The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABB LTD SPONSORED ADR 000375204 553,930 18,218,020 SH   DFND 1, 2 18,218,020 0 0
AES CORP COM 00130H105 1,186,934 44,271,361 SH   DFND 1, 2 44,271,211 0 150
AES CORP UNIT 99/99/9999 00130H204 206,600 2,000,000 SH   DFND 1, 2 2,000,000 0 0
ABBOTT LABS COM 002824100 6,538,418 54,559,742 SH   DFND 1, 2 54,525,525 0 34,217
ABBVIE INC COM 00287Y109 1,049,737 9,700,024 SH   DFND 1, 2 9,700,024 0 0
ABCELLERA BIOLOGICS INC COM 00288U106 61,023 1,796,911 SH   DFND 1, 2 1,796,911 0 0
ACTIVISION BLIZZARD INC COM 00507V109 2,150,540 23,125,561 SH   DFND 1, 2 23,106,875 0 18,686
ADAGENE INC ADS 005329107 16,573 923,269 SH   DFND 1, 2 923,269 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 73,789 1,832,804 SH   DFND 1, 2 1,832,804 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 7,016 1,321,200 SH   DFND 1, 2 1,321,200 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 1,244,919 2,619,327 SH   DFND 1, 2 2,619,306 0 21
ADVANCED DRAIN SYS INC DEL COM 00790R104 33,401 323,056 SH   DFND 1, 2 323,056 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 4,951 95,882 SH   DFND 1, 2 95,882 0 0
AIRBNB INC COM CL A 009066101 114,745 610,538 SH   DFND 1, 2 610,538 0 0
AIR LEASE CORP CL A 00912X302 536,395 10,946,840 SH   DFND 1, 2 10,946,840 0 0
AIR PRODS & CHEMS INC COM 009158106 2,008,912 7,140,275 SH   DFND 1, 2 7,134,938 0 5,337
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 45,187 199,272 SH   DFND 1, 2 197,010 0 2,262
ALLAKOS INC COM 01671P100 261,357 2,277,026 SH   DFND 1, 2 2,277,026 0 0
ALLEGHENY TECHNOLOGIES INC COM 01741R102 210,355 9,988,378 SH   DFND 1, 2 9,988,378 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 232,946 6,599,036 SH   DFND 1, 2 6,599,036 0 0
ALPHABET INC CAP STK CL C 02079K107 8,493,416 4,105,991 SH   DFND 1, 2 4,104,205 0 1,786
ALPHABET INC CAP STK CL A 02079K305 3,584,312 1,737,835 SH   DFND 1, 2 1,737,835 0 0
ALTERYX INC COM CL A 02156B103 11,034 133,000 SH   DFND 1, 2 133,000 0 0
ALTRIA GROUP INC COM 02209S103 839,598 16,410,839 SH   DFND 1, 2 16,410,839 0 0
AMAZON COM INC COM 023135106 9,694,989 3,133,582 SH   DFND 1, 2 3,133,575 0 7
AMBEV SA SPONSORED ADR 02319V103 3,091 1,128,200 SH   DFND 1, 2 1,128,200 0 0
AMERICA MOVIL SAB DE CV SPON ADR L SHS 02364W105 754,557 55,555,144 SH   DFND 1, 2 55,427,646 0 127,498
AMERICAN INTL GROUP INC COM NEW 026874784 1,079,231 23,354,888 SH   DFND 1, 2 23,354,117 0 771
AMERICAN TOWER CORP NEW COM 03027X100 593,402 2,483,251 SH   DFND 1, 2 2,479,506 0 3,745
AMERISOURCEBERGEN CORP COM 03073E105 226,716 1,920,183 SH   DFND 1, 2 1,920,183 0 0
AMETEK INC COM 031100100 349,752 2,738,631 SH   DFND 1, 2 2,737,031 0 1,600
AMGEN INC COM 031162100 490,019 1,969,450 SH   DFND 1, 2 1,969,450 0 0
AMPHENOL CORP NEW CL A 032095101 357,146 5,413,776 SH   DFND 1, 2 5,412,663 0 1,113
ANALOG DEVICES INC COM 032654105 298,506 1,924,851 SH   DFND 1, 2 1,924,851 0 0
ANGLOGOLD ASHANTI LIMITED SPONSORED ADR 035128206 185,275 8,433,075 SH   DFND 1, 2 8,433,075 0 0
ANHEUSER BUSCH INBEV SA/NV SPONSORED ADR 03524A108 761,643 12,093,739 SH   DFND 1, 2 12,060,769 0 32,970
ANTHEM INC COM 036752103 1,566,857 4,364,482 SH   DFND 1, 2 4,353,864 0 10,618
APOLLO GLOBAL MGMT INC COM CL A 03768E105 260,934 5,550,598 SH   DFND 1, 2 5,550,598 0 0
APPLE INC COM 037833100 2,119,075 17,355,090 SH   DFND 1, 2 17,353,035 0 2,055
APPFOLIO INC COM CL A 03783C100 7,636 54,000 SH   DFND 1, 2 54,000 0 0
APPLIED MATLS INC COM 038222105 2,367,378 17,720,393 SH   DFND 1, 2 17,711,087 0 9,306
APPLIED MOLECULAR TRANS INC COM 03824M109 28,840 655,300 SH   DFND 1, 2 655,300 0 0
ARAMARK COM 03852U106 452,625 11,980,533 SH   DFND 1, 2 11,980,533 0 0
ARCOSA INC COM 039653100 145,050 2,228,448 SH   DFND 1, 2 2,228,448 0 0
ARES MANAGEMENT CORPORATION CL A COM STK 03990B101 369,066 6,586,942 SH   DFND 1, 2 6,586,942 0 0
ARMSTRONG WORLD INDS INC NEW COM 04247X102 525,680 5,835,055 SH   DFND 1, 2 5,835,055 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 1,498,282 30,113,378 SH   DFND 1, 2 30,015,862 0 97,516
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 13,023 2,272,728 SH   DFND 1, 2 2,272,728 0 0
AVALARA INC COM 05338G106 20,118 150,778 SH   DFND 1, 2 150,778 0 0
AVALONBAY CMNTYS INC COM 053484101 371,625 2,014,119 SH   DFND 1, 2 2,014,119 0 0
AXON ENTERPRISE INC COM 05464C101 7,206 50,600 SH   DFND 1, 2 50,600 0 0
AZUL S A SPONSR ADR PFD 05501U106 8,589 425,427 SH   DFND 1, 2 425,427 0 0
BJS WHSL CLUB HLDGS INC COM 05550J101 65,299 1,455,608 SH   DFND 1, 2 1,455,608 0 0
