The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X Genomics Inc COM 88025U109 16,762 118,379 SH   SOLE   0 0 118,379
2U Inc COM 90214J101 250,958 6,272,370 SH   SOLE   5,200,808 0 1,071,562
Accolade Inc COM 00437E102 12,873 295,930 SH   SOLE   0 0 295,930
Activision Blizzard Inc COM 00507V109 48,755 525,093 SH   SOLE   0 0 525,093
Adaptive Biotechnologies Corp COM 00650F109 13,294 224,819 SH   SOLE   0 0 224,819
Adobe Inc COM 00724F101 46,071 92,120 SH   SOLE   0 0 92,120
AeroVironment Inc COM 008073108 13,359 153,731 SH   SOLE   0 0 153,731
Agnico Eagle Mines Ltd COM 008474108 3,659 51,894 SH   SOLE   51,894 0 0
Agora Inc COM 00851L103 48,894 1,235,941 SH   SOLE   0 0 1,235,941
Air Products and Chemicals Inc COM 009158106 3,150 11,528 SH   SOLE   11,528 0 0
Alamos Gold Inc COM 011532108 4,376 500,079 SH   SOLE   500,079 0 0
Albemarle Corp COM 012653101 1,460 9,900 SH   SOLE   9,900 0 0
Alibaba Group Holding Ltd COM 01609W102 187,212 804,418 SH   SOLE   0 0 804,418
Alphabet Inc COM 02079K107 56,990 32,531 SH   SOLE   0 0 32,531
Amazon.com Inc COM 023135106 170,549 52,365 SH   SOLE   0 0 52,365
Anaplan Inc COM 03272L108 24,079 335,134 SH   SOLE   0 0 335,134
AngloGold Ashanti Ltd COM 035128206 3,005 132,836 SH   SOLE   132,836 0 0
ANSYS Inc COM 03662Q105 9,062 24,910 SH   SOLE   0 0 24,910
Apple Inc COM 037833100 205,538 1,549,006 SH   SOLE   0 0 1,549,006
Aptiv PLC COM G6095L109 9,820 75,371 SH   SOLE   0 0 75,371
AquaBounty Technologies Inc COM 03842K200 1,724 196,788 SH   SOLE   0 0 196,788
Archer-Daniels-Midland Co COM 039483102 3,365 66,748 SH   SOLE   66,748 0 0
Arcturus Therapeutics Holdings COM 03969T109 12,046 277,686 SH   SOLE   0 0 277,686
Arrowhead Pharmaceuticals Inc COM 04280A100 12,179 158,731 SH   SOLE   0 0 158,731
Atlassian Corp PLC COM G06242104 41,513 177,504 SH   SOLE   0 0 177,504
Autodesk Inc COM 052769106 6,665 21,827 SH   SOLE   0 0 21,827
Avalara Inc COM 05338G106 39,789 241,309 SH   SOLE   0 0 241,309
B2Gold Corp COM 11777Q209 2,413 430,841 SH   SOLE   430,841 0 0
Baidu Inc COM 056752108 192,308 889,326 SH   SOLE   794,029 0 95,297
Baker Hughes Co COM 05722G100 2,046 98,110 SH   SOLE   95,915 0 2,195
Banco Bradesco SA COM 059460303 697 132,533 SH   SOLE   0 0 132,533
Barrick Gold Corp COM 067901108 5,240 230,037 SH   SOLE   230,037 0 0
Beam Therapeutics Inc COM 07373V105 16,674 204,242 SH   SOLE   0 0 204,242
Berkeley Lights Inc COM 084310101 6,137 68,642 SH   SOLE   0 0 68,642
BHP Group PLC COM 05545E209 13,846 261,094 SH   SOLE   261,094 0 0
Bilibili Inc COM 090040106 48,344 563,980 SH   SOLE   0 0 563,980
Boeing Co/The COM 097023105 280 1,306 SH   SOLE   0 0 1,306
BP PLC COM 055622104 3,669 178,810 SH   SOLE   178,810 0 0
Bristol Myers Squibb Co COM 110122108 14,652 236,211 SH   SOLE   0 0 236,211
Bunge Ltd COM G16962105 1,787 27,247 SH   SOLE   27,247 0 0
Burning Rock Biotech Ltd COM 12233L107 9,270 401,292 SH   SOLE   0 0 401,292
Cabot Oil & Gas Corp COM 127097103 2,012 123,595 SH   SOLE   119,829 0 3,766
