The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABB LTD SPONSORED ADR 000375204 370,894 13,268,828 SH   DFND 1, 2 13,268,828 0 0
AES CORP COM 00130H105 766,793 32,641,117 SH   DFND 1, 2 32,641,009 0 108
ASGN INC COM 00191U102 46,777 560,000 SH   DFND 1, 2 560,000 0 0
ABBOTT LABS COM 002824100 5,867,497 53,591,471 SH   DFND 1, 2 53,561,618 0 29,853
ABBVIE INC COM 00287Y109 843,444 7,871,621 SH   DFND 1, 2 7,871,621 0 0
ABCELLERA BIOLOGICS INC COM 00288U106 30,180 750,000 SH   DFND 1, 2 750,000 0 0
ACTIVISION BLIZZARD INC COM 00507V109 2,387,831 25,722,649 SH   DFND 1, 2 25,710,592 0 12,057
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 104,243 1,762,952 SH   DFND 1, 2 1,762,952 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 7,121 1,321,200 SH   DFND 1, 2 1,321,200 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 1,374,112 2,747,680 SH   DFND 1, 2 2,747,669 0 11
ADVANCED DRAIN SYS INC DEL COM 00790R104 27,001 323,056 SH   DFND 1, 2 323,056 0 0
AGNICO EAGLE MINES LTD COM 008474108 305 4,325 SH   DFND 1, 2 4,325 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 9,448 218,050 SH   DFND 1, 2 218,050 0 0
AIRBNB INC COM CL A 009066101 124,246 846,361 SH   DFND 1, 2 846,361 0 0
AIR LEASE CORP CL A 00912X302 554,459 12,482,188 SH   DFND 1, 2 12,482,188 0 0
AIR PRODS & CHEMS INC COM 009158106 1,710,928 6,262,253 SH   DFND 1, 2 6,258,324 0 3,929
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 44,490 191,119 SH   DFND 1, 2 189,213 0 1,906
ALLAKOS INC COM 01671P100 406,256 2,901,828 SH   DFND 1, 2 2,901,828 0 0
ALLEGHENY TECHNOLOGIES INC COM 01741R102 141,650 8,446,608 SH   DFND 1, 2 8,446,608 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 179,916 7,128,219 SH   DFND 1, 2 7,128,219 0 0
ALPHABET INC CAP STK CL C 02079K107 7,116,882 4,062,596 SH   DFND 1, 2 4,061,182 0 1,414
ALPHABET INC CAP STK CL A 02079K305 3,054,419 1,742,757 SH   DFND 1, 2 1,742,757 0 0
ALTERYX INC COM CL A 02156B103 92,703 761,173 SH   DFND 1, 2 761,173 0 0
ALTRIA GROUP INC COM 02209S103 685,571 16,722,394 SH   DFND 1, 2 16,722,394 0 0
AMAZON COM INC COM 023135106 10,161,934 3,119,976 SH   DFND 1, 2 3,119,971 0 5
AMBEV SA SPONSORED ADR 02319V103 3,452 1,128,200 SH   DFND 1, 2 1,128,200 0 0
AMERICA MOVIL SAB DE CV SPON ADR L SHS 02364W105 1,027,280 70,628,943 SH   DFND 1, 2 70,527,114 0 101,829
AMERICAN INTL GROUP INC COM NEW 026874784 766,522 20,246,224 SH   DFND 1, 2 20,245,558 0 666
AMERICAN TOWER CORP NEW COM 03027X100 871,840 3,886,688 SH   DFND 1, 2 3,883,771 0 2,917
AMERISOURCEBERGEN CORP COM 03073E105 187,736 1,920,380 SH   DFND 1, 2 1,920,380 0 0
AMETEK INC COM 031100100 307,603 2,545,027 SH   DFND 1, 2 2,543,521 0 1,506
AMGEN INC COM 031162100 538,148 2,340,586 SH   DFND 1, 2 2,340,586 0 0
AMPHENOL CORP NEW CL A 032095101 354,155 2,708,238 SH   DFND 1, 2 2,707,758 0 480
ANALOG DEVICES INC COM 032654105 259,680 1,757,801 SH   DFND 1, 2 1,757,800 0 1
ANGLOGOLD ASHANTI LIMITED SPONSORED ADR 035128206 184,233 8,144,689 SH   DFND 1, 2 8,144,689 0 0
ANHEUSER BUSCH INBEV SA/NV SPONSORED ADR 03524A108 641,837 9,168,650 SH   DFND 1, 2 9,142,091 0 26,559
ANTHEM INC COM 036752103 1,343,212 4,184,212 SH   DFND 1, 2 4,175,308 0 8,904
APOLLO GLOBAL MGMT INC COM CL A 03768E105 271,838 5,549,970 SH   DFND 1, 2 5,549,970 0 0
APPLE INC COM 037833100 2,162,123 16,291,804 SH   DFND 1, 2 16,290,174 0 1,630
APPFOLIO INC COM CL A 03783C100 9,722 54,000 SH   DFND 1, 2 54,000 0 0
APPLIED MATLS INC COM 038222105 1,514,042 17,543,863 SH   DFND 1, 2 17,535,186 0 8,677
APPLIED MOLECULAR TRANS INC COM 03824M109 20,164 655,300 SH   DFND 1, 2 655,300 0 0
ARAMARK COM 03852U106 461,147 11,984,079 SH   DFND 1, 2 11,984,079 0 0
ARCOSA INC COM 039653100 103,949 1,892,389 SH   DFND 1, 2 1,892,389 0 0
ARES MANAGEMENT CORPORATION CL A COM STK 03990B101 309,916 6,586,942 SH   DFND 1, 2 6,586,942 0 0
ARMSTRONG WORLD INDS INC COM 04247X102 434,031 5,834,536 SH   DFND 1, 2 5,834,536 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 1,299,831 25,988,655 SH   DFND 1, 2 25,906,037 0 82,618
AUTODESK INC COM 052769106 74,255 243,188 SH   DFND 1, 2 243,188 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 10,931 1,222,688 SH   DFND 1, 2 1,222,688 0 0
AVALARA INC COM 05338G106 24,855 150,734 SH   DFND 1, 2 150,734 0 0
AVALONBAY CMNTYS INC COM 053484101 329,306 2,052,648 SH   DFND 1, 2 2,052,648 0 0
AZUL S A SPONSR ADR PFD 05501U106 7,017 307,473 SH   DFND 1, 2 307,473 0 0
BWX TECHNOLOGIES INC COM 05605H100 564,128 9,358,462 SH   DFND 1, 2 9,358,462 0 0
