The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADVERUM BIOTECHNOLOGIES INC | COM | 00773U108 | 642 | 59,209 | SH | DFND | 59,209 | 0 | 0 | ||
| AKOUOS INC | COM | 00973J101 | 17,270 | 870,897 | SH | DFND | 870,897 | 0 | 0 | ||
| AMERICAN WELL CORP | CL A | 03044L105 | 6,291 | 248,352 | SH | DFND | 248,352 | 0 | 0 | ||
| BLUEBIRD BIO INC | COM | 09609G100 | 346 | 8,000 | SH | DFND | 8,000 | 0 | 0 | ||
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 617 | 5,500 | SH | DFND | 5,500 | 0 | 0 | ||
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 1,748 | 490,877 | SH | DFND | 490,877 | 0 | 0 | ||
| FREELINE THERAPEUTICS HLDGS | SPONSORED ADS | 35655L107 | 24,853 | 1,361,064 | SH | DFND | 1,361,064 | 0 | 0 | ||
| G1 THERAPEUTICS INC | COM | 3621LQ109 | 1,115 | 62,000 | SH | DFND | 62,000 | 0 | 0 | ||
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 987 | 22,800 | SH | DFND | 22,800 | 0 | 0 | ||
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 8 | 20,000 | SH | Call | DFND | 20,000 | 0 | 0 | |
| INOZYME PHARMA INC | COM | 45790W108 | 20,545 | 995,396 | SH | DFND | 995,396 | 0 | 0 | ||
| KEROS THERAPEUTICS INC | COM | 492327101 | 30,604 | 433,852 | SH | DFND | 433,852 | 0 | 0 | ||
| KEZAR LIFE SCIENCES INC | COM | 49372L100 | 705 | 135,000 | SH | DFND | 135,000 | 0 | 0 | ||
| LARIMAR THERAPEUTICS INC | COM | 517125100 | 32,439 | 1,515,148 | SH | DFND | 1,515,148 | 0 | 0 | ||
| ONCORUS INC | COM | 68236R103 | 54,312 | 1,679,906 | SH | DFND | 1,679,906 | 0 | 0 | ||
| ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 12,663 | 2,931,185 | SH | DFND | 2,931,185 | 0 | 0 | ||
| OVID THERAPEUTICS INC | COM | 690469101 | 1,911 | 827,260 | SH | DFND | 827,260 | 0 | 0 | ||
| PLIANT THERAPEUTICS INC | COM | 729139105 | 53,501 | 2,354,799 | SH | DFND | 2,354,799 | 0 | 0 | ||
| PRECISION BIOSCIENCES INC | COM | 74019P108 | 7,109 | 852,358 | SH | DFND | 852,358 | 0 | 0 | ||
| PRECISION BIOSCIENCES INC | COM | 74019P108 | 8 | 10,000 | SH | Call | DFND | 10,000 | 0 | 0 | |
| REPARE THERAPEUTICS INC | COM | 760273102 | 86,853 | 2,532,150 | SH | DFND | 2,532,150 | 0 | 0 | ||
| SPDR SER TR | S&P BIOTECH | 78464A870 | 54 | 10,000 | SH | Put | DFND | 10,000 | 0 | 0 | |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 415 | 3,000 | SH | DFND | 3,000 | 0 | 0 | ||