The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X Genomics Inc Class A CL A COM 88025U109 110,099 608,282 SH   DFND 1 608,282 0 0
10X Genomics Inc Class A CL A COM 88025U109 48,822 269,735 SH   DFND 2 155,934 0 113,801
10X Genomics Inc Class A CL A COM 88025U109 82,391 455,201 SH   DFND 3 353,315 0 101,886
10X Genomics Inc Class A CL A COM 88025U109 11,386 62,908 SH   SOLE 0 62,908 0 0
1Life Healthcare COM 68269G107 17 445 SH   DFND 3 445 0 0
2U COM 90214J101 10 273 SH   DFND 3 273 0 0
8x8 Inc COM 282914100 86 2,657 SH   DFND 3 2,657 0 0
ACM Research COM 00108J109 18 220 SH   DFND 3 220 0 0
AJ Gallagher & Co COM 363576109 136,400 1,093,208 SH   DFND 1 1,093,208 0 0
AJ Gallagher & Co COM 363576109 460,824 3,693,384 SH   DFND 2 3,455,796 0 237,588
AJ Gallagher & Co COM 363576109 90,522 725,509 SH   DFND 3 332,870 0 392,639
AJ Gallagher & Co COM 363576109 300,326 2,407,039 SH   SOLE 0 2,033,541 0 373,498
Abcellera Biologics Inc COM 00288U106 19,403 571,362 SH   DFND 1 571,362 0 0
Abcellera Biologics Inc COM 00288U106 5,390 158,715 SH   DFND 2 45,167 0 113,548
Abcellera Biologics Inc COM 00288U106 12,344 363,483 SH   DFND 3 263,318 0 100,165
Abcellera Biologics Inc COM 00288U106 2,098 61,793 SH   SOLE 0 61,793 0 0
Abiomed COM 003654100 334,931 1,050,830 SH   DFND 1 1,050,830 0 0
Abiomed COM 003654100 478,586 1,501,541 SH   DFND 2 1,379,405 0 122,136
Abiomed COM 003654100 108,783 341,302 SH   DFND 3 228,232 0 113,070
Abiomed COM 003654100 174,873 548,655 SH   SOLE 0 484,705 0 63,950
Acadia Pharmaceuticals Inc COM 004225108 14 544 SH   DFND 3 544 0 0
Accelerate Diagnostics COM 00430H102 3 418 SH   DFND 3 418 0 0
Accenture 'A' COM G1151C101 13 48 SH   DFND 3 48 0 0
Acutus Medical COM 005111109 6 424 SH   DFND 3 424 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 27,436 5,166,864 SH   DFND 1 5,166,864 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 14,135 2,662,011 SH   DFND 2 889,742 0 1,772,269
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 6,390 1,203,480 SH   DFND 3 1,203,480 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 12,931 2,435,162 SH   SOLE 0 2,435,162 0 0
Adicet Bio Inc COM 007002108 1,222 93,449 SH   DFND 1 93,449 0 0
Adicet Bio Inc COM 007002108 1,153 88,177 SH   SOLE 0 88,177 0 0
Advanced Micro Devices Inc COM 007903107 43 546 SH   DFND 3 546 0 0
Aerovironment COM 008073108 40,681 350,517 SH   DFND 1 350,517 0 0
Aerovironment COM 008073108 27,785 239,403 SH   DFND 2 79,659 0 159,744
Aerovironment COM 008073108 12,548 108,113 SH   DFND 3 108,113 0 0
Aerovironment COM 008073108 25,599 220,567 SH   SOLE 0 220,567 0 0
Affirm Holdings Inc Class A COM CL A 00827B106 79,234 1,120,389 SH   DFND 1 1,120,389 0 0
Affirm Holdings Inc Class A COM CL A 00827B106 97,864 1,383,820 SH   DFND 2 1,323,450 0 60,370
Affirm Holdings Inc Class A COM CL A 00827B106 7,200 101,811 SH   DFND 3 83,853 0 17,958
Affirm Holdings Inc Class A COM CL A 00827B106 42,770 604,774 SH   SOLE 0 604,774 0 0
Affirm Holdings Inc Class A - converted at IPO COM CL A 00827B106 175,709 2,484,575 SH   SOLE 0 2,484,575 0 0
Affirm Holdings Inc Class B - converted at IPO COM CL A 00827B106 175,709 2,484,575 SH   SOLE 0 2,484,575 0 0
Agios Pharmaceuticals Inc COM 00847X104 10 186 SH   DFND 3 186 0 0
Agora Inc ADR ADS 00851L103 21,314 423,988 SH   DFND 1 423,988 0 0
Agora Inc ADR ADS 00851L103 8,441 167,912 SH   SOLE 0 167,912 0 0
Albemarle Corp COM 012653101 104,480 715,079 SH   DFND 1 715,079 0 0
Albemarle Corp COM 012653101 297,866 2,038,641 SH   DFND 2 1,902,856 0 135,785
Albemarle Corp COM 012653101 59,948 410,296 SH   DFND 3 188,329 0 221,967
Albemarle Corp COM 012653101 213,798 1,463,267 SH   SOLE 0 1,246,384 0 216,883
Alector Inc COM 014442107 826 41,028 SH   DFND 1 41,028 0 0
Alector Inc COM 014442107 2,465 122,375 SH   DFND 2 122,375 0 0
Alector Inc COM 014442107 1,990 98,810 SH   DFND 3 98,810 0 0
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 499,333 2,202,325 SH   DFND 1 2,202,325 0 0
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 3,125,724 13,786,105 SH   DFND 2 6,732,500 0 7,053,605
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 366,062 1,614,528 SH   DFND 3 1,120,840 0 493,688
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 2,060,983 9,090,034 SH   SOLE 0 7,397,467 0 1,692,567
Align Technology Inc COM 016255101 15,892 29,346 SH   DFND 2 29,346 0 0
Alkermes Plc COM G01767105 4 192 SH   DFND 3 192 0 0
Allscripts Healthcare Solution COM 01988P108 11 744 SH   DFND 3 744 0 0
Alnylam Pharmaceuticals COM 02043Q107 375,094 2,656,661 SH   DFND 1 2,656,661 0 0
Alnylam Pharmaceuticals COM 02043Q107 564,525 3,998,334 SH   DFND 2 3,347,309 0 651,025
Alnylam Pharmaceuticals COM 02043Q107 155,070 1,098,306 SH   DFND 3 781,592 0 316,714
Alnylam Pharmaceuticals COM 02043Q107 327,795 2,321,662 SH   SOLE 0 2,102,531 0 219,131
Alphabet Inc Class A CAP STK CL A 02079K305 112,876 54,727 SH   DFND 1 54,727 0 0
Alphabet Inc Class A CAP STK CL A 02079K305 56,608 27,446 SH   DFND 2 18,349 0 9,097
Alphabet Inc Class A CAP STK CL A 02079K305 71,638 34,733 SH   DFND 3 24,912 0 9,821
Alphabet Inc Class A CAP STK CL A 02079K305 89,394 43,342 SH   SOLE 0 43,342 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 296,886 143,518 SH   DFND 1 143,518 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 1,575,961 761,838 SH   DFND 2 449,607 0 312,231
Alphabet Inc Class C CAP STK CL C 02079K107 236,051 114,110 SH   DFND 3 69,020 0 45,090
Alphabet Inc Class C CAP STK CL C 02079K107 600,794 290,431 SH   SOLE 0 191,336 0 99,095
Alteryx Inc COM 02156B103 28 336 SH   DFND 3 336 0 0
Amazon.Com COM 023135106 1,243,016 401,740 SH   DFND 1 401,740 0 0
Amazon.Com COM 023135106 4,779,670 1,544,779 SH   DFND 2 984,279 0 560,500
Amazon.Com COM 023135106 491,575 158,876 SH   DFND 3 109,670 0 49,206
Amazon.Com COM 023135106 2,605,714 842,161 SH   SOLE 0 698,420 0 143,741
Ambarella SHS G037AX101 29,234 291,200 SH   DFND 1 291,200 0 0
Ambarella SHS G037AX101 13,098 130,468 SH   DFND 2 42,469 0 87,999
Ambarella SHS G037AX101 5,720 56,979 SH   DFND 3 56,979 0 0
Ambarella SHS G037AX101 9,799 97,605 SH   SOLE 0 97,605 0 0
Amdocs COM G02602103 28 400 SH   DFND 3 400 0 0
Ameren COM 023608102 46,690 573,868 SH   DFND 1 573,868 0 0
Ameren COM 023608102 94 1,150 SH   DFND 2 1,150 0 0
Ameren COM 023608102 2,576 31,666 SH   DFND 3 31,666 0 0
American Electric Power COM 025537101 52,607 621,100 SH   DFND 1 621,100 0 0
American Electric Power COM 025537101 97 1,148 SH   DFND 2 1,148 0 0
American Electric Power COM 025537101 2,870 33,889 SH   DFND 3 33,889 0 0
American Superconductor Corp COM 030111207 9,696 511,400 SH   DFND 1 511,400 0 0
American Superconductor Corp COM 030111207 12,330 650,300 SH   SOLE 0 650,300 0 0
American Well Corp Class A COM 03044L105 1,068 61,505 SH   DFND 1 61,505 0 0
American Well Corp Class A COM 03044L105 3,243 186,680 SH   DFND 2 186,680 0 0
American Well Corp Class A COM 03044L105 2,624 151,086 SH   DFND 3 151,086 0 0
Amicus Therapeutics Inc COM 03152W109 5 538 SH   DFND 3 538 0 0
Amkor Technology COM 031652100 54 2,282 SH   DFND 3 2,282 0 0
Amneal Pharmaceuticals Inc COM 03168L105 3 452 SH   DFND 3 452 0 0
Analog Devices COM 032654105 26,593 171,478 SH   DFND 1 171,478 0 0
Analog Devices COM 032654105 599 3,863 SH   DFND 2 0 0 3,863
Analog Devices COM 032654105 162 1,047 SH   DFND 3 1,047 0 0
Analog Devices COM 032654105 25,774 166,197 SH   SOLE 0 166,197 0 0
Anaplan Inc Common COM 03272L108 16 306 SH   DFND 3 306 0 0
Annaly Capital Man. COM 035710409 64 7,446 SH   DFND 1 7,446 0 0
Anterix COM 03676C100 8 162 SH   DFND 3 162 0 0
Anthem Inc COM 036752103 181,687 506,163 SH   DFND 1 506,163 0 0
Anthem Inc COM 036752103 664,451 1,851,095 SH   DFND 2 1,728,223 0 122,872
Anthem Inc COM 036752103 134,976 376,031 SH   DFND 3 172,497 0 203,534
Anthem Inc COM 036752103 427,437 1,190,797 SH   SOLE 0 998,325 0 192,472
AppFolio COM 03783C100 39 277 SH   DFND 3 277 0 0
Appian Corp CL A 03782L101 293,186 2,205,234 SH   DFND 1 2,205,234 0 0
Appian Corp CL A 03782L101 339,814 2,555,954 SH   DFND 2 2,152,618 0 403,336
Appian Corp CL A 03782L101 37,249 280,173 SH   DFND 3 280,173 0 0
Appian Corp CL A 03782L101 121,538 914,163 SH   SOLE 0 914,163 0 0
Apple COM 037833100 25,989 212,759 SH   DFND 1 212,759 0 0
Apple COM 037833100 584 4,782 SH   DFND 2 0 0 4,782
Apple COM 037833100 159 1,299 SH   DFND 3 1,299 0 0
Apple COM 037833100 24,935 204,135 SH   SOLE 0 204,135 0 0
Applied Optoelectronics COM 03823U102 2 260 SH   DFND 3 260 0 0
Aptiv COM G6095L109 21 149 SH   DFND 3 149 0 0
Ares Capital Corp COM 04010L103 98,302 5,254,000 SH   DFND 1 5,254,000 0 0
Ares Capital Corp COM 04010L103 200 10,700 SH   DFND 2 10,700 0 0
Ares Capital Corp COM 04010L103 5,431 290,270 SH   DFND 3 290,270 0 0
Argan COM 04010E109 5 103 SH   DFND 3 103 0 0
Ascendis Pharma Adr 1:1 SPON ADR 04351P101 2,064 16,017 SH   DFND 1 16,017 0 0
Ascendis Pharma Adr 1:1 SPON ADR 04351P101 6,076 47,146 SH   DFND 2 47,146 0 0
Ascendis Pharma Adr 1:1 SPON ADR 04351P101 5,043 39,131 SH   DFND 3 39,131 0 0
Atlassian Corp Plc CL A G06242104 109,944 521,657 SH   DFND 1 521,657 0 0
Atlassian Corp Plc CL A G06242104 871,648 4,135,738 SH   DFND 2 1,294,853 0 2,840,885
Atlassian Corp Plc CL A G06242104 99,265 470,984 SH   DFND 3 378,834 0 92,150
Atlassian Corp Plc CL A G06242104 238,002 1,129,257 SH   SOLE 0 498,845 0 630,412
Atrion COM 049904105 6 9 SH   DFND 3 9 0 0
Autohome Inc - ADR SP ADR RP CL A 05278C107 34,331 368,082 SH   DFND 1 368,082 0 0
Autohome Inc - ADR SP ADR RP CL A 05278C107 127,227 1,364,070 SH   DFND 2 1,271,665 0 92,405
Autohome Inc - ADR SP ADR RP CL A 05278C107 25,588 274,346 SH   DFND 3 125,752 0 148,594
Autohome Inc - ADR SP ADR RP CL A 05278C107 86,375 926,073 SH   SOLE 0 776,217 0 149,856
Avangrid COM 05351W103 70,585 1,417,085 SH   DFND 1 1,417,085 0 0
Avangrid COM 05351W103 135 2,701 SH   DFND 2 2,701 0 0
Avangrid COM 05351W103 3,312 66,501 SH   DFND 3 66,501 0 0
