The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 1,704 69,939 SH   DFND 1,2 69,939 0 0
ABBVIE INC COM 00287Y109 36,431 340,000 SH   DFND 1,2 340,000 0 0
ABBVIE INC CALL 00287Y109 24,109 225,000 SH Call DFND 1,2 0 0 225,000
ACLARIS THERAPEUTICS INC COM 00461U105 971 150,000 SH   DFND 1,2 150,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 9,374 60,000 SH   DFND 1,2 60,000 0 0
ALIGOS THERAPEUTICS INC COM 01626L105 2,046 74,000 SH   DFND 1,2 74,000 0 0
ALLOT LTD SHS M0854Q105 5,609 533,192 SH   DFND   533,192 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 2,498 198,260 SH   DFND 1,2 198,260 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 11,503 133,448 SH   DFND 1,2 133,448 0 0
AMAZON COM INC COM 023135106 6,713 2,061 SH   DFND   2,061 0 0
AMICUS THERAPEUTICS INC COM 03152W109 6,136 265,753 SH   DFND 1,2 265,753 0 0
ARGENX SE SPONSORED ADR 04016X101 2,720 9,249 SH   DFND 1,2 9,249 0 0
ARKO CORP COM 041242108 5,400 600,000 SH   DFND   600,000 0 0
ARYA SCIENCES ACQUISITION CO COM CL A G3166W106 4,340 400,000 SH   DFND 1,2 400,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 3,936 23,599 SH   DFND 1,2 23,599 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 34,517 690,473 SH   DFND 1,2 690,473 0 0
ATHIRA PHARMA INC COM 04746L104 1,846 53,900 SH   DFND 1,2 53,900 0 0
AUDIOCODES LTD ORD M15342104 11,818 428,971 SH   DFND   428,971 0 0
AVROBIO INC COM 05455M100 9,143 655,874 SH   DFND 1,2 655,874 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 6,891 625,000 SH   DFND 1,2 625,000 0 0
BEYONDSPRING INC SHS G10830100 7,296 598,000 SH   DFND 1,2 598,000 0 0
BIOATLA INC COM 09077B104 1,701 50,000 SH   DFND 1,2 50,000 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 1,298 28,093 SH   DFND 1,2 28,093 0 0
BRIDGEBIO PHARMA INC COM 10806X102 11,228 157,900 SH   DFND 1,2 157,900 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 38,769 625,000 SH   DFND 1,2 625,000 0 0
BURLINGTON STORES INC COM 122017106 9,154 35,000 SH   DFND   35,000 0 0
C4 THERAPEUTICS INC COM STK 12529R107 14,601 443,824 SH   DFND 1,2 443,824 0 0
CAMTEK LTD ORD M20791105 8,764 400,000 SH   DFND   400,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 10,463 597,198 SH   DFND 1,2 597,198 0 0
CELLECTAR BIOSCIENCES INC COM PAR 15117F500 182 87,500 SH   DFND 1,2 87,500 0 0
CEREVEL THERAPEUTICS HLDNG I *W EXP 06/09/202 15678U102 940 166,332 SH   DFND 1,2 166,332 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 13,457 811,665 SH   DFND 1,2 811,665 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 3,198 201,666 SH   DFND 1,2 201,666 0 0
COGENT BIOSCIENCES INC COM 19240Q201 8,259 735,434 SH   DFND 1,2 735,434 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 4,854 384,039 SH   DFND 1,2 384,039 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 5,910 103,565 SH   DFND 1,2 103,565 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 4,780 216,980 SH   DFND 1,2 216,980 0 0
DYNE THERAPEUTICS INC COM 26818M108 2,100 100,000 SH   DFND 1,2 100,000 0 0
ESSA PHARMA INC COM NEW 29668H708 4,655 390,200 SH   DFND 1,2 390,200 0 0
FACEBOOK INC CL A 30303M102 10,926 39,998 SH   DFND   39,998 0 0
FATE THERAPEUTICS INC COM 31189P102 7,456 82,000 SH   DFND 1,2 82,000 0 0
GALECTO INC COM 36322Q107 4,669 391,787 SH   DFND 1,2 391,787 0 0
GALERA THERAPEUTICS INC COM 36338D108 4,784 467,662 SH   DFND 1,2 467,662 0 0
GAMIDA CELL LTD SHS M47364100 336 40,000 SH   DFND 1,2 40,000 0 0
GENERAC HLDGS INC COM 368736104 24,029 105,663 SH   DFND   105,663 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 1,281 100,000 SH   DFND 1,2 100,000 0 0
I MAB SPONSORED ADS 44975P103 8,573 181,820 SH   DFND 1,2 181,820 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117 288 100,000 SH   DFND 1,2 100,000 0 0
IMMATICS N.V SHS N44445109 8,884 823,391 SH   DFND 1,2 823,391 0 0
IMMUNOVANT INC COM 45258J102 7,852 170,000 SH   DFND 1,2 170,000 0 0
INHIBRX INC COM 45720L107 1,424 43,182 SH   DFND 1,2 43,182 0 0
ION ACQUISITION CORP 1 LTD SHS CL A G49392106 1,766 150,000 SH   DFND   150,000 0 0
IONIS PHARMACEUTICALS INC COM 462222100 5,190 91,800 SH   DFND 1,2 91,800 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 5,906 127,289 SH   DFND 1,2 127,289 0 0
JFROG LTD ORD SHS M6191J100 4,547 72,377 SH   DFND   72,377 0 0