Cactus Inc COM 127203107 863 33,120 SH   SOLE   33,120 0 0
Calyxt Inc COM 13173L107 9,602 2,275,265 SH   SOLE   0 0 2,275,265
Canadian Natural Resources Ltd COM 136385101 2,561 106,469 SH   SOLE   106,469 0 0
CareDx Inc COM 14167L103 55,719 769,063 SH   SOLE   0 0 769,063
Caterpillar Inc COM 149123101 16,772 92,142 SH   SOLE   0 0 92,142
Cellectis SA COM 15117K103 20,939 773,788 SH   SOLE   0 0 773,788
Cerus Corp COM 157085101 76,834 11,103,210 SH   SOLE   8,990,507 0 2,112,703
CF Industries Holdings Inc COM 125269100 1,890 48,830 SH   SOLE   48,830 0 0
ChampionX Corp COM 15872M104 1,074 70,218 SH   SOLE   68,841 0 1,377
Charles Schwab Corp/The COM 808513105 67,898 1,280,130 SH   SOLE   0 0 1,280,130
Chevron Corp COM 166764100 8,018 94,938 SH   SOLE   93,574 0 1,364
China Petroleum & Chemical Cor COM 16941R108 696 15,616 SH   SOLE   15,616 0 0
Cloudflare Inc COM 18915M107 45,170 594,415 SH   SOLE   0 0 594,415
CNOOC Ltd COM 126132109 679 7,413 SH   SOLE   7,413 0 0
Codexis Inc COM 192005106 18,530 848,839 SH   SOLE   0 0 848,839
Compugen Ltd COM M25722105 85,112 7,028,228 SH   SOLE   5,943,463 0 1,084,765
Concho Resources Inc COM 20605P101 1,535 26,306 SH   SOLE   25,314 0 992
ConocoPhillips COM 20825C104 2,106 52,671 SH   SOLE   52,671 0 0
Corteva Inc COM 22052L104 16,967 438,193 SH   SOLE   157,048 0 281,145
Coupa Software Inc COM 22266L106 35,007 103,292 SH   SOLE   0 0 103,292
CRISPR Therapeutics AG COM H17182108 587,456 3,836,823 SH   SOLE   3,291,640 0 545,183
Crowdstrike Holdings Inc COM 22788C105 42,227 199,351 SH   SOLE   0 0 199,351
Darling Ingredients Inc COM 237266101 1,189 20,622 SH   SOLE   20,622 0 0
Datadog Inc COM 23804L103 42,310 429,809 SH   SOLE   0 0 429,809
Deere & Co COM 244199105 27,313 101,517 SH   SOLE   0 0 101,517
Diamondback Energy Inc COM 25278X109 57 1,168 SH   SOLE   0 0 1,168
DocuSign Inc COM 256163106 321,885 1,447,976 SH   SOLE   473,527 0 974,449
Domino's Pizza Inc COM 25754A201 8,145 21,241 SH   SOLE   0 0 21,241
Editas Medicine Inc COM 28106W103 307,653 4,388,143 SH   SOLE   3,702,652 0 685,491
Elastic NV COM N14506104 44,640 305,484 SH   SOLE   0 0 305,484
Elbit Systems Ltd COM M3760D101 2,037 15,576 SH   SOLE   0 0 15,576
EOG Resources Inc COM 26875P101 2,884 57,837 SH   SOLE   56,317 0 1,520
Etsy Inc COM 29786A106 52,451 294,818 SH   SOLE   0 0 294,818
Exact Sciences Corp COM 30063P105 175,588 1,325,289 SH   SOLE   1,206,523 0 118,766
ExOne Co/The COM 302104104 13,827 1,457,036 SH   SOLE   1,457,036 0 0
Experience Investment Corp COM 30217C109 173 15,601 SH   SOLE   0 0 15,601
Exxon Mobil Corp COM 30231G102 6,064 147,120 SH   SOLE   143,990 0 3,130
Facebook Inc COM 30303M102 238,495 873,096 SH   SOLE   0 0 873,096
Fastly Inc COM 31188V100 64,094 733,591 SH   SOLE   0 0 733,591
Fate Therapeutics Inc COM 31189P102 48,890 537,664 SH   SOLE   0 0 537,664
Five9 Inc COM 338307101 47,548 272,635 SH   SOLE   0 0 272,635
FLIR Systems Inc COM 302445101 22,582 515,228 SH   SOLE   0 0 515,228