Avery Dennison Corporation COM 053611109 22 118 SH   DFND 3 118 0 0
Axogen Inc COM 05463X106 8,912 439,900 SH   DFND 1 439,900 0 0
Axogen Inc COM 05463X106 7,780 383,987 SH   DFND 2 129,412 0 254,575
Axogen Inc COM 05463X106 3,611 178,247 SH   DFND 3 178,247 0 0
Axogen Inc COM 05463X106 3,436 169,600 SH   SOLE 0 169,600 0 0
Axon Enterprise Inc COM 05464C101 113,750 798,695 SH   DFND 1 798,695 0 0
Axon Enterprise Inc COM 05464C101 264,783 1,859,167 SH   DFND 2 1,599,010 0 260,157
Axon Enterprise Inc COM 05464C101 63,062 442,787 SH   DFND 3 257,410 0 185,377
Axon Enterprise Inc COM 05464C101 176,426 1,238,775 SH   SOLE 0 1,060,521 0 178,254
Axonics Modulation Technologies COM 05465P101 14 230 SH   DFND 3 230 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 13,663 62,805 SH   DFND 1 62,805 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 793,106 3,645,628 SH   DFND 2 3,336,438 0 309,190
Baidu.com Sponsored ADR SPON ADR REP A 056752108 41,435 190,461 SH   DFND 3 28,481 0 161,980
Baidu.com Sponsored ADR SPON ADR REP A 056752108 1,659 7,628 SH   DFND 4 7,628 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 509 2,340 SH   SOLE 0 2,340 0 0
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 23,919 5,089,126 SH   DFND 1 5,089,126 0 0
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 160,927 34,239,687 SH   DFND 2 18,367,296 0 15,872,391
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 7,000 1,489,412 SH   DFND 3 1,489,412 0 0
Bandwidth COM 05988J103 20 161 SH   DFND 3 161 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 22,594 592,408 SH   DFND 1 592,408 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 16,578 434,663 SH   DFND 2 144,468 0 290,195
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 7,421 194,584 SH   DFND 3 194,584 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 11,217 294,100 SH   SOLE 0 294,100 0 0
Beam Therapeutics COM 07373V105 42 519 SH   DFND 3 519 0 0
BeiGene Ltd SPONSORED ADR 07725L102 142,161 408,415 SH   DFND 1 408,415 0 0
BeiGene Ltd SPONSORED ADR 07725L102 1,065,144 3,060,054 SH   DFND 2 1,153,036 0 1,907,018
BeiGene Ltd SPONSORED ADR 07725L102 98,264 282,302 SH   DFND 3 226,812 0 55,490
BeiGene Ltd SPONSORED ADR 07725L102 235,979 677,944 SH   SOLE 0 300,491 0 377,453
Benefitfocus Inc COM 08180D106 4,232 306,448 SH   DFND 1 306,448 0 0
Benefitfocus Inc COM 08180D106 3,999 289,591 SH   DFND 2 81,910 0 207,681
Benefitfocus Inc COM 08180D106 1,686 122,107 SH   DFND 3 122,107 0 0
Benefitfocus Inc COM 08180D106 3,126 226,368 SH   SOLE 0 226,368 0 0
Berkeley Lights Inc COM 084310101 25,859 514,820 SH   DFND 1 514,820 0 0
Berkeley Lights Inc COM 084310101 9,421 187,557 SH   DFND 2 135,336 0 52,221
Berkeley Lights Inc COM 084310101 12,925 257,312 SH   DFND 3 210,851 0 46,461
Berkeley Lights Inc COM 084310101 8,019 159,654 SH   SOLE 0 159,654 0 0
Beyond Meat Inc COM 08862E109 127,704 981,430 SH   DFND 1 981,430 0 0
Beyond Meat Inc COM 08862E109 515,445 3,961,308 SH   DFND 2 1,234,165 0 2,727,143
Beyond Meat Inc COM 08862E109 97,463 749,025 SH   DFND 3 574,200 0 174,825
Beyond Meat Inc COM 08862E109 141,853 1,090,169 SH   SOLE 0 507,876 0 582,293
Bilibili Inc ADR SPONSORED ADR 090040106 92,091 860,182 SH   DFND 1 860,182 0 0
Bilibili Inc ADR SPONSORED ADR 090040106 413,852 3,865,608 SH   DFND 2 1,207,487 0 2,658,121
Bilibili Inc ADR SPONSORED ADR 090040106 46,694 436,152 SH   DFND 3 345,661 0 90,491
Bilibili Inc ADR SPONSORED ADR 090040106 116,171 1,085,100 SH   SOLE 0 485,330 0 599,770
BioNTech ADR SPONS ADS 09075V102 62,023 568,031 SH   DFND 1 568,031 0 0
BioNTech ADR SPONS ADS 09075V102 485,890 4,449,952 SH   DFND 2 1,428,447 0 3,021,505
BioNTech ADR SPONS ADS 09075V102 53,970 494,276 SH   DFND 3 393,467 0 100,809
BioNTech ADR SPONS ADS 09075V102 133,840 1,225,753 SH   SOLE 0 546,686 0 679,067
Biomarin Pharmaceutical Inc COM 09061G101 6 82 SH   DFND 3 82 0 0
BlackRock Floating Rate Income COM 091941104 9,811 784,230 SH   DFND 1 784,230 0 0
Blackline COM 09239B109 65,793 606,942 SH   DFND 1 606,942 0 0
Blackline COM 09239B109 36,162 333,596 SH   DFND 2 111,022 0 222,574
Blackline COM 09239B109 16,257 149,972 SH   DFND 3 149,972 0 0
Blackline COM 09239B109 30,414 280,576 SH   SOLE 0 280,576 0 0
Blackrock Inc COM 09247X101 16 21 SH   DFND 3 21 0 0
Blue Apron Holdings Inc CL A 09523Q101 937 148,506 SH   DFND 1 148,506 0 0
Bluebird Bio Inc COM 09609G100 28 913 SH   DFND 3 913 0 0
Blueprint Medicines Corp COM 09627Y109 41 426 SH   DFND 3 426 0 0
Booking Holdings Inc COM 09857L108 120,763 51,833 SH   DFND 1 51,833 0 0
Booking Holdings Inc COM 09857L108 352,908 151,473 SH   DFND 2 141,211 0 10,262
Booking Holdings Inc COM 09857L108 75,217 32,284 SH   DFND 3 15,215 0 17,069
Booking Holdings Inc COM 09857L108 233,632 100,278 SH   SOLE 0 84,002 0 16,276
Box Inc COM 10316T104 22 979 SH   DFND 3 979 0 0
Brady Corp COM 104674106 13 245 SH   DFND 3 245 0 0
BridgeBio Pharma Inc COM 10806X102 3,003 48,748 SH   DFND 1 48,748 0 0
BridgeBio Pharma Inc COM 10806X102 8,914 144,703 SH   DFND 2 144,703 0 0
BridgeBio Pharma Inc COM 10806X102 7,342 119,194 SH   DFND 3 119,194 0 0
Bristol Myers Squibb COM 110122108 38 607 SH   DFND 3 607 0 0
British Amer.Tobacco - ADR SPONSORED ADR 110448107 3,850 99,377 SH   DFND 1 99,377 0 0
British Amer.Tobacco - ADR SPONSORED ADR 110448107 100 2,586 SH   DFND 2 0 0 2,586
British Amer.Tobacco - ADR SPONSORED ADR 110448107 31 813 SH   DFND 3 813 0 0
British Amer.Tobacco - ADR SPONSORED ADR 110448107 4,495 116,021 SH   SOLE 0 116,021 0 0
Broadridge Finl.Sltn. COM 11133T103 75,933 495,968 SH   DFND 1 495,968 0 0
Broadridge Finl.Sltn. COM 11133T103 299,535 1,956,469 SH   DFND 2 1,834,502 0 121,967
Broadridge Finl.Sltn. COM 11133T103 57,277 374,113 SH   DFND 3 171,796 0 202,317
Broadridge Finl.Sltn. COM 11133T103 184,751 1,206,734 SH   SOLE 0 1,012,261 0 194,473
Brookfield Renewable COM 11284V105 48,290 1,031,831 SH   DFND 1 1,031,831 0 0
Brookfield Renewable COM 11284V105 145 3,106 SH   DFND 2 3,106 0 0
Brookfield Renewable COM 11284V105 3,533 75,499 SH   DFND 3 75,499 0 0
Bumble Inc COM CL A 12047B105 24,952 400,000 SH   SOLE 0 400,000 0 0
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 52,445 1,948,186 SH   DFND 1 1,948,186 0 0
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 115,853 4,303,621 SH   DFND 2 2,919,699 0 1,383,922
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 5,345 198,549 SH   DFND 3 20,837 0 177,712
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 3,547 131,772 SH   SOLE 0 131,772 0 0
Butterfly Network Inc COM CL A 124155102 1,086 64,528 SH   DFND 1 64,528 0 0
Butterfly Network Inc COM CL A 124155102 3,286 195,222 SH   DFND 2 195,222 0 0
Butterfly Network Inc COM CL A 124155102 2,677 159,049 SH   DFND 3 159,049 0 0
Butterfly Network Inc COM CL A 124155102 14,582 866,410 SH   SOLE 0 866,410 0 0
C3.ai CL A 12468P104 8 117 SH   DFND 3 117 0 0
CEVA Inc COM 157210105 10,033 178,680 SH   DFND 1 178,680 0 0
CEVA Inc COM 157210105 8,768 156,153 SH   DFND 2 50,632 0 105,521
CEVA Inc COM 157210105 3,953 70,396 SH   DFND 3 70,396 0 0
CEVA Inc COM 157210105 4,632 82,500 SH   SOLE 0 82,500 0 0
CH Robinson Worldwide COM NEW 12541W209 28,982 303,694 SH   DFND 1 303,694 0 0
CH Robinson Worldwide COM NEW 12541W209 659 6,905 SH   DFND 2 0 0 6,905
CH Robinson Worldwide COM NEW 12541W209 177 1,856 SH   DFND 3 1,856 0 0
CH Robinson Worldwide COM NEW 12541W209 27,508 288,257 SH   SOLE 0 288,257 0 0
Calavo Growers Inc COM 128246105 9 113 SH   DFND 3 113 0 0
Cardlytics Inc COM 14161W105 17,815 162,400 SH   DFND 1 162,400 0 0
Cardlytics Inc COM 14161W105 13,712 125,000 SH   DFND 2 41,700 0 83,300
Cardlytics Inc COM 14161W105 6,152 56,077 SH   DFND 3 56,077 0 0
Cardlytics Inc COM 14161W105 11,211 102,200 SH   SOLE 0 102,200 0 0
Cargurus Inc COM 141788109 8 345 SH   DFND 3 345 0 0
Carvana COM 146869102 288,313 1,098,753 SH   DFND 1 1,098,753 0 0
Carvana COM 146869102 834,472 3,180,153 SH   DFND 2 1,712,421 0 1,467,732
Carvana COM 146869102 72,542 276,455 SH   DFND 3 230,376 0 46,079
Carvana COM 146869102 441,148 1,681,205 SH   SOLE 0 1,365,544 0 315,661
Cbre Group Inc CL A 12504L109 131,652 1,664,158 SH   DFND 1 1,664,158 0 0
Cbre Group Inc CL A 12504L109 403,812 5,104,439 SH   DFND 2 4,782,238 0 322,201
Cbre Group Inc CL A 12504L109 79,302 1,002,430 SH   DFND 3 470,489 0 531,941
Cbre Group Inc CL A 12504L109 249,663 3,155,895 SH   SOLE 0 2,639,513 0 516,382
Cemex ADR SPON ADR NEW 151290889 34,831 4,997,287 SH   DFND 1 4,997,287 0 0
Cemex ADR SPON ADR NEW 151290889 173,446 24,884,702 SH   DFND 2 10,176,754 0 14,707,948
Cemex ADR SPON ADR NEW 151290889 60,259 8,645,527 SH   DFND 3 1,226,134 0 7,419,393
Cemex ADR SPON ADR NEW 151290889 2,648 379,900 SH   DFND 4 379,900 0 0
Certara COM 15687V109 21,498 787,464 SH   SOLE 0 787,464 0 0
Cerus COM 157085101 7 1,143 SH   DFND 3 1,143 0 0
ChargePoint Holdings Inc COM CL A 15961R105 106,800 4,000,000 SH   SOLE 0 4,000,000 0 0
Chegg COM 163092109 487,557 5,691,764 SH   DFND 1 5,691,764 0 0
Chegg COM 163092109 680,688 7,946,398 SH   DFND 2 7,056,726 0 889,672
Chegg COM 163092109 101,297 1,182,548 SH   DFND 3 862,647 0 319,901
Chegg COM 163092109 266,358 3,109,485 SH   SOLE 0 2,838,580 0 270,905
Chewy Inc CL A 16679L109 243,553 2,875,143 SH   DFND 1 2,875,143 0 0
Chewy Inc CL A 16679L109 326,805 3,857,931 SH   DFND 2 3,687,131 0 170,800
Chewy Inc CL A 16679L109 12,364 145,958 SH   DFND 3 145,958 0 0
Chewy Inc CL A 16679L109 56,752 669,960 SH   SOLE 0 669,960 0 0
Chinook Therapeutics COM 16961L106 6,157 396,187 SH   DFND 1 396,187 0 0
Chinook Therapeutics COM 16961L106 3,507 225,682 SH   DFND 2 79,619 0 146,063
Chinook Therapeutics COM 16961L106 1,656 106,558 SH   DFND 3 106,558 0 0
Chinook Therapeutics COM 16961L106 1,819 117,058 SH   SOLE 0 117,058 0 0
Church & Dwight Co Inc COM 171340102 16 179 SH   DFND 3 179 0 0
Cimpress COM g2143t103 8 84 SH   DFND 3 84 0 0
Cisco Systems COM 17275R102 17,369 335,890 SH   DFND 1 335,890 0 0
Cisco Systems COM 17275R102 394 7,627 SH   DFND 2 0 0 7,627
