The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 112,806 796,655 SH   DFND   0 0 796,655
1LIFE HEALTHCARE INC COM 68269G107 265,466 6,081,698 SH   DFND   0 0 6,081,698
2U INC COM 90214J101 3,095 77,364 SH   DFND   0 0 77,364
89BIO INC COM 282559103 777 31,899 SH   DFND   0 0 31,899
908 DEVICES INC COM 65443P102 991 17,399 SH   DFND   0 0 17,399
ABCELLERA BIOLOGICS INC COM 00288U106 18,293 454,598 SH   DFND   0 0 454,598
ABIOMED INC COM 003654100 41,124 126,849 SH   DFND   0 0 126,849
ACCEL ENTERTAINMENT INC COM CL A1 00436Q106 24 2,400 SH   DFND   0 0 2,400
ACCOLADE INC COM 00437E102 69,883 1,606,501 SH   DFND   0 0 1,606,501
ACTIVISION BLIZZARD INC COM 00507V109 2,031 21,870 SH   DFND   0 0 21,870
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 140,422 2,374,798 SH   DFND   0 0 2,374,798
ADOBE SYSTEMS INCORPORATED COM 00724F101 61,104 122,178 SH   DFND   0 0 122,178
ADYEN NV 144A COMMONSTOCK N3501V104 76,005 32,608 SH   DFND   0 0 32,608
AFYA LTD CL A COM G01125106 6,201 245,101 SH   DFND   0 0 245,101
AGORA INC ADS 00851L103 30,589 773,221 SH   DFND   0 0 773,221
AIRBNB INC COM CL A 009066101 45,333 308,805 SH   DFND   0 0 308,805
ALAMOS GOLD INC NEW COM CL A 011532108 4,564 521,593 SH   DFND   0 0 521,593
ALASKA COMMUNICATIONS SYS GR COM 01167P101 738 200,000 SH   DFND   0 0 200,000
ALECTOR INC COM 014442107 31,047 2,052,028 SH   DFND   0 0 2,052,028
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 90,021 386,805 SH   DFND   0 0 386,805
ALLAKOS INC COM 01671P100 13,132 93,803 SH   DFND   0 0 93,803
ALLIANCE DATA SYSTEMS CORP COM 018581108 1,600 21,589 SH   DFND   0 0 21,589
ALLOGENE THERAPEUTICS INC COM 019770106 1 41 SH   DFND   0 0 41
ALLOVIR INC COM 019818103 509 13,234 SH   DFND   0 0 13,234
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 114,910 884,130 SH   DFND   0 0 884,130
ALPHABET INC CAP STK CL A 02079K305 69,822 39,838 SH   DFND   0 0 39,838
ALPHABET INC CAP STK CL C 02079K107 92,086 52,564 SH   DFND   0 0 52,564
ALTERYX INC COM CL A 02156B103 4 30 SH   DFND   0 0 30
ALTIMETER GROWTH CORP UNIT 99/99/9999 G0370L124 596 45,875 SH   DFND   0 0 45,875
AMAZON COM INC COM 023135106 505,061 155,073 SH   DFND   0 0 155,073
AMERICAN TOWER CORP NEW COM 03027X100 17,186 76,568 SH   DFND   0 0 76,568
AMERICAN WELL CORP CL A 03044L105 150 5,922 SH   DFND   0 0 5,922
AMICUS THERAPEUTICS INC COM 03152W109 52,131 2,257,751 SH   DFND   0 0 2,257,751
ANAPLAN INC COM 03272L108 3 41 SH   DFND   0 0 41
ANTERIX INC COM 03676C100 350 9,318 SH   DFND   0 0 9,318
APACHE CORP COM 037411105 2,286 161,076 SH   DFND   0 0 161,076
APPFOLIO INC COM CL A 03783C100 78,894 438,203 SH   DFND   0 0 438,203
APPLE INC COM 037833100 22,810 171,907 SH   DFND   0 0 171,907
APPLIED MATLS INC COM 038222105 14 168 SH   DFND   0 0 168
APPLIED OPTOELECTRONICS INC COM 03823U102 60 7,032 SH   DFND   0 0 7,032
ARCUS BIOSCIENCES INC COM 03969F109 8,198 315,811 SH   DFND   0 0 315,811
ARENA PHARMACEUTICALS INC COM NEW 040047607 48,919 636,714 SH   DFND   0 0 636,714
ARGENX SE SPONSORED ADR 04016X101 39,826 135,420 SH   DFND   0 0 135,420
ARISTA NETWORKS INC COM 040413106 8,725 30,027 SH   DFND   0 0 30,027
ARITZIA INC SUB VTG SHS ISIN CA04045U1021 SEDOL BDCG2C2 COMMONSTOCK 04045U102 15,396 760,559 SH   DFND   0 0 760,559