BWX TECHNOLOGIES INC COM 05605H100 684,215 10,376,322 SH   DFND 1, 2 10,376,322 0 0
BANCO BILBAO VIZCAYA ARGENTA SPONSORED ADR 05946K101 63,235 11,976,312 SH   DFND 1, 2 11,976,312 0 0
BK OF AMERICA CORP COM 060505104 976,312 25,234,218 SH   DFND 1, 2 25,234,218 0 0
BARRICK GOLD CORP COM 067901108 284,604 14,373,964 SH   DFND 1, 2 14,373,964 0 0
BAXTER INTL INC COM 071813109 757,787 8,984,901 SH   DFND 1, 2 8,984,901 0 0
BEIGENE LTD SPONSORED ADR 07725L102 2,013,664 5,797,151 SH   DFND 1, 2 5,788,616 0 8,535
BERKELEY LTS INC COM 084310101 33,164 660,248 SH   DFND 1, 2 660,248 0 0
BERKSHIRE HATHAWAY INC DEL CL A 084670108 16,971 44 SH   DFND 1, 2 44 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 355,836 1,392,833 SH   DFND 1, 2 1,389,785 0 3,048
BILL COM HLDGS INC COM 090043100 496,587 3,412,968 SH   DFND 1, 2 3,412,968 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 41,298 546,941 SH   DFND 1, 2 543,945 0 2,996
BLACKROCK INC COM 09247X101 2,069,125 2,744,377 SH   DFND 1, 2 2,739,046 0 5,331
BLACKSTONE GROUP INC COM 09260D107 1,216,322 16,319,894 SH   DFND 1, 2 16,319,894 0 0
BOEING CO COM 097023105 56,039 220,004 SH   DFND 1, 2 219,992 0 12
BOOKING HOLDINGS INC COM 09857L108 1,296,174 556,336 SH   DFND 1, 2 556,336 0 0
BRITISH AMERN TOB PLC SPONSORED ADR 110448107 357,798 9,259,331 SH   DFND 1, 2 9,227,841 0 31,490
BROADCOM INC COM 11135F101 15,408,693 33,235,928 SH   DFND 1, 2 33,209,006 0 26,922
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 336,474 7,561,214 SH   DFND 1, 2 7,561,214 0 0
BUMBLE INC COM CL A 12047B105 62,382 1,000,033 SH   DFND 1, 2 1,000,033 0 0
BURLINGTON STORES INC COM 122017106 724,949 2,426,170 SH   DFND 1, 2 2,424,658 0 1,512
CDK GLOBAL INC COM 12508E101 433,480 8,018,496 SH   DFND 1, 2 8,018,496 0 0
CIGNA CORP NEW COM 125523100 607,807 2,514,302 SH   DFND 1, 2 2,514,302 0 0
CMC MATERIALS INC COM 12571T100 131,358 743,017 SH   DFND 1, 2 743,017 0 0
CME GROUP INC COM 12572Q105 2,119,280 10,376,569 SH   DFND 1, 2 10,373,201 0 3,368
CMS ENERGY CORP COM 125896100 442,466 7,227,923 SH   DFND 1, 2 7,217,352 0 10,571
CSW INDUSTRIALS INC COM 126402106 32,482 240,607 SH   DFND 1, 2 240,607 0 0
CSX CORP COM 126408103 576,329 5,977,459 SH   DFND 1, 2 5,951,047 0 26,412
CVS HEALTH CORP COM 126650100 1,323,438 17,591,462 SH   DFND 1, 2 17,553,292 0 38,170
CABLE ONE INC COM 12685J105 191,695 105,282 SH   DFND 1, 2 105,275 0 7
CACTUS INC CL A 127203107 39,830 1,300,791 SH   DFND 1, 2 1,300,791 0 0
CANADIAN NATL RY CO COM 136375102 163,757 1,411,492 SH   DFND 1, 2 1,411,492 0 0
CANADIAN NAT RES LTD COM 136385101 146,600 4,743,065 SH   DFND 1, 2 4,743,065 0 0
CANNAE HLDGS INC COM 13765N107 14,025 353,987 SH   DFND 1, 2 353,987 0 0
CARRIER GLOBAL CORPORATION COM 14448C104 1,999,679 47,362,708 SH   DFND 1, 2 47,362,207 0 501
CATALENT INC COM 148806102 49,603 471,016 SH   DFND 1, 2 471,016 0 0
CATERPILLAR INC COM 149123101 1,960,242 8,454,057 SH   DFND 1, 2 8,454,057 0 0
CELANESE CORP DEL COM 150870103 968,472 6,464,598 SH   DFND 1, 2 6,458,538 0 6,060
CELLECTIS S A SPON ADS 15117K103 27,068 1,339,336 SH   DFND 1, 2 1,339,336 0 0
CENTENE CORP DEL COM 15135B101 1,582,153 24,755,800 SH   DFND 1, 2 24,749,698 0 6,102
CENTERPOINT ENERGY INC COM 15189T107 538,520 23,775,720 SH   DFND 1, 2 23,775,720 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 6,318,521 10,239,504 SH   DFND 1, 2 10,237,773 0 1,731
CHESAPEAKE ENERGY CORP COM 165167735 484 11,156 SH   DFND 1, 2 11,156 0 0
CHEVRON CORP NEW COM 166764100 4,028,498 38,439,497 SH   DFND 1, 2 38,401,211 0 38,286
CHIPOTLE MEXICAN GRILL INC COM 169656105 1,191,919 839,044 SH   DFND 1, 2 839,037 0 7
CHURCH & DWIGHT INC COM 171340102 1,008,712 11,547,930 SH   DFND 1, 2 11,547,930 0 0
CISCO SYS INC COM 17275R102 114,109 2,206,715 SH   DFND 1, 2 2,206,715 0 0
CITIGROUP INC COM NEW 172967424 136,749 1,879,718 SH   DFND 1, 2 1,879,718 0 0
CITIZENS FINANCIAL GROUP INC COM 174610105 893,051 20,222,365 SH   DFND 1, 2 20,222,365 0 0
CLOROX CO DEL COM 189054109 161,324 836,396 SH   DFND 1, 2 836,396 0 0
COCA COLA CO COM 191216100 15,401 292,178 SH   DFND 1, 2 291,989 0 189
COGNEX CORP COM 192422103 43,985 530,000 SH   DFND 1, 2 530,000 0 0
COLGATE PALMOLIVE CO COM 194162103 78,591 996,967 SH   DFND 1, 2 996,967 0 0
COLONY CAP INC NEW CL A COM 19626G108 128,422 19,818,174 SH   DFND 1, 2 19,818,174 0 0
COMCAST CORP NEW CL A 20030N101 11,891,228 219,742,386 SH   DFND 1, 2 219,525,293 0 217,093
CONCENTRIX CORP COM 20602D101 269,291 1,798,631 SH   DFND 1, 2 1,798,631 0 0