Cisco Systems COM 17275R102 104 2,008 SH   DFND 3 2,008 0 0
Cisco Systems COM 17275R102 16,433 317,784 SH   SOLE 0 317,784 0 0
Cloudera Inc COM 18914U100 39,811 3,271,228 SH   DFND 1 3,271,228 0 0
Cloudera Inc COM 18914U100 19,334 1,588,696 SH   DFND 2 527,375 0 1,061,321
Cloudera Inc COM 18914U100 8,687 713,766 SH   DFND 3 713,766 0 0
Cloudera Inc COM 18914U100 21,504 1,766,990 SH   SOLE 0 1,766,990 0 0
Cloudflare Inc CL A COM 18915M107 344,669 4,905,617 SH   DFND 1 4,905,617 0 0
Cloudflare Inc CL A COM 18915M107 1,199,387 17,070,696 SH   DFND 2 9,688,703 0 7,381,993
Cloudflare Inc CL A COM 18915M107 146,406 2,083,770 SH   DFND 3 1,425,796 0 657,974
Cloudflare Inc CL A COM 18915M107 417,003 5,935,135 SH   SOLE 0 3,969,204 0 1,965,931
Clover Health Investments Corp COM CL A 18914F103 38,875 5,142,177 SH   SOLE 0 5,142,177 0 0
Clovis Oncology COM 189464100 1 92 SH   DFND 3 92 0 0
CoStar Group COM 22160N109 274,527 334,019 SH   DFND 1 334,019 0 0
CoStar Group COM 22160N109 468,565 570,107 SH   DFND 2 541,569 0 28,538
CoStar Group COM 22160N109 43,342 52,734 SH   DFND 3 32,128 0 20,606
CoStar Group COM 22160N109 156,632 190,575 SH   SOLE 0 170,663 0 19,912
Coca Cola COM 191216100 24,632 467,320 SH   DFND 1 467,320 0 0
Coca Cola COM 191216100 589 11,165 SH   DFND 2 0 0 11,165
Coca Cola COM 191216100 160 3,028 SH   DFND 3 3,028 0 0
Coca Cola COM 191216100 24,593 466,580 SH   SOLE 0 466,580 0 0
Codexis COM 192005106 46,193 2,018,055 SH   DFND 1 2,018,055 0 0
Codexis COM 192005106 42,300 1,847,959 SH   DFND 2 606,765 0 1,241,194
Codexis COM 192005106 18,666 815,470 SH   DFND 3 815,470 0 0
Codexis COM 192005106 28,591 1,249,067 SH   SOLE 0 1,249,067 0 0
Cognyte Software ORD SHS M25133105 8 303 SH   DFND 3 303 0 0
Cohen & Steers Inc COM 19247A100 23 356 SH   DFND 3 356 0 0
Coherus BioSciences COM 19249H103 26 1,807 SH   DFND 3 1,807 0 0
Columbia Sportswear Co COM 198516106 10 95 SH   DFND 3 95 0 0
Commscope Holding Co Inc COM 20337X109 24 1,543 SH   DFND 3 1,543 0 0
Consolidated Edison COM 209115104 54,712 731,438 SH   DFND 1 731,438 0 0
Consolidated Edison COM 209115104 95 1,275 SH   DFND 2 1,275 0 0
Consolidated Edison COM 209115104 2,455 32,815 SH   DFND 3 32,815 0 0
Cooper Cos Inc/The COM 216648402 13,712 35,700 SH   DFND 2 35,700 0 0
Copa Holdings S A CL A P31076105 31,502 389,924 SH   DFND 1 389,924 0 0
Copa Holdings S A CL A P31076105 273,749 3,388,401 SH   DFND 2 2,208,693 0 1,179,708
Copa Holdings S A CL A P31076105 61,098 756,255 SH   DFND 3 96,057 0 660,198
Copa Holdings S A CL A P31076105 2,421 29,964 SH   DFND 4 29,964 0 0
Copa Holdings S A CL A P31076105 22,446 277,829 SH   SOLE 0 277,829 0 0
Cornerstone Ondemand Inc COM 21925Y103 45 1,043 SH   DFND 3 1,043 0 0
Coupa Software Inc COM 22266L106 98 387 SH   DFND 3 387 0 0
Coupang CL A 22266T109 105,752 2,142,895 SH   DFND 1 2,142,895 0 0
Coupang CL A 22266T109 693,571 14,054,118 SH   DFND 2 6,754,372 0 7,299,746
Coupang CL A 22266T109 94,241 1,909,645 SH   DFND 3 1,230,022 0 679,623
Coupang CL A 22266T109 915 18,547 SH   DFND 4 18,547 0 0
Coupang CL A 22266T109 193,887 3,928,818 SH   SOLE 0 1,776,464 0 2,152,354
Coursera Inc COM 22266M104 59,836 1,329,689 SH   DFND 1 1,329,689 0 0
Coursera Inc COM 22266M104 65,975 1,466,109 SH   DFND 2 1,355,387 0 110,722
Coursera Inc COM 22266M104 9,571 212,688 SH   DFND 3 167,050 0 45,638
Coursera Inc COM 22266M104 12,629 280,646 SH   SOLE 0 280,646 0 0
Credicorp COM G2519Y108 7,579 55,496 SH   DFND 1 55,496 0 0
Credicorp COM G2519Y108 129,359 947,201 SH   DFND 2 629,364 0 317,837
Credicorp COM G2519Y108 27,896 204,259 SH   DFND 3 27,114 0 177,145
Credicorp COM G2519Y108 1,246 9,127 SH   DFND 4 9,127 0 0
Credicorp COM G2519Y108 15,282 111,900 SH   SOLE 0 111,900 0 0
CrowdStrike Holdings COM 22788C105 25 138 SH   DFND 3 138 0 0
Cullen/Frost Bankers COM 229899109 12,893 118,545 SH   DFND 1 118,545 0 0
Cullen/Frost Bankers COM 229899109 289 2,654 SH   DFND 2 0 0 2,654
Cullen/Frost Bankers COM 229899109 77 707 SH   DFND 3 707 0 0
Cullen/Frost Bankers COM 229899109 13,207 121,435 SH   SOLE 0 121,435 0 0
CureVac N.V. - Converted at IPO COM N2451R105 171,031 1,870,009 SH   DFND 2 1,870,009 0 0
CureVac N.V. - Converted at IPO COM N2451R105 142,526 1,558,341 SH   SOLE 0 1,558,341 0 0
Curevac N.V. COM N2451R105 200,203 2,188,967 SH   DFND 2 1,716,690 0 472,277
Curevac N.V. COM N2451R105 19,461 212,784 SH   SOLE 0 212,784 0 0
CyberArk Software Ltd SHS M2682V108 32,862 254,077 SH   DFND 1 254,077 0 0
CyberArk Software Ltd SHS M2682V108 27,477 212,439 SH   DFND 2 70,544 0 141,895
CyberArk Software Ltd SHS M2682V108 12,332 95,348 SH   DFND 3 95,348 0 0
CyberArk Software Ltd SHS M2682V108 14,889 115,118 SH   SOLE 0 115,118 0 0
DTE Energy Co COM 233331107 60,432 453,900 SH   DFND 1 453,900 0 0
DTE Energy Co COM 233331107 112 838 SH   DFND 2 838 0 0
DTE Energy Co COM 233331107 3,211 24,117 SH   DFND 3 24,117 0 0
Dada Nexus Ltd ADR ADS 23344D108 80,466 2,964,859 SH   DFND 1 2,964,859 0 0
Dada Nexus Ltd ADR ADS 23344D108 94,875 3,495,753 SH   DFND 2 2,289,100 0 1,206,653
Dada Nexus Ltd ADR ADS 23344D108 871 32,079 SH   DFND 3 32,079 0 0
Dada Nexus Ltd ADR ADS 23344D108 19,121 704,517 SH   SOLE 0 704,517 0 0
Darden Restaurants COM 237194105 12 82 SH   DFND 3 82 0 0
Datadog COM 23804L103 131,714 1,580,443 SH   DFND 1 1,580,443 0 0
Datadog COM 23804L103 261,917 3,142,747 SH   DFND 2 2,969,742 0 173,005
Datadog COM 23804L103 32,049 384,557 SH   DFND 3 208,700 0 175,857
Datadog COM 23804L103 111,862 1,342,237 SH   SOLE 0 1,169,573 0 172,664
Deere & Co COM 244199105 93,958 251,131 SH   DFND 1 251,131 0 0
Deere & Co COM 244199105 26,109 69,785 SH   DFND 2 19,696 0 50,089
Deere & Co COM 244199105 61,281 163,792 SH   DFND 3 118,305 0 45,487
Deere & Co COM 244199105 10,548 28,192 SH   SOLE 0 28,192 0 0
Denali Therapeutics COM 24823R105 138,484 2,425,289 SH   DFND 1 2,425,289 0 0
Denali Therapeutics COM 24823R105 177,600 3,110,329 SH   DFND 2 2,976,854 0 133,475
Denali Therapeutics COM 24823R105 14,520 254,283 SH   DFND 3 225,199 0 29,084
Denali Therapeutics COM 24823R105 411,422 7,205,296 SH   SOLE 0 7,205,296 0 0
Dexcom Inc COM 252131107 253,022 704,032 SH   DFND 1 704,032 0 0
Dexcom Inc COM 252131107 1,142,457 3,178,878 SH   DFND 2 1,000,173 0 2,178,705
Dexcom Inc COM 252131107 204,840 569,966 SH   DFND 3 443,963 0 126,003
Dexcom Inc COM 252131107 315,315 877,362 SH   SOLE 0 407,333 0 470,029
Digimarc COM 25381B101 7,784 262,445 SH   DFND 1 262,445 0 0
Digimarc COM 25381B101 8,607 290,200 SH   DFND 2 95,327 0 194,873
Digimarc COM 25381B101 3,774 127,253 SH   DFND 3 127,253 0 0
Digimarc COM 25381B101 4,589 154,711 SH   SOLE 0 154,711 0 0
Docebo COM 25609L105 1,285 29,900 SH   DFND 2 29,900 0 0
Docebo COM 25609L105 13 300 SH   DFND 3 300 0 0
Dolby Laboratories 'A' COM 25659T107 14,825 150,174 SH   DFND 1 150,174 0 0
Dolby Laboratories 'A' COM 25659T107 344 3,481 SH   DFND 2 0 0 3,481
Dolby Laboratories 'A' COM 25659T107 91 918 SH   DFND 3 918 0 0
Dolby Laboratories 'A' COM 25659T107 14,379 145,651 SH   SOLE 0 145,651 0 0
Doordash Inc COM 25809K105 111,467 850,047 SH   DFND 1 850,047 0 0
Doordash Inc COM 25809K105 253,846 1,935,835 SH   DFND 2 1,819,541 0 116,294
Doordash Inc COM 25809K105 38,059 290,237 SH   DFND 3 147,202 0 143,035
Doordash Inc COM 25809K105 248,283 1,893,408 SH   SOLE 0 1,755,057 0 138,351
Dropbox CL A 26210C104 23 881 SH   DFND 3 881 0 0
Duck Creek Technologies SHS 264120106 16 355 SH   DFND 3 355 0 0
Duke Realty Corporation REIT COM 264411505 54,834 1,307,740 SH   DFND 1 1,307,740 0 0
Duke Realty Corporation REIT COM 264411505 117 2,800 SH   DFND 2 2,800 0 0
Duke Realty Corporation REIT COM 264411505 2,467 58,840 SH   DFND 3 58,840 0 0
EOG Resources COM 26875P101 69,372 956,464 SH   DFND 1 956,464 0 0
EOG Resources COM 26875P101 241,900 3,335,176 SH   DFND 2 3,112,033 0 223,143
EOG Resources COM 26875P101 35,441 488,646 SH   DFND 3 252,646 0 236,000
EOG Resources COM 26875P101 159,425 2,198,057 SH   SOLE 0 1,832,131 0 365,926
Ecolab COM 278865100 63,146 294,977 SH   DFND 1 294,977 0 0
Ecolab COM 278865100 29,639 138,454 SH   DFND 2 79,620 0 58,834
Ecolab COM 278865100 41,461 193,680 SH   DFND 3 139,964 0 53,716
Ecolab COM 278865100 5,765 26,932 SH   SOLE 0 26,932 0 0
Edwards Lifesciences Corp COM 28176E108 3,337 39,897 SH   DFND 1 39,897 0 0
Edwards Lifesciences Corp COM 28176E108 22,374 267,504 SH   DFND 2 267,504 0 0
Edwards Lifesciences Corp COM 28176E108 8,160 97,556 SH   DFND 3 97,556 0 0
Emergent Biosolutions Inc COM 29089Q105 39 423 SH   DFND 3 423 0 0
Equifax COM 294429105 9 52 SH   DFND 3 52 0 0
Estee Lauder 'A' COM 518439104 107,369 369,155 SH   DFND 1 369,155 0 0
Estee Lauder 'A' COM 518439104 432,223 1,486,067 SH   DFND 2 1,398,149 0 87,918
Estee Lauder 'A' COM 518439104 79,266 272,532 SH   DFND 3 125,510 0 147,022
Estee Lauder 'A' COM 518439104 255,752 879,325 SH   SOLE 0 736,880 0 142,445
Eventbrite Inc Class A COM CL A 29975E109 35,601 1,606,535 SH   DFND 1 1,606,535 0 0
Eventbrite Inc Class A COM CL A 29975E109 44,449 2,005,823 SH   DFND 2 1,909,026 0 96,797
Eventbrite Inc Class A COM CL A 29975E109 1,808 81,575 SH   DFND 3 81,575 0 0
Eventbrite Inc Class A COM CL A 29975E109 4,760 214,801 SH   SOLE 0 214,801 0 0
EverQuote Inc COM CL A 30041R108 26,091 718,967 SH   DFND 1 718,967 0 0
EverQuote Inc COM CL A 30041R108 10,008 275,780 SH   DFND 2 90,658 0 185,122
EverQuote Inc COM CL A 30041R108 4,600 126,745 SH   DFND 3 126,745 0 0
EverQuote Inc COM CL A 30041R108 8,403 231,550 SH   SOLE 0 231,550 0 0
Everbridge Inc COM 29978A104 40,085 330,786 SH   DFND 1 330,786 0 0
Everbridge Inc COM 29978A104 25,589 211,165 SH   DFND 2 70,289 0 140,876
Everbridge Inc COM 29978A104 11,521 95,072 SH   DFND 3 95,072 0 0
Everbridge Inc COM 29978A104 17,989 148,446 SH   SOLE 0 148,446 0 0
Eversource Energy COM 30040W108 46,412 536,000 SH   DFND 1 536,000 0 0
Eversource Energy COM 30040W108 93 1,077 SH   DFND 2 1,077 0 0
Eversource Energy COM 30040W108 2,438 28,161 SH   DFND 3 28,161 0 0
