The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris Therapeutics COMM 00461U105 12,368 1,911,573 SH   SOLE   1,911,573 0 0
Akouos, Inc ADR 00973J101 30,044 1,515,074 SH   SOLE   1,515,074 0 0
Amarin Corp ADR 023111206 5,724 1,170,584 SH   SOLE   1,170,584 0 0
Ascendis Pharma A/S ADR 04351P101 185,105 1,109,874 SH   SOLE   1,109,874 0 0
Athira Pharma, Inc. COMM 04746L104 17,439 509,168 SH   SOLE   509,168 0 0
Checkmate Pharmaceuticals Inc COMM 162818108 52,622 3,606,707 SH   SOLE   3,606,707 0 0
Coherus BioSciences COMM 19249H103 7,553 434,555 SH   SOLE   434,555 0 0
Galera Therapeutics, Inc COMM 36338D108 31,546 3,083,712 SH   SOLE   3,083,712 0 0
Inozyme Pharma, Inc. COMM 45790W108 41,864 2,028,308 SH   SOLE   2,028,308 0 0
Karuna Therapeutics, Inc. COMM 48576A100 198,348 1,952,441 SH   SOLE   1,952,441 0 0
Merus N.V. COMM N5749R100 22,983 1,311,039 SH   SOLE   1,311,039 0 0
Natera COMM 632307104 308,568 3,100,560 SH   SOLE   3,100,560 0 0
Nextcure, Inc COMM 00653E112 29,123 2,671,856 SH   SOLE   2,671,856 0 0
Nucana Biomed Ltd ADR 67022C106 25,144 5,599,999 SH   SOLE   5,599,999 0 0
Nucana Biomed Ltd Ordinary Shares GBOOBYWYV 10,776 2,400,000 SH   SOLE   2,400,000 0 0
ObsEva SA COMM H5861P103 9,879 4,749,623 SH   SOLE   4,749,623 0 0
PDS Biotechnology Corporation COMM 70465T107 305 142,635 SH   SOLE   142,635 0 0
Synlogic Inc. COMM 87166L100 1,242 574,972 SH   SOLE   574,972 0 0
Y-mAbs Therapeutics, Inc COMM 984241109 108,639 2,194,278 SH   SOLE   2,194,278 0 0
ACADIA Pharmaceuticals Inc COMM 004225108 8,801 164,625 SH   SOLE   164,625 0 0
Abbvie Inc COMM 00287Y109 31,459 293,596 SH   SOLE   293,596 0 0
Acceleron Pharma Inc COMM 00434H108 4,694 36,688 SH   SOLE   36,688 0 0
Aligos Therapeutics Inc COMM 01626L105 5,283 191,061 SH   SOLE   191,061 0 0
Amgen Inc COMM 031162100 37,859 164,663 SH   SOLE   164,663 0 0
Aptose Biosciences Inc COMM 03835T200 4,297 981,135 SH   SOLE   981,135 0 0
Arcus Biosciences Inc COMM 03969F109 4,836 186,278 SH   SOLE   186,278 0 0
Arena Pharmaceuticals Inc COMM 040047607 9,325 121,373 SH   SOLE   121,373 0 0
AstraZeneca PLC ADR 046353108 42,122 842,600 SH   SOLE   842,600 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 8,365 1,122,800 SH   SOLE   1,122,800 0 0
Bioatla Inc COMM 09077B104 102 3,000 SH   SOLE   3,000 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 14,429 164,545 SH   SOLE   164,545 0 0
Calithera Biosciences Inc COMM 13089P101 2,457 500,326 SH   SOLE   500,326 0 0
Calithera Biosciences Inc COMM 13089P101 123 25,000 SH Call SOLE   25,000 0 0
Calithera Biosciences Inc COMM 13089P101 737 150,000 SH Call SOLE   150,000 0 0
Calithera Biosciences Inc COMM 13089P101 1,964 400,000 SH Put SOLE   400,000 0 0
ChemoCentryx Inc COMM 16383L106 7,010 113,213 SH   SOLE   113,213 0 0
Cytokinetics Inc COMM 23282W605 10,564 508,394 SH   SOLE   508,394 0 0
Eli Lilly and Co COMM 532457108 6,232 36,909 SH   SOLE   36,909 0 0
Fate Therapeutics Inc COMM 31189P102 1,227 13,497 SH   SOLE   13,497 0 0
GW Pharmaceuticals PLC ADR 36197T103 11,629 100,762 SH   SOLE   100,762 0 0
Health Care Select Sector SPDR COMM 81369Y209 34,032 300,000 SH Put SOLE   300,000 0 0
Horizon Therapeutics PLC COMM G46188101 15,609 213,390 SH   SOLE   213,390 0 0
IGM Biosciences Inc COMM 449585108 3,985 45,131 SH   SOLE   45,131 0 0
Immatics NV COMM N44445109 3,016 279,532 SH   SOLE   279,532 0 0
Insmed Inc COMM 457669307 10,309 309,662 SH   SOLE   309,662 0 0
Intra-Cellular Therapies Inc COMM 46116X101 26,972 848,162 SH   SOLE   848,162 0 0
Iovance Biotherapeutics Inc COMM 462260100 4,640 100,000 SH Put SOLE   100,000 0 0
Jazz Pharmaceuticals PLC COMM G50871105 35,141 212,911 SH   SOLE   212,911 0 0
Jounce Therapeutics Inc COMM 481116101 6,477 925,280 SH   SOLE   925,280 0 0
Kadmon Holdings Inc COMM 48283N106 950 228,893 SH   SOLE   228,893 0 0
Kura Oncology Inc COMM 50127T109 3,941 120,677 SH   SOLE   120,677 0 0
Liquidia Corp COMM 53635D202 436 147,744 SH   SOLE   147,744 0 0
MacroGenics Inc COMM 556099109 10,488 458,807 SH   SOLE   458,807 0 0
Marinus Pharmaceuticals Inc COMM 56854Q200 3,343 274,027 SH   SOLE   274,027 0 0
Mirum Pharmaceuticals Inc COMM 604749101 7,944 454,974 SH   SOLE   454,974 0 0
Otonomy Inc COMM 68906L105 16,956 2,620,668 SH   SOLE   2,620,668 0 0
PTC Therapeutics Inc COMM 69366J200 19,315 316,478 SH   SOLE   316,478 0 0
Protagonist Therapeutics Inc COMM 00744E106 14,614 724,904 SH   SOLE   724,904 0 0
Puma Biotechnology Inc COMM 74587V107 6,460 629,650 SH   SOLE   629,650 0 0
Reata Pharmaceuticals Inc COMM 75615P103 18,412 148,937 SH   SOLE   148,937 0 0
Regenxbio Inc COMM 75901B107 12,298 271,114 SH   SOLE   271,114 0 0
Replimune Group Inc COMM 76029N106 763 20,000 SH   SOLE   20,000 0 0
Sarepta Therapeutics Inc COMM 803607100 8,840 51,848 SH   SOLE   51,848 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 8,293 372,909 SH   SOLE   372,909 0 0
TCR2 Therapeutics Inc COMM 87808K106 10,322 333,707 SH   SOLE   333,707 0 0
TG Therapeutics Inc COMM 88322Q108 3,406 65,474 SH   SOLE   65,474 0 0
United Therapeutics Corp COMM 91307C102 52,808 347,901 SH   SOLE   347,901 0 0
Zogenix Inc COMM 98978L204 1,791 89,579 SH   SOLE   89,579 0 0
iShares Russell 2000 ETF COMM 464287655 25,488 130,000 SH Put SOLE   130,000 0 0