CONOCOPHILLIPS COM 20825C104 4,250,693 80,245,103 SH   DFND 1, 2 80,232,212 0 12,891
CONSTELLATION BRANDS INC CL A 21036P108 226,585 993,793 SH   DFND 1, 2 993,793 0 0
CORTEXYME INC COM 22053A107 88,691 2,461,580 SH   DFND 1, 2 2,461,580 0 0
COSTCO WHSL CORP NEW COM 22160K105 489,193 1,388,322 SH   DFND 1, 2 1,381,145 0 7,177
COUSINS PPTYS INC COM NEW 222795502 35,926 1,016,286 SH   DFND 1, 2 1,016,286 0 0
CREE INC COM 225447101 1,044,894 9,663,314 SH   DFND 1, 2 9,663,314 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 3,046,915 17,703,600 SH   DFND 1, 2 17,702,997 0 603
CUMMINS INC COM 231021106 108,168 417,459 SH   DFND 1, 2 417,459 0 0
D R HORTON INC COM 23331A109 91,874 1,030,902 SH   DFND 1, 2 1,030,902 0 0
DANAHER CORPORATION COM 235851102 1,660,906 7,380,506 SH   DFND 1, 2 7,380,463 0 43
DANIMER SCIENTIFIC INC COM CL A 236272100 33,651 891,406 SH   DFND 1, 2 891,406 0 0
DARDEN RESTAURANTS INC COM 237194105 1,514,648 10,666,465 SH   DFND 1, 2 10,663,469 0 2,996
DEERE & CO COM 244199105 102,460 273,867 SH   DFND 1, 2 273,867 0 0
DEL TACO RESTAURANTS INC NEW COM 245496104 13,778 1,438,200 SH   DFND 1, 2 1,438,200 0 0
DEXCOM INC COM 252131107 234,323 652,002 SH   DFND 1, 2 652,001 0 1
DIAGEO PLC SPON ADR NEW 25243Q205 89,504 539,065 SH   DFND 1, 2 539,065 0 0
DIGITAL RLTY TR INC COM 253868103 1,343,744 9,540,627 SH   DFND 1, 2 9,535,292 0 5,335
DISCOVER FINL SVCS COM 254709108 1,595,619 16,797,500 SH   DFND 1, 2 16,797,113 0 387
DOLLAR GEN CORP NEW COM 256677105 1,029,084 5,079,103 SH   DFND 1, 2 5,079,066 0 37
DOLLAR TREE INC COM 256746108 301,779 2,636,543 SH   DFND 1, 2 2,636,543 0 0
DOW INC COM 260557103 2,070,464 32,379,697 SH   DFND 1, 2 32,321,805 0 57,892
DUN & BRADSTREET HLDGS INC COM 26484T106 465,762 19,561,627 SH   DFND 1, 2 19,561,627 0 0
DUPONT DE NEMOURS INC COM 26614N102 93,332 1,207,709 SH   DFND 1, 2 1,207,709 0 0
EOG RES INC COM 26875P101 4,004,170 55,205,925 SH   DFND 1, 2 55,190,972 0 14,953
EARGO INC COM 270087109 15,568 311,668 SH   DFND 1, 2 311,668 0 0
EAST WEST BANCORP INC COM 27579R104 782,294 10,598,571 SH   DFND 1, 2 10,598,571 0 0
EDISON INTL COM 281020107 396,906 6,773,109 SH   DFND 1, 2 6,772,161 0 948
EDWARDS LIFESCIENCES CORP COM 28176E108 1,579,642 18,887,161 SH   DFND 1, 2 18,887,089 0 72
ELECTRONIC ARTS INC COM 285512109 324,855 2,399,789 SH   DFND 1, 2 2,399,789 0 0
ENBRIDGE INC COM 29250N105 2,451,896 67,345,860 SH   DFND 1, 2 67,147,525 0 198,335
ENDAVA PLC ADS 29260V105 41,144 485,815 SH   DFND 1, 2 485,815 0 0
ENPHASE ENERGY INC COM 29355A107 152,175 938,424 SH   DFND 1, 2 938,424 0 0
ENPRO INDS INC COM 29355X107 38,612 452,824 SH   DFND 1, 2 452,824 0 0
EPAM SYS INC COM 29414B104 126,973 320,082 SH   DFND 1, 2 320,082 0 0
EQUIFAX INC COM 294429105 1,464,845 8,087,155 SH   DFND 1, 2 8,078,725 0 8,430
EQUINIX INC COM 29444U700 1,534,750 2,258,768 SH   DFND 1, 2 2,256,652 0 2,116
EQUITRANS MIDSTREAM CORP COM 294600101 369,532 45,300,261 SH   DFND 1, 2 45,300,261 0 0
ESCO TECHNOLOGIES INC COM 296315104 39,107 359,144 SH   DFND 1, 2 359,144 0 0
EURONET WORLDWIDE INC COM 298736109 148,508 1,073,854 SH   DFND 1, 2 1,073,854 0 0
EVERTEC INC COM 30040P103 52,892 1,421,072 SH   DFND 1, 2 1,421,072 0 0
EXELON CORP COM 30161N101 2,210,873 50,547,042 SH   DFND 1, 2 50,546,910 0 132
EXTRA SPACE STORAGE INC COM 30225T102 116,952 882,261 SH   DFND 1, 2 882,261 0 0
FTI CONSULTING INC COM 302941109 120,505 860,072 SH   DFND 1, 2 860,072 0 0
FACEBOOK INC CL A 30303M102 14,339,035 48,686,174 SH   DFND 1, 2 48,659,070 0 27,104
FAIR ISAAC CORP COM 303250104 14,144 29,100 SH   DFND 1, 2 29,100 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 3,416,150 24,292,463 SH   DFND 1, 2 24,292,390 0 73
FIRST REP BK SAN FRANCISCO C COM 33616C100 1,369,783 8,214,526 SH   DFND 1, 2 8,211,418 0 3,108
FLEETCOR TECHNOLOGIES INC COM 339041105 1,757,240 6,540,794 SH   DFND 1, 2 6,537,511 0 3,283
FORTIS INC COM 349553107 306 7,061 SH   DFND 1, 2 7,061 0 0
GALAPAGOS NV SPON ADR 36315X101 141,184 1,834,743 SH   DFND 1, 2 1,829,371 0 5,372
GALLAGHER ARTHUR J & CO COM 363576109 537,254 4,305,589 SH   DFND 1, 2 4,305,553 0 36
GAMING & LEISURE PPTYS INC COM 36467J108 587,702 13,852,740 SH   DFND 1, 2 13,852,740 0 0
GENERAC HLDGS INC COM 368736104 222,038 678,083 SH   DFND 1, 2 678,083 0 0
GENERAL DYNAMICS CORP COM 369550108 225,234 1,240,549 SH   DFND 1, 2 1,240,549 0 0
GENERAL MLS INC COM 370334104 1,554,359 25,347,517 SH   DFND 1, 2 25,347,459 0 58
GENMAB A/S SPONSORED ADS 372303206 103,681 3,266,508 SH   DFND 1, 2 3,266,508 0 0
