The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Akouos, Inc COMM 00973J101 21,014 1,515,074 SH   SOLE   1,515,074 0 0
Amarin Corp ADR 023111206 7,269 1,170,584 SH   SOLE   1,170,584 0 0
Ascendis Pharma A/S ADR 04351P101 67,265 521,923 SH   SOLE   521,923 0 0
Athira Pharma, Inc. COMM 04746L104 9,369 509,168 SH   SOLE   509,168 0 0
Bolt Biotherapeutics, Inc. COMM 097702104 90,649 2,754,437 SH   SOLE   2,754,437 0 0
Checkmate Pharmaceuticals Inc COMM 162818108 43,785 3,606,707 SH   SOLE   3,606,707 0 0
Coherus BioSciences COMM 19249H103 6,349 434,555 SH   SOLE   434,555 0 0
Galera Therapeutics, Inc COMM 36338D108 27,198 3,083,712 SH   SOLE   3,083,712 0 0
Inozyme Pharma, Inc. COMM 45790W108 40,160 2,028,308 SH   SOLE   2,028,308 0 0
Karuna Therapeutics, Inc. COMM 48576A100 234,742 1,952,441 SH   SOLE   1,952,441 0 0
Merus N.V. COMM N5749R100 27,388 1,311,039 SH   SOLE   1,311,039 0 0
Natera COMM 632307104 314,831 3,100,560 SH   SOLE   3,100,560 0 0
Nextcure, Inc COMM 65343E108 26,745 2,671,856 SH   SOLE   2,671,856 0 0
Nucana Biomed Ltd ADR 67022C106 27,944 5,599,999 SH   SOLE   5,599,999 0 0
Nucana Biomed Ltd Ordinary Shares GB00BYWYV 11,976 2,400,000 SH   SOLE   2,400,000 0 0
ObsEva SA COMM H5861P103 15,436 4,749,623 SH   SOLE   4,749,623 0 0
PDS Biotechnology Corporation COMM 70465T107 649 142,635 SH   SOLE   142,635 0 0
Synlogic Inc. COMM 87166L100 2,058 574,972 SH   SOLE   574,972 0 0
Y-mAbs Therapeutics, Inc COMM 984241109 66,355 2,194,278 SH   SOLE   2,194,278 0 0
Acceleron Pharma Inc COMM 00434H108 24,212 178,538 SH   SOLE   178,538 0 0
Agenus Inc COMM 00847G705 9,461 3,478,201 SH   SOLE   3,478,201 0 0
Align Technology Inc COMM 016255101 24,640 45,500 SH   SOLE   45,500 0 0
Aligos Therapeutics Inc COMM 01626L105 4,219 185,532 SH   SOLE   185,532 0 0
Amgen Inc COMM 031162100 9,671 38,868 SH   SOLE   38,868 0 0
Aptose Biosciences Inc COMM 03835T200 4,164 696,928 SH   SOLE   696,928 0 0
Arena Pharmaceuticals Inc COMM 040047607 6,346 91,448 SH   SOLE   91,448 0 0
AstraZeneca PLC ADR 046353108 51,497 1,035,732 SH   SOLE   1,035,732 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 3,852 378,774 SH   SOLE   378,774 0 0
Calithera Biosciences Inc COMM 13089P101 1,833 757,533 SH   SOLE   757,533 0 0
ChemoCentryx Inc COMM 16383L956 7,686 150,000 SH Put SOLE   150,000 0 0
ChemoCentryx Inc COMM 16383L106 9,223 179,999 SH   SOLE   179,999 0 0
Cytokinetics Inc COMM 23282W605 9,065 389,720 SH   SOLE   389,720 0 0
Dexcom Inc COMM 252131107 9,704 27,000 SH   SOLE   27,000 0 0
Eli Lilly and Co COMM 532457108 33,721 180,501 SH   SOLE   180,501 0 0
Exelixis Inc COMM 30161Q104 18,957 839,181 SH   SOLE   839,181 0 0
Fate Therapeutics Inc COMM 31189P102 4,518 54,795 SH   SOLE   54,795 0 0
Gilead Sciences Inc COMM 375558903 19,389 300,000 SH Call SOLE   300,000 0 0
Health Care Select Sector SPDR COMM 81369Y959 46,696 400,000 SH Put SOLE   400,000 0 0
Heron Therapeutics Inc COMM 427746902 4,053 250,000 SH Call SOLE   250,000 0 0
Horizon Therapeutics PLC COMM G46188101 12,333 133,997 SH   SOLE   133,997 0 0
Immatics NV COMM N44445109 4,317 385,099 SH   SOLE   385,099 0 0
Insmed Inc COMM 457669307 21,081 618,950 SH   SOLE   618,950 0 0
Insulet Corp COMM 45784P101 4,566 17,500 SH   SOLE   17,500 0 0
Intra-Cellular Therapies Inc COMM 46116X101 22,224 655,001 SH   SOLE   655,001 0 0
Jazz Pharmaceuticals PLC COMM G50871105 42,067 255,928 SH   SOLE   255,928 0 0
Jounce Therapeutics Inc COMM 481116101 5,256 511,822 SH   SOLE   511,822 0 0
Kura Oncology Inc COMM 50127T109 2,351 83,164 SH   SOLE   83,164 0 0
MacroGenics Inc COMM 556099109 2,331 73,201 SH   SOLE   73,201 0 0
Marinus Pharmaceuticals Inc COMM 56854Q200 5,733 370,351 SH   SOLE   370,351 0 0
Mirati Therapeutics Inc COMM 60468T105 23,645 138,030 SH   SOLE   138,030 0 0
Mirum Pharmaceuticals Inc COMM 604749101 9,442 476,401 SH   SOLE   476,401 0 0
Otonomy Inc COMM 68906L105 3,191 1,251,256 SH   SOLE   1,251,256 0 0
PTC Therapeutics Inc COMM 69366J200 22,105 466,840 SH   SOLE   466,840 0 0
Protagonist Therapeutics Inc COMM 74366E102 16,962 654,900 SH   SOLE   654,900 0 0
Puma Biotechnology Inc COMM 74587V107 3,353 344,917 SH   SOLE   344,917 0 0
Reata Pharmaceuticals Inc COMM 75615P103 23,780 238,520 SH   SOLE   238,520 0 0
Regenxbio Inc COMM 75901B107 12,339 361,735 SH   SOLE   361,735 0 0
Replimune Group Inc COMM 76029N106 4,339 142,209 SH   SOLE   142,209 0 0
Savara Inc COMM 805111101 3,614 1,737,450 SH   SOLE   1,737,450 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 6,678 298,644 SH   SOLE   298,644 0 0
TCR2 Therapeutics Inc COMM 87808K106 7,434 336,682 SH   SOLE   336,682 0 0
Uniqure NV COMM N90064101 14,390 427,122 SH   SOLE   427,122 0 0
United Therapeutics Corp COMM 91307C102 35,972 215,054 SH   SOLE   215,054 0 0
Vertex Pharmaceuticals Inc COMM 92532F100 9,820 45,700 SH   SOLE   45,700 0 0