BAKER HUGHES COMPANY CL A 05722G100 45,829 2,198,042 SH   DFND 1, 2 2,198,042 0 0
BANCO BILBAO VIZCAYA ARGENTA SPONSORED ADR 05946K101 50,514 10,143,453 SH   DFND 1, 2 10,143,453 0 0
BK OF AMERICA CORP COM 060505104 431,166 14,225,197 SH   DFND 1, 2 14,225,197 0 0
BANK NEW YORK MELLON CORP COM 064058100 464,117 10,935,833 SH   DFND 1, 2 10,935,833 0 0
BARRICK GOLD CORP COM 067901108 323,672 14,208,160 SH   DFND 1, 2 14,208,160 0 0
BAXTER INTL INC COM 071813109 1,006,301 12,541,872 SH   DFND 1, 2 12,541,834 0 38
BEIGENE LTD SPONSORED ADR 07725L102 1,386,442 5,368,630 SH   DFND 1, 2 5,361,947 0 6,683
BERKELEY LTS INC COM 084310101 13,618 152,308 SH   DFND 1, 2 152,308 0 0
BERKSHIRE HATHAWAY INC DEL CL A 084670108 19,825 57 SH   DFND 1, 2 57 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 1,040,041 4,485,479 SH   DFND 1, 2 4,482,642 0 2,837
BILL COM HLDGS INC COM 090043100 224,831 1,647,115 SH   DFND 1, 2 1,647,115 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 47,935 546,661 SH   DFND 1, 2 543,823 0 2,838
BLACKROCK INC COM 09247X101 1,941,391 2,690,700 SH   DFND 1, 2 2,686,233 0 4,467
BLACKSTONE GROUP INC COM CL A 09260D107 1,037,765 16,012,417 SH   DFND 1, 2 16,012,417 0 0
BLUEBIRD BIO INC COM 09609G100 48,795 1,127,687 SH   DFND 1, 2 1,127,687 0 0
BOOKING HOLDINGS INC COM 09857L108 1,568,695 704,313 SH   DFND 1, 2 704,313 0 0
BRITISH AMERN TOB PLC SPONSORED ADR 110448107 335,138 8,921,557 SH   DFND 1, 2 8,898,155 0 23,402
BROADCOM INC COM 11135F101 14,430,044 32,957,832 SH   DFND 1, 2 32,934,842 0 22,990
BURLINGTON STORES INC COM 122017106 634,489 2,425,888 SH   DFND 1, 2 2,424,453 0 1,435
CDK GLOBAL INC COM 12508E101 414,132 7,990,195 SH   DFND 1, 2 7,990,195 0 0
CIGNA CORP NEW COM 125523100 614,441 2,952,059 SH   DFND 1, 2 2,952,059 0 0
CMC MATERIALS INC COM 12571T100 112,428 743,078 SH   DFND 1, 2 743,078 0 0
CME GROUP INC COM 12572Q105 1,889,343 10,380,525 SH   DFND 1, 2 10,376,906 0 3,619
CMS ENERGY CORP COM 125896100 510,216 8,365,645 SH   DFND 1, 2 8,356,642 0 9,003
CSX CORP COM 126408103 1,040,176 11,463,495 SH   DFND 1, 2 11,440,934 0 22,561
CVS HEALTH CORP COM 126650100 1,201,376 17,589,914 SH   DFND 1, 2 17,562,360 0 27,554
CABLE ONE INC COM 12685J105 360,540 161,713 SH   DFND 1, 2 161,708 0 5
CACTUS INC CL A 127203107 32,585 1,249,900 SH   DFND 1, 2 1,249,900 0 0
CANADIAN NATL RY CO COM 136375102 123,832 1,127,951 SH   DFND 1, 2 1,127,951 0 0
CANADIAN NAT RES LTD COM 136385101 394,904 16,432,106 SH   DFND 1, 2 16,431,996 0 110
CANNAE HLDGS INC COM 13765N107 15,671 353,987 SH   DFND 1, 2 353,987 0 0
CARNIVAL CORP UNIT 99/99/9999 143658300 67,622 3,121,961 SH   DFND 1, 2 3,121,961 0 0
CARRIER GLOBAL CORPORATION COM 14448C104 1,188,803 31,516,519 SH   DFND 1, 2 31,516,183 0 336
CATERPILLAR INC COM 149123101 1,473,262 8,093,959 SH   DFND 1, 2 8,093,959 0 0
CELANESE CORP DEL COM 150870103 1,040,666 8,008,831 SH   DFND 1, 2 8,003,233 0 5,598
CELLECTIS S A SPON ADS 15117K103 36,242 1,339,336 SH   DFND 1, 2 1,339,336 0 0
CENTENE CORP DEL COM 15135B101 1,545,567 25,746,691 SH   DFND 1, 2 25,741,063 0 5,628
CENTERPOINT ENERGY INC COM 15189T107 593,778 27,438,922 SH   DFND 1, 2 27,438,922 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 6,744,024 10,194,820 SH   DFND 1, 2 10,193,211 0 1,609
CHEVRON CORP NEW COM 166764100 3,225,286 38,187,055 SH   DFND 1, 2 38,155,045 0 32,010
CHIPOTLE MEXICAN GRILL INC COM 169656105 1,171,794 845,142 SH   DFND 1, 2 845,137 0 5
CHURCH & DWIGHT INC COM 171340102 891,729 10,222,737 SH   DFND 1, 2 10,222,737 0 0
CISCO SYS INC COM 17275R102 98,713 2,205,875 SH   DFND 1, 2 2,205,875 0 0
CITIZENS FINL GROUP INC COM 174610105 1,167,754 32,658,824 SH   DFND 1, 2 32,658,824 0 0
CLOROX CO DEL COM 189054109 174,967 866,648 SH   DFND 1, 2 866,648 0 0
CLOUDERA INC COM 18914U100 4,123 296,400 SH   DFND 1, 2 296,400 0 0
COCA COLA CO COM 191216100 374,435 6,829,293 SH   DFND 1, 2 6,774,267 0 55,026
COGNEX CORP COM 192422103 42,551 530,000 SH   DFND 1, 2 530,000 0 0
COLGATE PALMOLIVE CO COM 194162103 85,240 996,843 SH   DFND 1, 2 996,843 0 0
COLONY CAP INC NEW CL A COM 19626G108 83,650 17,390,807 SH   DFND 1, 2 17,390,807 0 0
COMCAST CORP NEW CL A 20030N101 11,309,587 215,855,135 SH   DFND 1, 2 215,671,691 0 183,444
CONCENTRIX CORP COM 20602D101 165,300 1,674,774 SH   DFND 1, 2 1,674,774 0 0
CONCHO RES INC COM 20605P101 488,284 8,368,215 SH   DFND 1, 2 8,359,257 0 8,958
CONOCOPHILLIPS COM 20825C104 2,531,703 63,308,295 SH   DFND 1, 2 63,308,185 0 110
CONSTELLATION BRANDS INC CL A 21036P108 201,031 917,740 SH   DFND 1, 2 917,740 0 0
