The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 38,518 | 720,502 | SH | DFND | 1,2 | 720,502 | 0 | 0 | |
| ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 26,516 | 345,120 | SH | DFND | 1,2 | 345,120 | 0 | 0 | |
| ARVINAS INC | COM | 04335A105 | 13,941 | 164,150 | SH | DFND | 1,2 | 164,150 | 0 | 0 | |
| AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 2,420 | 175,000 | SH | DFND | 1,2 | 175,000 | 0 | 0 | |
| CALITHERA BIOSCIENCES INC | COM | 13089P101 | 9,059 | 1,845,000 | SH | DFND | 1,2 | 1,845,000 | 0 | 0 | |
| CALITHERA BIOSCIENCES INC | COM | 13089P101 | 2,455 | 500,000 | SH | Call | DFND | 1,2 | 500,000 | 0 | 0 |
| COLLEGIUM PHARMACEUTICAL INC | COM | 19459J104 | 8,440 | 421,383 | SH | DFND | 1,2 | 421,383 | 0 | 0 | |
| CONSTELLATION PHARMCETICLS I | COM | 210373106 | 29,514 | 1,024,800 | SH | DFND | 1,2 | 1,024,800 | 0 | 0 | |
| EXELIXIS INC | COM | 30161Q104 | 9,533 | 475,000 | SH | DFND | 1,2 | 475,000 | 0 | 0 | |
| FIBROGEN INC | COM | 31572Q808 | 6,176 | 166,500 | SH | Call | DFND | 1,2 | 166,500 | 0 | 0 |
| FORMA THERAPEUTICS HLDGS INC | SHS | 34633R104 | 8,250 | 236,400 | SH | DFND | 1,2 | 236,400 | 0 | 0 | |
| GERON CORP | COM | 374163103 | 8,038 | 5,055,189 | SH | DFND | 1,2 | 5,055,189 | 0 | 0 | |
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 25,790 | 595,473 | SH | DFND | 1,2 | 595,473 | 0 | 0 | |
| GW PHARMACEUTICALS PLC | ADS | 36197T103 | 45,010 | 390,000 | SH | DFND | 1,2 | 390,000 | 0 | 0 | |
| INSULET CORP | COM | 45784P101 | 15,338 | 60,000 | SH | DFND | 1,2 | 60,000 | 0 | 0 | |
| INTERSECT ENT INC | COM | 46071F103 | 29,836 | 1,302,871 | SH | DFND | 1,2 | 1,302,871 | 0 | 0 | |
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 4,241 | 75,000 | SH | DFND | 1,2 | 75,000 | 0 | 0 | |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 42,569 | 917,427 | SH | DFND | 1,2 | 917,427 | 0 | 0 | |
| KADMON HLDGS INC | COM | 48283N106 | 16,948 | 4,083,909 | SH | DFND | 1,2 | 4,083,909 | 0 | 0 | |
| MACROGENICS INC | COM | 556099109 | 28,330 | 1,239,287 | SH | DFND | 1,2 | 1,239,287 | 0 | 0 | |
| MERSANA THERAPEUTICS INC | COM | 59045L106 | 12,971 | 487,452 | SH | DFND | 1,2 | 487,452 | 0 | 0 | |
| MILLENDO THERAPEUTICS INC | COM | 60040X103 | 578 | 270,000 | SH | DFND | 1,2 | 270,000 | 0 | 0 | |
| OCULAR THERAPEUTIX INC | COM | 67576A100 | 17,723 | 856,162 | SH | DFND | 1,2 | 856,162 | 0 | 0 | |
| PROTHENA CORP PLC | SHS | G72800108 | 11,742 | 977,647 | SH | DFND | 1,2 | 977,647 | 0 | 0 | |
| PULMONX CORP | COM | 745848101 | 4,441 | 64,345 | SH | DFND | 1,2 | 64,345 | 0 | 0 | |
| PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 13,338 | 1,300,000 | SH | DFND | 1,2 | 1,300,000 | 0 | 0 | |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 38,388 | 700,000 | SH | DFND | 1,2 | 700,000 | 0 | 0 | |
| SAGE THERAPEUTICS INC | COM | 78667J108 | 39,312 | 454,417 | SH | DFND | 1,2 | 454,417 | 0 | 0 | |
| SILVERBACK THERAPEUTICS INC | COM | 82835W108 | 3,244 | 70,000 | SH | DFND | 1,2 | 70,000 | 0 | 0 | |
| THERAVANCE BIOPHARMA INC | COM | G8807B106 | 14,653 | 824,580 | SH | DFND | 1,2 | 824,580 | 0 | 0 | |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 | 22,769 | 150,000 | SH | DFND | 1,2 | 150,000 | 0 | 0 | |
| VERICEL CORP | COM | 92346J108 | 27,792 | 900,000 | SH | DFND | 1,2 | 900,000 | 0 | 0 | |
| ZYMEWORKS INC | COM | 98985W102 | 37,795 | 799,722 | SH | DFND | 1,2 | 799,722 | 0 | 0 | |