ARVINAS INC COM 04335A105 149,147 1,756,122 SH   DFND   0 0 1,756,122
ASANA INC CL A 04342Y104 89,420 3,026,048 SH   DFND   0 0 3,026,048
ASHTEAD GROUP ORD GBP010 ISIN GB0000536739 SEDOL 0053673 COMMONSTOCK G05320109 4 85 SH   DFND   0 0 85
ATLASSIAN CORP PLC CL A G06242104 52,688 225,288 SH   DFND   0 0 225,288
ATRICURE INC COM 04963C209 2 42 SH   DFND   0 0 42
AURINIA PHARMACEUTICALS INC COM 05156V102 2,493 180,250 SH   DFND   0 0 180,250
AUTODESK INC COM 052769106 160,659 526,163 SH   DFND   0 0 526,163
AVIDITY BIOSCIENCES INC COM 05370A108 250 9,795 SH   DFND   0 0 9,795
AXIS BANK LIMITED GDR REG S ISIN US05462W1099 SEDOL B06CDW2 COMMONSTOCK 05462W109 2,741 64,796 SH   DFND   0 0 64,796
AZEK CO INC CL A 05478C105 24,902 647,652 SH   DFND   0 0 647,652
AZUL S A SPONSR ADR PFD 05501U106 28,214 1,236,382 SH   DFND   0 0 1,236,382
BAMBUSER AB NPV ISIN SE0009663834 SEDOL BD8Z3Y2 COMMONSTOCK W1R91S102 14,395 7,997,407 SH   DFND   0 0 7,997,407
BARCLAYS BANK PLC IPTH SR B S&P 06746P621 8,893 529,667 SH   DFND   0 0 529,667
BASICFIT NV 144A REG S ISIN NL0011872650 SEDOL BD9Y9B7 COMMONSTOCK N10058100 17 457 SH   DFND   0 0 457
BEACON ROOFING SUPPLY INC COM 073685109 9,775 243,219 SH   DFND   0 0 243,219
BEAM THERAPEUTICS INC COM 07373V105 10,590 129,711 SH   DFND   0 0 129,711
BERKLEY W R CORP COM 084423102 5,429 81,738 SH   DFND   0 0 81,738
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 797 3,438 SH   DFND   0 0 3,438
BEYOND MEAT INC COM 08862E109 86,157 689,253 SH   DFND   0 0 689,253
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 8,683 101,307 SH   DFND   0 0 101,307
BLUEBIRD BIO INC COM 09609G100 11 251 SH   DFND   0 0 251
BOSTON SCIENTIFIC CORP COM 101137107 747 20,778 SH   DFND   0 0 20,778
BRP GROUP INC COM CL A 05589G102 13,509 450,738 SH   DFND   0 0 450,738
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 202 8,726 SH   DFND   0 0 8,726
CALIX INC COM 13100M509 111,614 3,750,470 SH   DFND   0 0 3,750,470
CARL ZEISS MEDITEC AG NPV ISIN DE0005313704 SEDOL 5922961 COMMONSTOCK D14895102 1,613 12,043 SH   DFND   0 0 12,043
CARVANA CO CL A 146869102 344,006 1,436,113 SH   DFND   0 0 1,436,113
CATAPULT GROUP INTERNATIONAL ISIN AU000000CAT9 SEDOL BTL0Y76 COMMONSTOCK Q2159P101 267 186,221 SH   DFND   0 0 186,221
CELLNEX TELECOM SAU EUR025 144A REG S ISIN ES0105066007 SEDOL COMMONSTOCK E2R41M104 12,158 202,299 SH   DFND   0 0 202,299
CELSIUS HLDGS INC COM NEW 15118V207 34,651 688,745 SH   DFND   0 0 688,745
CHARLES RIV LABS INTL INC COM 159864107 6,322 25,303 SH   DFND   0 0 25,303
CHART INDS INC COM PAR $0.01 16115Q308 71 607 SH   DFND   0 0 607
CHEGG INC COM 163092109 151,701 1,679,409 SH   DFND   0 0 1,679,409
CHEWY INC CL A 16679L109 39,716 441,834 SH   DFND   0 0 441,834
CHIPOTLE MEXICAN GRILL INC COM 169656105 35 25 SH   DFND   0 0 25
CHUBB LIMITED COM H1467J104 16,559 107,579 SH   DFND   0 0 107,579
CITIGROUP INC COM NEW 172967424 2 35 SH   DFND   0 0 35
CLEARFIELD INC COM 18482P103 1,113 45,011 SH   DFND   0 0 45,011
CLOUDFLARE INC CL A COM 18915M107 394,163 5,187,038 SH   DFND   0 0 5,187,038
CODEXIS INC COM 192005106 54,510 2,497,038 SH   DFND   0 0 2,497,038
