The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
908 DEVICES INC COM 65443P102 1,139 20,000 SH   SOLE   20,000 0 0
ACCELERON PHARMA INC COM 00434H108 1,775 13,872 SH   SOLE   13,872 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 1,776 30,028 SH   SOLE   30,028 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 2,979 68,752 SH   SOLE   68,752 0 0
ALECTOR INC COM 014442107 851 56,240 SH   SOLE   56,240 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 111,576 479,421 SH   SOLE   479,421 0 0
ALKERMES PLC SHS G01767105 3,246 162,716 SH   SOLE   162,716 0 0
ALLY FINL INC COM 02005N100 236,066 6,619,915 SH   SOLE   5,982,251 0 637,664
ALPHABET INC CAP STK CL A 02079K305 48,587 27,722 SH   SOLE   20,965 0 6,757
ALPHABET INC CAP STK CL C 02079K107 90,761 51,808 SH   SOLE   51,808 0 0
AMBARELLA INC SHS G037AX101 21,339 232,405 SH   SOLE   189,143 0 43,262
AMERICAN EAGLE OUTFITTERS IN COM 02553E106 63,532 3,165,500 SH   SOLE   2,669,326 0 496,174
AMERISOURCEBERGEN CORP COM 03073E105 83 845 SH   SOLE   845 0 0
AMGEN INC COM 031162100 82 358 SH   SOLE   358 0 0
ANALOG DEVICES INC COM 032654105 2,681 18,145 SH   SOLE   18,145 0 0
APPIAN CORP CL A 03782L101 809 4,993 SH   SOLE   4,993 0 0
APPLE INC COM 037833100 1,697 12,788 SH   SOLE   12,788 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 1,923 44,333 SH   SOLE   44,333 0 0
ARCUS BIOSCIENCES INC COM 03969F109 2,260 87,058 SH   SOLE   87,058 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 942 514,984 SH   SOLE   514,984 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 4,972 821,886 SH   SOLE   821,886 0 0
ATRECA INC CL A COM 04965G109 1,934 119,751 SH   SOLE   119,751 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 383 15,000 SH   SOLE   15,000 0 0
BARRICK GOLD CORP COM 067901108 107,035 4,698,629 SH   SOLE   4,033,167 0 665,462
BIO RAD LABS INC CL A 090572207 2,346 4,024 SH   SOLE   4,024 0 0
BIOATLA INC COM 09077B104 2,381 70,000 SH   SOLE   70,000 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 3,413 458,075 SH   SOLE   458,075 0 0
BIONTECH SE SPONSORED ADS 09075V102 16,641 204,139 SH   SOLE   204,139 0 0
BLUEBIRD BIO INC COM 09609G100 23,174 535,573 SH   SOLE   470,883 0 64,690
BLUEPRINT MEDICINES CORP COM 09627Y109 3,042 27,121 SH   SOLE   27,121 0 0
BOINGO WIRELESS INC COM 09739C102 1,503 118,198 SH   SOLE   118,198 0 0
BOOKING HOLDINGS INC COM 09857L108 239,790 107,661 SH   SOLE   93,221 0 14,440
CANADA GOOSE HLDGS INC SHS SUB VTG 135086106 3,488 117,149 SH   SOLE   117,149 0 0
CARDINAL HEALTH INC COM 14149Y108 3,182 59,419 SH   SOLE   59,419 0 0
CARRIER GLOBAL CORPORATION COM 14448C104 83,585 2,215,933 SH   SOLE   2,049,486 0 166,447
CARVANA CO CL A 146869102 11,669 48,714 SH   SOLE   48,714 0 0
CEDAR FAIR L P DEPOSITRY UNIT 150185106 7,366 187,233 SH   SOLE   187,233 0 0
CENTOGENE N V COM N1976T109 4,413 409,388 SH   SOLE   409,388 0 0
CIENA CORP COM NEW 171779309 870 16,465 SH   SOLE   16,465 0 0
CISCO SYS INC COM 17275R102 1,598 35,700 SH   SOLE   35,700 0 0
COGENT BIOSCIENCES INC COM 19240Q201 5,342 475,705 SH   SOLE   450,872 0 24,833
COHERUS BIOSCIENCES INC COM 19249H103 2,469 142,034 SH   SOLE   142,034 0 0
CREDIT ACCEP CORP MICH COM 225310101 43 123 SH   SOLE   123 0 0
CUREVAC N V COM N2451R105 1,348 16,623 SH   SOLE   16,623 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 1,988 303,465 SH   SOLE   303,465 0 0
DENALI THERAPEUTICS INC COM 24823R105 2,579 30,791 SH   SOLE   30,791 0 0
DISCOVERY INC COM SER A 25470F104 86 2,865 SH   SOLE   2,865 0 0
DISH NETWORK CORPORATION CL A 25470M109 215 6,644 SH   SOLE   6,644 0 0
EBAY INC. COM 278642103 1,140 22,679 SH   SOLE   22,679 0 0
