The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
890 5TH AVE PARTNERS INC UNIT 01/12/2026 28250A204 983 98,828 SH   DFND   98,828 0 0
ABBVIE INC COM 00287Y109 64,878 599,500 SH   DFND 1,2 599,500 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 4,965 300,000 SH   DFND 1,2 300,000 0 0
AFFIMED N V COM N01045108 8,060 1,018,965 SH   DFND 1,2 1,018,965 0 0
AGILE GROWTH CORP UNIT 03/09/2026 G01202129 496 50,000 SH   DFND   50,000 0 0
ALKURI GLOBAL ACQUISITION CO UNIT 01/01/2028 66981N202 1,482 150,000 SH   DFND   150,000 0 0
ALLOT LTD SHS M0854Q105 6,711 420,205 SH   DFND   420,205 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 2,102 198,260 SH   DFND 1,2 198,260 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 9,612 130,351 SH   DFND 1,2 130,351 0 0
AMAZON COM INC COM 023135106 8,543 2,761 SH   DFND   2,761 0 0
APOLLO STRATEGIC GROWTH CAPT SHS CL A G0411R106 1,485 150,000 SH   DFND   150,000 0 0
ARGENX SE SPONSORED ADR 04016X101 2,547 9,249 SH   DFND 1,2 9,249 0 0
ARKO CORP COM 041242108 4,056 408,000 SH   DFND   408,000 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108 5,200 500,000 SH   DFND 1,2 500,000 0 0
ARYA SCIENCES ACQUISITION CO COM CL A G3166W106 5,512 400,000 SH   DFND 1,2 400,000 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 47,755 960,473 SH   DFND 1,2 960,473 0 0
AUDIOCODES LTD ORD M15342104 12,832 475,624 SH   DFND   475,624 0 0
BAIDU INC SPON ADR REP A 056752108 5,439 25,000 SH   DFND   25,000 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 7,271 687,900 SH   DFND 1,2 687,900 0 0
BEIGENE LTD SPONSORED ADR 07725L102 7,275 20,900 SH   DFND 1,2 20,900 0 0
BIOGEN INC COM 09062X103 1,902 6,800 SH   DFND 1,2 6,800 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 7,931 241,000 SH   DFND 1,2 241,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 1,472 23,890 SH   DFND 1,2 23,890 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 12,626 200,000 SH   DFND 1,2 200,000 0 0
C4 THERAPEUTICS INC COM STK 12529R107 18,389 497,136 SH   DFND 1,2 497,136 0 0
CAESARSTONE LTD ORD SHS M20598104 7,348 535,148 SH   DFND   535,148 0 0
CAMTEK LTD ORD M20791105 2,384 79,746 SH   DFND   79,746 0 0
CATABASIS PHARMACEUTICALS IN COM NEW 14875P206 3,740 1,294,000 SH   DFND 1,2 1,294,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 4,539 220,320 SH   DFND 1,2 220,320 0 0
CEREVEL THERAPEUTICS HLDNG I *W EXP 06/09/202 15678U102 702 166,332 SH   DFND 1,2 166,332 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 12,525 912,240 SH   DFND 1,2 912,240 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 1,580 101,666 SH   DFND 1,2 101,666 0 0
CLARIM ACQUISITION CORP UNIT 99/99/9999 18049C207 2,985 300,000 SH   DFND   300,000 0 0
CM LIFE SCIENCES INC COM CL A 18978W109 298 20,000 SH   DFND 1,2 20,000 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 925 50,000 SH   DFND 1,2 50,000 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 4,343 284,224 SH   DFND 1,2 284,224 0 0
CURIS INC COM NEW 231269200 10,028 885,838 SH   DFND 1,2 885,838 0 0
CYBERARK SOFTWARE LTD SHS M2682V108 7,114 55,000 SH   DFND   55,000 0 0
CYCLACEL PHARMACEUTICALS INC COM 23254L603 3,614 508,322 SH   DFND 1,2 508,322 0 0
DFP HEALTHCARE ACQUISITNS CO COM CL A 23343Q100 1,621 162,759 SH   DFND 1,2 162,759 0 0
DYNE THERAPEUTICS INC COM 26818M108 6,989 450,064 SH   DFND 1,2 450,064 0 0