CORTEXYME INC COM 22053A107 71,685 2,580,455 SH   DFND 1, 2 2,580,455 0 0
COSTCO WHSL CORP NEW COM 22160K105 1,893,858 5,026,966 SH   DFND 1, 2 5,020,961 0 6,005
COUSINS PPTYS INC COM NEW 222795502 34,046 1,016,286 SH   DFND 1, 2 1,016,286 0 0
CREE INC COM 225447101 873,497 8,248,322 SH   DFND 1, 2 8,248,322 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 2,214,431 13,916,512 SH   DFND 1, 2 13,915,967 0 545
CUMMINS INC COM 231021106 94,805 417,461 SH   DFND 1, 2 417,461 0 0
DANAHER CORPORATION COM 235851102 1,365,022 6,145,758 SH   DFND 1, 2 6,145,726 0 32
DARDEN RESTAURANTS INC COM 237194105 1,252,491 10,514,569 SH   DFND 1, 2 10,511,776 0 2,793
DEERE & CO COM 244199105 75,583 281,239 SH   DFND 1, 2 281,239 0 0
DEL TACO RESTAURANTS INC NEW COM 245496104 13,030 1,438,200 SH   DFND 1, 2 1,438,200 0 0
DEXCOM INC COM 252131107 241,018 651,892 SH   DFND 1, 2 651,892 0 0
DIAGEO PLC SPON ADR NEW 25243Q205 75,659 467,632 SH   DFND 1, 2 467,632 0 0
DIGITAL RLTY TR INC COM 253868103 1,233,182 8,839,967 SH   DFND 1, 2 8,835,713 0 4,254
DISCOVER FINL SVCS COM 254709108 685,382 7,570,776 SH   DFND 1, 2 7,570,776 0 0
DOMINION ENERGY INC UNIT 99/99/9999 25746U133 68,977 687,500 SH   DFND 1, 2 687,500 0 0
DOW INC COM 260557103 1,941,900 34,989,274 SH   DFND 1, 2 34,942,583 0 46,691
DUN & BRADSTREET HLDGS INC COM 26484T106 180,815 7,261,640 SH   DFND 1, 2 7,261,640 0 0
DUPONT DE NEMOURS INC COM 26614N102 254,943 3,585,195 SH   DFND 1, 2 3,585,195 0 0
EOG RES INC COM 26875P101 2,807,237 56,290,897 SH   DFND 1, 2 56,278,404 0 12,493
EARGO INC COM 270087109 17,928 400,000 SH   DFND 1, 2 400,000 0 0
EAST WEST BANCORP INC COM 27579R104 613,533 12,099,059 SH   DFND 1, 2 12,099,059 0 0
EDISON INTL COM 281020107 696,415 11,085,910 SH   DFND 1, 2 11,085,090 0 820
EDWARDS LIFESCIENCES CORP COM 28176E108 1,628,259 17,849,508 SH   DFND 1, 2 17,849,455 0 53
ELECTRONIC ARTS INC COM 285512109 184,210 1,282,848 SH   DFND 1, 2 1,282,848 0 0
ENBRIDGE INC COM 29250N105 2,452,393 76,667,382 SH   DFND 1, 2 76,501,544 0 165,838
ENDAVA PLC ADS 29260V105 37,286 485,815 SH   DFND 1, 2 485,815 0 0
ENPHASE ENERGY INC COM 29355A107 164,659 938,389 SH   DFND 1, 2 938,389 0 0
ENPRO INDS INC COM 29355X107 17,669 233,971 SH   DFND 1, 2 233,971 0 0
EPAM SYS INC COM 29414B104 114,701 320,082 SH   DFND 1, 2 320,082 0 0
EQUIFAX INC COM 294429105 1,607,668 8,336,863 SH   DFND 1, 2 8,329,699 0 7,164
EQUINIX INC COM 29444U700 1,622,734 2,273,225 SH   DFND 1, 2 2,271,653 0 1,572
EQUITRANS MIDSTREAM CORP COM 294600101 378,804 47,140,572 SH   DFND 1, 2 47,140,572 0 0
EURONET WORLDWIDE INC COM 298736109 114,649 791,122 SH   DFND 1, 2 791,122 0 0
EVERTEC INC COM 30040P103 42,577 1,082,843 SH   DFND 1, 2 1,082,843 0 0
EXELON CORP COM 30161N101 1,978,270 46,857,669 SH   DFND 1, 2 46,857,570 0 99
EXTRA SPACE STORAGE INC COM 30225T102 100,019 863,279 SH   DFND 1, 2 863,279 0 0
FTI CONSULTING INC COM 302941109 39,448 353,100 SH   DFND 1, 2 353,100 0 0
FACEBOOK INC CL A 30303M102 13,297,886 48,682,099 SH   DFND 1, 2 48,658,914 0 23,185
FAIR ISAAC CORP COM 303250104 14,871 29,100 SH   DFND 1, 2 29,100 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 2,593,634 18,334,830 SH   DFND 1, 2 18,334,830 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 1,221,669 8,314,675 SH   DFND 1, 2 8,311,753 0 2,922
FLEETCOR TECHNOLOGIES INC COM 339041105 1,689,071 6,191,143 SH   DFND 1, 2 6,188,013 0 3,130
FORTIS INC COM 349553107 384 9,400 SH   DFND 1, 2 9,400 0 0
FOX CORP CL A COM 35137L105 13,793 473,666 SH   DFND 1, 2 473,666 0 0
GALAPAGOS NV SPON ADR 36315X101 124,110 1,251,101 SH   DFND 1, 2 1,251,101 0 0
GALLAGHER ARTHUR J & CO COM 363576109 532,224 4,303,001 SH   DFND 1, 2 4,302,974 0 27
GAMING & LEISURE PPTYS INC COM 36467J108 314,580 7,420,816 SH   DFND 1, 2 7,420,816 0 0
GENERAC HLDGS INC COM 368736104 169,604 745,805 SH   DFND 1, 2 745,805 0 0
GENERAL DYNAMICS CORP COM 369550108 184,621 1,240,566 SH   DFND 1, 2 1,240,566 0 0
GENERAL MLS INC COM 370334104 916,319 15,583,649 SH   DFND 1, 2 15,583,607 0 42
GENMAB A/S SPONSORED ADS 372303206 118,243 2,901,044 SH   DFND 1, 2 2,901,044 0 0
GERDAU SA SPON ADR REP PFD 373737105 603,428 129,208,943 SH   DFND 1, 2 128,896,424 0 312,519
GILEAD SCIENCES INC COM 375558103 2,711,533 46,548,996 SH   DFND 1, 2 46,524,390 0 24,606
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 648,410 17,618,548 SH   DFND 1, 2 17,617,079 0 1,469
GLOBAL PMTS INC COM 37940X102 382,479 1,777,265 SH   DFND 1, 2 1,777,244 0 21
