The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 51,149 265,460 SH   DFND 1 265,460 0 0
ABBVIE INC COM 00287Y109 2,594 23,973 SH   DFND 1 23,973 0 0
ADMA BIOLOGICS INC COM 000899104 53 30,075 SH   DFND 1 30,075 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108 237 89,815 SH   DFND 1 89,815 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 238 20,020 SH   DFND 1 20,020 0 0
ALPHABET INC CLASS A CL A 38259P508 373 181 SH   DFND 1 181 0 0
ALPHABET INC CLASS C CL C 38259P706 14,480 7,000 SH   DFND 1 0 0 7,000
ALPINE IMMUNE SCIENCES INC COM 02083G100 111 10,445 SH   DFND 1 10,445 0 0
ALTRIA GROUP INC COM 02209S103 19,893 388,840 SH   DFND 1 388,840 0 0
AMARIN CORP PLC-ADR SPONSORED ADR 023111206 93 15,000 SH   DFND 1 15,000 0 0
AMETEK INC COM 031100100 1,440 11,270 SH   DFND 1 11,270 0 0
AMGEN INC COM 031162100 8,116 32,620 SH   DFND 1 32,620 0 0
ANAVEX LIFE SCIENCES CORP COM 032797300 1,279 85,585 SH   DFND 1 85,585 0 0
ANHEUSER-BUSCH INBEV NV SPONSORED ADR 03524A108 7,100 112,960 SH   DFND 1 112,960 0 0
BANK OF AMERICA CORPORATION COM 060505104 1,808 46,740 SH   DFND 1 46,740 0 0
BANK OF NEW YORK MELLON CORP COM 064058100 31,971 676,070 SH   DFND 1 676,070 0 0
BECTON DICKINSON & CO COM 075887109 5,828 23,970 SH   DFND 1 23,970 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108 302,005 783 SH   DFND 1 783 0 0
BERKSHIRE HATHAWAY INC CLASS B CL B 084670702 1,888 7,390 SH   DFND 1 7,390 0 0
BHP BILLITON PLC SPONSORED ADR 05545E209 8,529 147,400 SH   DFND 1 147,400 0 0
BIODELIVERY SCIENCES INTERNATIONAL INC COM 09060J106 98 25,000 SH   DFND 1 25,000 0 0
BOEING CO COM 097023105 6,241 24,500 SH   DFND 1 24,500 0 0
BRISTOL-MYERS SQUIBB COMPANY COM 110122108 712 11,280 SH   DFND 1 11,280 0 0
BRITISH AMERICAN TOBACCO PLC SPONSORED ADR 110448107 916 23,650 SH   DFND 1 23,650 0 0
CIGNA CORPORATION COM 125509109 5,536 22,899 SH   DFND 1 22,899 0 0
CISCO SYSTEMS INC COM 17275R102 2,301 44,500 SH   DFND 1 44,500 0 0
COCA COLA CO COM 191216100 2,551 48,400 SH   DFND 1 48,400 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 61 19,959 SH   DFND 1 19,959 0 0
DANAHER CORP COM 235851102 42,459 188,640 SH   DFND 1 188,640 0 0
ECOLAB INC COM 278865100 450 2,100 SH   DFND 1 2,100 0 0
EXXON MOBIL CORPORATION COM 30231G102 15,094 270,350 SH   DFND 1 270,350 0 0
FORTIVE CORP COM 34959J108 4,640 65,680 SH   DFND 1 65,680 0 0
GILEAD SCIENCES INC COM 375558103 1,204 18,630 SH   DFND 1 18,630 0 0
HONEYWELL INTERNATIONAL INC COM 438516106 3,517 16,200 SH   DFND 1 16,200 0 0
INTUITIVE SURGICAL INC COM 46120E602 12,835 17,370 SH   DFND 1 17,370 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 2,079 13,700 SH   DFND 1 13,700 0 0
JOHNSON & JOHNSON COM 478160104 55,787 339,440 SH   DFND 1 339,440 0 0
THE KRAFT HEINZ COMPANY COM 500754106 1,186 29,650 SH   DFND 1 29,650 0 0
LINDE PUBLIC LIMITED COMPANY COM G5494J103 43,892 156,680 SH   DFND 1 156,680 0 0
LOCKHEED MARTIN CORP COM 539830109 2,287 6,190 SH   DFND 1 6,190 0 0
MASTERCARD INC CL A 57636Q104 3,561 10,000 SH   DFND 1 10,000 0 0
MEDTRONIC INC COM 585055106 9,339 79,060 SH   DFND 1 79,060 0 0
MERCK & CO INC COM 58933Y105 600 7,780 SH   DFND 1 7,780 0 0
METLIFE INC COM 59156R108 643 10,580 SH   DFND 1 10,580 0 0
MOODYS CORPORATION COM 20775CZK3 15,513 51,950 SH   DFND 1 51,950 0 0
NASDAQ INC COM 631103108 4,940 33,500 SH   DFND 1 33,500 0 0
NESTLE SA SPONSORED ADR 641069406 26,442 237,130 SH   DFND 1 237,130 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 7,881 116,900 SH   DFND 1 116,900 0 0
NOVOCURE LIMITED COM G6674U108 225 1,700 SH   DFND 1 1,700 0 0
NUTRIEN LTD COM 67077M108 19,406 360,110 SH   DFND 1 360,110 0 0
PARKER HANNIFIN CORPORATION COM 701094104 710 2,250 SH   DFND 1 2,250 0 0
PHILLIPS 66 COM 718546104 14,459 177,330 SH   DFND 1 177,330 0 0
PRUDENTIAL FINANCIAL INC COM 744320102 578 6,350 SH   DFND 1 6,350 0 0
ROCHE HOLDING AG COM 771195104 9,293 229,120 SH   DFND 1 229,120 0 0
ROPER TECHNOLOGIES INC COM 776696106 28,952 71,780 SH   DFND 1 71,780 0 0
ROYAL DUTCH SHELL PLC CLASS B COM 780259107 11,133 302,280 SH   DFND 1 302,280 0 0
STORE CAPITAL CORPORATION REIT 862121100 1,229 36,700 SH   DFND 1 36,700 0 0
TG THERAPEUTICS INC COM 88322Q108 241 5,000 SH   DFND 1 5,000 0 0
UNION PACIFIC CORP COM 907818108 899 4,080 SH   DFND 1 4,080 0 0
US BANCORP COM 902973304 21,755 393,330 SH   DFND 1 393,330 0 0
VANGUARD FTSE EMERGING MARKETS ETF COM 922042858 3,061 58,810 SH   DFND 1 58,810 0 0
VANGUARD S&P 500 ETF ETF 922908363 6,995 19,200 SH   DFND 1 19,200 0 0
VISA INC CLASS A CL A 92826C839 32,458 153,300 SH   DFND 1 153,300 0 0
VONTIER CORP COM 928881101 956 31,576 SH   DFND 1 31,576 0 0
WABTEC CORPORATION COM 929740108 5,860 74,023 SH   DFND 1 74,023 0 0
WATERS CORPORATION COM 941848103 13,239 46,590 SH   DFND 1 46,590 0 0
WELLS FARGO & CO COM 949746101 45,870 1,174,040 SH   DFND 1 1,174,040 0 0
VEEVA SYSTEMS INC-CLASS A CL A 922475108 522 2,000 SH   DFND 1 2,000 0 0