E MERGE TECHNOLOGY ACQUISITI COM CL A 26873Y104 975 100,000 SH   DFND   100,000 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 3,250 100,000 SH   DFND 1,2 100,000 0 0
EJF ACQUISITION CORP UNIT 03/10/2026 G2955B117 497 49,900 SH   DFND   49,900 0 0
ENPHASE ENERGY INC CALL 29355A107 37,297 230,000 SH Call DFND   0 0 230,000
EQUILLIUM INC COM 29446K106 1,817 254,184 SH   DFND 1,2 254,184 0 0
ESSA PHARMA INC COM NEW 29668H708 13,631 469,241 SH   DFND 1,2 469,241 0 0
EUCRATES BIOMEDICAL ACQU COR SHS G3141W106 3,007 304,025 SH   DFND 1,2 304,025 0 0
FALCON CAPITAL ACQUISITN COR COM CL A 30606L108 997 100,010 SH   DFND   100,010 0 0
FARFETCH LTD ORD SH CL A 30744W107 4,242 80,000 SH   DFND   80,000 0 0
FATE THERAPEUTICS INC COM 31189P102 9,054 109,807 SH   DFND 1,2 109,807 0 0
FINCH THERAPEUTICS GROUP INC COM 31773D101 2,387 150,000 SH   DFND 1,2 150,000 0 0
FINTECH EVOLUTION ACQUIS GRO UNIT 99/99/9999 G3R19A112 247 25,000 SH   DFND   25,000 0 0
FIVERR INTL LTD CALL M4R82T106 21,718 100,000 SH Call DFND   0 0 100,000
FOLEY TRASIMENE ACQUISTN COR COM CL A 34431F104 2,008 200,000 SH   DFND   200,000 0 0
FORESIGHT ACQUISITION CORP UNIT 01/29/2026 34552Y205 4,162 420,000 SH   DFND   420,000 0 0
FORUM MERGER IV CORP UNIT 03/15/2028 349875203 1,485 150,000 SH   DFND   150,000 0 0
FRAZIER LIFESCIENCES ACQU CO CL A SHS G3710A105 1,261 126,687 SH   DFND 1,2 126,687 0 0
GALECTO INC COM 36322Q107 2,722 448,016 SH   DFND 1,2 448,016 0 0
GALERA THERAPEUTICS INC COM 36338D108 2,852 323,348 SH   DFND 1,2 323,348 0 0
GAMIDA CELL LTD SHS M47364100 1,444 178,450 SH   DFND 1,2 178,450 0 0
GENERAC HLDGS INC COM 368736104 34,599 105,663 SH   DFND   105,663 0 0
GIGCAPITAL4 INC UNIT 99/99/9999 37518G200 1,727 175,000 SH   DFND   175,000 0 0
GLASS HOUSES ACQUISITION COR UNIT 03/25/2028 37714P202 902 89,884 SH   DFND   89,884 0 0
GLOBAL X FDS PUT 37954Y442 4,391 170,600 SH Put DFND   170,600 0 0
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103 3,274 212,600 SH   DFND 1,2 212,600 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 1,123 100,000 SH   DFND 1,2 100,000 0 0
HEALTHCARE CAPITAL CORP UNIT 12/31/2025 42228C200 3,948 400,000 SH   DFND   400,000 0 0
HEALTHCOR CATALIO ACQU CORP CL A SHS G44125105 2,000 200,000 SH   DFND 1,2 200,000 0 0
HIGHCAPE CAP ACQUISITION COR COM CL A 42984L105 2,055 172,396 SH   DFND 1,2 172,396 0 0
HIGHCAPE CAP ACQUISITION COR CALL 42984L105 1,013 85,000 SH Call DFND 1,2 0 0 85,000
I MAB SPONSORED ADS 44975P103 2,664 54,962 SH   DFND 1,2 54,962 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 4,747 201,984 SH   DFND 1,2 201,984 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117 295 100,000 SH   DFND 1,2 100,000 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 1,533 36,000 SH   DFND 1,2 36,000 0 0
IMMUNOVANT INC COM 45258J102 2,542 158,500 SH   DFND 1,2 158,500 0 0
INFLARX NV COM N44821101 3,900 1,000,000 SH   DFND 1,2 1,000,000 0 0
INHIBRX INC COM 45720L107 2,301 114,643 SH   DFND 1,2 114,643 0 0
INSTIL BIO INC COM 45783C101 2,383 95,000 SH   DFND 1,2 95,000 0 0
IONIS PHARMACEUTICALS INC COM 462222100 6,541 145,476 SH   DFND 1,2 145,476 0 0
ISHARES TR PUT 464287432 8,127 60,000 SH Put DFND   60,000 0 0
ISHARES TR PUT 464288224 10,206 420,000 SH Put DFND   420,000 0 0
ISHARES TR PUT 464287515 24,207 70,900 SH Put DFND   70,900 0 0
ISHARES TR PUT 464287655 46,397 210,000 SH Put DFND   210,000 0 0
JIYA ACQUISITION CORP COM CL A 47760M102 1,958 199,028 SH   DFND 1,2 199,028 0 0