EQUIFAX INC COM 294429105 35,417 183,659 SH   SOLE   183,659 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 40,635 1,562,869 SH   SOLE   1,383,753 0 179,116
FACEBOOK INC CL A 30303M102 143,591 525,667 SH   SOLE   470,691 0 54,976
FEDEX CORP COM 31428X106 151,197 582,377 SH   SOLE   488,478 0 93,899
FIVE PRIME THERAPEUTICS INC COM 33830X104 4,104 241,243 SH   SOLE   241,243 0 0
FOX CORP CL A COM 35137L105 43 1,473 SH   SOLE   1,473 0 0
FREEPORT-MCMORAN INC CL B 35671D857 129,886 4,991,758 SH   SOLE   4,036,147 0 955,611
FULCRUM THERAPEUTICS INC COM 359616109 978 83,550 SH   SOLE   83,550 0 0
GENERAL ELECTRIC CO COM 369604103 333,833 30,910,503 SH   SOLE   26,619,508 0 4,290,995
GENETRON HLDGS LTD ADS 37186H100 5,886 420,444 SH   SOLE   420,444 0 0
GILEAD SCIENCES INC COM 375558103 92,037 1,579,756 SH   SOLE   1,379,301 0 200,455
GOLDMAN SACHS GROUP INC COM 38141G104 84 320 SH   SOLE   320 0 0
HANESBRANDS INC COM 410345102 88 6,059 SH   SOLE   6,059 0 0
HCA HEALTHCARE INC COM 40412C101 81 490 SH   SOLE   490 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 112,642 2,501,484 SH   SOLE   2,501,484 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 2,723 85,055 SH   SOLE   85,055 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 2,704 193,123 SH   SOLE   193,123 0 0
IHS MARKIT LTD SHS G47567105 8,952 99,660 SH   SOLE   99,660 0 0
IMMATICS N.V SHS N44445109 2,470 228,960 SH   SOLE   228,960 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 1,602 755,593 SH   SOLE   755,593 0 0
INHIBRX INC COM 45720L107 1,982 60,105 SH   SOLE   60,105 0 0
INOVALON HLDGS INC COM CL A 45781D101 160 8,800 SH   SOLE   8,800 0 0
INTEL CORP COM 458140100 1,690 33,932 SH   SOLE   33,932 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 2,446 44,963 SH   SOLE   44,963 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 169 1,343 SH   SOLE   1,343 0 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 41 6,784 SH   SOLE   6,784 0 0
JD.COM INC SPON ADR CL A 47215P106 63,852 726,417 SH   SOLE   726,417 0 0
JOHNSON & JOHNSON COM 478160104 4,012 25,495 SH   SOLE   25,495 0 0
JOYY INC ADS REPSTG COM A 46591M109 39 483 SH   SOLE   483 0 0
KOHLS CORP COM 500255104 8,802 216,311 SH   SOLE   216,311 0 0
LAM RESEARCH CORP COM 512807108 74,223 157,162 SH   SOLE   139,271 0 17,891
LEAP THERAPEUTICS INC COM 52187K101 2,397 1,065,259 SH   SOLE   1,065,259 0 0
LIBERTY GLOBAL PLC SHS CL A G5480U104 358 14,800 SH   SOLE   14,800 0 0
LIVANOVA PLC SHS G5509L101 2,755 41,603 SH   SOLE   41,603 0 0
LIVERAMP HLDGS INC COM 53815P108 245 3,347 SH   SOLE   3,347 0 0
LOUISIANA PAC CORP COM 546347105 76,169 2,049,200 SH   SOLE   1,841,710 0 207,490
LUMEN TECHNOLOGIES INC COM 156700106 594 60,907 SH   SOLE   60,907 0 0
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 64,829 707,276 SH   SOLE   570,681 0 136,595
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 82 1,941 SH   SOLE   1,941 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 2,816 359,133 SH   SOLE   359,133 0 0
MANULIFE FINL CORP COM 56501R106 89 4,999 SH   SOLE   4,999 0 0
MEDALLIA INC COM 584021109 67,467 2,030,927 SH   SOLE   1,750,054 0 280,873
MELCO RESORTS AND ENTMNT LTD ADR 585464100 50,384 2,716,126 SH   SOLE   2,716,126 0 0
MERCK & CO. INC COM 58933Y105 119 1,452 SH   SOLE   1,452 0 0
MERSANA THERAPEUTICS INC COM 59045L106 2,951 110,906 SH   SOLE   110,906 0 0
MERUS N V COM N5749R100 4,018 229,233 SH   SOLE   229,233 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 286,513 2,074,524 SH   SOLE   1,851,472 0 223,052
MICRON TECHNOLOGY INC COM 595112103 315,158 4,192,043 SH   SOLE   3,710,122 0 481,921
