The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACTUS MED INC COM 005111109 7,347 255,000 SH   SOLE   255,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 10,911 807,656 SH   SOLE   807,656 0 0
AKOUOS INC COM 00973J101 9,108 459,290 SH   SOLE   459,290 0 0
ALIGOS THERAPEUTICS INC COM 01626L105 72,293 2,614,563 SH   SOLE   2,614,563 0 0
AMICUS THERAPEUTICS INC COM 03152W109 38,902 1,684,795 SH   SOLE   1,684,795 0 0
APPLE INC COM 037833100 137,653 1,037,404 SH   SOLE   1,037,404 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 7,123 83,100 SH   SOLE   83,100 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 22,094 197,000 SH   SOLE   197,000 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 126,738 3,070,957 SH   SOLE   3,070,957 0 0
CABLE ONE INC COM 12685J105 116,601 52,341 SH   SOLE   52,341 0 0
CATALENT INC COM 148806102 103,794 997,349 SH   SOLE   997,349 0 0
CHECKMATE PHARMACEUTICALS IN COM 162818108 31,662 2,170,100 SH   SOLE   2,170,100 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 17,250 598,951 SH   SOLE   598,951 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 3,019 847,906 SH   SOLE   847,906 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 3,829 271,378 SH   SOLE   271,378 0 0
EARGO INC COM 270087109 33,036 737,071 SH   SOLE   737,071 0 0
F-STAR THERAPEUTICS INC COM 30315R107 344 34,819 SH   SOLE   34,819 0 0
FLEXION THERAPEUTICS INC COM 33938J106 16,195 1,403,370 SH   SOLE   1,403,370 0 0
FREELINE THERAPEUTICS HLDGS SPONSORED ADS 35655L107 43,116 2,361,229 SH   SOLE   2,361,229 0 0
GALECTO INC COM 36322Q107 31,247 2,497,791 SH   SOLE   2,497,791 0 0
GALERA THERAPEUTICS INC COM 36338D108 30,271 2,959,021 SH   SOLE   2,959,021 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 130,952 3,622,471 SH   SOLE   3,622,471 0 0
INARI MED INC COM 45332Y109 6,303 72,212 SH   SOLE   72,212 0 0
INOGEN INC COM 45780L104 158,584 3,549,320 SH   SOLE   3,549,320 0 0
INSMED INC COM PAR $.01 457669307 14,318 430,107 SH   SOLE   430,107 0 0
INSPIRE MED SYS INC COM 457730109 7,524 40,000 SH   SOLE   40,000 0 0
INTERSECT ENT INC COM 46071F103 11,501 502,225 SH   SOLE   502,225 0 0
INOZYME PHARMA INC COM 45790W108 53,032 2,569,379 SH   SOLE   2,569,379 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 17,823 384,117 SH   SOLE   384,117 0 0
KINNATE BIOPHARMA INC COM 49705R105 11,934 300,000 SH   SOLE   300,000 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 16,955 2,530,585 SH   SOLE   2,530,585 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 42,692 2,445,147 SH   SOLE   2,445,147 0 0
MORPHIC HLDG INC COM 61775R105 88,755 2,645,446 SH   SOLE   2,645,446 0 0
NKARTA INC COM 65487U108 171,739 2,793,864 SH   SOLE   2,793,864 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 134,363 2,442,080 SH   SOLE   2,442,080 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 17,493 867,724 SH   SOLE   867,724 0 0
PULMONX CORP COM 745848101 12,910 187,047 SH   SOLE   187,047 0 0
SEASPINE HLDGS CORP COM 81255T108 23,367 1,339,085 SH   SOLE   1,339,085 0 0
SILK RD MED INC COM 82710M100 5,045 80,102 SH   SOLE   80,102 0 0
SPERO THERAPEUTICS INC COM 84833T103 11,182 576,702 SH   SOLE   576,702 0 0
SPRUCE BIOSCIENCES INC COM 85209E109 121,291 4,989,336 SH   SOLE   4,989,336 0 0
VANGUARD INDEX FDS TOTAL STK MKT 922908769 376,414 1,933,900 SH   SOLE   1,933,900 0 0
VAXCYTE INC COM 92243G108 11,078 416,937 SH   SOLE   416,937 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 18,261 2,608,755 SH   SOLE   2,608,755 0 0
ZOGENIX INC COM NEW 98978L204 6,513 325,814 SH   SOLE   325,814 0 0