The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100 8,290 200,000 SH   DFND 1 200,000 0 0
5 01 ACQUISITION CORP COM CL A 33836P105 5,085 500,000 SH   DFND 1 500,000 0 0
908 DEVICES INC COM 65443P102 29,503 545,322 SH   DFND 1 545,322 0 0
ACCELERON PHARMA INC COM 00434H108 54,374 425,000 SH   DFND 1 425,000 0 0
AGENUS INC COM NEW 00847G705 22,260 7,000,000 SH   DFND 1 7,000,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 19,158 742,549 SH   DFND 1 742,549 0 0
AKOUOS INC COM 00973J101 9,915 499,990 SH   DFND 1 499,990 0 0
ALBIREO PHARMA INC COM 01345P106 18,755 500,000 SH   DFND 1 500,000 0 0
ALIGOS THERAPEUTICS INC COM 01626L105 34,484 1,267,166 SH   DFND 1 1,267,166 0 0
ALLAKOS INC COM 01671P100 7,000 50,000 SH   DFND 1 50,000 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 76,009 881,770 SH   DFND 1 881,770 0 0
ANAPTYSBIO INC COM 032724106 13,975 650,000 SH   DFND 1 650,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 106,741 1,866,108 SH   DFND 1 1,866,108 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 1,537 20,000 SH   DFND 1 20,000 0 0
ARGENX SE SPONSORED ADR 04016X101 8,823 30,000 SH   DFND 1 30,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 16,678 100,000 SH   DFND 1 100,000 0 0
ATEA PHARMACEUTICALS INC COM 04683R106 259,830 6,411,355 SH   DFND 1 6,411,355 0 0
ATRECA INC CL A COM 04965G109 4,740 293,500 SH   DFND 1 293,500 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 3,774 422,167 SH   DFND 1 422,167 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 62,895 2,464,547 SH   DFND 1 2,464,547 0 0
AVROBIO INC COM 05455M100 3,402 244,032 SH   DFND 1 244,032 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 34,595 693,000 SH   DFND 1 693,000 0 0
AXSOME THERAPEUTICS INC COM 05464T104 16,294 200,000 SH   DFND 1 200,000 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 5,513 500,000 SH   DFND 1 500,000 0 0
BCTG ACQUISITION CORP COM 05492W103 9,152 800,000 SH   DFND 1 800,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 75,456 924,249 SH   DFND 1 924,249 0 0
BIOATLA INC COM 09077B104 75,416 2,292,060 SH   DFND 1 2,292,060 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 36,427 425,000 SH   DFND 1 425,000 0 0
BIONTECH SE SPONSORED ADS 09075V102 22,418 275,000 SH   DFND 1 275,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 25,234 225,000 SH   DFND 1 225,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 161,118 2,265,762 SH   DFND 1 2,265,762 0 0
C4 THERAPEUTICS INC COM STK 12529R107 80,021 2,490,065 SH   DFND 1 2,490,065 0 0
CABALETTA BIO INC COM 12674W109 23,767 1,904,424 SH   DFND 1 1,904,424 0 0
CARDIFF ONCOLOGY INC COM 14147L108 2,699 150,000 SH   DFND 1 150,000 0 0
CEREVEL THERAPEUTICS HLDNG I *W EXP 06/09/202 15678U102 753 133,331 SH   DFND 1 133,331 0 0
CHEMOCENTRYX INC COM 16383L106 74,304 1,200,000 SH   DFND 1 1,200,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 30,622 200,000 SH   DFND 1 200,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 11,414 200,000 SH   DFND 1 200,000 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 4,916 400,000 SH   DFND 1 400,000 0 0
FATE THERAPEUTICS INC COM 31189P102 909 10,000 SH   DFND 1 10,000 0 0
FOGHORN THERAPEUTICS INC COM 344174107 20,270 1,000,000 SH   DFND 1 1,000,000 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 155,654 4,460,000 SH   DFND 1 4,460,000 0 0
FS DEV CORP COM CL A 303020101 5,500 500,000 SH   DFND 1 500,000 0 0
GALECTO INC COM 36322Q107 26,464 2,150,732 SH   DFND 1 2,150,732 0 0
GENETRON HLDGS LTD ADS 37186H100 5,600 400,000 SH   DFND 1 400,000 0 0
GOSSAMER BIO INC COM 38341P102 8,204 848,382 SH   DFND 1 848,382 0 0
HARPOON THERAPEUTICS INC COM 41358P106 9,478 570,600 SH   DFND 1 570,600 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 10,248 800,000 SH   DFND 1 800,000 0 0
HELIX ACQUISITION CORP COM CL A G4444C102 4,742 430,000 SH   DFND 1 430,000 0 0
IGM BIOSCIENCES INC COM 449585108 52,974 600,000 SH   DFND 1 600,000 0 0
IMMUNOVANT INC COM 45258J102 72,193 1,562,952 SH   DFND 1 1,562,952 0 0
IMV INC COM 44974L103 716 234,374 SH   DFND 1 234,374 0 0
INSMED INC COM PAR $.01 457669307 9,987 300,000 SH   DFND 1 300,000 0 0