CONTROLADORA VUELA COMP DE A SPON ADR RP 10 21240E105 58,844 4,737,878 SH   DFND   0 0 4,737,878
CORECIVIC INC COM 21871N101 53 8,079 SH   DFND   0 0 8,079
COUPA SOFTWARE INC COM 22266L106 126,714 373,886 SH   DFND   0 0 373,886
COVETRUS INC COM 22304C100 0 8 SH   DFND   0 0 8
CREE INC COM 225447101 1,608 15,187 SH   DFND   0 0 15,187
CROWDSTRIKE HLDGS INC CL A 22788C105 62,634 295,695 SH   DFND   0 0 295,695
D R HORTON INC COM 23331A109 4,163 60,397 SH   DFND   0 0 60,397
DATADOG INC CL A COM 23804L103 25,194 255,933 SH   DFND   0 0 255,933
DELTA AIR LINES INC DEL COM NEW 247361702 369 9,167 SH   DFND   0 0 9,167
DENALI THERAPEUTICS INC COM 24823R105 269,694 3,219,843 SH   DFND   0 0 3,219,843
DEXCOM INC COM 252131107 94,573 255,798 SH   DFND   0 0 255,798
DISH NETWORK CORPORATION CL A 25470M109 58,227 1,800,452 SH   DFND   0 0 1,800,452
DISNEY WALT CO COM 254687106 16,751 92,455 SH   DFND   0 0 92,455
DIVERSIFIED GAS OIL PLC ORD GBP001 ISIN GB00BYX7JT74 SEDOL B COMMONSTOCK G2891G105 11,256 7,287,058 SH   DFND   0 0 7,287,058
DOCUSIGN INC COM 256163106 324,523 1,459,842 SH   DFND   0 0 1,459,842
DOWNEY FINL CORP COMMONSTOCK 261018105 0 200 SH   DFND   0 0 200
DRAFTKINGS INC COM CL A 26142R104 1,518 32,598 SH   DFND   0 0 32,598
DUCK CREEK TECHNOLOGIES INC SHS 264120106 892 20,599 SH   DFND   0 0 20,599
EARGO INC COM 270087109 25,260 563,581 SH   DFND   0 0 563,581
EHEALTH INC COM 28238P109 7,429 105,205 SH   DFND   0 0 105,205
EIDOS THERAPEUTICS INC COM 28249H104 43,839 333,176 SH   DFND   0 0 333,176
ELASTIC N V ORD SHS N14506104 12,204 83,516 SH   DFND   0 0 83,516
EMERGENT BIOSOLUTIONS INC COM 29089Q105 3,142 35,069 SH   DFND   0 0 35,069
ENPHASE ENERGY INC COM 29355A107 348,146 1,984,076 SH   DFND   0 0 1,984,076
EPAM SYS INC COM 29414B104 128,197 357,742 SH   DFND   0 0 357,742
EQUATOR EXPLORATION COM STK NPV COMMONSTOCK G3084F128 0 215,000 SH   DFND   0 0 215,000
ESPERION THERAPEUTICS INC NE COM 29664W105 29 1,124 SH   DFND   0 0 1,124
ETSY INC COM 29786A106 61,293 344,515 SH   DFND   0 0 344,515
EVENTBRITE INC COM CL A 29975E109 399 22,046 SH   DFND   0 0 22,046
EVEREST RE GROUP LTD COM G3223R108 4,371 18,671 SH   DFND   0 0 18,671
EVERI HLDGS INC COM 30034T103 24,955 1,807,011 SH   DFND   0 0 1,807,011
EXACT SCIENCES CORP COM 30063P105 178,733 1,349,029 SH   DFND   0 0 1,349,029
FACEBOOK INC CL A 30303M102 35,134 128,622 SH   DFND   0 0 128,622
FARFETCH LTD ORD SH CL A 30744W107 3,350 52,504 SH   DFND   0 0 52,504
FASTLY INC CL A 31188V100 5,912 67,671 SH   DFND   0 0 67,671
FATHOM HOLDINGS INC COM 31189V109 17,085 474,061 SH   DFND   0 0 474,061
FERGUSON PLC ORD GBP010 ISIN JE00BJVNSS43 SEDOL BJVNSS4 COMMONSTOCK G3421J106 13,021 107,220 SH   DFND   0 0 107,220
FLOOR & DECOR HLDGS INC CL A 339750101 134,597 1,449,623 SH   DFND   0 0 1,449,623
FLUIDRA SA EUR1 ISIN ES0137650018 SEDOL B28V440 COMMONSTOCK E52619108 13,753 536,527 SH   DFND   0 0 536,527
FOUR SEAS MERCANTILE HLDGS HKD010 ISIN KYG365451049 SEDOL 634 COMMONSTOCK G36545104 85 270,000 SH   DFND   0 0 270,000
FRANCO NEV CORP COM 351858105 9,164 73,121 SH   DFND   0 0 73,121
FRESHPET INC COM 358039105 277,980 1,957,747 SH   DFND   0 0 1,957,747
FRIENDLY ENERGY EXPLORATION COM NPV COMMONSTOCK 35846A200 0 690 SH   DFND   0 0 690