Exact Sciences COM 30063P105 140,694 1,067,643 SH   DFND 1 1,067,643 0 0
Exact Sciences COM 30063P105 222,098 1,685,371 SH   DFND 2 1,361,410 0 323,961
Exact Sciences COM 30063P105 66,502 504,642 SH   DFND 3 352,043 0 152,599
Exact Sciences COM 30063P105 143,557 1,089,370 SH   SOLE 0 958,849 0 130,521
Exelon Corporation COM 30161N101 974 22,268 SH   DFND 1 22,268 0 0
Expeditors Intl COM 302130109 14 126 SH   DFND 3 126 0 0
Exponent COM 30214U102 24 242 SH   DFND 3 242 0 0
Extreme Networks COM 30226D106 6 687 SH   DFND 3 687 0 0
Facebook Cl.A CL A 30303M102 238,209 808,775 SH   DFND 1 808,775 0 0
Facebook Cl.A CL A 30303M102 1,431,142 4,859,071 SH   DFND 2 2,346,212 0 2,512,859
Facebook Cl.A CL A 30303M102 198,125 672,683 SH   DFND 3 450,839 0 221,844
Facebook Cl.A CL A 30303M102 538,617 1,828,735 SH   SOLE 0 1,151,393 0 677,342
Farfetch ORD SHS CL A 30744W107 94,622 1,784,653 SH   DFND 1 1,784,653 0 0
Farfetch ORD SHS CL A 30744W107 304,336 5,740,024 SH   DFND 2 5,349,569 0 390,455
Farfetch ORD SHS CL A 30744W107 70,026 1,320,754 SH   DFND 3 683,505 0 637,249
Farfetch ORD SHS CL A 30744W107 262,563 4,952,156 SH   SOLE 0 3,940,314 0 1,011,842
Fastenal COM 311900104 49,692 988,303 SH   DFND 1 988,303 0 0
Fastenal COM 311900104 21,198 421,604 SH   DFND 2 403,267 0 18,337
Fastenal COM 311900104 4,293 85,391 SH   DFND 3 58,191 0 27,200
Fastenal COM 311900104 39,973 795,014 SH   SOLE 0 795,014 0 0
Ferrari NV COM N3167Y103 2,120,229 10,114,885 SH   DFND 2 8,208,946 0 1,905,939
Ferrari NV COM N3167Y103 419,858 2,003,000 SH   SOLE 0 2,003,000 0 0
Fibrogen Inc COM 31572Q808 13 377 SH   DFND 3 377 0 0
First Industrial REIT COM 32054K103 45,810 1,000,438 SH   DFND 1 1,000,438 0 0
First Industrial REIT COM 32054K103 96 2,100 SH   DFND 2 2,100 0 0
First Industrial REIT COM 32054K103 2,059 44,974 SH   DFND 3 44,974 0 0
First Republic Bank COM 33616C100 292,853 1,756,237 SH   DFND 1 1,756,237 0 0
First Republic Bank COM 33616C100 415,331 2,490,739 SH   DFND 2 2,394,399 0 96,340
First Republic Bank COM 33616C100 22,513 135,012 SH   DFND 3 117,098 0 17,914
First Republic Bank COM 33616C100 67,819 406,708 SH   SOLE 0 406,708 0 0
FirstCash COM 33767D105 20,097 306,030 SH   DFND 1 306,030 0 0
FirstCash COM 33767D105 1,071 16,313 SH   DFND 3 16,313 0 0
Fiverr Intl ORD SHS M4R82T106 22 100 SH   DFND 3 100 0 0
Fortis COM 349553107 1,321 30,457 SH   DFND 1 30,457 0 0
Fortive Corp COM 34959J108 7,704 109,062 SH   DFND 2 109,062 0 0
Fox COM 35137L105 13 359 SH   DFND 3 359 0 0
GAN COM G3728V109 10 572 SH   DFND 3 572 0 0
Gentex Corp COM 371901109 18 516 SH   DFND 3 516 0 0
Glaukos Corp COM 377322102 209,910 2,501,011 SH   DFND 1 2,501,011 0 0
Glaukos Corp COM 377322102 201,609 2,402,109 SH   DFND 2 2,163,893 0 238,216
Glaukos Corp COM 377322102 51,765 616,760 SH   DFND 3 479,436 0 137,324
Glaukos Corp COM 377322102 38,414 457,696 SH   SOLE 0 457,696 0 0
Global Blood Therapeutics Inc COM 37890U108 41 1,007 SH   DFND 3 1,007 0 0
Glu Mobile COM 379890106 68 5,417 SH   DFND 3 5,417 0 0
Grifols ADR SP ADR REP B NVT 398438408 49,548 2,865,701 SH   DFND 2 2,215,558 0 650,143
Grifols ADR SP ADR REP B NVT 398438408 6,682 386,447 SH   SOLE 0 386,447 0 0
HDFC Bank ADR ADR REPS 3 SHS 40415F101 67,105 863,755 SH   DFND 2 801,733 0 62,022
HDFC Bank ADR ADR REPS 3 SHS 40415F101 14,796 190,449 SH   DFND 3 99,294 0 91,155
HDFC Bank ADR ADR REPS 3 SHS 40415F101 81,628 1,050,686 SH   SOLE 0 947,394 0 103,292
HEICO COM 422806109 13,705 108,944 SH   DFND 1 108,944 0 0
HEICO COM 422806109 7,067 56,177 SH   SOLE 0 56,177 0 0
HEICO 'A' CL A 422806208 59,858 526,920 SH   DFND 1 526,920 0 0
HEICO 'A' CL A 422806208 107,038 942,233 SH   DFND 2 905,162 0 37,071
HEICO 'A' CL A 422806208 3,779 33,263 SH   DFND 3 33,263 0 0
HEICO 'A' CL A 422806208 9,310 81,956 SH   SOLE 0 81,956 0 0
HUYA ADR ADS REP SHS A 44852D108 52,904 2,715,802 SH   DFND 1 2,715,802 0 0
HUYA ADR ADS REP SHS A 44852D108 64,208 3,296,114 SH   DFND 2 1,949,146 0 1,346,968
HUYA ADR ADS REP SHS A 44852D108 7,564 388,295 SH   DFND 3 20,266 0 368,029
HUYA ADR ADS REP SHS A 44852D108 12,885 661,423 SH   SOLE 0 661,423 0 0
Halozyme Therapeutics COM 40637H109 42 1,006 SH   DFND 3 1,006 0 0
Harris Corp COM 502431109 12 61 SH   DFND 3 61 0 0
Health Catalyst Inc COM 42225T107 1,927 41,208 SH   DFND 1 41,208 0 0
Health Catalyst Inc COM 42225T107 5,698 121,823 SH   DFND 2 121,823 0 0
Health Catalyst Inc COM 42225T107 4,668 99,799 SH   DFND 3 99,799 0 0
Healthcare Services Group Inc COM 421906108 4 157 SH   DFND 3 157 0 0
Heron Therapeutics Inc COM 427746102 5 308 SH   DFND 3 308 0 0
Hillenbrand COM 431571108 8 170 SH   DFND 3 170 0 0
Home Depot COM 437076102 19 61 SH   DFND 3 61 0 0
Homology Medicines COM 438083107 5 481 SH   DFND 3 481 0 0
Hormel Foods Corp COM 440452100 13 264 SH   DFND 3 264 0 0
Howard Hughes COM 44267D107 64,001 672,774 SH   DFND 1 672,774 0 0
Howard Hughes COM 44267D107 139,448 1,465,873 SH   DFND 2 1,368,093 0 97,780
Howard Hughes COM 44267D107 29,649 311,672 SH   DFND 3 150,434 0 161,238
Howard Hughes COM 44267D107 93,825 986,284 SH   SOLE 0 828,038 0 158,246
Hubbell COM 443510607 18 96 SH   DFND 3 96 0 0
Hubspot Inc COM 443573100 73 160 SH   DFND 3 160 0 0
Hutchison China Meditech SPONSORED ADR 44842L103 3,943 139,564 SH   DFND 1 139,564 0 0
Hutchison China Meditech SPONSORED ADR 44842L103 5,186 183,589 SH   DFND 3 0 0 183,589
ICICI Bank ADR ADR 45104G104 129,991 8,109,230 SH   DFND 1 8,109,230 0 0
ICICI Bank ADR ADR 45104G104 149,307 9,314,196 SH   DFND 2 8,669,941 0 644,255
ICICI Bank ADR ADR 45104G104 72,641 4,531,550 SH   DFND 3 2,711,083 0 1,820,467
ICICI Bank ADR ADR 45104G104 7,381 460,474 SH   DFND 4 460,474 0 0
ICICI Bank ADR ADR 45104G104 133,822 8,348,251 SH   SOLE 0 7,170,272 0 1,177,979
IPG Photonics Corp COM 44980X109 25,470 120,747 SH   DFND 1 120,747 0 0
IPG Photonics Corp COM 44980X109 24,121 114,351 SH   DFND 2 38,083 0 76,268
IPG Photonics Corp COM 44980X109 10,881 51,583 SH   DFND 3 51,583 0 0
IPG Photonics Corp COM 44980X109 19,055 90,336 SH   SOLE 0 90,336 0 0
Iac/Interactivecorp COM 44891N109 48,088 222,312 SH   DFND 1 222,312 0 0
Iac/Interactivecorp COM 44891N109 159,710 738,338 SH   DFND 2 684,425 0 53,913
Iac/Interactivecorp COM 44891N109 36,288 167,760 SH   DFND 3 77,993 0 89,767
Iac/Interactivecorp COM 44891N109 115,024 531,755 SH   SOLE 0 445,111 0 86,644
Iclick Interactive Asia G SPON ADR 45113Y104 36,553 3,105,623 SH   DFND 1 3,105,623 0 0
Iclick Interactive Asia G SPON ADR 45113Y104 9,845 836,416 SH   DFND 2 836,416 0 0
Iclick Interactive Asia G SPON ADR 45113Y104 351 29,830 SH   DFND 3 29,830 0 0
Iclick Interactive Asia G SPON ADR 45113Y104 8,139 691,490 SH   SOLE 0 691,490 0 0
Ii-Vi Inc COM 902104108 45 664 SH   DFND 3 664 0 0
Illumina COM 452327109 771,353 2,008,417 SH   DFND 1 2,008,417 0 0
Illumina COM 452327109 4,873,195 12,688,629 SH   DFND 2 8,973,806 0 3,714,823
Illumina COM 452327109 379,698 988,643 SH   DFND 3 744,502 0 244,141
Illumina COM 452327109 2,207,441 5,747,646 SH   SOLE 0 4,963,225 0 784,421
InMode SHS M5425M103 27 369 SH   DFND 3 369 0 0
Incyte Corp COM 45337C102 13 165 SH   DFND 3 165 0 0
Infinera COM 45667G103 28 2,941 SH   DFND 3 2,941 0 0
Infosys Ltd ADR SPONSORED ADR 456788108 18,743 1,001,245 SH   DFND 1 1,001,245 0 0
Infosys Ltd ADR SPONSORED ADR 456788108 14,444 771,582 SH   DFND 2 89,658 0 681,924
Infosys Ltd ADR SPONSORED ADR 456788108 12,907 689,499 SH   DFND 3 567,082 0 122,417
Infosys Ltd ADR SPONSORED ADR 456788108 3,069 163,946 SH   DFND 4 163,946 0 0
Inogen Inc COM 45780L104 7 141 SH   DFND 3 141 0 0
Inphi Corp COM 45772F107 100 560 SH   DFND 3 560 0 0
Insmed Inc COM 457669307 27 787 SH   DFND 3 787 0 0
Inspire Medical Systems COM 457730109 43 208 SH   DFND 3 208 0 0
Interactive Brokers Group COM 45841N107 38,874 532,232 SH   DFND 1 532,232 0 0
Interactive Brokers Group COM 45841N107 146,814 2,010,045 SH   DFND 2 1,891,157 0 118,888
Interactive Brokers Group COM 45841N107 28,501 390,212 SH   DFND 3 182,222 0 207,990
Interactive Brokers Group COM 45841N107 86,229 1,180,579 SH   SOLE 0 984,919 0 195,660
Intercept Pharmaceuticals Inc COM 45845P108 2 101 SH   DFND 3 101 0 0
Intersect ENT COM 46071F103 8 361 SH   DFND 3 361 0 0
Intuitive Surgical COM NEW 46120E602 98,663 133,520 SH   DFND 1 133,520 0 0
Intuitive Surgical COM NEW 46120E602 780,486 1,056,224 SH   DFND 2 331,268 0 724,956
Intuitive Surgical COM NEW 46120E602 89,005 120,449 SH   DFND 3 96,726 0 23,723
Intuitive Surgical COM NEW 46120E602 213,421 288,820 SH   SOLE 0 127,644 0 161,176
Invesco Senior Income Trust COM 46131H107 10,739 2,556,949 SH   DFND 1 2,556,949 0 0
Invesco Senior Income Trust COM 46131H107 2,683 638,746 SH   DFND 3 638,746 0 0
Ionis Pharmaceuticals COM 462222100 1,663 36,982 SH   DFND 1 36,982 0 0
Ionis Pharmaceuticals COM 462222100 4,948 110,048 SH   DFND 2 110,048 0 0
Ionis Pharmaceuticals COM 462222100 4,088 90,929 SH   DFND 3 90,929 0 0
Ironwood Pharmaceuticals Inc COM 46333X108 10 935 SH   DFND 3 935 0 0
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 12,476 2,515,293 SH   DFND 1 2,515,293 0 0
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 108,663 21,907,790 SH   DFND 2 12,006,315 0 9,901,475
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 46,236 9,321,827 SH   DFND 3 1,245,074 0 8,076,753
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 2,046 412,444 SH   DFND 4 412,444 0 0
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 10,409 2,098,498 SH   SOLE 0 2,098,498 0 0
Itron Inc COM 465741106 18 204 SH   DFND 3 204 0 0
J&J Snack Foods Corp COM 466032109 13 83 SH   DFND 3 83 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 121,447 1,440,140 SH   DFND 1 1,440,140 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 8,090 95,934 SH   DFND 2 95,934 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 197 2,331 SH   DFND 3 2,331 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 24,619 291,937 SH   SOLE 0 291,937 0 0