INSPIRE MED SYS INC COM 457730109 18,809 100,000 SH   DFND 1 100,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 16,320 300,000 SH Put DFND 1 300,000 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 235,305 750,000 SH Put DFND 1 750,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 98,030 500,000 SH Put DFND 1 500,000 0 0
ITEOS THERAPEUTICS INC COM 46565G104 10,146 300,000 SH   DFND 1 300,000 0 0
KADMON HLDGS INC COM 48283N106 3,528 850,000 SH   DFND 1 850,000 0 0
KURA ONCOLOGY INC COM 50127T109 21,229 650,000 SH   DFND 1 650,000 0 0
MERUS N V COM N5749R100 6,136 350,000 SH   DFND 1 350,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 468 200,000 SH   DFND 1 200,000 0 0
MIRAGEN THERAPEUTICS INC COM NEW 60463E202 1,532 93,126 SH   DFND 1 93,126 0 0
MIRATI THERAPEUTICS INC COM 60468T105 71,383 325,000 SH   DFND 1 325,000 0 0
MORPHIC HLDG INC COM 61775R105 6,710 200,000 SH   DFND 1 200,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 46,954 1,700,000 SH   DFND 1 1,700,000 0 0
NEKTAR THERAPEUTICS COM 640268108 680 40,000 SH   DFND 1 40,000 0 0
NOVUS THERAPEUTICS INC COM 67011N204 21,363 1,415,500 SH   DFND 1 1,415,500 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 148,169 3,195,544 SH   DFND 1 3,195,544 0 0
OMEROS CORP COM 682143102 57,140 4,000,000 SH   DFND 1 4,000,000 0 0
OMEROS CORP COM 682143102 14,290 1,000,000 SH Call DFND 1 1,000,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 1,109 256,649 SH   DFND 1 256,649 0 0
OTONOMY INC COM 68906L105 16,822 2,600,000 SH   DFND 1 2,600,000 0 0
PANACEA ACQUISITION CORP UNIT 99/99/9999 698102209 3,190 250,000 SH   DFND 1 250,000 0 0
PLIANT THERAPEUTICS INC COM 729139105 13,891 611,409 SH   DFND 1 611,409 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 57,739 1,074,145 SH   DFND 1 1,074,145 0 0
PRECISION BIOSCIENCES INC COM 74019P108 2,890 346,524 SH   DFND 1 346,524 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 8,474 350,000 SH   DFND 1 350,000 0 0
QUOTIENT LTD SHS G73268107 7,815 1,500,000 SH   DFND 1 1,500,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 61,810 500,000 SH   DFND 1 500,000 0 0
REPARE THERAPEUTICS INC COM 760273102 10,290 300,000 SH   DFND 1 300,000 0 0
REPLIMUNE GROUP INC COM 76029N106 4,769 125,000 SH   DFND 1 125,000 0 0
REVOLUTION MEDICINES INC COM 76155X100 98,780 2,495,066 SH   DFND 1 2,495,066 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 75,051 1,368,550 SH   DFND 1 1,368,550 0 0
SAREPTA THERAPEUTICS INC COM 803607100 11,934 70,000 SH   DFND 1 70,000 0 0
SILVERBACK THERAPEUTICS INC COM 82835W108 23,170 500,000 SH   DFND 1 500,000 0 0
SORRENTO THERAPEUTICS INC COM NEW 83587F202 30,713 4,500,000 SH   DFND 1 4,500,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 186,940 500,000 SH Put DFND 1 500,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 211,170 1,500,000 SH Put DFND 1 1,500,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 9,065 125,000 SH   DFND 1 125,000 0 0
STOKE THERAPEUTICS INC COM 86150R107 89,043 1,437,807 SH   DFND 1 1,437,807 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 69,965 1,714,269 SH   DFND 1 1,714,269 0 0
TCR2 THERAPEUTICS INC COM 87808K106 15,465 500,000 SH   DFND 1 500,000 0 0
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 6,975 500,000 SH   DFND 1 500,000 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 9,773 550,000 SH   DFND 1 550,000 0 0
TRICIDA INC COM 89610F101 3,017 427,975 SH   DFND 1 427,975 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 291,501 2,392,297 SH   DFND 1 2,392,297 0 0
TWIST BIOSCIENCE CORP COM 90184D100 31,790 225,000 SH   DFND 1 225,000 0 0
UNIQURE NV SHS N90064101 9,032 250,000 SH   DFND 1 250,000 0 0
VESPER HEALTHCARE ACQSTN COR UNIT 99/99/9999 92538T203 4,848 400,000 SH   DFND 1 400,000 0 0
VIELA BIO INC COM 926613100 51,408 1,429,200 SH   DFND 1 1,429,200 0 0
X4 PHARMACEUTICALS INC COM 98420X103 669 103,980 SH   DFND 1 103,980 0 0
Y-MABS THERAPEUTICS INC COM 984241109 82,268 1,661,647 SH   DFND 1 1,661,647 0 0
ZAI LAB LTD ADR 98887Q104 25,592 189,092 SH   DFND 1 189,092 0 0
ZYMEWORKS INC COM 98985W102 56,712 1,200,000 SH   DFND 1 1,200,000 0 0