JOHNSON & JOHNSON COM 478160104 53,226 338,200 SH   DFND 1,2 338,200 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 4,560 240,140 SH   DFND 1,2 240,140 0 0
KORNIT DIGITAL LTD SHS M6372Q113 11,443 128,381 SH   DFND   128,381 0 0
KRONOS BIO INC COM 50107A104 1,045 35,000 SH   DFND 1,2 35,000 0 0
KRYSTAL BIOTECH INC COM 501147102 6,063 101,044 SH   DFND 1,2 101,044 0 0
KURA ONCOLOGY INC COM 50127T109 15,399 471,494 SH   DFND 1,2 471,494 0 0
KYMERA THERAPEUTICS INC COM 501575104 9,157 147,700 SH   DFND 1,2 147,700 0 0
LEAP THERAPEUTICS INC COM 52187K101 1,800 800,000 SH   DFND 1,2 800,000 0 0
LIFESCI ACQUISITION II CORP COM 53229E103 1,062 100,000 SH   DFND 1,2 100,000 0 0
LILLY ELI & CO COM 532457108 69,224 410,000 SH   DFND 1,2 410,000 0 0
MERCK & CO. INC COM 58933Y105 59,616 728,808 SH   DFND 1,2 728,808 0 0
MERCK & CO. INC CALL 58933Y105 10,634 130,000 SH Call DFND 1,2 0 0 130,000
MICROSOFT CORP COM 594918104 10,573 47,536 SH   DFND   47,536 0 0
MIRAGEN THERAPEUTICS INC COM 60463E103 502 30,497 SH   DFND 1,2 30,497 0 0
MIRATI THERAPEUTICS INC COM 60468T105 6,541 29,779 SH   DFND 1,2 29,779 0 0
NICE LTD SPONSORED ADR 653656108 21,118 74,481 SH   DFND   74,481 0 0
NICE SYS INC NOTE 1.250% 1/1 65366HAB9 856 250,000 SH   DFND   250,000 0 0
NOVA MEASURING INSTRUMENTS L COM M7516K103 5,515 78,113 SH   DFND   78,113 0 0
NOVARTIS AG SPONSORED ADR 66987V109 40,510 429,000 SH   DFND 1,2 429,000 0 0
NOVARTIS AG CALL 66987V109 11,332 120,000 SH Call DFND 1,2 0 0 120,000
OLEMA PHARMACEUTICALS INC COM 68062P106 731 15,200 SH   DFND 1,2 15,200 0 0
ONCORUS INC COM 68236R103 28,395 903,111 SH   DFND 1,2 903,111 0 0
ORGENESIS INC COM NEW 68619K204 161 35,712 SH   DFND 1,2 35,712 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 6,167 182,200 SH   DFND 1,2 182,200 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 29 129,500 SH   DFND 1,2 129,500 0 0
PALO ALTO NETWORKS INC COM 697435105 13,459 37,871 SH   DFND   37,871 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 1,375 550,000 SH   DFND 1,2 550,000 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 5,502 100,000 SH   DFND 1,2 100,000 0 0
REPARE THERAPEUTICS INC COM 760273102 7,693 224,300 SH   DFND 1,2 224,300 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 4,113 75,000 SH   DFND 1,2 75,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 740 8,554 SH   DFND 1,2 8,554 0 0
SAREPTA THERAPEUTICS INC COM 803607100 12,787 75,000 SH   DFND 1,2 75,000 0 0
SAREPTA THERAPEUTICS INC PUT 803607100 12,787 75,000 SH Put DFND 1,2 75,000 0 0
SAREPTA THERAPEUTICS INC CALL 803607100 63,081 370,000 SH Call DFND 1,2 0 0 370,000
SHATTUCK LABS INC COM 82024L103 2,898 55,300 SH   DFND 1,2 55,300 0 0
SIGILON THERAPEUTICS INC COM 82657L107 26,061 567,460 SH   DFND 1,2 567,460 0 0
SILVERBACK THERAPEUTICS INC COM 82835W108 8,075 174,261 SH   DFND 1,2 174,261 0 0
SPDR SER TR PUT 78464A870 42,234 300,000 SH Put DFND 1,2 300,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 2,270 31,300 SH   DFND 1,2 31,300 0 0
SUTRO BIOPHARMA INC COM 869367102 4,377 201,600 SH   DFND 1,2 201,600 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 16,589 745,900 SH   DFND 1,2 745,900 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 8,037 832,878 SH   DFND   832,878 0 0
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 279 20,000 SH   DFND 1,2 20,000 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 9,220 626,759 SH   DFND 1,2 626,759 0 0
UNIQURE NV SHS N90064101 7,804 216,000 SH   DFND 1,2 216,000 0 0
VARONIS SYS INC COM 922280102 9,035 55,225 SH   DFND   55,225 0 0
VERINT SYS INC COM 92343X100 8,532 127,000 SH   DFND   127,000 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 7,235 1,033,603 SH   DFND 1,2 1,033,603 0 0
VINCERA PHARMA INC COM 92731L106 972 46,465 SH   DFND 1,2 46,465 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 5,287 2,725,000 SH   DFND 1,2 2,725,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 3,266 414,959 SH   DFND 1,2 414,959 0 0
Y-MABS THERAPEUTICS INC COM 984241109 6,487 131,016 SH   DFND 1,2 131,016 0 0
YUMANITY THERAPEUTICS INC COM 98872L102 2,217 130,434 SH   DFND 1,2 130,434 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 9,910 190,796 SH   DFND 1,2 190,796 0 0
ZYMEWORKS INC COM 98985W102 11,579 245,000 SH   DFND 1,2 245,000 0 0