The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100 45,847 1,106,070 SH   DFND 1 0 1,106,070 0
5 01 ACQUISITION CORP COM CL A 33836P105 5,085 500,000 SH   DFND 1 0 500,000 0
AC IMMUNE SA SHS H00263105 50,752 9,816,658 SH   DFND 1 0 9,816,658 0
ALX ONCOLOGY HLDGS INC COM 00166B105 46,620 540,837 SH   DFND 1 0 540,837 0
AMARIN CORP PLC SPONS ADR NEW 023111206 52,624 10,761,593 SH   DFND 1 0 10,761,593 0
ARCUS BIOSCIENCES INC COM 03969F109 71,448 2,752,222 SH   DFND 1 0 2,752,222 0
ARGENX SE SPONSORED ADR 04016X101 18,378 62,491 SH   DFND 1 0 62,491 0
BCTG ACQUISITION CORP COM 05492W103 9,152 800,000 SH   DFND 1 0 800,000 0
CALITHERA BIOSCIENCES INC COM 13089P101 21,414 4,361,238 SH   DFND 1 0 4,361,238 0
CALLIDITAS THERAPEUTICS AB SPONSERED ADS 13124Q106 25,493 750,000 SH   DFND 1 0 750,000 0
CIDARA THERAPEUTICS INC COM 171757107 7,479 3,739,704 SH   DFND 1 0 3,739,704 0
COGENT BIOSCIENCES INC COM 19240Q201 17,208 1,532,282 SH   DFND 1 0 1,532,282 0
CONTRAFECT CORP COM NEW 212326300 8,080 1,600,000 SH   DFND 1 0 1,600,000 0
CORVUS PHARMACEUTICALS INC COM 221015100 6,920 1,943,712 SH   DFND 1 0 1,943,712 0
CTI BIOPHARMA CORP COM 12648L601 22,314 6,929,690 SH   DFND 1 0 6,929,690 0
CURIS INC COM NEW 231269200 5,135 626,945 SH   DFND 1 0 626,945 0
CYTOKINETICS INC COM NEW 23282W605 101,366 4,878,035 SH   DFND 1 0 4,878,035 0
CYTOMX THERAPEUTICS INC COM 23284F105 36,526 5,576,471 SH   DFND 1 0 5,576,471 0
ERYTECH PHARMA SPONSORED ADR 29604W108 6,119 625,000 SH   DFND 1 0 625,000 0
ESSA PHARMA INC COM NEW 29668H708 44,204 3,705,289 SH   DFND 1 0 3,705,289 0
EUCRATES BIOMEDICAL ACQU COR UNIT 10/23/2027 G3141W114 5,330 500,000 SH   DFND 1 0 500,000 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 17,668 1,038,678 SH   DFND 1 0 1,038,678 0
FORTE BIOSCIENCES INC COM 34962G109 26,171 718,788 SH   DFND 1 0 718,788 0
FORWARD PHARMA A/S SPONSORD ADS NEW 34986J204 4,557 647,299 SH   DFND 1 0 647,299 0
FRAZIER LIFESCIENCES ACQU CO UNIT 12/09/2025 G3710A121 5,205 500,000 SH   DFND 1 0 500,000 0
F-STAR THERAPEUTICS INC COM 30315R107 255 25,844 SH   DFND 1 0 25,844 0
GALMED PHARMACEUTICALS LTD SHS M47238106 5,597 1,799,694 SH   DFND 1 0 1,799,694 0
GAMIDA CELL LTD SHS M47364100 11,273 1,343,667 SH   DFND 1 0 1,343,667 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 9,710 4,012,404 SH   DFND 1 0 4,012,404 0
GLYCOMIMETICS INC COM 38000Q102 35,886 9,544,262 SH   DFND 1 0 9,544,262 0
GRITSTONE ONCOLOGY INC COM 39868T105 10,620 2,695,418 SH   DFND 1 0 2,695,418 0
IDEAYA BIOSCIENCES INC COM 45166A102 45,175 3,226,769 SH   DFND 1 0 3,226,769 0
IMMUNOVANT INC COM 45258J102 23,759 514,370 SH   DFND 1 0 514,370 0
INFINITY PHARMACEUTICALS INC COM 45665G303 36,945 17,426,968 SH   DFND 1 0 17,426,968 0