GALAPAGOS NV NPV ISIN BE0003818359 SEDOL B07Q2V5 COMMONSTOCK B44170106 27,791 282,227 SH   DFND   0 0 282,227
GEOPARK LTD USD SHS G38327105 4,861 374,212 SH   DFND   0 0 374,212
GLAUKOS CORP COM 377322102 66,057 877,723 SH   DFND   0 0 877,723
GLOBANT S A COM L44385109 121,487 558,280 SH   DFND   0 0 558,280
GOLDEN MINERALS CO COM 381119106 36 46,847 SH   DFND   0 0 46,847
GOLDMAN SACHS GROUP INC COM 38141G104 91,089 345,412 SH   DFND   0 0 345,412
GOODRX HLDGS INC COM CL A 38246G108 645 15,980 SH   DFND   0 0 15,980
GROCERY OUTLET HLDG CORP COM 39874R101 3,914 99,718 SH   DFND   0 0 99,718
GTT COMMUNICATIONS INC COM 362393100 107 30,000 SH   DFND   0 0 30,000
GUARDANT HEALTH INC COM 40131M109 1,062 8,244 SH   DFND   0 0 8,244
H & E EQUIPMENT SERVICES INC COM 404030108 3,912 131,235 SH   DFND   0 0 131,235
HDFC BANK LTD SPONSORED ADS 40415F101 10,219 141,426 SH   DFND   0 0 141,426
HEALTHEQUITY INC COM 42226A107 1,553 22,272 SH   DFND   0 0 22,272
HEALTHSTREAM INC COM 42222N103 7,558 346,059 SH   DFND   0 0 346,059
HEARUSA INC NEW COMMONSTOCK 422360305 0 375 SH   DFND   0 0 375
HEICO CORP NEW CL A 422806208 5,914 50,521 SH   DFND   0 0 50,521
HEICO CORP NEW COM 422806109 2,653 20,039 SH   DFND   0 0 20,039
HELLOFRESH SE ISIN DE000A161408 SEDOL BYWH8S0 COMMONSTOCK D3R2MA100 50,566 639,835 SH   DFND   0 0 639,835
HUBSPOT INC COM 443573100 238,920 602,663 SH   DFND   0 0 602,663
ICICI BANK LIMITED ADR 45104G104 4,198 282,518 SH   DFND   0 0 282,518
IDEXX LABS INC COM 45168D104 4,801 9,605 SH   DFND   0 0 9,605
ILLUMINA INC COM 452327109 2,657 7,182 SH   DFND   0 0 7,182
IMPINJ INC COM 453204109 43,146 1,030,466 SH   DFND   0 0 1,030,466
INARI MED INC COM 45332Y109 17,671 202,436 SH   DFND   0 0 202,436
INFINERA CORP COM 45667G103 146,477 13,976,811 SH   DFND   0 0 13,976,811
INPHI CORP COM 45772F107 1,632 10,172 SH   DFND   0 0 10,172
INSPIRE MED SYS INC COM 457730109 181,536 965,156 SH   DFND   0 0 965,156
INSULET CORP COM 45784P101 4,611 18,036 SH   DFND   0 0 18,036
INTERBREW PLC GDREACH REPR 1 A SH REG S COMMONSTOCK 45845T308 0 200 SH   DFND   0 0 200
INTL GNRL INSURANCE HLDNGS L SHS G4809J106 15,565 1,926,423 SH   DFND   0 0 1,926,423
INTUITIVE SURGICAL INC COM NEW 46120E602 139,352 170,336 SH   DFND   0 0 170,336
INVITAE CORP COM 46185L103 293,255 7,013,993 SH   DFND   0 0 7,013,993
IRHYTHM TECHNOLOGIES INC COM 450056106 96,085 405,061 SH   DFND   0 0 405,061
IROBOT CORP COM 462726100 8 100 SH   DFND   0 0 100
IWG PLC ORD GBP001 ISIN JE00BYVQYS01 SEDOL BYVQYS0 COMMONSTOCK G4969N103 71 15,127 SH   DFND   0 0 15,127
JAMF HLDG CORP COM 47074L105 7,323 244,769 SH   DFND   0 0 244,769
JPMORGAN CHASE & CO COM 46625H100 2,041 16,060 SH   DFND   0 0 16,060
JUST EAT TAKEAWAYCOM NV EUR004 144A REG S ISIN NL0012015705 COMMONSTOCK ZZDLN2RN7 862 7,631 SH   DFND   0 0 7,631
KAMBI GROUP PLC EUR0003 ISIN MT0000780107 SEDOL BMNQDC1 COMMONSTOCK X4170A107 54 1,130 SH   DFND   0 0 1,130
KB HOME COM 48666K109 189 5,636 SH   DFND   0 0 5,636
KIRKLAND LAKE GOLD LTD COM 49741E100 13,676 331,390 SH   DFND   0 0 331,390
KORNIT DIGITAL LTD SHS M6372Q113 142,031 1,593,527 SH   DFND   0 0 1,593,527
KRYSTAL BIOTECH INC COM 501147102 407 6,783 SH   DFND   0 0 6,783