GODADDY INC CL A 380237107 772,207 9,308,117 SH   DFND 1, 2 9,295,000 0 13,117
GOL LINHAS AEREAS INTELIGENT SPON ADR PFD NEW 38045R206 10,218 1,040,553 SH   DFND 1, 2 1,040,553 0 0
GOODRX HLDGS INC COM CL A 38246G108 60,514 1,500,102 SH   DFND 1, 2 1,500,102 0 0
GOSSAMER BIO INC COM 38341P102 2,102 217,388 SH   DFND 1, 2 217,388 0 0
GRACO INC COM 384109104 30,387 420,000 SH   DFND 1, 2 420,000 0 0
GRIFOLS S A SP ADR REP B NVT 398438408 30,402 1,645,166 SH   DFND 1, 2 1,645,166 0 0
GROCERY OUTLET HLDG CORP COM 39874R101 142,369 3,627,238 SH   DFND 1, 2 3,627,238 0 0
GUARDANT HEALTH INC COM 40131M109 192,766 1,495,702 SH   DFND 1, 2 1,495,702 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 49,536 687,591 SH   DFND 1, 2 677,628 0 9,963
HALLIBURTON CO COM 406216101 17,394 920,301 SH   DFND 1, 2 920,301 0 0
HASBRO INC COM 418056107 105,257 1,125,265 SH   DFND 1, 2 1,125,100 0 165
HEALTH CATALYST INC COM 42225T107 58,145 1,335,737 SH   DFND 1, 2 1,335,737 0 0
HEICO CORP NEW COM 422806109 142,525 1,076,471 SH   DFND 1, 2 1,076,471 0 0
HEICO CORP NEW CL A 422806208 83,944 716,771 SH   DFND 1, 2 716,739 0 32
HENRY JACK & ASSOC INC COM 426281101 32,478 203,397 SH   DFND 1, 2 203,339 0 58
HILTON GRAND VACATIONS INC COM 43283X105 210,859 6,725,978 SH   DFND 1, 2 6,725,978 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A203 940,831 8,456,842 SH   DFND 1, 2 8,445,504 0 11,338
HOME DEPOT INC COM 437076102 333,787 1,256,635 SH   DFND 1, 2 1,256,467 0 168
HONEYWELL INTL INC COM 438516106 1,494,236 7,025,875 SH   DFND 1, 2 7,012,385 0 13,490
HORMEL FOODS CORP COM 440452100 471,295 10,111,634 SH   DFND 1, 2 10,066,274 0 45,360
HUAZHU GROUP LTD SPONSORED ADS 44332N106 34,460 765,258 SH   DFND 1, 2 765,258 0 0
HUBSPOT INC COM 443573100 371,873 938,031 SH   DFND 1, 2 938,031 0 0
HUMANA INC COM 444859102 1,628,295 3,969,154 SH   DFND 1, 2 3,960,044 0 9,110
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 145,890 4,572,702 SH   DFND 1, 2 4,572,702 0 0
HUYA INC ADS REP SHS A 44852D108 54,844 2,751,822 SH   DFND 1, 2 2,751,822 0 0
ICF INTL INC COM 44925C103 20,167 271,320 SH   DFND 1, 2 271,320 0 0
ICICI BANK LIMITED ADR 45104G104 463,022 31,162,978 SH   DFND 1, 2 30,861,220 0 301,758
IDEXX LABS INC COM 45168D104 96,463 192,976 SH   DFND 1, 2 192,976 0 0
INARI MED INC COM 45332Y109 39,281 450,000 SH   DFND 1, 2 450,000 0 0
INCYTE CORP COM 45337C102 590,577 6,789,813 SH   DFND 1, 2 6,782,305 0 7,508
INFOSYS LTD SPONSORED ADR 456788108 340,470 20,086,908 SH   DFND 1, 2 19,934,370 0 152,538
INSULET CORP COM 45784P101 76,650 299,849 SH   DFND 1, 2 299,849 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 12,543 193,200 SH   DFND 1, 2 193,200 0 0
INTEL CORP COM 458140100 4,659,997 93,549,148 SH   DFND 1, 2 93,482,470 0 66,678
INTERCONTINENTAL EXCHANGE IN COM 45866F104 2,594,382 22,507,660 SH   DFND 1, 2 22,483,587 0 24,073
INTERNATIONAL BUSINESS MACHS COM 459200101 29,107 231,231 SH   DFND 1, 2 231,231 0 0
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 412,907 3,793,690 SH   DFND 1, 2 3,793,214 0 476
INTUIT COM 461202103 69,474 182,899 SH   DFND 1, 2 182,899 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 78,943 96,496 SH   DFND 1, 2 96,496 0 0
IRIDIUM COMMUNICATIONS INC COM 46269C102 268,306 6,822,792 SH   DFND 1, 2 6,822,792 0 0
ISHARES TR CORE S&P500 ETF 464287200 6,688 17,917 SH   DFND 1, 2 12,221 0 5,696
ISHARES TR MSCI EAFE ETF 464287465 23,189 315,407 SH   DFND 1, 2 315,407 0 0
ISHARES TR GLOBAL 100 ETF 464287572 633 10,051 SH   DFND 1, 2 10,051 0 0
ISHARES TR RUS 1000 ETF 464287622 208 987 SH   DFND 1, 2 987 0 0
ISHARES TR MSCI ACWI ETF 464288257 8,346 92,053 SH   DFND 1, 2 90,893 0 1,160
JPMORGAN CHASE & CO COM 46625H100 4,517,047 35,552,430 SH   DFND 1, 2 35,532,333 0 20,097
JACOBS ENGR GROUP INC COM 469814107 436,554 4,006,550 SH   DFND 1, 2 4,006,550 0 0
JAMF HLDG CORP COM 47074L105 7,480 250,000 SH   DFND 1, 2 250,000 0 0
JOHNSON & JOHNSON COM 478160104 2,875,647 18,272,260 SH   DFND 1, 2 18,244,806 0 27,454
KLA CORP COM NEW 482480100 2,214,834 8,553,978 SH   DFND 1, 2 8,553,967 0 11
KKR & CO INC COM 48251W104 918,395 22,682,024 SH   DFND 1, 2 22,682,024 0 0
KT CORP SPONSORED ADR 48268K101 98,974 8,989,442 SH   DFND 1, 2 8,989,442 0 0
KARUNA THERAPEUTICS INC COM 48576A100 38,015 374,200 SH   DFND 1, 2 374,200 0 0
KEURIG DR PEPPER INC COM 49271V100 1,213,145 37,910,791 SH   DFND 1, 2 37,909,113 0 1,678
KEYCORP COM 493267108 1,124,007 68,495,225 SH   DFND 1, 2 68,495,225 0 0
KONINKLIJKE PHILIPS N V NY REG SH NEW 500472303 76,740 1,409,419 SH   DFND 1, 2 1,409,419 0 0