GERDAU SA SPON ADR REP PFD 373737105 661,824 123,954,242 SH   DFND 1, 2 123,573,369 0 380,873
GILEAD SCIENCES INC COM 375558103 2,587,415 40,030,211 SH   DFND 1, 2 39,990,076 0 40,135
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 709,866 19,889,711 SH   DFND 1, 2 19,888,017 0 1,694
GLOBAL PMTS INC COM 37940X102 350,089 1,736,723 SH   DFND 1, 2 1,736,694 0 29
GODADDY INC CL A 380237107 793,244 10,225,729 SH   DFND 1, 2 10,209,131 0 16,598
GOL LINHAS AEREAS INTELIGENT SPON ADR PFD NEW 38045R206 7,828 1,023,293 SH   DFND 1, 2 1,023,293 0 0
GOODRX HLDGS INC COM CL A 38246G108 21,977 563,236 SH   DFND 1, 2 563,236 0 0
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103 17,287 1,122,533 SH   DFND 1, 2 1,122,533 0 0
GRACO INC COM 384109104 30,080 420,000 SH   DFND 1, 2 420,000 0 0
GRIFOLS S A SP ADR REP B NVT 398438408 22,850 1,353,836 SH   DFND 1, 2 1,353,836 0 0
GROCERY OUTLET HLDG CORP COM 39874R101 133,809 3,627,238 SH   DFND 1, 2 3,627,238 0 0
GUARDANT HEALTH INC COM 40131M109 271,771 1,780,354 SH   DFND 1, 2 1,780,354 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 62,723 779,886 SH   DFND 1, 2 761,337 0 18,549
HASBRO INC COM 418056107 64,407 670,061 SH   DFND 1, 2 669,870 0 191
HEALTH CATALYST INC COM 42225T107 23,169 495,377 SH   DFND 1, 2 495,377 0 0
HEICO CORP NEW COM 422806109 123,847 984,474 SH   DFND 1, 2 984,474 0 0
HEICO CORP NEW CL A 422806208 103,540 910,852 SH   DFND 1, 2 910,799 0 53
HENRY JACK & ASSOC INC COM 426281101 15,247 99,861 SH   DFND 1, 2 99,817 0 44
HILTON GRAND VACATIONS INC COM 43283X105 253,805 6,769,948 SH   DFND 1, 2 6,769,948 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A203 1,679,909 13,891,527 SH   DFND 1, 2 13,877,467 0 14,060
HOME DEPOT INC COM 437076102 835,775 2,738,001 SH   DFND 1, 2 2,737,806 0 195
HONEYWELL INTL INC COM 438516106 1,704,272 7,850,768 SH   DFND 1, 2 7,834,594 0 16,174
HORMEL FOODS CORP COM 440452100 493,534 10,328,865 SH   DFND 1, 2 10,274,543 0 54,322
HUAZHU GROUP LTD SPONSORED ADS 44332N106 133,258 2,427,279 SH   DFND 1, 2 2,427,279 0 0
HUBSPOT INC COM 443573100 55,465 122,114 SH   DFND 1, 2 122,113 0 1
HUMANA INC COM 444859102 1,624,208 3,873,550 SH   DFND 1, 2 3,862,680 0 10,870
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 160,832 5,700,564 SH   DFND 1, 2 5,700,564 0 0
HUYA INC ADS REP SHS A 44852D108 65,630 3,369,109 SH   DFND 1, 2 3,369,109 0 0
ICF INTL INC COM 44925C103 23,713 271,320 SH   DFND 1, 2 271,320 0 0
ITT INC COM 45073V108 223,809 2,461,875 SH   DFND 1, 2 2,461,875 0 0
ICICI BANK LIMITED ADR 45104G104 576,604 35,966,644 SH   DFND 1, 2 35,596,776 0 369,868
IDEXX LABS INC COM 45168D104 94,883 193,912 SH   DFND 1, 2 193,912 0 0
INARI MED INC COM 45332Y109 48,150 450,000 SH   DFND 1, 2 450,000 0 0
INCYTE CORP COM 45337C102 447,189 5,502,635 SH   DFND 1, 2 5,493,258 0 9,377
INFOSYS LTD SPONSORED ADR 456788108 375,270 20,045,682 SH   DFND 1, 2 19,863,271 0 182,411
ING GROEP N.V. SPONSORED ADR 456837103 32,923 2,674,503 SH   DFND 1, 2 2,674,503 0 0
INSULET CORP COM 45784P101 20,326 77,900 SH   DFND 1, 2 77,900 0 0
INTEL CORP COM 458140100 6,388,865 99,828,667 SH   DFND 1, 2 99,739,684 0 88,983
INTERCONTINENTAL EXCHANGE IN COM 45866F104 2,490,603 22,302,306 SH   DFND 1, 2 22,273,168 0 29,138
INTERNATIONAL BUSINESS MACHS COM 459200101 30,814 231,233 SH   DFND 1, 2 231,233 0 0
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 845,170 6,053,790 SH   DFND 1, 2 6,053,242 0 548
INTUIT COM 461202103 70,075 182,934 SH   DFND 1, 2 182,934 0 0
IRIDIUM COMMUNICATIONS INC COM 46269C102 285,797 6,928,410 SH   DFND 1, 2 6,928,410 0 0
ISHARES TR CORE S&P500 ETF 464287200 9,144 23,076 SH   DFND 1, 2 15,647 0 7,429
ISHARES TR MSCI EAFE ETF 464287465 21,017 275,816 SH   DFND 1, 2 275,816 0 0
ISHARES TR RUS 1000 ETF 464287622 213 957 SH   DFND 1, 2 957 0 0
ISHARES TR MSCI ACWI ETF 464288257 8,523 89,749 SH   DFND 1, 2 86,578 0 3,171
JPMORGAN CHASE & CO COM 46625H100 5,834,601 38,321,985 SH   DFND 1, 2 38,297,641 0 24,344
JACOBS ENGR GROUP INC COM 469814107 518,170 4,008,434 SH   DFND 1, 2 4,008,434 0 0
JAMF HLDG CORP COM 47074L105 4,415 125,000 SH   DFND 1, 2 125,000 0 0
JOHNSON & JOHNSON COM 478160104 3,005,322 18,285,963 SH   DFND 1, 2 18,253,242 0 32,721
KLA CORP COM NEW 482480100 2,753,017 8,337,381 SH   DFND 1, 2 8,337,352 0 29
KKR & CO INC COM 48251W104 1,233,779 25,256,470 SH   DFND 1, 2 25,256,470 0 0
KADANT INC COM 48282T104 47,313 255,734 SH   DFND 1, 2 255,734 0 0
KARUNA THERAPEUTICS INC COM 48576A100 44,990 374,200 SH   DFND 1, 2 374,200 0 0
