400,000 SH   SOLE   400,000 0 0
MARAVAI LIFESCIENCES HLDGS I COM CL A 56600D107 98,421 2,761,545 SH   SOLE   2,761,545 0 0
MEDICUS SCIENCES ACQUISITION UNIT 99/99/9999 G5960S116 5,122 520,000 SH   SOLE   520,000 0 0
MEDTRONIC PLC SHS G5960L103 120,989 1,024,200 SH   SOLE   1,024,200 0 0
MERUS N V COM N5749R100 10,173 487,000 SH   SOLE   487,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 81,487 475,700 SH   SOLE   475,700 0 0
NATERA INC COM 632307104 40,169 395,600 SH   SOLE   395,600 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 50,706 521,400 SH   SOLE   521,400 0 0
NUVATION BIO INC COM CL A 67080N101 78,604 7,521,941 SH   SOLE   7,521,941 0 0
NUVATION BIO INC *W EXP 07/07/202 67080N119 267 99,999 SH   SOLE   99,999 0 0
ONCOSEC MED INC COM 68234L306 16,552 3,470,000 SH   SOLE   3,470,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 31,347 4,317,800 SH   SOLE   4,317,800 0 0
ORGANOGENESIS HLDGS INC COM 68621F102 26,663 1,463,403 SH   SOLE   1,463,403 0 0
PHARVARIS N V COM N69605108 11,192 400,000 SH   SOLE   400,000 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 14,826 4,285,000 SH   SOLE   4,285,000 0 0
SANA BIOTECHNOLOGY INC COM 799566104 24,511 732,321 SH   SOLE   732,321 0 0
SCYNEXIS INC COM NEW 811292200 10,034 1,263,769 SH   SOLE   1,263,769 0 0
SEAGEN INC COM 81181C104 80,247 577,900 SH   SOLE   577,900 0 0
SHATTUCK LABS INC COM 82024L103 38,900 1,330,385 SH   SOLE   1,330,385 0 0
SI BONE INC COM 825704109 18,373 577,570 SH   SOLE   577,570 0 0
SIGILON THERAPEUTICS INC COM 82657L107 19,019 850,968 SH   SOLE   850,968 0 0
SOTERA HEALTH CO COM 83601L102 28,979 1,161,000 SH   SOLE   1,161,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 85,997 3,846,000 SH   SOLE   3,846,000 0 0
TERNS PHARMACEUTICALS INC COM 880881107 8,800 400,000 SH   SOLE   400,000 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 43,121 4,015,000 SH   SOLE   4,015,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 66,809 310,900 SH   SOLE   310,900 0 0
VESPER HEALTHCARE ACQSTN COR UNIT 99/99/9999 92538T203 6,930 600,000 SH   SOLE   600,000 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 54,815 1,263,300 SH   SOLE   1,263,300 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 52,186 326,000 SH   SOLE   326,000 0 0