KRAFT HEINZ CO COM 500754106 298,697 8,617,863 SH   DFND 1, 2 8,617,863 0 0
KRATOS DEFENSE & SEC SOLUTIO COM NEW 50077B207 92,627 3,376,853 SH   DFND 1, 2 3,376,853 0 0
KRONOS BIO INC COM 50107A104 17,922 600,000 SH   DFND 1, 2 600,000 0 0
KULICKE & SOFFA INDS INC COM 501242101 16,931 532,263 SH   DFND 1, 2 532,263 0 0
L3HARRIS TECHNOLOGIES INC COM 502431109 1,492,017 7,893,441 SH   DFND 1, 2 7,893,102 0 339
LAM RESEARCH CORP COM 512807108 81,371 172,298 SH   DFND 1, 2 172,298 0 0
LAMB WESTON HLDGS INC COM 513272104 422,914 5,371,029 SH   DFND 1, 2 5,370,496 0 533
LAS VEGAS SANDS CORP COM 517834107 269,314 4,519,939 SH   DFND 1, 2 4,519,939 0 0
LAUDER ESTEE COS INC CL A 518439104 474,246 1,782,306 SH   DFND 1, 2 1,782,284 0 22
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 19,531 693,588 SH   DFND 1, 2 693,588 0 0
LESLIES INC COM 527064109 37,969 1,368,250 SH   DFND 1, 2 1,368,250 0 0
LIBERTY BROADBAND CORP COM SER C 530307305 59,083 373,071 SH   DFND 1, 2 373,071 0 0
LIGHTSPEED POS INC SUB VTG SHS 53227R106 86,763 1,231,036 SH   DFND 1, 2 1,231,036 0 0
LILLY ELI & CO COM 532457108 1,919,173 11,368,121 SH   DFND 1, 2 11,363,400 0 4,721
LIVERAMP HLDGS INC COM 53815P108 108,592 1,483,698 SH   DFND 1, 2 1,483,698 0 0
LOCKHEED MARTIN CORP COM 539830109 844,120 2,377,966 SH   DFND 1, 2 2,377,794 0 172
LOMA NEGRA CORP SPONSORED ADS 54150E104 51,363 8,351,682 SH   DFND 1, 2 8,351,682 0 0
MGIC INVT CORP WIS COM 552848103 8,315 662,526 SH   DFND 1, 2 662,526 0 0
MKS INSTRS INC COM 55306N104 572,280 3,803,788 SH   DFND 1, 2 3,803,788 0 0
MSCI INC COM 55354G100 593,392 1,329,335 SH   DFND 1, 2 1,329,324 0 11
MANULIFE FINL CORP COM 56501R106 198 11,100 SH   DFND 1, 2 11,100 0 0
MARKETAXESS HLDGS INC COM 57060D108 71,268 124,909 SH   DFND 1, 2 124,909 0 0
MARSH & MCLENNAN COS INC COM 571748102 2,549,823 21,798,682 SH   DFND 1, 2 21,766,789 0 31,893
MARRIOTT INTL INC NEW CL A 571903202 274,302 2,079,307 SH   DFND 1, 2 2,079,307 0 0
MASTERCARD INCORPORATED CL A 57636Q104 3,501,226 9,809,011 SH   DFND 1, 2 9,807,428 0 1,583
MATTEL INC COM 577081102 68,801 3,942,725 SH   DFND 1, 2 3,942,725 0 0
MAXIM INTEGRATED PRODS INC COM 57772K101 210,240 2,371,569 SH   DFND 1, 2 2,371,569 0 0
MERCADOLIBRE INC COM 58733R102 905,303 539,024 SH   DFND 1, 2 539,024 0 0
MERCK & CO. INC COM 58933Y105 2,834,077 34,650,648 SH   DFND 1, 2 34,631,386 0 19,262
METTLER TOLEDO INTERNATIONAL COM 592688105 488,481 428,612 SH   DFND 1, 2 428,612 0 0
MICROSOFT CORP COM 594918104 20,461,448 91,995,988 SH   DFND 1, 2 91,945,377 0 50,611
MICRON TECHNOLOGY INC COM 595112103 1,491,300 19,836,813 SH   DFND 1, 2 19,827,576 0 9,237
MOLINA HEALTHCARE INC COM 60855R100 210,230 988,482 SH   DFND 1, 2 988,482 0 0
MOLSON COORS BEVERAGE CO CL B 60871R209 192,786 4,266,122 SH   DFND 1, 2 4,266,122 0 0
MONDELEZ INTL INC CL A 609207105 1,184,933 20,266,548 SH   DFND 1, 2 20,266,486 0 62
MONGODB INC CL A 60937P106 217,184 604,901 SH   DFND 1, 2 604,901 0 0
MOODYS CORP COM 615369105 1,594,639 5,495,436 SH   DFND 1, 2 5,492,542 0 2,894
MOSAIC CO NEW COM 61945C103 53,688 2,333,266 SH   DFND 1, 2 2,333,266 0 0
NMI HLDGS INC CL A 629209305 32,003 1,412,927 SH   DFND 1, 2 1,412,927 0 0
NASDAQ INC COM 631103108 188,712 1,421,665 SH   DFND 1, 2 1,421,665 0 0
NATIONAL GRID PLC SPONSORED ADR NE 636274409 10,296 174,632 SH   DFND 1, 2 174,632 0 0
NCINO INC COM 63947U107 12,129 167,500 SH   DFND 1, 2 167,500 0 0
NETAPP INC COM 64110D104 1,786,053 26,965,153 SH   DFND 1, 2 26,965,153 0 0
NETFLIX INC COM 64110L106 8,591,059 15,888,455 SH   DFND 1, 2 15,884,021 0 4,434
NETEASE INC SPONSORED ADS 64110W102 6,449 67,340 SH   DFND 1, 2 67,340 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 327,082 3,412,649 SH   DFND 1, 2 3,412,616 0 33
NEWMONT CORP COM 651639106 144,834 2,418,333 SH   DFND 1, 2 2,418,333 0 0
NEXTERA ENERGY INC COM 65339F101 715,523 9,274,536 SH   DFND 1, 2 9,268,422 0 6,114
NEXTERA ENERGY INC UNIT 09/01/2022S 65339F796 84,642 1,429,759 SH   DFND 1, 2 1,429,759 0 0
NIKE INC CL B 654106103 1,055,391 7,460,081 SH   DFND 1, 2 7,455,376 0 4,705
NORFOLK SOUTHN CORP COM 655844108 1,594,030 6,709,087 SH   DFND 1, 2 6,700,064 0 9,023
NORTHROP GRUMMAN CORP COM 666807102 4,346,337 14,264,105 SH   DFND 1, 2 14,248,740 0 15,365
NOVANTA INC COM 67000B104 44,959 380,300 SH   DFND 1, 2 380,300 0 0
NOVO-NORDISK A S ADR 670100205 330,466 4,718,588 SH   DFND 1, 2 4,700,910 0 17,678
NUCANA PLC SPONSORED ADR 67022C106 19,833 4,417,153 SH   DFND 1, 2 4,417,153 0 0