KEURIG DR PEPPER INC COM 49271V100 1,468,987 42,740,344 SH   DFND 1, 2 42,738,404 0 1,940
KEYCORP COM 493267108 1,398,498 69,994,897 SH   DFND 1, 2 69,994,897 0 0
KONINKLIJKE PHILIPS N V NY REG SH NEW 500472303 91,452 1,611,355 SH   DFND 1, 2 1,611,355 0 0
KRAFT HEINZ CO COM 500754106 490,240 12,255,988 SH   DFND 1, 2 12,255,988 0 0
KRATOS DEFENSE & SEC SOLUTIO COM NEW 50077B207 113,366 4,155,647 SH   DFND 1, 2 4,155,647 0 0
KRONOS BIO INC COM 50107A104 17,562 600,000 SH   DFND 1, 2 600,000 0 0
KULICKE & SOFFA INDS INC COM 501242101 85,995 1,751,063 SH   DFND 1, 2 1,751,063 0 0
LGI HOMES INC COM 50187T106 105,175 704,406 SH   DFND 1, 2 704,406 0 0
L3HARRIS TECHNOLOGIES INC COM 502431109 1,745,029 8,609,701 SH   DFND 1, 2 8,609,310 0 391
LAM RESEARCH CORP COM 512807108 114,934 193,783 SH   DFND 1, 2 193,776 0 7
LAMB WESTON HLDGS INC COM 513272104 86,539 1,116,900 SH   DFND 1, 2 1,116,275 0 625
LAS VEGAS SANDS CORP COM 517834107 231,190 3,804,279 SH   DFND 1, 2 3,804,279 0 0
LAUDER ESTEE COS INC CL A 518439104 411,134 1,412,746 SH   DFND 1, 2 1,412,717 0 29
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 19,328 666,018 SH   DFND 1, 2 666,018 0 0
LESLIES INC COM 527064109 41,826 1,707,879 SH   DFND 1, 2 1,707,879 0 0
LIBERTY BROADBAND CORP COM SER C 530307305 55,964 372,723 SH   DFND 1, 2 372,723 0 0
LIGHTSPEED POS INC SUB VTG SHS 53227R106 114,255 1,817,650 SH   DFND 1, 2 1,817,650 0 0
LILLY ELI & CO COM 532457108 1,660,831 8,891,360 SH   DFND 1, 2 8,891,301 0 59
LIVERAMP HLDGS INC COM 53815P108 72,367 1,394,899 SH   DFND 1, 2 1,394,899 0 0
LOCKHEED MARTIN CORP COM 539830109 662,223 1,792,176 SH   DFND 1, 2 1,791,979 0 197
LOMA NEGRA CORP SPONSORED ADS 54150E104 52,718 8,328,288 SH   DFND 1, 2 8,328,288 0 0
LOWES COS INC COM 548661107 3,257 17,127 SH   DFND 1, 2 17,122 0 5
MGIC INVT CORP WIS COM 552848103 42,956 3,101,550 SH   DFND 1, 2 3,101,550 0 0
MGM GROWTH PPTYS LLC CL A COM 55303A105 33,436 1,025,019 SH   DFND 1, 2 1,025,019 0 0
MKS INSTRS INC COM 55306N104 668,214 3,603,788 SH   DFND 1, 2 3,603,788 0 0
MSCI INC COM 55354G100 579,234 1,381,591 SH   DFND 1, 2 1,381,576 0 15
MAGNOLIA OIL & GAS CORP CL A 559663109 22,960 2,000,000 SH   DFND 1, 2 2,000,000 0 0
MARKETAXESS HLDGS INC COM 57060D108 14,539 29,200 SH   DFND 1, 2 29,200 0 0
MARSH & MCLENNAN COS INC COM 571748102 2,659,952 21,839,482 SH   DFND 1, 2 21,790,846 0 48,636
MARRIOTT INTL INC NEW CL A 571903202 289,832 1,956,870 SH   DFND 1, 2 1,956,870 0 0
MASTERCARD INCORPORATED CL A 57636Q104 4,282,516 12,027,838 SH   DFND 1, 2 12,025,848 0 1,990
MATTEL INC COM 577081102 102,662 5,153,739 SH   DFND 1, 2 5,153,739 0 0
MERCADOLIBRE INC COM 58733R102 588,734 402,077 SH   DFND 1, 2 402,077 0 0
MERCK & CO. INC COM 58933Y105 2,557,763 33,179,434 SH   DFND 1, 2 33,157,049 0 22,385
METTLER TOLEDO INTERNATIONAL COM 592688105 541,412 468,475 SH   DFND 1, 2 468,475 0 0
MICROSOFT CORP COM 594918104 21,271,570 90,228,967 SH   DFND 1, 2 90,169,325 0 59,642
MICRON TECHNOLOGY INC COM 595112103 1,695,645 19,223,000 SH   DFND 1, 2 19,213,984 0 9,016
MOLINA HEALTHCARE INC COM 60855R100 231,068 988,484 SH   DFND 1, 2 988,484 0 0
MOLSON COORS BEVERAGE CO CL B 60871R209 234,115 4,577,037 SH   DFND 1, 2 4,577,037 0 0
MONDELEZ INTL INC CL A 609207105 873,444 14,922,512 SH   DFND 1, 2 14,922,430 0 82
MONGODB INC CL A 60937P106 134,673 503,584 SH   DFND 1, 2 503,584 0 0
MONSTER BEVERAGE CORP NEW COM 61174X109 18,232 200,159 SH   DFND 1, 2 200,159 0 0
MOODYS CORP COM 615369105 1,544,445 5,172,405 SH   DFND 1, 2 5,168,737 0 3,668
NMI HLDGS INC CL A 629209305 33,402 1,412,927 SH   DFND 1, 2 1,412,927 0 0
NVR INC COM 62944T105 814,468 172,889 SH   DFND 1, 2 172,889 0 0
NASDAQ INC COM 631103108 209,671 1,421,884 SH   DFND 1, 2 1,421,884 0 0
NCINO INC COM 63947U107 11,176 167,500 SH   DFND 1, 2 167,500 0 0
NETAPP INC COM 64110D104 1,882,493 25,905,967 SH   DFND 1, 2 25,905,967 0 0
NETFLIX INC COM 64110L106 8,808,865 16,886,545 SH   DFND 1, 2 16,881,245 0 5,300
NETEASE INC SPONSORED ADS 64110W102 121,506 1,177,517 SH   DFND 1, 2 1,177,517 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 152,744 1,572,326 SH   DFND 1, 2 1,572,326 0 0
NEWELL BRANDS INC COM 651229106 4,017 150,001 SH   DFND 1, 2 150,001 0 0
NEWMONT CORP COM 651639106 132,228 2,193,927 SH   DFND 1, 2 2,193,927 0 0
NEXTERA ENERGY INC COM 65339F101 818,794 10,829,428 SH   DFND 1, 2 10,816,648 0 12,780
NEXTERA ENERGY INC UNIT 09/01/2022S 65339F796 82,082 1,429,759 SH   DFND 1, 2 1,429,759 0 0