JDS Uniphase Corporation COM 925550105 18 1,142 SH   DFND 3 1,142 0 0
JFROG Ltd ORD SHS M6191J100 23,183 522,500 SH   DFND 1 522,500 0 0
JFROG Ltd ORD SHS M6191J100 10,718 241,566 SH   DFND 2 80,266 0 161,300
JFROG Ltd ORD SHS M6191J100 4,825 108,736 SH   DFND 3 108,736 0 0
JFROG Ltd ORD SHS M6191J100 12,259 276,300 SH   SOLE 0 276,300 0 0
Jack Henry & Associates COM 426281101 11 71 SH   DFND 3 71 0 0
Jaguar Health - US indemnity shares COM 47010C409 0 2,033,592 SH   SOLE 0 2,033,592 0 0
John Wiley & Sons Inc COM 968223206 8 153 SH   DFND 3 153 0 0
Johnson & Johnson COM 478160104 15 89 SH   DFND 3 89 0 0
Jumia Technologies Ag ADR SPONSORED ADS 48138M105 325,217 9,171,365 SH   DFND 2 9,051,653 0 119,712
KE Holdings ADR ADR 482497104 123,824 2,173,106 SH   DFND 1 2,173,106 0 0
KE Holdings ADR ADR 482497104 679,384 11,923,195 SH   DFND 2 5,506,586 0 6,416,609
KE Holdings ADR ADR 482497104 58,829 1,032,447 SH   DFND 3 740,103 0 292,344
KE Holdings ADR ADR 482497104 287,090 5,038,427 SH   SOLE 0 3,757,385 0 1,281,042
Kaleido Biosciences Inc COM 483347100 2,983 368,288 SH   DFND 1 368,288 0 0
Kaleido Biosciences Inc COM 483347100 2,342 289,103 SH   SOLE 0 289,103 0 0
Keysight Technologies COM 49338L103 24 169 SH   DFND 3 169 0 0
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 76,280 1,939,975 SH   DFND 1 1,939,975 0 0
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 182,531 4,642,183 SH   DFND 2 2,810,018 0 1,832,165
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 12,272 312,103 SH   DFND 3 28,234 0 283,869
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 15,459 393,153 SH   SOLE 0 393,153 0 0
Korea Electric Power ADR SPONSORED ADR 500631106 19 1,900 SH   DFND 2 1,900 0 0
Korea Electric Power ADR SPONSORED ADR 500631106 1,624 158,319 SH   DFND 3 158,319 0 0
LUFAX Holdings LTD COM 54975P102 89,129 6,138,374 SH   DFND 1 6,138,374 0 0
LUFAX Holdings LTD COM 54975P102 163,681 11,272,762 SH   DFND 2 6,800,047 0 4,472,715
LUFAX Holdings LTD COM 54975P102 1,063 73,205 SH   DFND 3 73,205 0 0
LUFAX Holdings LTD COM 54975P102 11,656 802,735 SH   SOLE 0 802,735 0 0
Lci Industries COM 50189K103 11 86 SH   DFND 3 86 0 0
Lemonade Inc COM 52567D107 113,510 1,218,829 SH   DFND 1 1,218,829 0 0
Lemonade Inc COM 52567D107 150,300 1,613,875 SH   DFND 2 1,540,735 0 73,140
Lemonade Inc COM 52567D107 5,827 62,572 SH   DFND 3 62,572 0 0
Lemonade Inc COM 52567D107 69,416 745,370 SH   SOLE 0 745,370 0 0
LendingTree COM 52603B107 67,579 317,272 SH   DFND 1 317,272 0 0
LendingTree COM 52603B107 121,559 570,699 SH   DFND 2 413,303 0 157,396
LendingTree COM 52603B107 37,590 176,477 SH   DFND 3 132,015 0 44,462
LendingTree COM 52603B107 75,360 353,803 SH   SOLE 0 316,227 0 37,576
Li Auto ADR SPONS ADS 50202M102 30,013 1,200,501 SH   DFND 1 1,200,501 0 0
Li Auto ADR SPONS ADS 50202M102 106,552 4,262,093 SH   DFND 2 3,822,234 0 439,859
Li Auto ADR SPONS ADS 50202M102 22,206 888,249 SH   DFND 3 408,579 0 479,670
Li Auto ADR SPONS ADS 50202M102 70,633 2,825,325 SH   SOLE 0 2,375,847 0 449,478
Liberty Broadband Corp COM 530307305 11 70 SH   DFND 3 70 0 0
Lightspeed POS COM 53227R106 21 335 SH   DFND 3 335 0 0
LivePerson Inc COM 538146101 25,963 492,291 SH   DFND 1 492,291 0 0
LivePerson Inc COM 538146101 19,985 378,927 SH   DFND 2 126,267 0 252,660
LivePerson Inc COM 538146101 9,005 170,744 SH   DFND 3 170,744 0 0
LivePerson Inc COM 538146101 13,073 247,880 SH   SOLE 0 247,880 0 0
Liveramp Holdings Inc COM 53815P108 31,927 615,401 SH   DFND 1 615,401 0 0
Liveramp Holdings Inc COM 53815P108 16,932 326,365 SH   DFND 2 109,119 0 217,246
Liveramp Holdings Inc COM 53815P108 7,708 148,578 SH   DFND 3 148,578 0 0
Liveramp Holdings Inc COM 53815P108 15,308 295,075 SH   SOLE 0 295,075 0 0
Lowes Cos COM 548661107 13 69 SH   DFND 3 69 0 0
Lumentum Hdgs COM 55024U109 15 168 SH   DFND 3 168 0 0
Lyft Inc Class A Common CL A COM 55087P104 131,642 2,083,603 SH   DFND 1 2,083,603 0 0
Lyft Inc Class A Common CL A COM 55087P104 282,078 4,464,666 SH   DFND 2 4,199,811 0 264,855
Lyft Inc Class A Common CL A COM 55087P104 47,811 756,736 SH   DFND 3 381,207 0 375,529
Lyft Inc Class A Common CL A COM 55087P104 246,848 3,907,067 SH   SOLE 0 3,547,084 0 359,983
MakeMyTrip SHS V5633W109 83,438 2,642,107 SH   DFND 2 1,977,940 0 664,167
Markel Corp COM 570535104 62,631 54,958 SH   DFND 1 54,958 0 0
Markel Corp COM 570535104 228,438 200,451 SH   DFND 2 187,674 0 12,777
Markel Corp COM 570535104 46,220 40,557 SH   DFND 3 18,990 0 21,567
Markel Corp COM 570535104 144,319 126,638 SH   SOLE 0 106,111 0 20,527
MarketAxess Holdings COM 57060D108 297,403 597,291 SH   DFND 1 597,291 0 0
MarketAxess Holdings COM 57060D108 409,820 823,064 SH   DFND 2 684,095 0 138,969
MarketAxess Holdings COM 57060D108 60,491 121,487 SH   DFND 3 112,203 0 9,284
MarketAxess Holdings COM 57060D108 101,595 204,039 SH   SOLE 0 204,039 0 0
Martin Marietta Materials COM 573284106 184,158 548,382 SH   DFND 1 548,382 0 0
Martin Marietta Materials COM 573284106 582,719 1,735,213 SH   DFND 2 1,621,335 0 113,878
Martin Marietta Materials COM 573284106 118,625 353,241 SH   DFND 3 165,130 0 188,111
Martin Marietta Materials COM 573284106 386,180 1,149,960 SH   SOLE 0 968,568 0 181,392
Masimo Corp COM 574795100 2,443 10,638 SH   DFND 1 10,638 0 0
Masimo Corp COM 574795100 7,215 31,415 SH   DFND 2 31,415 0 0
Masimo Corp COM 574795100 5,981 26,045 SH   DFND 3 26,045 0 0
Mastercard Inc-Class A CL A 57636Q104 467,147 1,312,026 SH   DFND 1 1,312,026 0 0
Mastercard Inc-Class A CL A 57636Q104 1,051,635 2,953,617 SH   DFND 2 2,787,128 0 166,489
Mastercard Inc-Class A CL A 57636Q104 154,610 434,237 SH   DFND 3 223,263 0 210,974
Mastercard Inc-Class A CL A 57636Q104 487,734 1,369,847 SH   SOLE 0 1,172,488 0 197,359
McDonald's COM 580135101 21,419 95,560 SH   DFND 1 95,560 0 0
McDonald's COM 580135101 480 2,141 SH   DFND 2 0 0 2,141
McDonald's COM 580135101 131 584 SH   DFND 3 584 0 0
McDonald's COM 580135101 20,373 90,894 SH   SOLE 0 90,894 0 0
Medifast Inc COM 58470H101 28 134 SH   DFND 3 134 0 0
Medtronic COM G5960L103 17,592 148,924 SH   DFND 1 148,924 0 0
Medtronic COM G5960L103 347 2,939 SH   DFND 2 0 0 2,939
Medtronic COM G5960L103 111 938 SH   DFND 3 938 0 0
Medtronic COM G5960L103 17,156 145,229 SH   SOLE 0 145,229 0 0
MercadoLibre COM 58733R102 394,877 268,233 SH   DFND 1 268,233 0 0
MercadoLibre COM 58733R102 5,642,096 3,832,581 SH   DFND 2 3,191,880 0 640,701
MercadoLibre COM 58733R102 162,317 110,259 SH   DFND 3 90,136 0 20,123
MercadoLibre COM 58733R102 9,698 6,588 SH   DFND 4 6,588 0 0
MercadoLibre COM 58733R102 619,581 420,871 SH   SOLE 0 420,871 0 0
Mercury Computer Systems COM 589378108 14 205 SH   DFND 3 205 0 0
Meredith Corp COM 589433101 9 293 SH   DFND 3 293 0 0
Mettler-Toledo COM 592688105 99,790 86,347 SH   DFND 1 86,347 0 0
Mettler-Toledo COM 592688105 535,631 463,473 SH   DFND 2 324,605 0 138,868
Mettler-Toledo COM 592688105 4,254 3,681 SH   DFND 3 3,681 0 0
Mettler-Toledo COM 592688105 33,309 28,822 SH   SOLE 0 28,822 0 0
MiMedx Group COM 602496101 5 513 SH   DFND 3 513 0 0
Microsoft COM 594918104 233,416 990,014 SH   DFND 1 990,014 0 0
Microsoft COM 594918104 751,228 3,186,274 SH   DFND 2 2,988,428 0 197,846
Microsoft COM 594918104 141,319 599,394 SH   DFND 3 275,439 0 323,955
Microsoft COM 594918104 481,455 2,042,055 SH   SOLE 0 1,732,937 0 309,118
Mobile Telesystems ADR SPONSORED ADR 607409109 248 29,700 SH   DFND 1 29,700 0 0
Moderna Inc COM 60770K107 694,462 5,303,260 SH   DFND 1 5,303,260 0 0
Moderna Inc COM 60770K107 3,499,885 26,726,883 SH   DFND 2 20,353,359 0 6,373,524
Moderna Inc COM 60770K107 314,833 2,404,223 SH   DFND 3 1,776,551 0 627,672
Moderna Inc COM 60770K107 1,427,800 10,903,398 SH   SOLE 0 9,542,957 0 1,360,441
Modine Manufacturing Co COM 607828100 8 558 SH   DFND 3 558 0 0
MongoDB Inc COM 60937P106 68 253 SH   DFND 3 253 0 0
Monolithic Power Systems Inc COM 609839105 29 83 SH   DFND 3 83 0 0
Moody's Corp COM 615369105 209,603 701,928 SH   DFND 1 701,928 0 0
Moody's Corp COM 615369105 763,988 2,558,481 SH   DFND 2 2,391,130 0 167,351
Moody's Corp COM 615369105 153,199 513,039 SH   DFND 3 235,475 0 277,564
Moody's Corp COM 615369105 481,283 1,611,744 SH   SOLE 0 1,346,300 0 265,444
NIO Inc ADR SPON ADS 62914V106 84,750 2,174,189 SH   DFND 1 2,174,189 0 0
NIO Inc ADR SPON ADS 62914V106 2,366,772 60,717,609 SH   DFND 2 46,249,493 0 14,468,116
NIO Inc ADR SPON ADS 62914V106 76,508 1,962,751 SH   DFND 3 1,576,263 0 386,488
NIO Inc ADR SPON ADS 62914V106 1,058,900 27,165,212 SH   SOLE 0 24,538,927 0 2,626,285
NV5 Global COM 62945V109 13 138 SH   DFND 3 138 0 0
NVIDIA COM 67066G104 323,768 606,387 SH   DFND 1 606,387 0 0
NVIDIA COM 67066G104 1,558,816 2,919,514 SH   DFND 2 1,207,247 0 1,712,267
NVIDIA COM 67066G104 162,038 303,482 SH   DFND 3 245,592 0 57,890
NVIDIA COM 67066G104 844,952 1,582,514 SH   SOLE 0 1,218,750 0 363,764
Nano Dimension ADR SPONS ADS 63008G203 14 1,600 SH   DFND 3 1,600 0 0
Nanobiotix ADR COM 63009J107 12,780 850,841 SH   DFND 1 850,841 0 0
Nanobiotix ADR COM 63009J107 8,248 549,159 SH   SOLE 0 549,159 0 0
National Instruments Corp COM 636518102 22,339 517,283 SH   DFND 1 517,283 0 0
National Instruments Corp COM 636518102 499 11,555 SH   DFND 2 0 0 11,555
National Instruments Corp COM 636518102 135 3,129 SH   DFND 3 3,129 0 0
National Instruments Corp COM 636518102 20,989 486,023 SH   SOLE 0 486,023 0 0
Nektar Therapeutics COM 640268108 31 1,542 SH   DFND 3 1,542 0 0
NetEase.com ADR SPONSORED ADR 64110W102 97,061 939,971 SH   DFND 1 939,971 0 0
NetEase.com ADR SPONSORED ADR 64110W102 567,752 5,498,281 SH   DFND 2 1,636,140 0 3,862,141
NetEase.com ADR SPONSORED ADR 64110W102 69,178 669,944 SH   DFND 3 538,845 0 131,099
NetEase.com ADR SPONSORED ADR 64110W102 164,281 1,590,947 SH   SOLE 0 703,060 0 887,887
Netflix Inc COM 64110L106 679,649 1,302,858 SH   DFND 1 1,302,858 0 0
Netflix Inc COM 64110L106 2,229,776 4,274,385 SH   DFND 2 2,269,158 0 2,005,227
