The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 22,691 519,844 SH   SOLE   519,844 0 0
4D MOLECULAR THERAPEUTICS IN COM 35104E100 24,881 600,256 SH   SOLE   600,256 0 0
908 DEVICES INC COM 65443P102 4,414 77,500 SH   SOLE   77,500 0 0
ABCELLERA BIOLOGICS INC COM 00288U106 805 20,000 SH   SOLE   20,000 0 0
ACCOLADE INC COM 00437E102 27,256 626,591 SH   SOLE   626,591 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 2,156 400,000 SH   SOLE   400,000 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 53,504 904,854 SH   SOLE   904,854 0 0
ADMA BIOLOGICS INC COM 000899104 32,340 16,584,802 SH   SOLE   16,584,802 0 0
AGILE THERAPEUTICS INC COM 00847L100 45,690 15,919,925 SH   SOLE   15,919,925 0 0
ALBIREO PHARMA INC COM 01345P106 88,529 2,360,139 SH   SOLE   2,360,139 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 43,118 6,285,458 SH   SOLE   6,285,458 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 28,869 1,143,790 SH   SOLE   1,143,790 0 0
AMERICAN WELL CORP CL A 03044L105 13,298 525,000 SH   SOLE   525,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 579,837 25,112,048 SH   SOLE   25,112,048 0 0
AMYRIS INC COM NEW 03236M200 20,583 3,333,332 SH   SOLE   3,333,332 0 0
ANAPTYSBIO INC COM 032724106 25,700 1,195,336 SH   SOLE   1,195,336 0 0
ANAVEX LIFE SCIENCES CORP COM NEW 032797300 4,212 780,007 SH   SOLE   780,007 0 0
AQUESTIVE THERAPEUTICS INC COM 03843E104 7,414 1,385,720 SH   SOLE   1,385,720 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 44,178 575,007 SH   SOLE   575,007 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 82,164 1,070,814 SH   SOLE   1,070,814 0 0
ATEA PHARMACEUTICALS INC COM 04683R106 129,903 3,109,224 SH   SOLE   3,109,224 0 0
ATHENEX INC COM 04685N103 149,669 13,532,467 SH   SOLE   13,532,467 0 0
ATHIRA PHARMA INC COM 04746L104 106,682 3,114,805 SH   SOLE   3,114,805 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 31,538 1,235,818 SH   SOLE   1,235,818 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 11,140 1,000,000 SH   SOLE   1,000,000 0 0
BCTG ACQUISITION CORP COM 05492W103 5,720 500,000 SH   SOLE   500,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 476,883 6,706,268 SH   SOLE   6,706,268 0 0
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 3,465 150,000 SH   SOLE   150,000 0 0
C4 THERAPEUTICS INC COM STK 12529R107 104,643 3,158,566 SH   SOLE   3,158,566 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 75,340 4,544,062 SH   SOLE   4,544,062 0 0
COGENT BIOSCIENCES INC COM 19240Q201 35,810 3,188,750 SH   SOLE   3,188,750 0 0
COHERUS BIOSCIENCES INC COM 19249H103 81,197 4,671,836 SH   SOLE   4,671,836 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 41,223 2,058,068 SH   SOLE   2,058,068 0 0
COLLEGIUM PHARMACEUTICAL INC NOTE 2.625% 2/1 19459JAA2 173,250 17,500,000 PRN   SOLE   17,500,000 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 49,898 1,047,404 SH   SOLE   1,047,404 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 27,184 2,150,641 SH   SOLE   2,150,641 0 0
CONSONANCE HFW ACQUISITION C UNIT 99/99/9999 G2445M129 5,235 500,000 SH   SOLE   500,000 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 51,634 3,659,381 SH   SOLE   3,659,381 0 0
CURIS INC COM NEW 231269200 10,238 1,250,000 SH   SOLE   1,250,000 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 16,880 2,577,043 SH   SOLE   2,577,043 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 17,280 6,595,505 SH   SOLE   6,595,505 0 0
DEERFIELD HEALTHCARE TECH AC COM CL A 244413100 312 20,000 SH   SOLE   20,000 0 0
DEERFIELD HEALTHCARE TECH AC UNIT 07/16/2025 244413209 4,500 300,000 SH   SOLE   300,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 17,624 800,000 SH   SOLE   800,000 0 0
DYNE THERAPEUTICS INC COM 26818M108 8,400 400,000 SH   SOLE   400,000 0 0