LEMONADE INC COM 52567D107 12,407 101,278 SH   DFND   0 0 101,278
LESLIES INC COM 527064109 29,516 1,063,648 SH   DFND   0 0 1,063,648
LGI HOMES INC COM 50187T106 79,065 746,957 SH   DFND   0 0 746,957
LI NING CO LTD HKD01 ISIN KYG5496K1242 SEDOL B01JCK9 COMMONSTOCK G5496K124 32 4,678 SH   DFND   0 0 4,678
LIBERTY MEDIA CORP DEL COM A BRAVES GRP 531229706 3,029 121,801 SH   DFND   0 0 121,801
LIBERTY MEDIA CORP DEL COM C BRAVES GRP 531229888 5,499 221,016 SH   DFND   0 0 221,016
LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854 2,735 64,201 SH   DFND   0 0 64,201
LINDBLAD EXPEDITIONS HLDGS I COM 535219109 4,388 256,332 SH   DFND   0 0 256,332
LIVE NATION ENTERTAINMENT IN COM 538034109 21 282 SH   DFND   0 0 282
LIVEPERSON INC COM 538146101 62 1,000 SH   DFND   0 0 1,000
LOVESAC COMPANY COM 54738L109 1,231 28,568 SH   DFND   0 0 28,568
LULULEMON ATHLETICA INC COM 550021109 15,351 44,107 SH   DFND   0 0 44,107
LYFT INC CL A COM 55087P104 2,177 44,319 SH   DFND   0 0 44,319
MAG SILVER CORP COM 55903Q104 31,688 1,544,260 SH   DFND   0 0 1,544,260
MAGENTA THERAPEUTICS INC COM 55910K108 33,071 4,218,206 SH   DFND   0 0 4,218,206
MAGNOLIA OIL & GAS CORP CL A 559663109 3,089 437,549 SH   DFND   0 0 437,549
MARTIN MARIETTA MATLS INC COM 573284106 27,059 95,289 SH   DFND   0 0 95,289
MASTERCARD INCORPORATED CL A 57636Q104 28,208 79,028 SH   DFND   0 0 79,028
MATCH GROUP INC NEW COM 57667L107 134,413 889,037 SH   DFND   0 0 889,037
MAXAR TECHNOLOGIES INC COM 57778K105 49,995 1,295,548 SH   DFND   0 0 1,295,548
MERCADOLIBRE INC COM 58733R102 237,065 141,513 SH   DFND   0 0 141,513
MGP INGREDIENTS INC NEW COM 55303J106 989 21,012 SH   DFND   0 0 21,012
MICROSOFT CORP COM 594918104 63,520 285,586 SH   DFND   0 0 285,586
MOLECULAR TEMPLATES INC COM 608550109 1,214 129,321 SH   DFND   0 0 129,321
MONGODB INC CL A 60937P106 264,969 737,994 SH   DFND   0 0 737,994
MONOLITHIC PWR SYS INC COM 609839105 16,240 44,345 SH   DFND   0 0 44,345
NATERA INC COM 632307104 147,008 1,477,173 SH   DFND   0 0 1,477,173
NATIONAL VISION HLDGS INC COM 63845R107 27 607 SH   DFND   0 0 607
NESCO HLDGS INC COM 64083J104 5,281 716,538 SH   DFND   0 0 716,538
NETCOMPANY GROUP AS DKK1 144A ISIN DK0060952919 SEDOL BFYDWS1 COMMONSTOCK K7020C102 101,888 989,848 SH   DFND   0 0 989,848
NETFLIX INC COM 64110L106 568,883 1,052,065 SH   DFND   0 0 1,052,065
NEVRO CORP COM 64157F103 1,622 9,370 SH   DFND   0 0 9,370
NEW PAC METALS CORP COM NPV ISIN CA64782A1075 SEDOL BMW5909 COMMONSTOCK 64782A107 13,240 2,100,663 SH   DFND   0 0 2,100,663
NEW PROVIDENCE ACQUISITION COM CL A 64822P106 1,000 73,628 SH   DFND   0 0 73,628
NEW YORK TIMES CO CL A 650111107 144,011 2,781,746 SH   DFND   0 0 2,781,746
NIKE INC CL B 654106103 21,517 152,094 SH   DFND   0 0 152,094
NIU TECHNOLOGIES ADS 65481N100 15 547 SH   DFND   0 0 547
NORDSTROM INC COM 655664100 2,993 95,894 SH   DFND   0 0 95,894
NORTHERN DATA AG ORD SHS ISIN DE000A0SMU87 SEDOL BWT5WX6 COMMONSTOCK D5S1LG112 327 3,452 SH   DFND   0 0 3,452
NV5 GLOBAL INC COM 62945V109 51 644 SH   DFND   0 0 644
NVIDIA CORPORATION COM 67066G104 117,771 225,529 SH   DFND   0 0 225,529
NYXOAH SA NPV ISIN BE0974358906 SEDOL BN782G7 COMMONSTOCK B6S7WD106 5,729 296,342 SH   DFND   0 0 296,342