Netflix Inc COM 64110L106 244,133 467,992 SH   DFND 3 354,279 0 113,713
Netflix Inc COM 64110L106 1,117,733 2,142,646 SH   SOLE 0 1,671,244 0 471,402
Nevro Corp COM 64157F103 21 154 SH   DFND 3 154 0 0
New Relic COM 64829B100 52 840 SH   DFND 3 840 0 0
Newmont Mining COM 651639106 392 6,510 SH   DFND 1 6,510 0 0
NextEra Energy COM 65339F101 55,895 739,248 SH   DFND 1 739,248 0 0
NextEra Energy COM 65339F101 113 1,500 SH   DFND 2 1,500 0 0
NextEra Energy COM 65339F101 3,104 41,059 SH   DFND 3 41,059 0 0
Nic Inc COM 62914B100 27 800 SH   DFND 3 800 0 0
Nike COM 654106103 14 105 SH   DFND 3 105 0 0
Novocure Ltd ORD SHS G6674U108 330,071 2,497,135 SH   DFND 1 2,497,135 0 0
Novocure Ltd ORD SHS G6674U108 535,839 4,053,858 SH   DFND 2 3,588,841 0 465,017
Novocure Ltd ORD SHS G6674U108 85,688 648,265 SH   DFND 3 466,451 0 181,814
Novocure Ltd ORD SHS G6674U108 220,037 1,664,674 SH   SOLE 0 1,498,499 0 166,175
Nucana Plc ADR SPONSORED ADR 67022C106 12,076 2,420,041 SH   DFND 1 2,420,041 0 0
Nucana Plc ADR SPONSORED ADR 67022C106 6,183 1,238,989 SH   SOLE 0 1,238,989 0 0
Nutanix Inc COM 67059N108 16 621 SH   DFND 3 621 0 0
OneConnect Financial Technology ADR COM 68248T105 30,370 2,054,800 SH   DFND 1 2,054,800 0 0
OneConnect Financial Technology ADR COM 68248T105 9,540 645,469 SH   DFND 2 215,951 0 429,518
OneConnect Financial Technology ADR COM 68248T105 4,339 293,568 SH   DFND 3 293,568 0 0
Opko Health Inc COM 68375N103 31 7,300 SH   DFND 3 7,300 0 0
Oscar Health Inc COM 687793109 35,214 1,310,029 SH   DFND 1 1,310,029 0 0
Oscar Health Inc COM 687793109 122,408 4,553,857 SH   DFND 2 4,045,343 0 508,514
Oscar Health Inc COM 687793109 27,840 1,035,696 SH   DFND 3 514,002 0 521,694
Oscar Health Inc COM 687793109 83,289 3,098,553 SH   SOLE 0 2,614,915 0 483,638
Oscar Health Inc - converted at IPO COM 687793109 32,351 1,203,533 SH   DFND 2 413,947 0 789,586
Oscar Health Inc - converted at IPO COM 687793109 28,580 1,063,253 SH   SOLE 0 1,063,253 0 0
Outset Medical COM 690145107 19 346 SH   DFND 3 346 0 0
Oxford Industries Inc COM 691497309 6 73 SH   DFND 3 73 0 0
Ozon Holdings COM 69269L104 13,854 247,078 SH   DFND 1 247,078 0 0
Ozon Holdings COM 69269L104 94,006 1,676,582 SH   DFND 2 872,602 0 803,980
Ozon Holdings COM 69269L104 364 6,494 SH   DFND 3 6,494 0 0
Pacific Biosciences of California COM 69404D108 19 561 SH   DFND 3 561 0 0
Pacira BioSciences COM 695127100 67,405 961,697 SH   DFND 1 961,697 0 0
Pacira BioSciences COM 695127100 35,158 501,612 SH   DFND 2 215,965 0 285,647
Pacira BioSciences COM 695127100 19,884 283,694 SH   DFND 3 252,519 0 31,175
Pacira BioSciences COM 695127100 24,425 348,478 SH   SOLE 0 348,478 0 0
PagerDuty COM 69553P100 25 615 SH   DFND 3 615 0 0
Paychex COM 704326107 11 116 SH   DFND 3 116 0 0
Peloton Interactive Inc CL A COM 70614W100 195,330 1,737,190 SH   DFND 1 1,737,190 0 0
Peloton Interactive Inc CL A COM 70614W100 1,141,348 10,150,730 SH   DFND 2 3,178,884 0 6,971,846
Peloton Interactive Inc CL A COM 70614W100 163,833 1,457,068 SH   DFND 3 1,147,740 0 309,328
Peloton Interactive Inc CL A COM 70614W100 315,335 2,804,477 SH   SOLE 0 1,273,041 0 1,531,436
Penumbra Inc COM 70975L107 136,217 503,425 SH   DFND 1 503,425 0 0
Penumbra Inc COM 70975L107 173,137 639,873 SH   DFND 2 611,432 0 28,441
Penumbra Inc COM 70975L107 6,935 25,630 SH   DFND 3 25,630 0 0
Penumbra Inc COM 70975L107 30,970 114,457 SH   SOLE 0 114,457 0 0
Pepsico COM 713448108 31,211 220,650 SH   DFND 1 220,650 0 0
Pepsico COM 713448108 710 5,017 SH   DFND 2 0 0 5,017
Pepsico COM 713448108 192 1,357 SH   DFND 3 1,357 0 0
Pepsico COM 713448108 29,654 209,640 SH   SOLE 0 209,640 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 123,190 14,527,147 SH   DFND 1 14,527,147 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 418,709 49,376,054 SH   DFND 2 22,495,595 0 26,880,459
Petrobras Common ADR SPONSORED ADR 71654V408 106,950 12,611,971 SH   DFND 3 1,820,790 0 10,791,181
Petrobras Common ADR SPONSORED ADR 71654V408 4,657 549,189 SH   DFND 4 549,189 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 10,639 1,254,653 SH   SOLE 0 1,254,653 0 0
Petrobras Pref ADR SP ADR NON VTG 71654V101 16,940 1,983,615 SH   DFND 1 1,983,615 0 0
Petrobras Pref ADR SP ADR NON VTG 71654V101 108,476 12,702,116 SH   DFND 2 7,137,758 0 5,564,358
Petrobras Pref ADR SP ADR NON VTG 71654V101 450 52,675 SH   DFND 3 52,675 0 0
Pinduoduo Inc ADR SPONSORED ADS 722304102 262,505 1,960,750 SH   DFND 1 1,960,750 0 0
Pinduoduo Inc ADR SPONSORED ADS 722304102 2,223,543 16,608,476 SH   DFND 2 6,569,249 0 10,039,227
Pinduoduo Inc ADR SPONSORED ADS 722304102 224,767 1,678,872 SH   DFND 3 1,356,949 0 321,923
Pinduoduo Inc ADR SPONSORED ADS 722304102 886,165 6,619,102 SH   SOLE 0 4,415,364 0 2,203,738
Pinterest COM 72352L106 178,540 2,411,724 SH   DFND 1 2,411,724 0 0
Pinterest COM 72352L106 233,877 3,159,215 SH   DFND 2 3,018,188 0 141,027
Pinterest COM 72352L106 9,048 122,226 SH   DFND 3 122,226 0 0
Pinterest COM 72352L106 42,953 580,211 SH   SOLE 0 580,211 0 0
Plantronics Inc COM 727493108 10 254 SH   DFND 3 254 0 0
Pluralsight COM CL A 72941B106 44 1,972 SH   DFND 3 1,972 0 0
Procter & Gamble COM 742718109 39,801 293,883 SH   DFND 1 293,883 0 0
Procter & Gamble COM 742718109 884 6,526 SH   DFND 2 0 0 6,526
Procter & Gamble COM 742718109 241 1,783 SH   DFND 3 1,783 0 0
Procter & Gamble COM 742718109 37,393 276,106 SH   SOLE 0 276,106 0 0
Progyny COM 74340E103 19 436 SH   DFND 3 436 0 0
Prologis Inc REIT COM 74340W103 60,685 572,500 SH   DFND 1 572,500 0 0
Prologis Inc REIT COM 74340W103 127 1,200 SH   DFND 2 1,200 0 0
Prologis Inc REIT COM 74340W103 2,735 25,800 SH   DFND 3 25,800 0 0
Proofpoint Inc COM 743424103 19 154 SH   DFND 3 154 0 0
Ptc Therapeutics Inc COM 69366J200 12 246 SH   DFND 3 246 0 0
Puma Biotechnology COM 74587V107 2 252 SH   DFND 3 252 0 0
Pure Storage Inc COM 74624M102 32 1,470 SH   DFND 3 1,470 0 0
Q2 Holdings Inc COM 74736L109 31,898 318,346 SH   DFND 1 318,346 0 0
Q2 Holdings Inc COM 74736L109 19,081 190,434 SH   DFND 2 63,487 0 126,947
Q2 Holdings Inc COM 74736L109 8,648 86,306 SH   DFND 3 86,306 0 0
Q2 Holdings Inc COM 74736L109 12,248 122,235 SH   SOLE 0 122,235 0 0
Quaker Chemical Corp COM 747316107 21 86 SH   DFND 3 86 0 0
Quanterix Corp COM 74766Q101 19,578 334,835 SH   DFND 1 334,835 0 0
Quanterix Corp COM 74766Q101 10,476 179,177 SH   SOLE 0 179,177 0 0
QuantumScape Corp COM CL A 74767V109 40,869 913,279 SH   SOLE 0 913,279 0 0
Quest Diagnostics COM 74834L100 21 160 SH   DFND 3 160 0 0
Quidel Corp COM 74838J101 16 128 SH   DFND 3 128 0 0
Rambus Inc COM 750917106 14 699 SH   DFND 3 699 0 0
Redfin COM 75737F108 263,622 3,958,889 SH   DFND 1 3,958,889 0 0
Redfin COM 75737F108 318,696 4,785,945 SH   DFND 2 4,577,659 0 208,286
Redfin COM 75737F108 20,496 307,790 SH   DFND 3 266,193 0 41,597
Redfin COM 75737F108 56,488 848,295 SH   SOLE 0 848,295 0 0
Regeneron Pharmaceuticals COM 75886F107 30 63 SH   DFND 3 63 0 0
Relay Therapeutics Inc COM 75943R102 911 26,347 SH   DFND 1 26,347 0 0
Relay Therapeutics Inc COM 75943R102 2,764 79,950 SH   DFND 2 79,950 0 0
Relay Therapeutics Inc COM 75943R102 2,247 64,989 SH   DFND 3 64,989 0 0
ResMed COM 761152107 77,733 400,642 SH   DFND 1 400,642 0 0
ResMed COM 761152107 276,311 1,424,139 SH   DFND 2 1,332,196 0 91,943
ResMed COM 761152107 62,871 324,043 SH   DFND 3 168,180 0 155,863
ResMed COM 761152107 184,708 952,004 SH   SOLE 0 801,058 0 150,946
Research in Motion COM 09228F103 26 3,082 SH   DFND 3 3,082 0 0
Rexford Industrial Realty REIT COM 76169C100 58,938 1,169,400 SH   DFND 1 1,169,400 0 0
Rexford Industrial Realty REIT COM 76169C100 126 2,500 SH   DFND 2 2,500 0 0
Rexford Industrial Realty REIT COM 76169C100 2,646 52,500 SH   DFND 3 52,500 0 0
Ringcentral Inc COM 76680R206 129 433 SH   DFND 3 433 0 0
Ritchie Bros Auctioneers (USA) COM 767744105 97,032 1,657,249 SH   DFND 2 1,545,186 0 112,063
Ritchie Bros. Auctioneers COM 767744105 68,159 1,164,258 SH   DFND 2 634,766 0 529,492
Ritchie Bros. Auctioneers COM 767744105 22,939 391,823 SH   SOLE 0 391,823 0 0
Robert Half International Inc COM 770323103 10 132 SH   DFND 3 132 0 0
Roku COM CL A 77543R102 465,377 1,428,544 SH   DFND 1 1,428,544 0 0
Roku COM CL A 77543R102 584,172 1,793,205 SH   DFND 2 1,713,742 0 79,463
Roku COM CL A 77543R102 23,241 71,343 SH   DFND 3 71,343 0 0
Roku COM CL A 77543R102 102,916 315,916 SH   SOLE 0 315,916 0 0
Rollins Inc COM 775711104 21 605 SH   DFND 3 605 0 0
Royal Caribbean Cruises COM V7780T103 22,537 263,257 SH   DFND 1 263,257 0 0
Royal Caribbean Cruises COM V7780T103 1,210 14,132 SH   DFND 3 14,132 0 0
Rubius Therapeutics Inc COM 78116T103 23,506 887,000 SH   DFND 1 887,000 0 0
Rubius Therapeutics Inc COM 78116T103 4,095 154,531 SH   DFND 2 59,484 0 95,047
Rubius Therapeutics Inc COM 78116T103 1,929 72,775 SH   DFND 3 72,775 0 0
Rubius Therapeutics Inc COM 78116T103 94,858 3,579,565 SH   SOLE 0 3,579,565 0 0
Ryanair ADR SPONSORED ADR NE 783513203 17,121 148,877 SH   DFND 1 148,877 0 0
Ryanair ADR SPONSORED ADR NE 783513203 1,155,644 10,049,078 SH   DFND 2 8,721,885 0 1,327,193
Ryanair ADR SPONSORED ADR NE 783513203 12,641 109,918 SH   DFND 3 32,679 0 77,239
Ryanair ADR SPONSORED ADR NE 783513203 7,527 65,456 SH   SOLE 0 65,456 0 0
S&P Global Inc COM 78409V104 82,659 234,247 SH   DFND 1 234,247 0 0
S&P Global Inc COM 78409V104 311,331 882,283 SH   DFND 2 826,823 0 55,460
S&P Global Inc COM 78409V104 60,827 172,377 SH   DFND 3 79,601 0 92,776
S&P Global Inc COM 78409V104 194,386 550,871 SH   SOLE 0 462,430 0 88,441
SCP Pool Corporation COM 73278L105 32 93 SH   DFND 3 93 0 0
SEA Ltd ADR ADR 81141R100 517,636 2,318,846 SH   DFND 1 2,318,846 0 0
SEA Ltd ADR ADR 81141R100 982,402 4,400,850 SH   DFND 2 3,676,209 0 724,641
SEA Ltd ADR ADR 81141R100 136,427 611,149 SH   DFND 3 287,037 0 324,112
SEA Ltd ADR ADR 81141R100 507,370 2,272,859 SH   SOLE 0 1,965,804 0 307,055
Sage Therapeutics Inc COM 78667J108 796 10,632 SH   DFND 1 10,632 0 0
Sage Therapeutics Inc COM 78667J108 2,461 32,882 SH   DFND 2 32,882 0 0