IONIS PHARMACEUTICALS INC COM 462222100 77,147 1,364,461 SH   DFND 1 0 1,364,461 0
JIYA ACQUISITION CORP COM CL A 47760M102 3,090 300,000 SH   DFND 1 0 300,000 0
KURA ONCOLOGY INC COM 50127T109 40,691 1,245,912 SH   DFND 1 0 1,245,912 0
KYMERA THERAPEUTICS INC COM 501575104 163,101 2,630,658 SH   DFND 1 0 2,630,658 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 37,493 10,963,000 SH   DFND 1 0 10,963,000 0
LIFESCI ACQUISITION II CORP COM 53229E103 1,062 100,000 SH   DFND 1 0 100,000 0
MEI PHARMA INC COM NEW 55279B202 10,690 4,049,162 SH   DFND 1 0 4,049,162 0
MERUS N V COM N5749R100 101,772 5,805,571 SH   DFND 1 0 5,805,571 0
MIRAGEN THERAPEUTICS INC COM NEW 60463E202 160 9,747 SH   DFND 1 0 9,747 0
MOLECULAR TEMPLATES INC COM 608550109 20,180 2,149,057 SH   DFND 1 0 2,149,057 0
NOVUS THERAPEUTICS INC COM 67011N204 11,754 763,279 SH   DFND 1 0 763,279 0
OLEMA PHARMACEUTICALS INC COM 68062P106 320,285 6,661,503 SH   DFND 1 0 6,661,503 0
OVID THERAPEUTICS INC COM 690469101 10,446 4,522,051 SH   DFND 1 0 4,522,051 0
PANACEA ACQUISITION CORP UNIT 99/99/9999 698102209 126 9,837 SH   DFND 1 0 9,837 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 5,009 150,787 SH   DFND 1 0 150,787 0
PIERIS PHARMACEUTICALS INC COM 720795103 13,736 5,494,582 SH   DFND 1 0 5,494,582 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 86,156 4,273,588 SH   DFND 1 0 4,273,588 0
REGULUS THERAPEUTICS INC COM NEW 75915K200 4,558 3,376,207 SH   DFND 1 0 3,376,207 0
RELAY THERAPEUTICS INC COM 75943R102 127,720 3,073,147 SH   DFND 1 0 3,073,147 0
REPARE THERAPEUTICS INC COM 760273102 101,946 2,972,191 SH   DFND 1 0 2,972,191 0
REVOLUTION MEDICINES INC COM 76155X100 109,587 2,768,049 SH   DFND 1 0 2,768,049 0
REZOLUTE INC COM NEW 76200L309 2,357 190,814 SH   DFND 1 0 190,814 0
SELECTA BIOSCIENCES INC COM 816212104 10,014 3,304,963 SH   DFND 1 0 3,304,963 0
SPERO THERAPEUTICS INC COM 84833T103 43,497 2,243,278 SH   DFND 1 0 2,243,278 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 4 50 SH   DFND 1 0 50 0
SUNESIS PHARMACEUTICALS INC COM NEW 867328874 3,437 1,727,308 SH   DFND 1 0 1,727,308 0
SUTRO BIOPHARMA INC COM 869367102 40,254 1,854,162 SH   DFND 1 0 1,854,162 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 19,538 878,524 SH   DFND 1 0 878,524 0
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 13,322 954,996 SH   DFND 1 0 954,996 0
VERASTEM INC COM 92337C104 23,816 11,180,994 SH   DFND 1 0 11,180,994 0
X4 PHARMACEUTICALS INC COM 98420X103 5,098 792,892 SH   DFND 1 0 792,892 0
XENCOR INC COM 98401F105 55,181 1,264,754 SH   DFND 1 0 1,264,754 0
XENON PHARMACEUTICALS INC COM 98420N105 53,820 3,499,346 SH   DFND 1 0 3,499,346 0
XOMA CORP DEL COM NEW 98419J206 184,562 4,182,243 SH   DFND 1 0 4,182,243 0