NUCOR CORP COM 670346105 252,406 4,745,386 SH   DFND 1, 2 4,740,836 0 4,550
NVIDIA CORPORATION COM 67066G104 35,805 68,566 SH   DFND 1, 2 68,566 0 0
OAK STR HEALTH INC COM 67181A107 217,179 3,551,005 SH   DFND 1, 2 3,551,005 0 0
OKTA INC CL A 679295105 459,753 1,808,200 SH   DFND 1, 2 1,808,200 0 0
OLD DOMINION FREIGHT LINE IN COM 679580100 220,599 1,130,232 SH   DFND 1, 2 1,130,232 0 0
ON SEMICONDUCTOR CORP COM 682189105 588,638 17,984,669 SH   DFND 1, 2 17,984,669 0 0
ONECONNECT FINL TECHNOLOGY C SPONSORED ADS 68248T105 78,795 3,997,710 SH   DFND 1, 2 3,997,710 0 0
OTIS WORLDWIDE CORP COM 68902V107 39,501 584,771 SH   DFND 1, 2 584,771 0 0
PG&E CORP COM 69331C108 406,530 32,626,796 SH   DFND 1, 2 32,626,796 0 0
PNC FINL SVCS GROUP INC COM 693475105 2,781,967 18,672,064 SH   DFND 1, 2 18,653,940 0 18,124
PPG INDS INC COM 693506107 636,303 4,412,033 SH   DFND 1, 2 4,412,033 0 0
PACCAR INC COM 693718108 225,408 2,612,513 SH   DFND 1, 2 2,612,513 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 254,420 9,808,026 SH   DFND 1, 2 9,808,026 0 0
PARK HOTELS RESORTS INC COM 700517105 157,446 9,180,544 SH   DFND 1, 2 9,180,544 0 0
PAYCHEX INC COM 704326107 1,465,097 15,723,898 SH   DFND 1, 2 15,723,898 0 0
PAYPAL HLDGS INC COM 70450Y103 412,580 1,761,657 SH   DFND 1, 2 1,761,657 0 0
PEBBLEBROOK HOTEL TR COM 70509V100 132,736 7,060,404 SH   DFND 1, 2 7,060,404 0 0
PEPSICO INC COM 713448108 366,207 2,469,904 SH   DFND 1, 2 2,469,882 0 22
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 32,042 2,853,278 SH   DFND 1, 2 2,853,278 0 0
PFIZER INC COM 717081103 206,457 5,608,732 SH   DFND 1, 2 5,608,732 0 0
PHILIP MORRIS INTL INC COM 718172109 5,207,108 62,902,637 SH   DFND 1, 2 62,897,761 0 4,876
PHREESIA INC COM 71944F106 51,311 945,659 SH   DFND 1, 2 945,659 0 0
PINTEREST INC CL A 72352L106 326,330 4,951,894 SH   DFND 1, 2 4,951,894 0 0
PIONEER NAT RES CO COM 723787107 592,345 5,200,927 SH   DFND 1, 2 5,183,575 0 17,352
PLUG POWER INC COM NEW 72919P202 215,320 6,349,764 SH   DFND 1, 2 6,349,764 0 0
PROCTER AND GAMBLE CO COM 742718109 572,989 4,118,791 SH   DFND 1, 2 4,118,749 0 42
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 141,879 2,433,610 SH   DFND 1, 2 2,433,610 0 0
PUBLIC STORAGE COM 74460D109 239,364 1,036,842 SH   DFND 1, 2 1,036,518 0 324
QUALCOMM INC COM 747525103 906,818 5,954,247 SH   DFND 1, 2 5,954,247 0 0
RADIAN GROUP INC COM 750236101 56,270 2,778,751 SH   DFND 1, 2 2,778,751 0 0
RAYTHEON TECHNOLOGIES CORP COM 75513E101 2,173,978 30,401,311 SH   DFND 1, 2 30,400,480 0 831
REALPAGE INC COM 75606N109 50,794 582,229 SH   DFND 1, 2 582,229 0 0
REGENERON PHARMACEUTICALS COM 75886F107 659,361 1,364,826 SH   DFND 1, 2 1,364,826 0 0
RELX PLC SPONSORED ADR 759530108 321,026 13,002,707 SH   DFND 1, 2 13,002,707 0 0
REVANCE THERAPEUTICS INC COM 761330109 32,928 1,161,900 SH   DFND 1, 2 1,161,900 0 0
RINGCENTRAL INC CL A 76680R206 853,017 2,250,883 SH   DFND 1, 2 2,250,883 0 0
RIO TINTO PLC SPONSORED ADR 767204100 202,352 2,686,989 SH   DFND 1, 2 2,686,989 0 0
ROYAL DUTCH SHELL PLC SPON ADR B 780259107 34,374 1,021,775 SH   DFND 1, 2 978,327 0 43,448
ROYAL DUTCH SHELL PLC SPONS ADR A 780259206 464 13,204 SH   DFND 1, 2 13,204 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 3,160 416,396 SH   DFND 1, 2 416,396 0 0
RYANAIR HOLDINGS PLC SPONSORED ADS 783513203 1,004,722 9,133,790 SH   DFND 1, 2 9,125,132 0 8,658
S&P GLOBAL INC COM 78409V104 1,350,409 4,107,966 SH   DFND 1, 2 4,107,641 0 325
SPDR S&P 500 ETF TR TR UNIT 78462F103 6,570 17,661 SH   DFND 1, 2 12,654 0 5,007
SVB FINANCIAL GROUP COM 78486Q101 759,649 1,958,716 SH   DFND 1, 2 1,958,716 0 0
SVMK INC COM 78489X103 151,395 5,925,450 SH   DFND 1, 2 5,925,450 0 0
SABRE CORP COM 78573M104 4,464 371,400 SH   DFND 1, 2 371,400 0 0
SAGE THERAPEUTICS INC COM 78667J108 5,970 69,010 SH   DFND 1, 2 69,010 0 0
SAIA INC COM 78709Y105 86,641 479,208 SH   DFND 1, 2 479,208 0 0
SANDSTORM GOLD LTD COM NEW 80013R206 9,761 1,361,300 SH   DFND 1, 2 1,361,300 0 0
SAP SE SPON ADR 803054204 271,601 2,081,302 SH   DFND 1, 2 2,077,116 0 4,186
SAREPTA THERAPEUTICS INC COM 803607100 25,860 151,678 SH   DFND 1, 2 151,678 0 0
SCHLUMBERGER LTD COM 806857108 644,859 29,539,913 SH   DFND 1, 2 29,482,132 0 57,781
SCHRODINGER INC COM 80810D103 24,585 310,500 SH   DFND 1, 2 310,500 0 0
SEA LTD SPONSORD ADS 81141R100 188,019 944,581 SH   DFND 1, 2 944,581 0 0
SEAGEN INC COM 81181C104 3,181,551 18,155,088 SH   DFND 1, 2 18,147,920 0 7,168
SEMPRA ENERGY COM 816851109 2,295,341 18,017,073 SH   DFND 1, 2 17,993,972 0 23,101