JOHNSON & JOHNSON COM 478160104 74,598 453,900 SH   DFND 1,2 453,900 0 0
JOHNSON & JOHNSON CALL 478160104 32,870 200,000 SH Call DFND 1,2 0 0 200,000
KALVISTA PHARMACEUTICALS INC COM 483497103 6,651 258,880 SH   DFND 1,2 258,880 0 0
KORNIT DIGITAL LTD SHS M6372Q113 14,708 148,381 SH   DFND   148,381 0 0
KURA ONCOLOGY INC COM 50127T109 20,291 717,751 SH   DFND 1,2 717,751 0 0
KYMERA THERAPEUTICS INC COM 501575104 9,619 247,527 SH   DFND 1,2 247,527 0 0
LANDCADIA HOLDINGS IV INC UNIT 05/01/2025 51477A203 1,485 150,000 SH   DFND   150,000 0 0
LANDOS BIOPHARMA INC COM 515069102 674 70,000 SH   DFND 1,2 70,000 0 0
LARIMAR THERAPEUTICS INC COM 517125100 1,461 100,000 SH   DFND 1,2 100,000 0 0
LAVA THERAPEUTICS NV SHS N51517105 3,249 213,894 SH   DFND 1,2 213,894 0 0
LEFTERIS ACQUISITION CORP COM CL A 52470X109 1,181 120,000 SH   DFND   120,000 0 0
LIFESCI ACQUISITION II CORP COM 53229E103 2,474 244,000 SH   DFND 1,2 244,000 0 0
LILLY ELI & CO COM 532457108 80,183 429,200 SH   DFND 1,2 429,200 0 0
LIONHEART ACQUISITION CORP I COM CL A 53625R104 982 100,000 SH   DFND   100,000 0 0
LIVE OAK MOBILITY ACQUISI CO UNIT 03/01/2028 538126202 749 75,000 SH   DFND   75,000 0 0
LIVEPERSON INC COM 538146101 13,712 260,000 SH   DFND   260,000 0 0
LONGVIEW ACQUISITION CORP II UNIT 99/99/9999 54319Q204 3,012 300,000 SH   DFND 1,2 300,000 0 0
MCAP ACQUISITION CORP UNIT 02/18/2030 55282T208 995 100,000 SH   DFND   100,000 0 0
MDH ACQUISITION CORP UNIT 99/99/9999 55283P205 308 31,000 SH   DFND   31,000 0 0
MERCK & CO. INC COM 58933Y105 62,351 808,808 SH   DFND 1,2 808,808 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 4,423 1,312,415 SH   DFND 1,2 1,312,415 0 0
MERUS N V COM N5749R100 1,608 76,992 SH   DFND 1,2 76,992 0 0
MICROSOFT CORP COM 594918104 15,923 67,536 SH   DFND   67,536 0 0
MIRATI THERAPEUTICS INC COM 60468T105 5,101 29,779 SH   DFND 1,2 29,779 0 0
MOHAWK GROUP HLDGS INC COM 608189106 7,405 251,015 SH   DFND   251,015 0 0
MOHAWK GROUP HLDGS INC CALL 608189106 10,490 355,600 SH Call DFND   0 0 355,600
NEUBASE THERAPEUTICS INC COM 64132K102 236 31,900 SH   DFND 1,2 31,900 0 0
NICE LTD SPONSORED ADR 653656108 8,606 39,481 SH   DFND   39,481 0 0
NICE SYS INC NOTE 1.250% 1/1 65366HAB9 666 250,000 SH   DFND   250,000 0 0
NKARTA INC COM 65487U108 3,323 101,006 SH   DFND 1,2 101,006 0 0
NOBLE ROCK ACQUISITION CORP UNIT 01/31/2028 G6546R127 277 28,000 SH   DFND   28,000 0 0
NORTHERN STAR INVSTMNT CORP COM CLASS A 66573W107 1,554 155,367 SH   DFND   155,367 0 0
NOVA MEASURING INSTRUMENTS L COM M7516K103 779 8,556 SH   DFND   8,556 0 0
NURIX THERAPEUTICS INC COM 67080M103 6,687 215,076 SH   DFND 1,2 215,076 0 0
OMEGA ALPHA SPAC CL A G6749V107 990 100,000 SH   DFND 1,2 100,000 0 0
ONCORUS INC COM 68236R103 12,571 903,111 SH   DFND 1,2 903,111 0 0
ONTO INNOVATION INC COM 683344105 8,214 125,000 SH   DFND   125,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 9,921 1,366,564 SH   DFND 1,2 1,366,564 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 4,163 169,900 SH   DFND 1,2 169,900 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 131 129,500 SH   DFND 1,2 129,500 0 0
PALO ALTO NETWORKS INC COM 697435105 10,403 32,300 SH   DFND   32,300 0 0
PERRIGO CO PLC CALL G97822103 8,499 210,000 SH Call DFND   0 0 210,000