EIDOS THERAPEUTICS INC COM 28249H104 90,385 686,922 SH   SOLE   686,922 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,719 139,890 SH   SOLE   139,890 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 26,221 696,633 SH   SOLE   696,633 0 0
FERRARI N V COM N3167Y103 1,423 6,200 SH   SOLE   6,200 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 43,625 1,250,000 SH   SOLE   1,250,000 0 0
FORTE BIOSCIENCES INC COM 34962G109 12,744 350,000 SH   SOLE   350,000 0 0
FREQUENCY THERAPEUTICS INC COM 35803L108 114,935 3,259,635 SH   SOLE   3,259,635 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 26,273 2,235,983 SH   SOLE   2,235,983 0 0
GALERA THERAPEUTICS INC COM 36338D108 3,325 325,000 SH   SOLE   325,000 0 0
GERON CORP COM 374163103 21,404 13,461,538 SH   SOLE   13,461,538 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 245,771 5,674,711 SH   SOLE   5,674,711 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 18,170 502,622 SH   SOLE   502,622 0 0
HEALTH CATALYST INC COM 42225T107 12,018 276,084 SH   SOLE   276,084 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 5,765 450,000 SH   SOLE   450,000 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 225,597 3,084,042 SH   SOLE   3,084,042 0 0
IMMATICS N.V SHS N44445109 26,975 2,500,000 SH   SOLE   2,500,000 0 0
IMMUNOVANT INC COM 45258J102 64,666 1,400,000 SH   SOLE   1,400,000 0 0
INARI MED INC COM 45332Y109 58,353 668,500 SH   SOLE   668,500 0 0
INVITAE CORP COM 46185L103 304,563 7,284,466 SH   SOLE   7,284,466 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 425,316 9,166,304 SH   SOLE   9,166,304 0 0
IVERIC BIO INC COM 46583P102 30,976 4,482,713 SH   SOLE   4,482,713 0 0
KADMON HLDGS INC COM 48283N106 65,202 15,711,334 SH   SOLE   15,711,334 0 0
KODIAK SCIENCES INC COM 50015M109 110,408 751,533 SH   SOLE   751,533 0 0
KRONOS BIO INC COM 50107A104 83,041 2,780,097 SH   SOLE   2,780,097 0 0
LEAP THERAPEUTICS INC COM 52187K101 19,072 8,476,496 SH   SOLE   8,476,496 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 704 25,000 SH   SOLE   25,000 0 0
LIFESCI ACQUISITION II CORP COM 53229E103 3,201 300,000 SH   SOLE   300,000 0 0
LONGVIEW ACQUISITION CORP UNIT 99/99/9999 543195200 15,155 700,000 SH   SOLE   700,000 0 0
LYRA THERAPEUTICS INC COM 55234L105 36,737 3,222,561 SH   SOLE   3,222,561 0 0
MACROGENICS INC COM 556099109 28,828 1,261,060 SH   SOLE   1,261,060 0 0
MARAVAI LIFESCIENCES HLDGS I COM LA A 56600D107 9,818 350,000 SH   SOLE   350,000 0 0
MEIRAGTX HLDGS PLC COM G59665102 104,970 6,933,277 SH   SOLE   6,933,277 0 0
MIRATI THERAPEUTICS INC COM 60468T105 811,244 3,693,516 SH   SOLE   3,693,516 0 0
MOLECULAR TEMPLATES INC COM 608550109 3,867 411,818 SH   SOLE   411,818 0 0
MORPHIC HLDG INC COM 61775R105 16,339 487,000 SH   SOLE   487,000 0 0
MOTUS GI HLDGS INC COM 62014P108 3,906 4,210,542 SH   SOLE   4,210,542 0 0
NANOBIOTIX SA SPONSORED ADS 63009J107 18,150 1,100,000 SH   SOLE   1,100,000 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 22,592 337,800 SH   SOLE   337,800 0 0
NEPTUNE WELLNESS SOLUTIONS I COM 64079L105 34,655 22,214,683 SH   SOLE   22,214,683 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 182,040 1,899,215 SH   SOLE   1,899,215 0 0
NEVRO CORP COM 64157F103 169,217 977,565 SH   SOLE   977,565 0 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7 165,420 9,000,000 PRN   SOLE   9,000,000 0 0
NOVAVAX INC COM NEW 670002401 116,305 1,043,000 SH   SOLE   1,043,000 0 0
ONCORUS INC COM 68236R103 64,336 1,989,987 SH   SOLE   1,989,987 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 93 420,875 SH   SOLE   420,875 0 0
OUTSET MED INC COM 690145107 161,870 2,847,822 SH   SOLE   2,847,822 0 0