Freeport-McMoRan Inc COM 35671D857 9,090 349,343 SH   SOLE   349,343 0 0
Garmin Ltd COM H2906T109 6,719 56,149 SH   SOLE   0 0 56,149
Guardant Health Inc COM 40131M109 17,096 132,648 SH   SOLE   0 0 132,648
Guidewire Software Inc COM 40171V100 74,811 581,148 SH   SOLE   0 0 581,148
Halliburton Co COM 406216101 1,657 87,675 SH   SOLE   86,423 0 1,252
HDFC Bank Ltd COM 40415F101 49,201 680,883 SH   SOLE   0 0 680,883
HEICO Corp COM 422806109 277 2,094 SH   SOLE   0 0 2,094
Helmerich & Payne Inc COM 423452101 736 31,766 SH   SOLE   31,282 0 484
Hess Corp COM 42809H107 2,139 40,512 SH   SOLE   39,345 0 1,167
Honeywell International Inc COM 438516106 402 1,890 SH   SOLE   0 0 1,890
HubSpot Inc COM 443573100 27,048 68,228 SH   SOLE   0 0 68,228
Huntsman Corp COM 447011107 1,039 41,334 SH   SOLE   41,334 0 0
HUYA Inc COM 44852D108 62,026 3,112,174 SH   SOLE   1,152,672 0 1,959,502
Incyte Corp COM 45337C102 16,591 190,740 SH   SOLE   0 0 190,740
Intellia Therapeutics Inc COM 45826J105 277,677 5,104,362 SH   SOLE   4,037,130 0 1,067,232
Interactive Brokers Group Inc COM 45841N107 66,111 1,085,213 SH   SOLE   0 0 1,085,213
Intercontinental Exchange Inc COM 45866F104 363,056 3,149,065 SH   SOLE   1,209,344 0 1,939,721
International Paper Co COM 460146103 5,518 110,988 SH   SOLE   110,988 0 0
Intuit Inc COM 461202103 75,041 197,555 SH   SOLE   0 0 197,555
Invitae Corp COM 46185L103 470,597 11,255,614 SH   SOLE   9,368,479 0 1,887,135
Ionis Pharmaceuticals Inc COM 462222100 18,272 323,168 SH   SOLE   0 0 323,168
Iovance Biotherapeutics Inc COM 462260100 205,269 4,423,910 SH   SOLE   3,474,577 0 949,333
Iridium Communications Inc COM 46269C102 83,107 2,113,329 SH   SOLE   2,080,312 0 33,017
JD.com Inc COM 47215P106 123,715 1,407,450 SH   SOLE   0 0 1,407,450
KE Holdings Inc COM 482497104 205,388 3,337,470 SH   SOLE   1,824,643 0 1,512,827
Kratos Defense & Security Solu COM 50077B207 21,327 777,518 SH   SOLE   0 0 777,518
L3Harris Technologies Inc COM 502431109 600 3,175 SH   SOLE   0 0 3,175
LendingClub Corp COM 52603A208 48,030 4,548,260 SH   SOLE   2,812,360 0 1,735,900
LendingTree Inc COM 52603B107 312,573 1,141,653 SH   SOLE   604,848 0 536,805
Liberty Oilfield Services Inc COM 53115L104 859 83,344 SH   SOLE   81,926 0 1,418
Lightspeed POS Inc COM 53227R106 79,209 1,126,447 SH   SOLE   0 0 1,126,447
Linde PLC COM G5494J103 4,924 18,687 SH   SOLE   18,687 0 0
LivePerson Inc COM 538146101 82,906 1,332,248 SH   SOLE   0 0 1,332,248
Lockheed Martin Corp COM 539830109 614 1,730 SH   SOLE   0 0 1,730
Marathon Petroleum Corp COM 56585A102 1,653 39,978 SH   SOLE   38,885 0 1,093
MarketAxess Holdings Inc COM 57060D108 23,463 41,122 SH   SOLE   0 0 41,122
Materialise NV COM 57667T100 143,938 2,655,198 SH   SOLE   2,645,352 0 9,846
MercadoLibre Inc COM 58733R102 294,445 175,765 SH   SOLE   0 0 175,765
Microsoft Corp COM 594918104 46,013 206,874 SH   SOLE   0 0 206,874
Mimecast Ltd COM G14838109 64,421 1,133,379 SH   SOLE   0 0 1,133,379