PHASEBIO PHARMACEUTICALS INC COM 717224109 2,595 750,000 SH   DFND 1,2 750,000 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 1,671 650,000 SH   DFND 1,2 650,000 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 1,426 43,356 SH   DFND 1,2 43,356 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 5,235 202,134 SH   DFND 1,2 202,134 0 0
RADA ELECTR INDS LTD COM PAR NEW M81863124 4,899 407,925 SH   DFND   407,925 0 0
REINVENT TECHNOLOGY PARTNERS SHS CL A G74847107 4,685 468,012 SH   DFND   468,012 0 0
REPARE THERAPEUTICS INC COM 760273102 7,614 248,100 SH   DFND 1,2 248,100 0 0
RESEARCH ALLIANCE CORP II COM CL A 760873109 6,150 600,000 SH   DFND 1,2 600,000 0 0
REVOLUTION ACCELERTN ACQU CO COM CL A 76156P106 1,115 109,994 SH   DFND   109,994 0 0
SANOFI SPONSORED ADR 80105N105 49,356 997,900 SH   DFND 1,2 997,900 0 0
SARISSA CAPITAL ACQUISITN CO CL A G7823W102 242 23,900 SH   DFND 1,2 23,900 0 0
SHATTUCK LABS INC COM 82024L103 4,113 140,665 SH   DFND 1,2 140,665 0 0
SIGILON THERAPEUTICS INC COM 82657L107 8,072 362,239 SH   DFND 1,2 362,239 0 0
SILVERBACK THERAPEUTICS INC COM 82835W108 7,321 167,799 SH   DFND 1,2 167,799 0 0
SPARTAN ACQUISITION CORP II COM 846775104 523 50,000 SH   DFND   50,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 10,129 137,672 SH   DFND 1,2 137,672 0 0
STARBOARD VALUE ACQUISITN CO COM CL A 85521J109 1,697 170,937 SH   DFND   170,937 0 0
STOKE THERAPEUTICS INC COM 86150R107 5,854 150,729 SH   DFND 1,2 150,729 0 0
STRATIM CLOUD ACQUISITION CO UNIT 03/05/2026 86309R206 500 50,000 SH   DFND   50,000 0 0
SUTRO BIOPHARMA INC COM 869367102 6,710 294,825 SH   DFND 1,2 294,825 0 0
SWITCHBACK II CORPORATION COM CL A G8633T115 1,019 103,698 SH   DFND   103,698 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 14,268 638,093 SH   DFND 1,2 638,093 0 0
TAILWIND INTERNATNAL ACQ COR UNIT 99/99/9999 G8662F127 1,484 150,000 SH   DFND   150,000 0 0
TERNS PHARMACEUTICALS INC COM 880881107 1,540 70,000 SH   DFND 1,2 70,000 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 9,611 832,878 SH   DFND   832,878 0 0
TEVA PHARMACEUTICAL INDS LTD CALL 881624209 10,257 888,800 SH Call DFND   0 0 888,800
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 7,567 720,000 SH   DFND 1,2 720,000 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 7,201 670,459 SH   DFND 1,2 670,459 0 0
TURMERIC ACQUISITION CORP CL A G9127T108 2,144 219,440 SH   DFND 1,2 219,440 0 0
UNUM THERAPEUTICS INC COM 19240Q201 6,695 762,569 SH   DFND 1,2 762,569 0 0
VARONIS SYS INC COM 922280102 7,120 138,675 SH   DFND   138,675 0 0
VECTOIQ ACQUISITION CORP II UNIT 99/99/9999 92244F208 507 50,000 SH   DFND   50,000 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 6,699 801,256 SH   DFND 1,2 801,256 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 1,188 5,530 SH   DFND 1,2 5,530 0 0
VINCERX PHARMA INC COM NEW 92731L106 1,809 93,708 SH   DFND 1,2 93,708 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 8,897 4,177,158 SH   DFND 1,2 4,177,158 0 0
VPC IMPACT ACQU HOLDI III IN UNIT 99/99/9999 91835J207 987 100,000 SH   DFND   100,000 0 0
VPC IMPACT ACQUISITION HLDG UNIT 03/05/2026 G9460L100 986 100,000 SH   DFND   100,000 0 0
WIX COM LTD SHS M98068105 1,592 5,700 SH   DFND   5,700 0 0
YUMANITY THERAPEUTICS INC COM 98872L102 3,776 208,609 SH   DFND 1,2 208,609 0 0
ZAI LAB LTD ADR 98887Q104 8,778 65,788 SH   DFND 1,2 65,788 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 7,599 175,140 SH   DFND 1,2 175,140 0 0
Z-WORK ACQUISITION CORP UNIT 99/99/9999 98880C201 498 50,000 SH   DFND   50,000 0 0