OAK STR HEALTH INC COM 67181A107 120,897 1,976,735 SH   DFND   0 0 1,976,735
OCADO GROUP PLC ORD GBP002 ISIN GB00B3MBS747 SEDOL B3MBS74 COMMONSTOCK G6718L106 325,492 10,411,702 SH   DFND   0 0 10,411,702
OKTA INC CL A 679295105 358,044 1,408,179 SH   DFND   0 0 1,408,179
ONEWATER MARINE INC CL A COM 68280L101 29,913 1,028,277 SH   DFND   0 0 1,028,277
OPTION CARE HEALTH INC COM NEW 68404L201 29,178 1,865,631 SH   DFND   0 0 1,865,631
OUTSET MED INC COM 690145107 3,850 67,735 SH   DFND   0 0 67,735
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 1,153 44,431 SH   DFND   0 0 44,431
PAGERDUTY INC COM 69553P100 5,891 141,262 SH   DFND   0 0 141,262
PALOMAR HLDGS INC COM 69753M105 11,166 125,689 SH   DFND   0 0 125,689
PAYPAL HLDGS INC COM 70450Y103 46,428 198,239 SH   DFND   0 0 198,239
PDF SOLUTIONS INC COM 693282105 619 28,645 SH   DFND   0 0 28,645
PELOTON INTERACTIVE INC CL A COM 70614W100 532,651 3,510,751 SH   DFND   0 0 3,510,751
PENN NATL GAMING INC COM 707569109 59,943 694,027 SH   DFND   0 0 694,027
PENN TREATY AMERN CORP COM NEW COMMONSTOCK 707874400 0 125 SH   DFND   0 0 125
PENSKE AUTOMOTIVE GRP INC COM 70959W103 3,484 58,660 SH   DFND   0 0 58,660
PINDUODUO INC SPONSORED ADS 722304102 33,127 186,454 SH   DFND   0 0 186,454
PINTEREST INC CL A 72352L106 81,819 1,241,558 SH   DFND   0 0 1,241,558
POOL CORP COM 73278L105 120,657 323,912 SH   DFND   0 0 323,912
PROFOUND MED CORP COM NEW 74319B502 2,743 133,416 SH   DFND   0 0 133,416
PROVENTION BIO INC COM 74374N102 39,973 2,359,682 SH   DFND   0 0 2,359,682
PULMONX CORP COM 745848101 76,102 1,102,602 SH   DFND   0 0 1,102,602
PURPLE INNOVATION INC COM 74640Y106 42,654 1,294,913 SH   DFND   0 0 1,294,913
Q2 HLDGS INC COM 74736L109 80,758 638,256 SH   DFND   0 0 638,256
QORVO INC COM 74736K101 4,554 27,388 SH   DFND   0 0 27,388
QUANTERIX CORP COM 74766Q101 142,999 3,075,251 SH   DFND   0 0 3,075,251
QUIDEL CORP COM 74838J101 6,635 36,931 SH   DFND   0 0 36,931
REDFIN CORP COM 75737F108 45,623 664,766 SH   DFND   0 0 664,766
REGENERON PHARMACEUTICALS COM 75886F107 2,757 5,707 SH   DFND   0 0 5,707
RELAY THERAPEUTICS INC COM 75943R102 85,902 2,066,931 SH   DFND   0 0 2,066,931
RENAISSANCERE HLDGS LTD COM G7496G103 7 43 SH   DFND   0 0 43
RENALYTIX AI PLC ADS 75973T101 40,812 2,550,740 SH   DFND   0 0 2,550,740
RENALYTIX AI PLC ORD GBP00025 ISIN GB00BYWL4Y04 SEDOL BYWL4Y0 COMMONSTOCK G7489R108 1,362 204,427 SH   DFND   0 0 204,427
REPARE THERAPEUTICS INC COM 760273102 111 3,236 SH   DFND   0 0 3,236
REPLIGEN CORP COM 759916109 92,102 480,625 SH   DFND   0 0 480,625
REYNA SILVER CORP COM NPV ISIN CA76170Q1063 SEDOL BMG11D0 COMMONSTOCK 76170Q106 2,502 2,326,909 SH   DFND   0 0 2,326,909
RHYTHM PHARMACEUTICALS INC COM 76243J105 11,462 385,532 SH   DFND   0 0 385,532
RIGHTMOVE ORD GBP0001 ISIN GB00BGDT3G23 SEDOL BGDT3G2 COMMONSTOCK G7565D106 7,567 850,563 SH   DFND   0 0 850,563
RINGCENTRAL INC CL A 76680R206 194,969 514,472 SH   DFND   0 0 514,472
RODGERS SILICON VALLEY AQ CO UNIT 11/30/2025 774873202 40,939 3,066,627 SH   DFND   0 0 3,066,627
ROKU INC COM CL A 77543R102 715,142 2,153,913 SH   DFND   0 0 2,153,913
ROYALTY PHARMA PLC SHS CLASS A G7709Q104 5,062 101,141 SH   DFND   0 0 101,141