NIKE INC CL B 654106103 935,912 7,042,700 SH   DFND 1, 2 7,036,781 0 5,919
NORFOLK SOUTHN CORP COM 655844108 1,766,616 6,578,567 SH   DFND 1, 2 6,567,817 0 10,750
NORTHROP GRUMMAN CORP COM 666807102 4,276,280 13,213,417 SH   DFND 1, 2 13,194,858 0 18,559
NOVAVAX INC COM NEW 670002401 42,608 235,000 SH   DFND 1, 2 235,000 0 0
NOVANTA INC COM 67000B104 65,077 493,422 SH   DFND 1, 2 493,422 0 0
NOVO-NORDISK A S ADR 670100205 343,402 5,072,371 SH   DFND 1, 2 5,050,176 0 22,195
NUCANA PLC SPONSORED ADR 67022C106 22,042 4,417,153 SH   DFND 1, 2 4,417,153 0 0
NUCOR CORP COM 670346105 147,791 1,841,168 SH   DFND 1, 2 1,835,714 0 5,454
NVIDIA CORPORATION COM 67066G104 36,609 68,566 SH   DFND 1, 2 68,566 0 0
OAK STR HEALTH INC COM 67181A107 412,329 7,597,730 SH   DFND 1, 2 7,597,730 0 0
OKTA INC CL A 679295105 505,677 2,294,049 SH   DFND 1, 2 2,294,049 0 0
OLD DOMINION FREIGHT LINE IN COM 679580100 242,121 1,007,119 SH   DFND 1, 2 1,007,119 0 0
OLINK HLDG AB SPONSORED ADS 680710100 36,000 1,000,000 SH   DFND 1, 2 1,000,000 0 0
ON SEMICONDUCTOR CORP COM 682189105 754,464 18,131,794 SH   DFND 1, 2 18,131,794 0 0
ONECONNECT FINL TECHNOLOGY C SPONSORED ADS 68248T105 80,445 5,442,803 SH   DFND 1, 2 5,442,803 0 0
PG&E CORP COM 69331C108 491,109 41,939,243 SH   DFND 1, 2 41,939,243 0 0
PNC FINL SVCS GROUP INC COM 693475105 3,241,998 18,481,279 SH   DFND 1, 2 18,458,789 0 22,490
PPG INDS INC COM 693506107 688,857 4,584,432 SH   DFND 1, 2 4,584,432 0 0
PACCAR INC COM 693718108 242,836 2,613,390 SH   DFND 1, 2 2,613,390 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 264,386 7,937,125 SH   DFND 1, 2 7,937,125 0 0
PARK HOTELS & RESORTS INC COM 700517105 139,080 6,444,877 SH   DFND 1, 2 6,444,877 0 0
PAYCHEX INC COM 704326107 1,363,358 13,908,274 SH   DFND 1, 2 13,908,274 0 0
PAYPAL HLDGS INC COM 70450Y103 683,572 2,814,907 SH   DFND 1, 2 2,814,907 0 0
PEBBLEBROOK HOTEL TR COM 70509V100 151,308 6,229,246 SH   DFND 1, 2 6,229,246 0 0
PEPSICO INC COM 713448108 464,690 3,284,526 SH   DFND 1, 2 3,284,495 0 31
PFIZER INC COM 717081103 44,182 1,219,493 SH   DFND 1, 2 1,219,493 0 0
PHILIP MORRIS INTL INC COM 718172109 6,206,961 69,942,196 SH   DFND 1, 2 69,941,450 0 746
PHREESIA INC COM 71944F106 41,440 795,384 SH   DFND 1, 2 795,384 0 0
PINTEREST INC CL A 72352L106 310,998 4,200,979 SH   DFND 1, 2 4,200,979 0 0
PIONEER NAT RES CO COM 723787107 811,191 5,107,375 SH   DFND 1, 2 5,086,251 0 21,124
POOL CORP COM 73278L105 54,168 156,900 SH   DFND 1, 2 156,898 0 2
PROCTER AND GAMBLE CO COM 742718109 576,153 4,254,245 SH   DFND 1, 2 4,254,210 0 35
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 146,559 2,434,138 SH   DFND 1, 2 2,434,138 0 0
QUALCOMM INC COM 747525103 598,849 4,517,869 SH   DFND 1, 2 4,517,869 0 0
QUALTRICS INTL INC COM CL A 747601201 67,885 2,062,759 SH   DFND 1, 2 2,062,759 0 0
RADIAN GROUP INC COM 750236101 64,606 2,778,751 SH   DFND 1, 2 2,778,751 0 0
RAYTHEON TECHNOLOGIES CORP COM 75513E101 2,146,561 27,778,914 SH   DFND 1, 2 27,777,952 0 962
REGENERON PHARMACEUTICALS COM 75886F107 610,427 1,290,161 SH   DFND 1, 2 1,290,161 0 0
RELX PLC SPONSORED ADR 759530108 342,716 13,631,888 SH   DFND 1, 2 13,631,888 0 0
REVANCE THERAPEUTICS INC COM 761330109 43,200 1,545,630 SH   DFND 1, 2 1,545,630 0 0
RINGCENTRAL INC CL A 76680R206 612,034 2,054,632 SH   DFND 1, 2 2,054,632 0 0
RIO TINTO PLC SPONSORED ADR 767204100 212,453 2,734,980 SH   DFND 1, 2 2,734,980 0 0
ROYAL DUTCH SHELL PLC SPON ADR B 780259107 2,088 55,387 SH   DFND 1, 2 28 0 55,359
RUBIUS THERAPEUTICS INC COM 78116T103 11,034 416,396 SH   DFND 1, 2 416,396 0 0
RYANAIR HOLDINGS PLC SPONSORED ADS 783513203 1,100,318 9,568,633 SH   DFND 1, 2 9,557,692 0 10,941
S&P GLOBAL INC COM 78409V104 1,747,178 4,951,337 SH   DFND 1, 2 4,950,959 0 378
SPDR S&P 500 ETF TR TR UNIT 78462F103 5,531 14,011 SH   DFND 1, 2 10,399 0 3,612
SVB FINANCIAL GROUP COM 78486Q101 972,245 1,969,463 SH   DFND 1, 2 1,969,463 0 0
SVMK INC COM 78489X103 89,648 4,893,450 SH   DFND 1, 2 4,893,450 0 0
SABRE CORP COM 78573M104 5,500 371,400 SH   DFND 1, 2 371,400 0 0
SAIA INC COM 78709Y105 138,858 602,211 SH   DFND 1, 2 602,211 0 0
SANA BIOTECHNOLOGY INC COM 799566104 40,164 1,200,000 SH   DFND 1, 2 1,200,000 0 0
SANDSTORM GOLD LTD COM NEW 80013R206 9,257 1,361,300 SH   DFND 1, 2 1,361,300 0 0
SAP SE SPON ADR 803054204 272,936 2,233,179 SH   DFND 1, 2 2,228,110 0 5,069
SCHLUMBERGER LTD COM 806857108 710,849 26,143,516 SH   DFND 1, 2 26,069,822 0 73,694
SCHRODINGER INC COM 80810D103 17,706 232,084 SH   DFND 1, 2 232,084 0 0
