The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X Genomics Inc CL A Common 88025U109 8,351 58,977 SH   SOLE   58,977 0 0
Aclaris Therapeutics, Inc. Common 00461U105 10,657 1,647,214 SH   SOLE   1,647,214 0 0
Akero Therapeutics Inc Common 00973Y108 16,342 633,426 SH   SOLE   633,426 0 0
Aligos Therapeutics Inc Common 01626L105 98,075 3,547,030 SH   SOLE   3,547,030 0 0
ALX Oncology Holdings Inc Common 00166B105 363,768 4,220,048 SH   SOLE   4,220,048 0 0
Amyris, Inc Common 03236M200 81,274 13,161,847 SH   SOLE   13,161,847 0 0
Arcutis Biotherapeutics Inc Common 03969K108 24,393 867,170 SH   SOLE   867,170 0 0
Arrowhead Pharmaceuticals Inc Common 04280A100 15,737 205,091 SH   SOLE   205,091 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 299,828 1,797,745 SH   SOLE   1,797,745 0 0
Atricure Inc Common 04963C209 3,595 64,573 SH   SOLE   64,573 0 0
Aurinia Pharmaceuticals Inc. Common 05156V102 6,925 500,732 SH   SOLE   500,732 0 0
Avadel Pharmaceuticals PLC ADR 05337M104 23,554 3,526,093 SH   SOLE   3,526,093 0 0
Calliditas Therapeutics ADR SPONSORED ADS 13124Q106 10,457 311,030 SH   SOLE   311,030 0 0
Celldex Therapeutics Inc Common 15117B202 22,634 1,291,875 SH   SOLE   1,291,875 0 0
Chinook Therapeutics Inc Common 16961L106 19,131 1,206,266 SH   SOLE   1,206,266 0 0
Codexis, Inc Common 192005106 8,473 388,144 SH   SOLE   388,144 0 0
Constellation Pharmaceutical Common 210373106 4,041 140,298 SH   SOLE   140,298 0 0
Crinetics Pharmaceuticals Inc Common 22663K107 32,959 2,335,889 SH   SOLE   2,335,889 0 0
Curis Inc Common 231269200 11,466 1,400,000 SH   SOLE   1,400,000 0 0
Cymabay Therapeutics Inc Common 23257D103 3,360 585,394 SH   SOLE   585,394 0 0
Cytokinetics Inc Common 23282W605 14,546 700,000 SH   SOLE   700,000 0 0
Dyne Therapeutics Inc Common 26818M108 6,615 315,000 SH   SOLE   315,000 0 0
Eiger BioPharmaceuticals Inc Common 28249U105 22,015 1,791,257 SH   SOLE   1,791,257 0 0
Essa Pharma Inc Common 29668H708 22,594 1,893,907 SH   SOLE   1,893,907 0 0
Genetron Holdings Ltd ADS 37186H100 88,758 6,339,860 SH   SOLE   6,339,860 0 0
Harmony Biosciences Holdings Inc Common 413197104 163,916 4,534,341 SH   SOLE   4,534,341 0 0
Homology Medicines, Inc. Common 438083107 9,632 853,143 SH   SOLE   853,143 0 0
IGM Biosciences Inc Common 449585108 1,766 20,000 SH   SOLE   20,000 0 0
Immunovant Inc Common 45258J102 16,059 347,662 SH   SOLE   347,662 0 0
Iveric Bio Inc Common 46583P102 41,229 5,966,527 SH   SOLE   5,966,527 0 0
Kadmon Holdings Inc Common 48283N106 24,142 5,817,459 SH   SOLE   5,817,459 0 0
Kala Pharmaceuticals, Inc. Common 483119103 5,335 786,883 SH   SOLE   786,883 0 0
KalVista Pharmaceuticals Inc. Common 483497103 30,731 1,618,296 SH   SOLE   1,618,296 0 0
Kura Oncology Inc Common 50127T109 17,155 525,262 SH   SOLE   525,262 0 0
Larimar Therapeutics Inc Common 517125100 17,121 799,662 SH   SOLE   799,662 0 0
Legend Biotech Corp Sponsored SPONSORED ADS 52490G102 77,581 2,755,007 SH   SOLE   2,755,007 0 0
Matinas Biopharma Hldgs Inc Common 576810105 8,774 6,451,612 SH   SOLE   6,451,612 0 0
Mereo Biopharma Group PLC ADS 589492107 15,111 4,220,938 SH   SOLE   4,220,938 0 0
Metacrine Inc Common 59101E103 1,151 146,426 SH   SOLE   146,426 0 0
New Frontier Health Corp Ord Shs G6461G106 122,980 14,300,000 SH   SOLE   14,300,000 0 0
Nkarta Inc Common 65487U108 31,486 512,225 SH   SOLE   512,225 0 0
Novavax Inc Common 670002401 17,561 157,487 SH   SOLE   157,487 0 0
Olema Pharmaceuticals Inc Common 68062P106 59,551 1,238,575 SH   SOLE   1,238,575 0 0
Orchard Therapeutics plc ADS 68570P101 5,727 1,325,736 SH   SOLE   1,325,736 0 0
Ovid Therapeutics Inc Common 690469101 2,888 1,250,000 SH   SOLE   1,250,000 0 0
Passage Bio Inc Common 702712100 38,024 1,487,038 SH   SOLE   1,487,038 0 0
Poseida Therapeutics Inc Common 73730P108 10,163 926,447 SH   SOLE   926,447 0 0
Precision Biosciences Inc Common 74019P108 1,170 140,255 SH   SOLE   140,255 0 0
Revolution Medicines Inc Common 76155X100 661 16,690 SH   SOLE   16,690 0 0
Rocket Pharmaceuticals Inc Common 77313F106 17,032 310,584 SH   SOLE   310,584 0 0
Sierra Oncology, Inc Common 82640U404 30,731 1,917,074 SH   SOLE   1,917,074 0 0
Sinovac Biotech Ltd. SHS P8696W104 38,173 5,900,000 SH   SOLE   5,900,000 0 0
Tarsus Pharmaceuticals Inc Common 87650L103 134,117 3,245,035 SH   SOLE   3,245,035 0 0
Tricida, Inc. Common 89610F101 1,232 174,763 SH   SOLE   174,763 0 0
Verona Pharma PLC ADR ADS 925050106 21,340 3,048,507 SH   SOLE   3,048,507 0 0
VYNE Therapeutics Inc Common 92941V100 1,484 939,513 SH   SOLE   939,513 0 0
Zai Lab Ltd ADR ADR 98887Q104 23,685 175,000 SH   SOLE   175,000 0 0
Zogenix Inc Common 98978L204 20,120 1,006,494 SH   SOLE   1,006,494 0 0
Zymeworks Inc Common 98985W102 13,519 286,064 SH   SOLE   286,064 0 0