SAFARICOM PLC KES005 ISIN KE1000001402 SEDOL B2QN3J6 COMMONSTOCK V74587102 29,081 92,720,974 SH   DFND   0 0 92,720,974
SAFETY INS GROUP INC COM 78648T100 99 1,270 SH   DFND   0 0 1,270
SALESFORCE COM INC COM 79466L302 39,008 175,291 SH   DFND   0 0 175,291
SAREPTA THERAPEUTICS INC COM 803607100 110,368 647,355 SH   DFND   0 0 647,355
SCHRODINGER INC COM 80810D103 53,702 678,222 SH   DFND   0 0 678,222
SCIENTIFIC GAMES CORP COM 80874P109 452 10,892 SH   DFND   0 0 10,892
SCOTTS MIRACLE GRO CO CL A 810186106 75,555 379,405 SH   DFND   0 0 379,405
SEMLER SCIENTIFIC INC COM USD0001 COMMONSTOCK 81684M104 5,197 55,290 SH   DFND   0 0 55,290
SENESTECH INC COM NEW 81720R208 59 34,278 SH   DFND   0 0 34,278
SENSEONICS HLDGS INC COM 81727U105 12,624 14,480,109 SH   DFND   0 0 14,480,109
SERES THERAPEUTICS INC COM 81750R102 78,007 3,183,974 SH   DFND   0 0 3,183,974
SERVICENOW INC COM 81762P102 59,778 108,603 SH   DFND   0 0 108,603
SHAKE SHACK INC CL A 819047101 251,807 2,970,127 SH   DFND   0 0 2,970,127
SHERWIN WILLIAMS CO COM 824348106 1,174 1,598 SH   DFND   0 0 1,598
SHOCKWAVE MED INC COM 82489T104 193,150 1,862,229 SH   DFND   0 0 1,862,229
SHOP APOTHEKE EUROPE NV NPV 144A REG S ISIN NL0012044747 SEDOL COMMONSTOCK N7975Z103 9 48 SH   DFND   0 0 48
SHOPIFY INC CL A 82509L107 461,041 407,298 SH   DFND   0 0 407,298
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SI BONE INC COM 825704109 77,354 2,587,075 SH   DFND   0 0 2,587,075
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SILK RD MED INC COM 82710M100 7,456 118,382 SH   DFND   0 0 118,382
SILVERCREST METALS INC COM 828363101 93,765 8,386,866 SH   DFND   0 0 8,386,866
SINTX TECHNOLOGIES INC COM NEW 829392307 0 71 SH   DFND   0 0 71
SITEONE LANDSCAPE SUPPLY INC COM 82982L103 40,206 253,457 SH   DFND   0 0 253,457
SITIME CORP COM 82982T106 22,795 203,653 SH   DFND   0 0 203,653
SKEENA RESOURCES COM NPVPOST REV SPLT ISIN CA83056P8064 SEDOL COMMONSTOCK 83056P806 10,716 3,968,668 SH   DFND   0 0 3,968,668
SLACK TECHNOLOGIES INC COM CL A 83088V102 6 137 SH   DFND   0 0 137
SMARTSHEET INC COM CL A 83200N103 1,006 14,514 SH   DFND   0 0 14,514
SNAP INC CL A 83304A106 162,778 3,251,000 SH   DFND   0 0 3,251,000
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SONOS INC COM 83570H108 5,413 231,414 SH   DFND   0 0 231,414
SPDR GOLD TR GOLD SHS 78463V107 15,106 84,694 SH   DFND   0 0 84,694
SPLUNK INC COM 848637104 229 1,350 SH   DFND   0 0 1,350
SPORTSMANS WHSE HLDGS INC COM 84920Y106 1,044 59,483 SH   DFND   0 0 59,483
SPOTIFY TECHNOLOGY S A SHS L8681T102 228,182 725,170 SH   DFND   0 0 725,170
SPROUT SOCIAL INC COM CL A 85209W109 23,207 511,053 SH   DFND   0 0 511,053
SQUARE INC CL A 852234103 213,826 982,475 SH   DFND   0 0 982,475
SS&C TECHNOLOGIES HLDGS INC COM 78467J100 43,245 594,428 SH   DFND   0 0 594,428
STAAR SURGICAL CO COM PAR $0.01 852312305 17 214 SH   DFND   0 0 214
STAMPS COM INC COM NEW 852857200 385 1,961 SH   DFND   0 0 1,961
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STOKE THERAPEUTICS INC COM 86150R107 91,089 1,470,841 SH   DFND   0 0 1,470,841
STONECO LTD COM CL A G85158106 136,063 1,621,344 SH   DFND   0 0 1,621,344
SUNRUN INC COM 86771W105 125,619 1,810,599 SH   DFND   0 0 1,810,599
