The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADAMAS PHARMACEUTICALS INC COM 00548A106 11,873 2,742,000 SH   DFND   2,742,000 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 6,001 12,000 SH   DFND   12,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 24,204 104,000 SH   DFND   104,000 0 0
ALKERMES PLC SHS G01767105 44,209 2,216,000 SH   DFND   2,216,000 0 0
AMAZON COM INC COM 023135106 16,610 5,100 SH   DFND   5,100 0 0
AMRYT PHARMA PLC SPONSORED ADS 03217L106 2,832 200,000 SH   DFND   200,000 0 0
ANAPLAN INC COM 03272L108 6,035 84,000 SH   DFND   84,000 0 0
ARGENX SE SPONSORED ADR 04016X101 23,527 80,000 SH   DFND   80,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 15,875 2,624,000 SH   DFND   2,624,000 0 0
AUTOZONE INC COM 053332102 32,705 27,589 SH   DFND   27,589 0 0
AVANOS MED INC COM 05350V106 7,157 156,000 SH   DFND   156,000 0 0
AVANTOR INC COM 05352A100 15,426 548,000 SH   DFND   548,000 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 12,380 248,000 SH   DFND   248,000 0 0
AYTU BIOSCIENCE INC COM 054754874 7,973 1,333,334 SH   DFND   1,333,334 0 0
B & G FOODS INC NEW COM 05508R106 29,505 1,064,000 SH   DFND   1,064,000 0 0
BAUDAX BIO INC COM 07160F107 3,538 3,503,351 SH   DFND   3,503,351 0 0
BIO RAD LABS INC CL A 090572207 19,237 33,000 SH   DFND   33,000 0 0
BIOGEN INC COM 09062X103 63,174 258,000 SH   DFND   258,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 49,026 572,000 SH   DFND   572,000 0 0
BIONTECH SE SPONSORED ADS 09075V102 19,239 236,000 SH   DFND   236,000 0 0
BLUCORA INC COM 095229100 21,128 1,328,000 SH   DFND   1,328,000 0 0
BLUEBIRD BIO INC COM 09609G100 37,991 878,000 SH   DFND   878,000 0 0
BOSTON SCIENTIFIC CORP COM 101137107 17,975 500,000 SH   DFND   500,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 64,263 1,036,000 SH   DFND   1,036,000 0 0
BURLINGTON STORES INC COM 122017106 25,486 97,443 SH   DFND   97,443 0 0
CAMPBELL SOUP CO COM 134429109 37,133 768,000 SH   DFND   768,000 0 0
CARPARTS COM INC COM 14427M107 6,815 550,000 SH   DFND   550,000 0 0
CARTERS INC COM 146229109 4,930 52,404 SH   DFND   52,404 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 33,400 10,000,000 SH   DFND   10,000,000 0 0
CENTRAL GARDEN & PET CO CL A NON-VTG 153527205 38,655 1,064,000 SH   DFND   1,064,000 0 0
CERECOR INC COM 15671L109 79,555 30,134,285 SH   DFND   30,134,285 0 0
CLEVELAND BIOLABS INC COM NEW 185860202 1,104 320,053 SH   DFND   320,053 0 0
CLOROX CO DEL COM 189054109 12,115 60,000 SH   DFND   60,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 10,829 2,256,000 SH   DFND   2,256,000 0 0
COCA COLA CO COM 191216100 32,904 600,000 SH   DFND   600,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 11,024 72,000 SH   DFND   72,000 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 5,296 25,000 SH   DFND   25,000 0 0
CYCLO THERAPEUTICS INC *W EXP 11/14/202 23254X110 156 50,000 SH   DFND   50,000 0 0
CYCLO THERAPEUTICS INC COM NEW 23254X201 435 100,000 SH   DFND   100,000 0 0
DEXCOM INC COM 252131107 23,662 64,000 SH   DFND   64,000 0 0
DICKS SPORTING GOODS INC COM 253393102 18,684 332,389 SH   DFND   332,389 0 0
DYNATRACE INC COM NEW 268150109 5,885 136,000 SH   DFND   136,000 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 16,951 364,000 SH   DFND   364,000 0 0
EDGEWELL PERS CARE CO COM 28035Q102 11,619 336,000 SH   DFND   336,000 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 57,088 1,356,000 SH   DFND   1,356,000 0 0
ENERGIZER HLDGS INC NEW COM 29272W109 41,252 978,000 SH   DFND   978,000 0 0
EYEGATE PHARMACEUTICALS INC COM NEW 30233M503 8,950 1,815,500 SH   DFND   1,815,500 0 0
FIVE BELOW INC COM 33829M101 46,927 268,185 SH   DFND   268,185 0 0
FRONTDOOR INC COM 35905A109 32,938 656,000 SH   DFND   656,000 0 0
GEOVAX LABS INC *W EXP 09/29/202 373678119 887 391,700 SH   DFND   391,700 0 0
HOSTESS BRANDS INC CL A 44109J106 23,102 1,578,000 SH   DFND   1,578,000 0 0