SERVICENOW INC COM 81762P102 1,514,692 2,751,842 SH   DFND 1, 2 2,750,424 0 1,418
SHAW COMMUNICATIONS INC CL B CONV 82028K200 289 16,452 SH   DFND 1, 2 16,452 0 0
SHERWIN WILLIAMS CO COM 824348106 507,867 691,196 SH   DFND 1, 2 691,191 0 5
SHOPIFY INC CL A 82509L107 129,240 114,175 SH   DFND 1, 2 114,175 0 0
SILK RD MED INC COM 82710M100 20,191 320,600 SH   DFND 1, 2 320,600 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 91,372 2,679,532 SH   DFND 1, 2 2,679,532 0 0
SMARTSHEET INC COM CL A 83200N103 233,033 3,363,130 SH   DFND 1, 2 3,361,773 0 1,357
SNOWFLAKE INC CL A 833445109 29,596 105,173 SH   DFND 1, 2 105,173 0 0
SOUTH ST CORP COM 840441109 57,954 801,571 SH   DFND 1, 2 801,571 0 0
SQUARE INC CL A 852234103 194,776 894,945 SH   DFND 1, 2 894,945 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 47,296 597,024 SH   DFND 1, 2 597,024 0 0
STATE STR CORP COM 857477103 1,446,523 19,875,829 SH   DFND 1, 2 19,875,756 0 73
STMICROELECTRONICS N V NY REGISTRY 861012102 39,012 1,038,668 SH   DFND 1, 2 1,036,446 0 2,222
SUN LIFE FINANCIAL INC. COM 866796105 342 7,700 SH   DFND 1, 2 7,700 0 0
SUNCOR ENERGY INC NEW COM 867224107 252,989 15,083,338 SH   DFND 1, 2 15,083,338 0 0
SYNNEX CORP COM 87162W100 56,977 699,625 SH   DFND 1, 2 699,625 0 0
TFI INTL INC COM 87241L109 199,135 3,860,255 SH   DFND 1, 2 3,860,255 0 0
TJX COS INC NEW COM 872540109 80,270 1,175,427 SH   DFND 1, 2 1,175,427 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 3,824,031 35,073,683 SH   DFND 1, 2 35,044,414 0 29,269
TC ENERGY CORP COM 87807B107 1,291,487 31,746,048 SH   DFND 1, 2 31,745,543 0 505
TELADOC HEALTH INC COM 87918A105 16,490 82,466 SH   DFND 1, 2 82,466 0 0
TELUS CORPORATION COM 87971M103 474 23,908 SH   DFND 1, 2 23,908 0 0
TERADATA CORP DEL COM 88076W103 61,216 2,724,359 SH   DFND 1, 2 2,724,359 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 256,065 26,535,430 SH   DFND 1, 2 26,491,859 0 43,571
TEXAS INSTRS INC COM 882508104 99,559 606,851 SH   DFND 1, 2 606,811 0 40
THERMO FISHER SCIENTIFIC INC COM 883556102 433,193 930,051 SH   DFND 1, 2 928,576 0 1,475
TOLL BROTHERS INC COM 889478103 17,744 408,184 SH   DFND 1, 2 408,184 0 0
TOPBUILD CORP COM 89055F103 27,060 147,000 SH   DFND 1, 2 147,000 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 68,024 1,205,663 SH   DFND 1, 2 1,205,663 0 0
TOTAL SE SPONSORED ADS 89151E109 57,977 1,358,730 SH   DFND 1, 2 1,327,770 0 30,960
TRADEWEB MKTS INC CL A 892672106 9,767 156,400 SH   DFND 1, 2 156,400 0 0
TRANSDIGM GROUP INC COM 893641100 3,908,348 6,315,575 SH   DFND 1, 2 6,314,159 0 1,416
TRAVELERS COMPANIES INC COM 89417E109 2,124,851 15,137,500 SH   DFND 1, 2 15,137,500 0 0
TRIMBLE INC COM 896239100 1,484,659 22,235,592 SH   DFND 1, 2 22,210,640 0 24,952
TRINITY INDS INC COM 896522109 327,731 12,416,814 SH   DFND 1, 2 12,416,814 0 0
TRIP COM GROUP LTD ADS 89677Q107 299,809 8,888,764 SH   DFND 1, 2 8,869,236 0 19,528
TRUIST FINL CORP COM 89832Q109 3,598,926 75,093,553 SH   DFND 1, 2 75,029,977 0 63,576
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 866,806 6,261,306 SH   DFND 1, 2 6,252,361 0 8,945
UNILEVER PLC SPON ADR NEW 904767704 195,569 3,235,370 SH   DFND 1, 2 3,235,370 0 0
UNION PAC CORP COM 907818108 1,577,537 7,576,492 SH   DFND 1, 2 7,558,566 0 17,926
UNITEDHEALTH GROUP INC COM 91324P102 6,262,044 17,859,164 SH   DFND 1, 2 17,848,419 0 10,745
UPSTART HLDGS INC COM 91680M107 34,638 850,000 SH   DFND 1, 2 850,000 0 0
UPWORK INC COM 91688F104 44,718 1,295,431 SH   DFND 1, 2 1,295,431 0 0
V F CORP COM 918204108 493,050 5,772,747 SH   DFND 1, 2 5,772,747 0 0
VAIL RESORTS INC COM 91879Q109 532,969 1,910,558 SH   DFND 1, 2 1,910,558 0 0
VALE S A SPONSORED ADS 91912E105 2,113,882 126,124,389 SH   DFND 1, 2 125,927,682 0 196,707
VANGUARD TAX-MANAGED INTL FD FTSE DEV MKT ETF 921943858 5,299 111,491 SH   DFND 1, 2 111,426 0 65
VANGUARD INTL EQUITY INDEX F TT WRLD ST ETF 922042742 7,117 76,937 SH   DFND 1, 2 73,211 0 3,726
VENTAS INC COM 92276F100 122,847 2,505,032 SH   DFND 1, 2 2,505,032 0 0
VERISIGN INC COM 92343E102 936,273 4,326,583 SH   DFND 1, 2 4,326,583 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 2,106,446 35,854,827 SH   DFND 1, 2 35,813,634 0 41,193
VERTEX PHARMACEUTICALS INC COM 92532F100 1,580,021 6,685,422 SH   DFND 1, 2 6,682,599 0 2,823
VERTEX INC CL A 92538J106 52,878 1,517,306 SH   DFND 1, 2 1,517,306 0 0
VIACOMCBS INC CL B 92556H206 99,372 2,666,983 SH   DFND 1, 2 2,666,983 0 0
VIATRIS INC COM 92556V106 13,042 695,971 SH   DFND 1, 2 695,898 0 73