PHREESIA INC COM 71944F106 5,426 100,000 SH   SOLE   100,000 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 54,471 885,556 SH   SOLE   885,556 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 8,642 787,745 SH   SOLE   787,745 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 4,104 203,591 SH   SOLE   203,591 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 14,733 608,544 SH   SOLE   608,544 0 0
PROVENTION BIO INC COM 74374N102 71,561 4,224,389 SH   SOLE   4,224,389 0 0
PULMONX CORP COM 745848101 26,573 385,000 SH   SOLE   385,000 0 0
QUOTIENT LTD SHS G73268107 84,406 16,200,818 SH   SOLE   16,200,818 0 0
RAPT THERAPEUTICS INC COM 75382E109 31,155 1,577,481 SH   SOLE   1,577,481 0 0
REGENERON PHARMACEUTICALS COM 75886F107 26,656 55,175 SH   SOLE   55,175 0 0
RELAY THERAPEUTICS INC COM 75943R102 96,810 2,329,407 SH   SOLE   2,329,407 0 0
REPLIGEN CORP COM 759916109 18,684 97,500 SH   SOLE   97,500 0 0
RETROPHIN INC NOTE 2.500% 9/1 761299AB2 442,521 45,000,000 PRN   SOLE   45,000,000 0 0
REVOLUTION MEDICINES INC COM 76155X100 8,877 224,224 SH   SOLE   224,224 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 186,284 3,396,867 SH   SOLE   3,396,867 0 0
SAGE THERAPEUTICS INC COM 78667J108 38,064 440,000 SH   SOLE   440,000 0 0
SC HEALTH CORP UNIT 99/99/9999 G78516302 10,990 1,000,000 SH   SOLE   1,000,000 0 0
SCYNEXIS INC COM NEW 811292200 18,360 2,400,000 SH   SOLE   2,400,000 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 1,068 66,655 SH   SOLE   66,655 0 0
SIGILON THERAPEUTICS INC COM 82657L107 6,004 125,000 SH   SOLE   125,000 0 0
SILK RD MED INC COM 82710M100 29,292 465,100 SH   SOLE   465,100 0 0
SOCIAL CAPITAL HEDOSOPHIA HLD SHS CL A G8251L105 671 40,000 SH   SOLE   40,000 0 0
SOLID BIOSCIENCES INC COM 83422E105 81,893 10,803,857 SH   SOLE   10,803,857 0 0
SOTERA HEALTH CO COM 83601L102 8,232 300,000 SH   SOLE   300,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 28,156 200,000 SH Put SOLE   200,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 302,968 4,177,721 SH   SOLE   4,177,721 0 0
STOKE THERAPEUTICS INC COM 86150R107 41,616 671,978 SH   SOLE   671,978 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 6,672 300,000 SH   SOLE   300,000 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 53,580 1,296,416 SH   SOLE   1,296,416 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 12,485 470,440 SH   SOLE   470,440 0 0
TCR2 THERAPEUTICS INC COM 87808K106 12,372 400,000 SH   SOLE   400,000 0 0
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 20,880 1,500,000 SH   SOLE   1,500,000 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 95,218 3,493,607 SH   SOLE   3,493,607 0 0
UROVANT SCIENCES LTD SHS G9381B108 50,274 3,116,831 SH   SOLE   3,116,831 0 0
VANECK VECTORS ETF TR PHARMACEUTICAL 92189F692 13,294 200,000 SH Put SOLE   200,000 0 0
VAXCYTE INC COM 92243G108 22,585 850,000 SH   SOLE   850,000 0 0
VBI VACCINES INC COM NEW 91822J103 151,366 55,042,465 SH   SOLE   55,042,465 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 20,222 2,888,889 SH   SOLE   2,888,889 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 39,254 3,410,412 SH   SOLE   3,410,412 0 0
VERU INC COM 92536C103 28,113 3,250,000 SH   SOLE   3,250,000 0 0
VIATRIS INC COM 92556V106 18,823 1,004,419 SH   SOLE   1,004,419 0 0
VIEWRAY INC COM 92672L107 9,366 2,451,748 SH   SOLE   2,451,748 0 0
VINCERA PHARMA INC COM 92731L106 6,273 300,000 SH   SOLE   300,000 0 0
VINCERA PHARMA INC *W EXP 12/24/202 92731L114 990 300,000 SH   SOLE   300,000 0 0
VYNE THERAPEUTICS INC COM NEW 92941V100 36,145 22,876,410 SH   SOLE   22,876,410 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 19,675 2,500,000 SH   SOLE   2,500,000 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 54,537 1,050,003 SH   SOLE   1,050,003 0 0
ZYMEWORKS INC COM 98985W102 203,265 4,300,999 SH   SOLE   4,300,999 0 0