MICROSOFT CORP COM 594918104 5,560 24,998 SH   SOLE   24,998 0 0
MODERNA INC COM 60770K107 1,171 11,207 SH   SOLE   11,207 0 0
MOMO INC ADR 60879B107 86 6,167 SH   SOLE   6,167 0 0
MOTOROLA SOLUTIONS INC COM NEW 620076307 273 1,606 SH   SOLE   1,606 0 0
MYOVANT SCIENCES LTD COM G637AM102 6,189 224,083 SH   SOLE   224,083 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 18,069 270,172 SH   SOLE   239,053 0 31,119
NIELSEN HLDGS PLC SHS EUR G6518L108 355 17,000 SH   SOLE   17,000 0 0
NOAH HLDGS LTD SPON ADS CL A 65487X102 81,624 1,707,263 SH   SOLE   1,707,263 0 0
OMNICOM GROUP INC COM 681919106 85 1,364 SH   SOLE   1,364 0 0
ONECONNECT FINL TECHNOLOGY C SPONSORED ADS 68248T105 37,266 1,890,739 SH   SOLE   1,890,739 0 0
ORACLE CORP COM 68389X105 2,062 31,874 SH   SOLE   31,874 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 2,920 675,969 SH   SOLE   675,969 0 0
OVID THERAPEUTICS INC COM 690469101 917 396,870 SH   SOLE   396,870 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 11,420 440,260 SH   SOLE   408,716 0 31,544
PAYPAL HLDGS INC COM 70450Y103 3,068 13,099 SH   SOLE   13,099 0 0
PERKINELMER INC COM 714046109 2,035 14,180 SH   SOLE   14,180 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 85 7,531 SH   SOLE   7,531 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 1,272 508,768 SH   SOLE   508,768 0 0
PLANET FITNESS INC CL A 72703H101 14,485 186,591 SH   SOLE   186,591 0 0
PROTHENA CORP PLC SHS G72800108 1,540 128,223 SH   SOLE   128,223 0 0
PRUDENTIAL FINL INC COM 744320102 85 1,088 SH   SOLE   1,088 0 0
QUANTERIX CORP COM 74766Q101 14,806 318,410 SH   SOLE   294,919 0 23,491
ROKU INC COM CL A 77543R102 1,880 5,661 SH   SOLE   5,661 0 0
SANGAMO THERAPEUTICS INC COM 800677106 3,407 218,336 SH   SOLE   218,336 0 0
SCHLUMBERGER LTD COM 806857108 121 5,551 SH   SOLE   5,551 0 0
SEAWORLD ENTMT INC COM 81282V100 7,157 226,546 SH   SOLE   226,546 0 0
SIGNET JEWELERS LIMITED SHS G81276100 7,891 289,383 SH   SOLE   289,383 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 8,263 242,308 SH   SOLE   242,308 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 98,326 643,155 SH   SOLE   537,194 0 105,961
STARBUCKS CORP COM 855244109 7,237 67,648 SH   SOLE   67,648 0 0
STEEL DYNAMICS INC COM 858119100 32,656 885,714 SH   SOLE   885,714 0 0
STORE CAP CORP COM 862121100 82 2,414 SH   SOLE   2,414 0 0
SYNEOS HEALTH INC CL A 87166B102 3,259 47,839 SH   SOLE   47,839 0 0
TECHNIPFMC PLC COM G87110105 20,761 2,208,594 SH   SOLE   2,208,594 0 0
TRIP COM GROUP LTD ADS 89677Q107 264,426 7,839,504 SH   SOLE   7,160,846 0 678,658
TWILIO INC CL A 90138F102 955 2,820 SH   SOLE   2,820 0 0
ULTA BEAUTY INC COM 90384S303 55,128 191,975 SH   SOLE   164,330 0 27,645
UNITED STATES STL CORP NEW COM 912909108 24,642 1,469,435 SH   SOLE   1,205,354 0 264,081
UNIVERSAL HLTH SVCS INC CL B 913903100 81 589 SH   SOLE   589 0 0
VAIL RESORTS INC COM 91879Q109 4,769 17,094 SH   SOLE   17,094 0 0
WABTEC COM 929740108 55,990 764,886 SH   SOLE   661,499 0 103,387
WARRIOR MET COAL INC COM 93627C101 17,272 810,120 SH   SOLE   676,820 0 133,300
WAVE LIFE SCIENCES LTD SHS Y95308105 1,624 206,384 SH   SOLE   206,384 0 0
WYNDHAM HOTELS & RESORTS INC COM 98311A105 6,324 106,399 SH   SOLE   106,399 0 0
XILINX INC COM 983919101 1,306 9,209 SH   SOLE   9,209 0 0
YUM CHINA HLDGS INC COM 98850P109 76,736 1,342,969 SH   SOLE   1,342,969 0 0
ZAI LAB LTD ADR 98887Q104 7,262 53,656 SH   SOLE   53,656 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105 199,307 6,834,953 SH   SOLE   5,850,690 0 984,263
ZYMEWORKS INC COM 98985W102 2,473 52,327 SH   SOLE   52,327 0 0