ILLUMINA INC COM 452327109 18,500 50,000 SH   DFND   50,000 0 0
INCYTE CORP COM 45337C102 58,972 678,000 SH   DFND   678,000 0 0
KRAFT HEINZ CO COM 500754106 13,864 400,000 SH   DFND   400,000 0 0
KUBIENT INC *W EXP 07/09/202 50116V115 1,108 275,000 SH   DFND   275,000 0 0
LANTHEUS HLDGS INC COM 516544103 70,148 5,200,000 SH   DFND   5,200,000 0 0
LIMINAL BIOSCIENCES INC COM 53272L103 2,374 565,242 SH   DFND   565,242 0 0
LIVANOVA PLC SHS G5509L101 11,388 172,000 SH   DFND   172,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 35,130 316,000 SH   DFND   316,000 0 0
MEDIGUS LTD *W EXP 07/23/202 58471G128 1,095 1,285,715 SH   DFND   1,285,715 0 0
MEDTRONIC PLC SHS G5960L103 29,988 256,000 SH   DFND   256,000 0 0
MICROSOFT CORP COM 594918104 12,900 58,000 SH   DFND   58,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 1,170 500,000 SH   DFND   500,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 59,742 272,000 SH   DFND   272,000 0 0
MONDELEZ INTL INC CL A 609207105 22,920 392,000 SH   DFND   392,000 0 0
MOTUS GI HLDGS INC COM 62014P108 329 347,221 SH   DFND   347,221 0 0
NATERA INC COM 632307104 11,544 116,000 SH   DFND   116,000 0 0
NEPTUNE WELLNESS SOLUTIONS I COM 64079L105 6,500 4,166,666 SH   DFND   4,166,666 0 0
NUVASIVE INC COM 670704105 30,418 540,000 SH   DFND   540,000 0 0
OBALON THERAPEUTICS INC COM NEW 67424L209 1,650 1,100,000 SH   DFND   1,100,000 0 0
OREILLY AUTOMOTIVE INC COM 67103H107 40,995 90,583 SH   DFND   90,583 0 0
POLARITYTE INC COM 731094108 1,149 1,689,220 SH   DFND   1,689,220 0 0
POST HLDGS INC COM 737446104 17,778 176,000 SH   DFND   176,000 0 0
PROCTER AND GAMBLE CO COM 742718109 12,105 87,000 SH   DFND   87,000 0 0
PTC THERAPEUTICS INC COM 69366J200 43,697 716,000 SH   DFND   716,000 0 0
REGENERON PHARMACEUTICALS COM 75886F107 63,771 132,000 SH   DFND   132,000 0 0
REWALK ROBOTICS LTD SHS M8216Q200 1,841 1,394,944 SH   DFND   1,394,944 0 0
REZOLUTE INC COM NEW 76200L309 4,005 333,990 SH   DFND   333,990 0 0
ROSS STORES INC COM 778296103 26,071 212,284 SH   DFND   212,284 0 0
SELECTA BIOSCIENCES INC COM 816212104 4,957 1,636,000 SH   DFND   1,636,000 0 0
SI BONE INC COM 825704109 9,688 324,000 SH   DFND   324,000 0 0
SIYATA MOBILE INC *W EXP 09/24/202 83013Q152 1,268 150,000 SH   DFND   150,000 0 0
SMARTSHEET INC COM CL A 83200N103 5,682 82,000 SH   DFND   82,000 0 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108 32,709 9,592,000 SH   DFND   9,592,000 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 78,499 3,120,000 SH   DFND   3,120,000 0 0
SURGALIGN HOLDINGS INC COM 86882C105 955 436,000 SH   DFND   436,000 0 0
TARGET ORD COM 87612E106 31,544 178,687 SH   DFND   178,687 0 0
TELA BIO INC COM 872381108 3,850 256,000 SH   DFND   256,000 0 0
TENAX THERAPEUTICS INC COM NEW 88032L209 3,757 2,019,995 SH   DFND   2,019,995 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 18,165 39,000 SH   DFND   39,000 0 0
TITAN MED INC COM NEW 88830X819 477 278,787 SH   DFND   278,787 0 0
UBER TECHNOLOGIES INC COM 90353T100 9,180 180,000 SH   DFND   180,000 0 0
ULTA BEAUTY INC COM 90384S303 39,715 138,304 SH   DFND   138,304 0 0
UNITEDHEALTH GROUP INC COM 91324P102 35,068 100,000 SH   DFND   100,000 0 0
V F CORP COM 918204108 4,252 49,781 SH   DFND   49,781 0 0
VANDA PHARMACEUTICALS INC COM 921659108 70,946 5,399,277 SH   DFND   5,399,277 0 0
VAXART INC COM NEW 92243A200 831 145,523 SH   DFND   145,523 0 0
VIATRIS INC COM 92556V106 17,541 936,000 SH   DFND   936,000 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 24,253 3,392,000 SH   DFND   3,392,000 0 0
WALMART INC COM 931142103 53,368 370,225 SH   DFND   370,225 0 0
WHOLE EARTH BRANDS INC COM CL A 96684W100 12,077 1,108,000 SH   DFND   1,108,000 0 0
WORKDAY INC CL A 98138H101 7,188 30,000 SH   DFND   30,000 0 0
WYNN RESORTS LTD COM 983134107 6,770 60,000 SH   DFND   60,000 0 0
ZYMEWORKS INC COM 98985W102 21,267 450,000 SH   DFND   450,000 0 0