SUNTIMES MEDIA GROUP INC CLASS A COM USD001 NO STOCKHOLDER EQU COMMONSTOCK 86688Q100 0 650 SH   DFND   0 0 650
SVB FINANCIAL GROUP COM 78486Q101 9,243 23,832 SH   DFND   0 0 23,832
SVMK INC COM 78489X103 3,595 140,702 SH   DFND   0 0 140,702
TACTILE SYS TECHNOLOGY INC COM 87357P100 115 2,559 SH   DFND   0 0 2,559
TAL EDUCATION GROUP SPONSORED ADS 874080104 112,736 1,576,508 SH   DFND   0 0 1,576,508
TALON THERAPEUTICS CVR NEW COMMONSTOCK 874CNT108 0 125 SH   DFND   0 0 125
TANDEM DIABETES CARE INC COM NEW 875372203 133,045 1,390,517 SH   DFND   0 0 1,390,517
TAYSHA GENE THERAPIES INC COM SHS 877619106 1,088 41,003 SH   DFND   0 0 41,003
TELADOC HEALTH INC COM 87918A105 276,959 1,385,072 SH   DFND   0 0 1,385,072
TENCENT HOLDINGS LIMITED HKD000002 ISIN KYG875721634 SEDOL BM COMMONSTOCK G87572163 96,201 1,322,562 SH   DFND   0 0 1,322,562
TESLA INC COM 88160R101 1,467,843 2,080,070 SH   DFND   0 0 2,080,070
THOR INDS INC COM 885160101 4,611 49,581 SH   DFND   0 0 49,581
T-MOBILE US INC COM 872590104 23,706 175,794 SH   DFND   0 0 175,794
TRANSDIGM GROUP INC COM 893641100 10,339 16,707 SH   DFND   0 0 16,707
TREAN INS GROUP INC COM 89457R101 453 34,545 SH   DFND   0 0 34,545
TRUPANION INC COM 898202106 71,245 595,146 SH   DFND   0 0 595,146
TWILIO INC CL A 90138F102 95,458 282,004 SH   DFND   0 0 282,004
TWITTER INC COM 90184L102 4,570 84,388 SH   DFND   0 0 84,388
UBER TECHNOLOGIES INC COM 90353T100 1,365 26,761 SH   DFND   0 0 26,761
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 3,223 23,284 SH   DFND   0 0 23,284
UNITY SOFTWARE INC COM 91332U101 134,608 877,096 SH   DFND   0 0 877,096
VANECK VECTORS ETF TR GOLD MINERS ETF 92189F106 13,150 365,082 SH   DFND   0 0 365,082
VEEVA SYS INC CL A COM 922475108 16,558 60,818 SH   DFND   0 0 60,818
VERACYTE INC COM 92337F107 145,070 2,964,235 SH   DFND   0 0 2,964,235
VERIZON COMMUNICATIONS INC COM 92343V104 9,866 167,932 SH   DFND   0 0 167,932
VESPER HEALTHCARE ACQSTN COR COM CL A 92538T104 13,469 1,190,886 SH   DFND   0 0 1,190,886
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VISA INC COM CL A 92826C839 358 1,639 SH   DFND   0 0 1,639
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WHEATON PRECIOUS METALS CORP COM 962879102 3,257 78,037 SH   DFND   0 0 78,037
WHITEHORSE GOLD CORP COM NPV ISIN CA96525N1033 SEDOL BMFKG99 COMMONSTOCK 96525N103 810 262,551 SH   DFND   0 0 262,551
WHITING PETE CORP NEW COM NEW 966387508 24,235 969,413 SH   DFND   0 0 969,413
WILLOW BIOSCIENCES INC COM NPV POST REV SPLIT ISIN CA97111B40 COMMONSTOCK 97111B404 898 977,399 SH   DFND   0 0 977,399
WILLSCOT MOBIL MINI HLDNG CO COM CL A 971378104 10,523 454,180 SH   DFND   0 0 454,180
WORKDAY INC CL A 98138H101 23,673 98,798 SH   DFND   0 0 98,798
WUXI BIOLOGICS CAYMAN INC USD00000083 144A REG S COMMONSTOCK G97008117 121,031 9,128,967 SH   DFND   0 0 9,128,967
XP INC CL A G98239109 25,766 649,501 SH   DFND   0 0 649,501
XYLEM INC COM 98419M100 36,438 357,971 SH   DFND   0 0 357,971
ZAI LAB LTD ADR 98887Q104 152,396 1,126,024 SH   DFND   0 0 1,126,024
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ZILLOW GROUP INC CL C CAP STK 98954M200 115,297 888,268 SH   DFND   0 0 888,268
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