VICI PPTYS INC COM 925652109 382,492 14,995,775 SH   DFND 1, 2 14,995,775 0 0
VIOMI TECHNOLOGY CO LTD SPONSORED ADS 92762J103 1,931 375,000 SH   DFND 1, 2 375,000 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 302,636 11,300,804 SH   DFND 1, 2 11,300,804 0 0
VISA INC COM CL A 92826C839 4,594,896 21,007,691 SH   DFND 1, 2 20,980,480 0 27,211
WABTEC COM 929740108 319,447 4,364,930 SH   DFND 1, 2 4,364,930 0 0
WASTE CONNECTIONS INC COM 94106B101 1,027,968 10,023,835 SH   DFND 1, 2 10,023,710 0 125
WASTE MGMT INC DEL COM 94106L109 248,631 2,108,735 SH   DFND 1, 2 2,108,708 0 27
WEBSTER FINL CORP CONN COM 947890109 35,895 851,600 SH   DFND 1, 2 851,600 0 0
WELLS FARGO CO NEW COM 949746101 214,534 7,108,494 SH   DFND 1, 2 7,108,494 0 0
WESTERN ALLIANCE BANCORP COM 957638109 126,261 2,106,103 SH   DFND 1, 2 2,106,103 0 0
WYNN RESORTS LTD COM 983134107 749,206 6,640,130 SH   DFND 1, 2 6,640,126 0 4
XCEL ENERGY INC COM 98389B100 909,076 13,635,600 SH   DFND 1, 2 13,626,656 0 8,944
XENON PHARMACEUTICALS INC COM 98420N105 16,237 1,055,726 SH   DFND 1, 2 1,055,726 0 0
XPENG INC ADS 98422D105 45,294 1,057,525 SH   DFND 1, 2 1,057,525 0 0
YEXT INC COM 98585N106 18,667 1,187,449 SH   DFND 1, 2 1,187,449 0 0
YETI HLDGS INC COM 98585X104 53,455 780,700 SH   DFND 1, 2 780,700 0 0
YUM BRANDS INC COM 988498101 360,085 3,315,758 SH   DFND 1, 2 3,315,727 0 31
YUM CHINA HLDGS INC COM 98850P109 149,884 2,625,389 SH   DFND 1, 2 2,607,911 0 17,478
ZEBRA TECHNOLOGIES CORPORATI CL A 989207105 75,316 195,967 SH   DFND 1, 2 195,967 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 285,494 1,852,775 SH   DFND 1, 2 1,852,775 0 0
ZOETIS INC CL A 98978V103 96,165 581,060 SH   DFND 1, 2 581,060 0 0
AON PLC SHS CL A G0403H108 2,123,044 10,055,114 SH   DFND 1, 2 10,050,763 0 4,351
ARCH CAP GROUP LTD ORD G0450A105 394,214 10,929,135 SH   DFND 1, 2 10,929,135 0 0
ATLASSIAN CORP PLC CL A G06242104 72,651 310,631 SH   DFND 1, 2 310,631 0 0
AXALTA COATING SYS LTD COM G0750C108 39,959 1,399,600 SH   DFND 1, 2 1,399,600 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 456,918 5,330,978 SH   DFND 1, 2 5,330,978 0 0
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 109,317 418,504 SH   DFND 1, 2 418,504 0 0
BROOKFIELD PROPERTY PARTRS L UNIT LTD PARTN G16249107 41,298 2,854,032 SH   DFND 1, 2 2,854,032 0 0
CREDICORP LTD COM G2519Y108 25,360 154,615 SH   DFND 1, 2 154,615 0 0
COSAN LTD SHS A G25343107 6,653 361,000 SH   DFND 1, 2 361,000 0 0
EVEREST RE GROUP LTD COM G3223R108 525,513 2,245,190 SH   DFND 1, 2 2,245,190 0 0
FABRINET SHS G3323L100 29,423 379,209 SH   DFND 1, 2 379,209 0 0
FRESH DEL MONTE PRODUCE INC ORD G36738105 7,984 331,700 SH   DFND 1, 2 331,700 0 0
HELEN OF TROY LTD COM G4388N106 53,463 240,618 SH   DFND 1, 2 240,618 0 0
LINDE PLC SHS G5494J103 925,180 3,511,186 SH   DFND 1, 2 3,511,170 0 16
NEW FRONTIER HEALTH CORP ORD SHS G6461G106 18,846 2,191,400 SH   DFND 1, 2 2,191,400 0 0
NIELSEN HLDGS PLC SHS EUR G6518L108 17,873 856,400 SH   DFND 1, 2 856,400 0 0
NORWEGIAN CRUISE LINE HLDG L SHS G66721104 86,295 3,393,424 SH   DFND 1, 2 3,393,424 0 0
NOVOCURE LTD ORD SHS G6674U108 1,428,492 8,255,270 SH   DFND 1, 2 8,255,270 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 271,610 4,775,147 SH   DFND 1, 2 4,775,147 0 0
RENAISSANCERE HLDGS LTD COM G7496G103 190,314 1,147,716 SH   DFND 1, 2 1,147,716 0 0
ROYALTY PHARMA PLC SHS CLASS A G7709Q104 823,390 16,451,353 SH   DFND 1, 2 16,451,353 0 0
CHUBB LIMITED COM H1467J104 3,451,338 22,424,737 SH   DFND 1, 2 22,408,141 0 16,596
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 1,137,163 7,426,716 SH   DFND 1, 2 7,419,802 0 6,914
UBS GROUP AG SHS H42097107 563,452 40,267,546 SH   DFND 1, 2 40,267,546 0 0
GLOBANT S A COM L44385109 86,289 396,531 SH   DFND 1, 2 396,531 0 0
NEXA RES S A COM L67359106 60,338 6,259,130 SH   DFND 1, 2 6,259,130 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 2,850,187 5,841,973 SH   DFND 1, 2 5,831,052 0 10,921
ELASTIC N V ORD SHS N14506104 338,675 2,317,630 SH   DFND 1, 2 2,317,630 0 0
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 3,531,600 38,529,786 SH   DFND 1, 2 38,502,736 0 27,050
YANDEX N V SHS CLASS A N97284108 685,738 9,855,407 SH   DFND 1, 2 9,834,686 0 20,721
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 18,508 626,752 SH   DFND 1, 2 626,752 0 0
ROYAL CARIBBEAN GROUP COM V7780T103 928,646 12,434,736 SH   DFND 1, 2 12,434,736 0 0
FLEX LTD ORD Y2573F102 415,903 23,131,437 SH   DFND 1, 2 23,131,437 0 0