SEA LTD SPONSORD ADS 81141R100 220,715 988,735 SH   DFND 1, 2 988,735 0 0
SEAGEN INC COM 81181C104 2,172,948 15,650,554 SH   DFND 1, 2 15,641,590 0 8,964
SEER INC COM CL A 81578P106 30,840 616,551 SH   DFND 1, 2 616,551 0 0
SEMPRA ENERGY COM 816851109 2,674,340 20,172,935 SH   DFND 1, 2 20,145,709 0 27,226
SERVICENOW INC COM 81762P102 1,416,525 2,832,470 SH   DFND 1, 2 2,830,710 0 1,760
SHAW COMMUNICATIONS INC CL B CONV 82028K200 321 12,358 SH   DFND 1, 2 12,358 0 0
SHERWIN WILLIAMS CO COM 824348106 368,284 498,866 SH   DFND 1, 2 498,859 0 7
SHOPIFY INC CL A 82509L107 85,743 77,490 SH   DFND 1, 2 77,490 0 0
SIGNIFY HEALTH INC CL A COM 82671G100 29,260 1,000,000 SH   DFND 1, 2 1,000,000 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 124,518 2,679,532 SH   DFND 1, 2 2,679,532 0 0
SMARTSHEET INC COM CL A 83200N103 97,665 1,528,009 SH   DFND 1, 2 1,526,284 0 1,725
SNOWFLAKE INC CL A 833445109 17,732 77,338 SH   DFND 1, 2 77,338 0 0
SOUTH ST CORP COM 840441109 73,899 941,264 SH   DFND 1, 2 941,264 0 0
SQUARE INC CL A 852234103 247,937 1,091,991 SH   DFND 1, 2 1,091,991 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 62,932 597,024 SH   DFND 1, 2 597,024 0 0
STATE STR CORP COM 857477103 926,783 11,028,534 SH   DFND 1, 2 11,028,437 0 97
STMICROELECTRONICS N V NY REGISTRY 861012102 68,728 1,835,694 SH   DFND 1, 2 1,779,033 0 56,661
SUN CTRY AIRLS HLDGS INC COM 866683105 23,996 700,000 SH   DFND 1, 2 700,000 0 0
SUN LIFE FINANCIAL INC. COM 866796105 292 5,784 SH   DFND 1, 2 5,784 0 0
SUNCOR ENERGY INC NEW COM 867224107 231,819 11,089,719 SH   DFND 1, 2 11,089,719 0 0
SYNNEX CORP COM 87162W100 12,434 108,272 SH   DFND 1, 2 108,272 0 0
TFI INTL INC COM 87241L109 349,375 4,685,138 SH   DFND 1, 2 4,685,138 0 0
TJX COS INC NEW COM 872540109 321,661 4,862,604 SH   DFND 1, 2 4,862,604 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 3,916,600 33,185,883 SH   DFND 1, 2 33,153,715 0 32,168
TC ENERGY CORP COM 87807B107 1,237,190 27,011,554 SH   DFND 1, 2 27,011,554 0 0
TELUS CORPORATION COM 87971M103 460 23,103 SH   DFND 1, 2 23,103 0 0
TELUS INTL CDA INC SUB VTG SHS 87975H100 129,663 4,633,841 SH   DFND 1, 2 4,633,841 0 0
TERADATA CORP DEL COM 88076W103 107,614 2,792,259 SH   DFND 1, 2 2,792,259 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 168,613 14,612,168 SH   DFND 1, 2 14,556,901 0 55,267
TEXAS INSTRS INC COM 882508104 694,578 3,675,721 SH   DFND 1, 2 3,675,711 0 10
THERMO FISHER SCIENTIFIC INC COM 883556102 486,106 1,065,151 SH   DFND 1, 2 1,063,614 0 1,537
TOLL BROTHERS INC COM 889478103 102,603 1,808,615 SH   DFND 1, 2 1,808,615 0 0
TOPBUILD CORP COM 89055F103 44,195 211,024 SH   DFND 1, 2 211,024 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 78,453 1,203,086 SH   DFND 1, 2 1,203,086 0 0
TOTAL SE SPONSORED ADS 89151E109 91,332 1,939,936 SH   DFND 1, 2 1,900,229 0 39,707
TRANSDIGM GROUP INC COM 893641100 3,794,112 6,453,548 SH   DFND 1, 2 6,452,030 0 1,518
TRAVELERS COMPANIES INC COM 89417E109 2,481,340 16,498,274 SH   DFND 1, 2 16,498,274 0 0
TRIMBLE INC COM 896239100 1,619,690 20,822,221 SH   DFND 1, 2 20,792,625 0 29,596
TRINITY INDS INC COM 896522109 364,433 12,793,085 SH   DFND 1, 2 12,793,085 0 0
TRIP COM GROUP LTD ADS 89677Q107 450,285 11,362,279 SH   DFND 1, 2 11,338,256 0 24,023
TRUPANION INC COM 898202106 9,244 121,300 SH   DFND 1, 2 121,300 0 0
TRUIST FINL CORP COM 89832Q109 3,206,033 54,968,965 SH   DFND 1, 2 54,893,074 0 75,891
UFP INDUSTRIES INC COM 90278Q108 7,838 103,344 SH   DFND 1, 2 103,344 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 617,570 5,424,122 SH   DFND 1, 2 5,412,622 0 11,500
UNILEVER PLC SPON ADR NEW 904767704 263,135 4,712,768 SH   DFND 1, 2 4,712,768 0 0
UNION PAC CORP COM 907818108 1,499,671 6,803,938 SH   DFND 1, 2 6,782,524 0 21,414
UNITEDHEALTH GROUP INC COM 91324P102 7,032,097 18,899,258 SH   DFND 1, 2 18,886,701 0 12,557
UPSTART HLDGS INC COM 91680M107 45,419 352,465 SH   DFND 1, 2 352,465 0 0
UPWORK INC COM 91688F104 48,228 1,077,246 SH   DFND 1, 2 1,077,246 0 0
V F CORP COM 918204108 645,541 8,077,303 SH   DFND 1, 2 8,061,497 0 15,806
VAIL RESORTS INC COM 91879Q109 242,420 831,174 SH   DFND 1, 2 831,174 0 0
VALE S A SPONSORED ADS 91912E105 2,904,190 167,132,674 SH   DFND 1, 2 166,942,359 0 190,315
VANGUARD TAX-MANAGED INTL FD FTSE DEV MKT ETF 921943858 5,986 121,553 SH   DFND 1, 2 121,514 0 39
VANGUARD INTL EQUITY INDEX F TT WRLD ST ETF 922042742 7,767 79,990 SH   DFND 1, 2 72,927 0 7,063
VENTAS INC COM 92276F100 94,442 1,770,564 SH   DFND 1, 2 1,770,564 0 0