Sage Therapeutics Inc COM 78667J108 1,964 26,235 SH   DFND 3 26,235 0 0
Sailpoint Technologies Holding COM 78781P105 20 388 SH   DFND 3 388 0 0
Salesforce.com COM 79466L302 94,509 446,071 SH   DFND 1 446,071 0 0
Salesforce.com COM 79466L302 763,051 3,601,504 SH   DFND 2 1,187,700 0 2,413,804
Salesforce.com COM 79466L302 84,840 400,434 SH   DFND 3 321,583 0 78,851
Salesforce.com COM 79466L302 203,438 960,204 SH   SOLE 0 425,443 0 534,761
Sana Biotechnology Inc COM 799566104 57,198 1,708,922 SH   DFND 1 1,708,922 0 0
Sana Biotechnology Inc COM 799566104 72,202 2,157,230 SH   DFND 2 2,157,230 0 0
Sana Biotechnology Inc COM 799566104 4,199 125,446 SH   DFND 3 125,446 0 0
Sana Biotechnology Inc COM 799566104 30,406 908,448 SH   SOLE 0 908,448 0 0
Sana Biotechnology Inc - converted at IPO COM 799566104 170,279 5,087,499 SH   SOLE 0 5,087,499 0 0
Sarepta Therapeutics Inc COM 803607100 15 205 SH   DFND 3 205 0 0
Schrodinger COM 80810D103 18 242 SH   DFND 3 242 0 0
Schweitzer-Maudit Int. COM 808541106 13 265 SH   DFND 3 265 0 0
Seagen Inc COM 81181C104 20 147 SH   DFND 3 147 0 0
Seer COM CL A 81578P106 11 223 SH   DFND 3 223 0 0
Service Corp.Intl. COM 817565104 70,241 1,375,924 SH   DFND 1 1,375,924 0 0
Service Corp.Intl. COM 817565104 252,883 4,953,630 SH   DFND 2 4,626,386 0 327,244
Service Corp.Intl. COM 817565104 52,326 1,024,994 SH   DFND 3 471,061 0 553,933
Service Corp.Intl. COM 817565104 168,079 3,292,445 SH   SOLE 0 2,752,581 0 539,864
Shake Shack Inc COM 819047101 20 174 SH   DFND 3 174 0 0
Sherwin-Williams Co COM 824348106 12,274 16,631 SH   DFND 2 16,631 0 0
ShockWave Medical Inc COM 82489T104 21,673 166,381 SH   DFND 1 166,381 0 0
ShockWave Medical Inc COM 82489T104 26,739 205,276 SH   DFND 2 121,972 0 83,304
ShockWave Medical Inc COM 82489T104 15,987 122,729 SH   DFND 3 122,729 0 0
ShockWave Medical Inc COM 82489T104 11,188 85,892 SH   SOLE 0 85,892 0 0
Shopify 'A' CL A 82509L107 1,269,776 1,147,561 SH   DFND 1 1,147,561 0 0
Shopify 'A' CL A 82509L107 3,612,814 3,265,083 SH   DFND 2 2,266,494 0 998,589
Shopify 'A' CL A 82509L107 381,398 344,689 SH   DFND 3 238,478 0 106,211
Shopify 'A' CL A 82509L107 1,229,329 1,111,007 SH   SOLE 0 883,761 0 227,246
Silicon Laboratories Inc COM 826919102 18 127 SH   DFND 3 127 0 0
Silicon Motion Technology ADR COM 82706C108 18,690 314,693 SH   DFND 1 314,693 0 0
Silicon Motion Technology ADR COM 82706C108 346 5,822 SH   DFND 2 0 0 5,822
Silicon Motion Technology ADR COM 82706C108 115 1,937 SH   DFND 3 1,937 0 0
Silicon Motion Technology ADR COM 82706C108 17,773 299,259 SH   SOLE 0 299,259 0 0
Silk Road Medical COM 82710M100 12 235 SH   DFND 3 235 0 0
SiteOne Landscape Supply COM 82982L103 81,868 479,490 SH   DFND 1 479,490 0 0
SiteOne Landscape Supply COM 82982L103 288,900 1,692,045 SH   DFND 2 1,578,441 0 113,604
SiteOne Landscape Supply COM 82982L103 61,290 358,969 SH   DFND 3 166,410 0 192,559
SiteOne Landscape Supply COM 82982L103 188,172 1,102,097 SH   SOLE 0 922,326 0 179,771
Six Flags Entertainment Corp COM 83001A102 30,799 662,776 SH   DFND 1 662,776 0 0
Six Flags Entertainment Corp COM 83001A102 1,570 33,775 SH   DFND 3 33,775 0 0
Smartsheet COM 83200N103 23 353 SH   DFND 3 353 0 0
Snap Inc CL A 83304A106 101,361 1,938,439 SH   DFND 1 1,938,439 0 0
Snap Inc CL A 83304A106 132,815 2,539,973 SH   DFND 2 2,425,890 0 114,083
Snap Inc CL A 83304A106 5,127 98,057 SH   DFND 3 98,057 0 0
Snap Inc CL A 83304A106 24,326 465,206 SH   SOLE 0 465,206 0 0
Snowflake Inc COM 833445109 81,496 355,441 SH   DFND 1 355,441 0 0
Snowflake Inc COM 833445109 140,280 611,828 SH   DFND 2 572,359 0 39,469
Snowflake Inc COM 833445109 14,078 61,402 SH   DFND 3 36,035 0 25,367
Snowflake Inc COM 833445109 89,301 389,485 SH   SOLE 0 364,481 0 25,004
Sohu.com COM 83410S108 3,146 200,140 SH   DFND 3 0 0 200,140
Solaredge Technologies Inc COM 83417M104 57 200 SH   DFND 3 200 0 0
Sorrento Therapeutics COM 83587F202 46 5,531 SH   DFND 3 5,531 0 0
Splunk Inc COM 848637104 13,675 100,940 SH   DFND 1 100,940 0 0
Splunk Inc COM 848637104 19,085 140,866 SH   DFND 2 46,703 0 94,163
Splunk Inc COM 848637104 8,537 63,010 SH   DFND 3 63,010 0 0
Splunk Inc COM 848637104 10,010 73,884 SH   SOLE 0 73,884 0 0
Spotify Technology SA SHS L8681T102 343,842 1,283,232 SH   DFND 1 1,283,232 0 0
Spotify Technology SA SHS L8681T102 4,253,024 15,872,454 SH   DFND 2 11,252,658 0 4,619,796
Spotify Technology SA SHS L8681T102 144,309 538,568 SH   DFND 3 397,217 0 141,351
Spotify Technology SA SHS L8681T102 893,413 3,334,252 SH   SOLE 0 2,773,984 0 560,268
Sprout Social COM 85209W109 18,545 321,078 SH   DFND 1 321,078 0 0
Sprout Social COM 85209W109 10,527 182,258 SH   DFND 2 60,130 0 122,128
Sprout Social COM 85209W109 4,573 79,167 SH   DFND 3 79,167 0 0
Sprout Social COM 85209W109 8,541 147,870 SH   SOLE 0 147,870 0 0
Staar Surgical COM PAR $0.01 852312305 139,190 1,320,465 SH   DFND 1 1,320,465 0 0
Staar Surgical COM PAR $0.01 852312305 146,146 1,386,450 SH   DFND 2 953,235 0 433,215
Staar Surgical COM PAR $0.01 852312305 51,423 487,836 SH   DFND 3 378,114 0 109,722
Staar Surgical COM PAR $0.01 852312305 102,892 976,113 SH   SOLE 0 896,625 0 79,488
Stamps.Com COM NEW 852857200 11 55 SH   DFND 3 55 0 0
Stanley Black & Decker COM 854502101 15 77 SH   DFND 3 77 0 0
Stericycle Inc COM 858912108 40,479 599,594 SH   DFND 1 599,594 0 0
Stericycle Inc COM 858912108 149,068 2,208,083 SH   DFND 2 2,060,692 0 147,391
Stericycle Inc COM 858912108 30,150 446,594 SH   DFND 3 204,902 0 241,692
Stericycle Inc COM 858912108 99,494 1,473,773 SH   SOLE 0 1,233,441 0 240,332
Stitch Fix COM CL A 860897107 108,878 2,197,781 SH   DFND 1 2,197,781 0 0
Stitch Fix COM CL A 860897107 140,592 2,837,947 SH   DFND 2 2,709,182 0 128,765
Stitch Fix COM CL A 860897107 5,563 112,284 SH   DFND 3 112,284 0 0
Stitch Fix COM CL A 860897107 25,665 518,075 SH   SOLE 0 518,075 0 0
StoneCo COM CL A G85158106 6,370 104,056 SH   DFND 2 104,056 0 0
Stratasys SHS M85548101 5,861 226,300 SH   DFND 1 226,300 0 0
Stratasys SHS M85548101 9,415 363,520 SH   DFND 2 116,470 0 247,050
Stratasys SHS M85548101 3,968 153,190 SH   DFND 3 153,190 0 0
Stratasys SHS M85548101 3,745 144,600 SH   SOLE 0 144,600 0 0
Stryker COM 863667101 13 54 SH   DFND 3 54 0 0
Summit Therapeutics New Listing COM 86627T108 1,074 183,027 SH   DFND 1 183,027 0 0
Summit Therapeutics New Listing COM 86627T108 1,111 189,234 SH   SOLE 0 189,234 0 0
Sunpower Corp COM 867652406 53 1,591 SH   DFND 3 1,591 0 0
SurveyMonkey COM 78489X103 20 1,095 SH   DFND 3 1,095 0 0
Sutro Biopharma COM 869367102 23,726 1,042,428 SH   DFND 1 1,042,428 0 0
Sutro Biopharma COM 869367102 14,867 653,226 SH   SOLE 0 653,226 0 0
Symantec Corp COM 668771108 10 462 SH   DFND 3 462 0 0
Synopsys COM 871607107 34 137 SH   DFND 3 137 0 0
T. Rowe Price COM 74144T108 16,328 95,149 SH   DFND 1 95,149 0 0
T. Rowe Price COM 74144T108 373 2,176 SH   DFND 2 0 0 2,176
T. Rowe Price COM 74144T108 101 588 SH   DFND 3 588 0 0
T. Rowe Price COM 74144T108 15,445 90,006 SH   SOLE 0 90,006 0 0
TAL Education Group ADR ADS REPSTG COM 874080104 73,729 1,369,160 SH   DFND 1 1,369,160 0 0
TAL Education Group ADR ADS REPSTG COM 874080104 1,758,082 32,647,754 SH   DFND 2 24,111,125 0 8,536,629
TAL Education Group ADR ADS REPSTG COM 874080104 67,228 1,248,427 SH   DFND 3 1,003,439 0 244,988
TAL Education Group ADR ADS REPSTG COM 874080104 159,628 2,964,316 SH   SOLE 0 1,307,519 0 1,656,797
TJX Companies COM 872540109 8,735 132,048 SH   DFND 2 132,048 0 0
TSMC ADR SPONSORED ADR 874039100 51,009 431,260 SH   DFND 1 431,260 0 0
TSMC ADR SPONSORED ADR 874039100 710,051 6,003,136 SH   DFND 2 4,639,217 0 1,363,919
TSMC ADR SPONSORED ADR 874039100 2,399 20,279 SH   DFND 3 20,279 0 0
TSMC ADR SPONSORED ADR 874039100 159,047 1,344,661 SH   SOLE 0 1,172,587 0 172,074
Tabula Rasa HealthCare Inc COM 873379101 25,842 561,175 SH   DFND 1 561,175 0 0
Tabula Rasa HealthCare Inc COM 873379101 8,177 177,567 SH   DFND 2 58,076 0 119,491
Tabula Rasa HealthCare Inc COM 873379101 3,740 81,211 SH   DFND 3 81,211 0 0
Tabula Rasa HealthCare Inc COM 873379101 8,854 192,274 SH   SOLE 0 192,274 0 0
Tandem Diabetes Care COM NEW 875372203 17,490 198,192 SH   DFND 1 198,192 0 0
Tandem Diabetes Care COM NEW 875372203 17 188 SH   DFND 3 188 0 0
Tandem Diabetes Care COM NEW 875372203 13,094 148,377 SH   SOLE 0 148,377 0 0
Tata Motors Ltd ADR COM 876568502 85,042 4,090,544 SH   DFND 1 4,090,544 0 0
Tata Motors Ltd ADR COM 876568502 59,165 2,845,826 SH   DFND 2 2,845,826 0 0
Tata Motors Ltd ADR COM 876568502 923 44,402 SH   DFND 3 44,402 0 0
Tata Motors Ltd ADR COM 876568502 35,365 1,701,035 SH   SOLE 0 1,701,035 0 0
Teladoc COM 87918A105 415,597 2,286,643 SH   DFND 1 2,286,643 0 0
Teladoc COM 87918A105 595,044 3,273,972 SH   DFND 2 2,791,608 0 482,364
Teladoc COM 87918A105 164,298 903,980 SH   DFND 3 639,687 0 264,293
Teladoc COM 87918A105 267,987 1,474,484 SH   SOLE 0 1,308,614 0 165,870
Telus Corp COM 87971M103 8 397 SH   DFND 3 397 0 0
Tenable Holdings COM 88025T102 11 315 SH   DFND 3 315 0 0
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 82,746 4,038,349 SH   DFND 1 4,038,349 0 0
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 653,443 31,890,815 SH   DFND 2 23,948,057 0 7,942,758
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 38,859 1,896,502 SH   DFND 3 889,287 0 1,007,215
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 168,160 8,206,949 SH   SOLE 0 7,231,478 0 975,471
Teradyne COM 880770102 102,207 839,968 SH   DFND 1 839,968 0 0
Teradyne COM 880770102 530,819 4,362,418 SH   DFND 2 4,163,269 0 199,149
Teradyne COM 880770102 74,417 611,577 SH   DFND 3 281,385 0 330,192
Teradyne COM 880770102 233,303 1,917,347 SH   SOLE 0 1,602,405 0 314,942
Tesla Inc COM 88160R101 1,342,774 2,010,352 SH   DFND 1 2,010,352 0 0
Tesla Inc COM 88160R101 6,600,751 9,882,400 SH   DFND 2 7,158,310 0 2,724,090
Tesla Inc COM 88160R101 591,142 885,036 SH   DFND 3 655,199 0 229,837