VERISIGN INC COM 92343E102 1,076,074 5,413,936 SH   DFND 1, 2 5,413,936 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 1,082,223 18,610,541 SH   DFND 1, 2 18,564,129 0 46,412
VERTEX PHARMACEUTICALS INC COM 92532F100 1,298,481 6,042,569 SH   DFND 1, 2 6,038,994 0 3,575
VERTEX INC CL A 92538J106 33,356 1,517,555 SH   DFND 1, 2 1,517,555 0 0
VICI PPTYS INC COM 925652109 1,215,970 43,059,235 SH   DFND 1, 2 43,059,235 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 606,153 11,822,763 SH   DFND 1, 2 11,822,763 0 0
VISA INC COM CL A 92826C839 4,408,397 20,820,561 SH   DFND 1, 2 20,788,015 0 32,546
WASTE CONNECTIONS INC COM 94106B101 1,032,939 9,566,489 SH   DFND 1, 2 9,566,354 0 135
WASTE MGMT INC DEL COM 94106L109 272,497 2,111,941 SH   DFND 1, 2 2,111,905 0 36
WEBSTER FINL CORP CONN COM 947890109 46,932 851,600 SH   DFND 1, 2 851,600 0 0
WELLS FARGO CO NEW COM 949746101 189,674 4,854,712 SH   DFND 1, 2 4,854,712 0 0
WESTERN ALLIANCE BANCORP COM 957638109 391,336 4,143,752 SH   DFND 1, 2 4,143,752 0 0
WYNN RESORTS LTD COM 983134107 1,101,127 8,783,001 SH   DFND 1, 2 8,757,538 0 25,463
XCEL ENERGY INC COM 98389B100 670,217 10,077,017 SH   DFND 1, 2 10,066,340 0 10,677
XENON PHARMACEUTICALS INC COM 98420N105 18,897 1,055,726 SH   DFND 1, 2 1,055,726 0 0
XPENG INC ADS 98422D105 104,650 2,866,333 SH   DFND 1, 2 2,866,333 0 0
YETI HLDGS INC COM 98585X104 77,504 1,073,312 SH   DFND 1, 2 1,073,312 0 0
YUM BRANDS INC COM 988498101 381,427 3,523,879 SH   DFND 1, 2 3,523,836 0 43
YUM CHINA HLDGS INC COM 98850P109 77,274 1,305,286 SH   DFND 1, 2 1,284,562 0 20,724
ZEBRA TECHNOLOGIES CORPORATI CL A 989207105 95,080 195,969 SH   DFND 1, 2 195,967 0 2
ZIMMER BIOMET HOLDINGS INC COM 98956P102 564,584 3,526,888 SH   DFND 1, 2 3,526,888 0 0
ZOETIS INC CL A 98978V103 91,505 581,060 SH   DFND 1, 2 581,060 0 0
AON PLC SHS CL A G0403H108 2,034,441 8,838,427 SH   DFND 1, 2 8,833,794 0 4,633
ARCH CAP GROUP LTD ORD G0450A105 419,402 10,930,464 SH   DFND 1, 2 10,930,464 0 0
ATLASSIAN CORP PLC CL A G06242104 189,831 903,935 SH   DFND 1, 2 903,935 0 0
AXALTA COATING SYS LTD COM G0750C108 41,400 1,399,600 SH   DFND 1, 2 1,399,600 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 381,272 5,578,232 SH   DFND 1, 2 5,578,232 0 0
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 946 3,423 SH   DFND 1, 2 3,423 0 0
CREDICORP LTD COM G2519Y108 19,600 143,515 SH   DFND 1, 2 143,515 0 0
ESSENT GROUP LTD COM G3198U102 40,272 848,009 SH   DFND 1, 2 848,009 0 0
EVEREST RE GROUP LTD COM G3223R108 463,196 1,868,678 SH   DFND 1, 2 1,868,678 0 0
FABRINET SHS G3323L100 51,181 566,225 SH   DFND 1, 2 566,225 0 0
GENPACT LIMITED SHS G3922B107 39,951 933,000 SH   DFND 1, 2 933,000 0 0
HELEN OF TROY LTD COM G4388N106 94,079 446,591 SH   DFND 1, 2 446,591 0 0
LINDE PLC SHS G5494J103 1,288,846 4,600,882 SH   DFND 1, 2 4,600,847 0 35
NORWEGIAN CRUISE LINE HLDG L SHS G66721104 96,030 3,480,624 SH   DFND 1, 2 3,480,624 0 0
NOVOCURE LTD ORD SHS G6674U108 1,205,168 9,117,624 SH   DFND 1, 2 9,117,624 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 276,925 5,981,098 SH   DFND 1, 2 5,981,098 0 0
PATRIA INVESTMENTS LIMITED COM CL A G69451105 39,222 2,251,524 SH   DFND 1, 2 2,251,524 0 0
RENAISSANCERE HLDGS LTD COM G7496G103 184,450 1,151,017 SH   DFND 1, 2 1,151,017 0 0
ROYALTY PHARMA PLC SHS CLASS A G7709Q104 717,510 16,449,101 SH   DFND 1, 2 16,449,101 0 0
VINCI PARTNERS INVTS LTD COM CL A G9451V109 14,323 1,089,181 SH   DFND 1, 2 1,089,181 0 0
CHUBB LIMITED COM H1467J104 3,541,119 22,413,023 SH   DFND 1, 2 22,392,742 0 20,281
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 593,191 4,868,689 SH   DFND 1, 2 4,859,882 0 8,807
UBS GROUP AG SHS H42097107 743,119 47,988,912 SH   DFND 1, 2 47,988,912 0 0
GLOBANT S A COM L44385109 91,978 443,031 SH   DFND 1, 2 443,031 0 0
NEXA RES S A COM L67359106 58,404 5,697,982 SH   DFND 1, 2 5,697,982 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 3,383,188 5,492,708 SH   DFND 1, 2 5,481,254 0 11,454
ELASTIC N V ORD SHS N14506104 270,974 2,436,820 SH   DFND 1, 2 2,436,820 0 0
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 4,237,650 40,726,344 SH   DFND 1, 2 40,694,058 0 32,286
YANDEX N V SHS CLASS A N97284108 744,304 11,619,215 SH   DFND 1, 2 11,593,967 0 25,248
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 34,470 1,091,499 SH   DFND 1, 2 1,091,499 0 0
ROYAL CARIBBEAN GROUP COM V7780T103 1,262,082 14,742,586 SH   DFND 1, 2 14,742,586 0 0
FLEX LTD ORD Y2573F102 396,072 21,631,437 SH   DFND 1, 2 21,631,437 0 0