Tesla Inc COM 88160R101 2,296,525 3,438,272 SH   SOLE 0 2,880,182 0 558,090
Texas Roadhouse Inc COM 882681109 13 131 SH   DFND 3 131 0 0
The Trade Desk COM CL A 88339J105 700,770 1,075,362 SH   DFND 1 1,075,362 0 0
The Trade Desk COM CL A 88339J105 1,398,400 2,145,905 SH   DFND 2 1,651,696 0 494,209
The Trade Desk COM CL A 88339J105 148,475 227,841 SH   DFND 3 155,418 0 72,423
The Trade Desk COM CL A 88339J105 443,427 680,458 SH   SOLE 0 533,947 0 146,511
Thermo Fisher Scientific COM 883556102 83,008 181,883 SH   DFND 1 181,883 0 0
Thermo Fisher Scientific COM 883556102 324,343 710,686 SH   DFND 2 666,739 0 43,947
Thermo Fisher Scientific COM 883556102 61,947 135,736 SH   DFND 3 62,627 0 73,109
Thermo Fisher Scientific COM 883556102 194,453 426,077 SH   SOLE 0 356,048 0 70,029
Thor Industries Inc COM 885160101 18 133 SH   DFND 3 133 0 0
TransMedics Group COM 89377M109 17 400 SH   DFND 3 400 0 0
Trimble Navigation COM 896239100 28 359 SH   DFND 3 359 0 0
Trip.com Group Sponsored ADR AMERICAN DEP SHS 89677Q107 141,034 3,558,770 SH   DFND 2 2,844,097 0 714,673
Trupanion COM 898202106 15,059 197,600 SH   DFND 1 197,600 0 0
Trupanion COM 898202106 26,602 349,065 SH   DFND 2 114,944 0 234,121
Trupanion COM 898202106 11,830 155,225 SH   DFND 3 155,225 0 0
Trupanion COM 898202106 56,014 735,000 SH   SOLE 0 735,000 0 0
Twilio Inc CL A 90138F102 510,544 1,498,250 SH   DFND 1 1,498,250 0 0
Twilio Inc CL A 90138F102 806,538 2,366,881 SH   DFND 2 2,254,001 0 112,880
Twilio Inc CL A 90138F102 68,444 200,857 SH   DFND 3 131,944 0 68,913
Twilio Inc CL A 90138F102 232,940 683,589 SH   SOLE 0 622,585 0 61,004
Ultragenyx COM 90400D108 13 115 SH   DFND 3 115 0 0
United Parcel Service CL B 911312106 46,824 275,450 SH   DFND 1 275,450 0 0
United Parcel Service CL B 911312106 1,042 6,129 SH   DFND 2 0 0 6,129
United Parcel Service CL B 911312106 283 1,665 SH   DFND 3 1,665 0 0
United Parcel Service CL B 911312106 43,928 258,418 SH   SOLE 0 258,418 0 0
Unity Biotechnology Inc COM 91381U101 1,488 248,000 SH   DFND 1 248,000 0 0
Unity Biotechnology Inc COM 91381U101 21,330 3,555,014 SH   SOLE 0 3,555,014 0 0
Upwork Inc COM 91688F104 97,459 2,176,888 SH   DFND 1 2,176,888 0 0
Upwork Inc COM 91688F104 53,646 1,198,258 SH   DFND 2 491,219 0 707,039
Upwork Inc COM 91688F104 28,991 647,548 SH   DFND 3 588,000 0 59,548
Upwork Inc COM 91688F104 54,354 1,214,079 SH   SOLE 0 1,214,079 0 0
Uxin ADR ADS 91818X108 1,417 1,211,500 SH   DFND 1 1,211,500 0 0
Uxin ADR ADS 91818X108 661 564,600 SH   SOLE 0 564,600 0 0
Vale SA ADR ADR 91912E105 50,124 2,884,021 SH   DFND 1 2,884,021 0 0
Vale SA ADR ADR 91912E105 349,638 20,117,285 SH   DFND 2 10,426,791 0 9,690,494
Vale SA ADR ADR 91912E105 1,344 77,347 SH   DFND 3 77,347 0 0
Varonis Systems Inc COM 922280102 33 639 SH   DFND 3 639 0 0
Vedanta Ltd ADR COM 92242Y100 15,159 1,206,000 SH   DFND 1 1,206,000 0 0
Vedanta Ltd ADR COM 92242Y100 677 53,880 SH   DFND 3 53,880 0 0
Vedanta Ltd ADR COM 92242Y100 18,122 1,441,655 SH   SOLE 0 1,441,655 0 0
Veeco Instruments COM 922417100 12,171 586,854 SH   DFND 1 586,854 0 0
Veeco Instruments COM 922417100 10,674 514,648 SH   DFND 2 169,068 0 345,580
Veeco Instruments COM 922417100 4,753 229,175 SH   DFND 3 229,175 0 0
Veeva Systems Inc Class A COM 922475108 1,207 4,619 SH   DFND 1 4,619 0 0
Veeva Systems Inc Class A COM 922475108 3,679 14,084 SH   DFND 2 14,084 0 0
Veeva Systems Inc Class A COM 922475108 3,015 11,541 SH   DFND 3 11,541 0 0
Verint Systems Inc COM 92343X100 18 395 SH   DFND 3 395 0 0
Verisk Analytics COM 92345Y106 10,163 57,521 SH   DFND 2 57,521 0 0
ViewRay COM 92672L107 4 911 SH   DFND 3 911 0 0
Vir Biotechnology Inc COM 92764N102 1,050 20,477 SH   DFND 1 20,477 0 0
Vir Biotechnology Inc COM 92764N102 3,143 61,306 SH   DFND 2 61,306 0 0
Vir Biotechnology Inc COM 92764N102 2,611 50,928 SH   DFND 3 50,928 0 0
Vir Biotechnology Inc COM 92764N102 188,901 3,684,437 SH   SOLE 0 3,684,437 0 0
Visa Inc-Class A Shares COM CL A 92826C839 15,316 72,337 SH   DFND 2 72,337 0 0
Voya Prime Rate Trust SH BEN INT 92913A100 2,003 431,655 SH   DFND 1 431,655 0 0
Voya Prime Rate Trust SH BEN INT 92913A100 1,891 407,624 SH   DFND 3 407,624 0 0
Vroom Inc COM 92918V109 162,627 4,170,986 SH   DFND 1 4,170,986 0 0
Vroom Inc COM 92918V109 241,821 6,202,137 SH   DFND 2 5,928,200 0 273,937
Vroom Inc COM 92918V109 8,098 207,694 SH   DFND 3 207,694 0 0
Vroom Inc COM 92918V109 37,296 956,550 SH   SOLE 0 956,550 0 0
Vuzix COM 92921W300 25 1,000 SH   DFND 3 1,000 0 0
Vyne Therapeutics Inc COM 92941V209 333 48,706 SH   DFND 1 48,706 0 0
Vyne Therapeutics Inc COM 92941V209 343 50,056 SH   SOLE 0 50,056 0 0
WD-40 Co COM 929236107 18 58 SH   DFND 3 58 0 0
WEC Energy Group COM 92939U106 1,426 15,233 SH   DFND 1 15,233 0 0
Wabtec COM 929740108 36,221 457,572 SH   DFND 1 457,572 0 0
Wabtec COM 929740108 140,137 1,770,304 SH   DFND 2 1,657,125 0 113,179
Wabtec COM 929740108 27,497 347,362 SH   DFND 3 161,073 0 186,289
Wabtec COM 929740108 85,989 1,086,273 SH   SOLE 0 905,517 0 180,756
Wal-Mart Stores COM 931142103 14 101 SH   DFND 3 101 0 0
Waters COM 941848103 6,289 22,132 SH   DFND 1 22,132 0 0
Waters COM 941848103 17,421 61,306 SH   DFND 2 61,306 0 0
Waters COM 941848103 3,045 10,717 SH   DFND 3 7,178 0 3,539
Waters COM 941848103 869 3,057 SH   SOLE 0 3,057 0 0
Watsco Inc COM 942622200 203,702 781,217 SH   DFND 1 781,217 0 0
Watsco Inc COM 942622200 238,533 914,797 SH   DFND 2 877,322 0 37,475
Watsco Inc COM 942622200 13,061 50,091 SH   DFND 3 44,135 0 5,956
Watsco Inc COM 942622200 64,788 248,468 SH   SOLE 0 248,468 0 0
Wayfair Inc Class A CL A 94419L101 820,668 2,607,366 SH   DFND 1 2,607,366 0 0
Wayfair Inc Class A CL A 94419L101 1,124,578 3,572,924 SH   DFND 2 3,323,480 0 249,444
Wayfair Inc Class A CL A 94419L101 102,603 325,981 SH   DFND 3 249,986 0 75,995
Wayfair Inc Class A CL A 94419L101 638,309 2,027,987 SH   SOLE 0 1,965,118 0 62,869
Wheaton Precious Metals COM 962879102 312 8,165 SH   DFND 1 8,165 0 0
Williams-Sonoma Inc COM 969904101 14 76 SH   DFND 3 76 0 0
Wix Com SHS M98068105 909,267 3,256,453 SH   DFND 2 1,854,679 0 1,401,774
Wix Com SHS M98068105 133 478 SH   DFND 3 478 0 0
Workday Inc CL A 98138H101 375,152 1,510,092 SH   DFND 1 1,510,092 0 0
Workday Inc CL A 98138H101 1,444,109 5,812,942 SH   DFND 2 2,634,090 0 3,178,852
Workday Inc CL A 98138H101 149,679 602,498 SH   DFND 3 488,620 0 113,878
Workday Inc CL A 98138H101 573,221 2,307,373 SH   SOLE 0 1,611,688 0 695,685
XPEL COM 98379L100 18 342 SH   DFND 3 342 0 0
Xencor Inc COM 98401F105 19 431 SH   DFND 3 431 0 0
Xperi Holding Corp COM 98390M103 45 2,066 SH   DFND 3 2,066 0 0
Xylem COM 98419M100 82,899 788,160 SH   DFND 1 788,160 0 0
Xylem COM 98419M100 23,081 219,441 SH   DFND 2 62,107 0 157,334
Xylem COM 98419M100 54,224 515,540 SH   DFND 3 372,361 0 143,179
Xylem COM 98419M100 9,337 88,771 SH   SOLE 0 88,771 0 0
Yatsen Holding Ltd ADR COM 985194109 17,013 1,377,603 SH   DFND 1 1,377,603 0 0
Yatsen Holding Ltd ADR COM 985194109 41,320 3,345,774 SH   DFND 2 1,734,485 0 1,611,289
Yatsen Holding Ltd ADR COM 985194109 170 13,736 SH   DFND 3 13,736 0 0
Yelp COM 985817105 10 262 SH   DFND 3 262 0 0
Yext Inc COM 98585N106 69,499 4,799,673 SH   DFND 1 4,799,673 0 0
Yext Inc COM 98585N106 73,755 5,093,578 SH   DFND 2 3,987,668 0 1,105,910
Yext Inc COM 98585N106 11,979 827,273 SH   DFND 3 804,316 0 22,957
Yext Inc COM 98585N106 23,102 1,595,432 SH   SOLE 0 1,595,432 0 0
Zai Lab ADR ADR 98887Q104 177,207 1,328,089 SH   DFND 1 1,328,089 0 0
Zai Lab ADR ADR 98887Q104 241,407 1,809,241 SH   DFND 2 873,296 0 935,945
Zai Lab ADR ADR 98887Q104 49,769 372,994 SH   DFND 3 195,612 0 177,382
Zai Lab ADR ADR 98887Q104 47,341 354,800 SH   SOLE 0 354,800 0 0
Zillow Group Inc Class A CL A 98954M101 153,004 1,164,589 SH   DFND 1 1,164,589 0 0
Zillow Group Inc Class A CL A 98954M101 252,724 1,923,612 SH   DFND 2 1,746,927 0 176,685
Zillow Group Inc Class A CL A 98954M101 17,469 132,964 SH   DFND 3 132,964 0 0
Zillow Group Inc Class A CL A 98954M101 45,572 346,869 SH   SOLE 0 346,869 0 0
Zillow Group Inc Class C CL C CAP STK 98954M200 198,426 1,530,592 SH   DFND 1 1,530,592 0 0
Zillow Group Inc Class C CL C CAP STK 98954M200 414,896 3,200,368 SH   DFND 2 2,496,447 0 703,921
Zillow Group Inc Class C CL C CAP STK 98954M200 105,767 815,849 SH   DFND 3 533,836 0 282,013
Zillow Group Inc Class C CL C CAP STK 98954M200 283,331 2,185,522 SH   SOLE 0 1,914,583 0 270,939
Zoom Video Communications Inc CL A 98980L101 486,926 1,515,534 SH   DFND 1 1,515,534 0 0
Zoom Video Communications Inc CL A 98980L101 1,345,929 4,189,142 SH   DFND 2 2,334,427 0 1,854,715
Zoom Video Communications Inc CL A 98980L101 121,423 377,922 SH   DFND 3 312,406 0 65,516
Zoom Video Communications Inc CL A 98980L101 648,383 2,018,062 SH   SOLE 0 1,621,666 0 396,396
Zuora Inc Class A COM CL A 98983V106 26,325 1,778,724 SH   DFND 1 1,778,724 0 0
Zuora Inc Class A COM CL A 98983V106 14,372 971,110 SH   DFND 2 321,798 0 649,312
Zuora Inc Class A COM CL A 98983V106 6,407 432,887 SH   DFND 3 432,887 0 0
Zuora Inc Class A COM CL A 98983V106 9,801 662,236 SH   SOLE 0 662,236 0 0
Zynex COM 98986M103 7 437 SH   DFND 3 437 0 0
Zynga Inc COM 98986T108 35 3,427 SH   DFND 3 3,427 0 0
iQIYI Inc ADR SPON ADR 46267X108 26,240 1,578,813 SH   DFND 1 1,578,813 0 0
iQIYI Inc ADR SPON ADR 46267X108 7,943 477,924 SH   DFND 2 477,924 0 0
iQIYI Inc ADR SPON ADR 46267X108 172 10,353 SH   DFND 3 10,353 0 0
iQIYI Inc ADR SPON ADR 46267X108 3,049 183,441 SH   SOLE 0 183,441 0 0
iRobot COM 462726100 15,246 124,785 SH   DFND 3 113,997 0 10,788
iRobot COM 462726100 28,871 236,300 SH   DFND 2 95,159 0 141,141
iRobot COM 462726100 24,408 199,768 SH   DFND 1 199,768 0 0
iRobot COM 462726100 37,103 303,674 SH   SOLE 0 303,674 0 0
iShares Physical Silver ETC COM 46428Q109 55,377 2,372,000 SH   DFND 1 2,372,000 0 0
iShares Physical Silver ETC COM 46428Q109 2,839 121,600 SH   DFND 3 121,600 0 0
j2 Global COM 48123V102 9 73 SH   DFND 3 73 0 0
nLIGHT COM 65487K100 18 542 SH   DFND 3 542 0 0