MongoDB Inc COM 60937P106 54,098 150,674 SH   SOLE   0 0 150,674
Mosaic Co/The COM 61945C103 1,386 60,213 SH   SOLE   60,213 0 0
NanoString Technologies Inc COM 63009R109 88,960 1,330,140 SH   SOLE   1,245,673 0 84,467
Netflix Inc COM 64110L106 155,294 287,194 SH   SOLE   0 0 287,194
Newmont Corp COM 651639106 4,759 79,467 SH   SOLE   79,467 0 0
Niu Technologies COM 65481N100 8,649 308,354 SH   SOLE   0 0 308,354
Nomad Foods Ltd COM G6564A105 1,709 67,236 SH   SOLE   67,236 0 0
Nucor Corp COM 670346105 2,834 53,285 SH   SOLE   53,285 0 0
Nutrien Ltd COM 67077M108 9,519 197,658 SH   SOLE   197,658 0 0
NVIDIA Corp COM 67066G104 52,846 101,199 SH   SOLE   0 0 101,199
NXP Semiconductors NV COM N6596X109 15,577 97,964 SH   SOLE   0 0 97,964
Occidental Petroleum Corp COM 674599105 1,441 83,225 SH   SOLE   81,343 0 1,882
Oceaneering International Inc COM 675232102 956 120,310 SH   SOLE   120,310 0 0
Oil States International Inc COM 678026105 751 149,604 SH   SOLE   149,604 0 0
Okta Inc COM 679295105 37,469 147,365 SH   SOLE   0 0 147,365
Opendoor Technologies Inc COM 683712103 55,270 2,431,580 SH   SOLE   0 0 2,431,580
Organovo Holdings Inc COM 68620A203 5,886 478,570 SH   SOLE   371,410 0 107,160
Pacific Biosciences of Califor COM 69404D108 130,196 5,019,138 SH   SOLE   4,387,295 0 631,843
Packaging Corp of America COM 695156109 2,397 17,382 SH   SOLE   17,382 0 0
PagerDuty Inc COM 69553P100 265,193 6,359,550 SH   SOLE   4,195,415 0 2,164,135
PayPal Holdings Inc COM 70450Y103 427,247 1,824,281 SH   SOLE   555,570 0 1,268,711
Peloton Interactive Inc COM 70614W100 137,403 905,635 SH   SOLE   0 0 905,635
Personalis Inc COM 71535D106 39,287 1,073,118 SH   SOLE   0 0 1,073,118
Petroleo Brasileiro SA COM 71654V408 646 57,511 SH   SOLE   57,511 0 0
Phillips 66 COM 718546104 1,470 21,025 SH   SOLE   21,025 0 0
Phreesia Inc COM 71944F106 16,700 307,770 SH   SOLE   0 0 307,770
Pinduoduo Inc COM 722304102 148,315 834,776 SH   SOLE   0 0 834,776
Pinterest Inc COM 72352L106 248,697 3,773,852 SH   SOLE   970,602 0 2,803,250
Pioneer Natural Resources Co COM 723787107 1,631 14,325 SH   SOLE   14,012 0 313
Pluristem Therapeutics Inc COM 72940R300 803 113,628 SH   SOLE   0 0 113,628
Proto Labs Inc COM 743713109 244,008 1,590,666 SH   SOLE   1,526,024 0 64,642
Pure Storage Inc COM 74624M102 284,195 12,569,420 SH   SOLE   11,336,785 0 1,232,635
Raven Industries Inc COM 754212108 7,447 225,050 SH   SOLE   0 0 225,050
Regeneron Pharmaceuticals Inc COM 75886F107 26,048 53,918 SH   SOLE   0 0 53,918
Rio Tinto PLC COM 767204100 9,243 122,886 SH   SOLE   122,886 0 0
Roku Inc COM 77543R102 814,879 2,454,307 SH   SOLE   1,771,857 0 682,450
Royal Dutch Shell PLC COM 780259206 5,558 158,179 SH   SOLE   158,179 0 0
salesforce.com Inc COM 79466L302 40,880 183,704 SH   SOLE   0 0 183,704
Sarepta Therapeutics Inc COM 803607100 14,223 83,424 SH   SOLE   0 0 83,424
Schlumberger NV COM 806857108 3,114 142,656 SH   SOLE   140,484 0 2,172
Schrodinger Inc/United States COM 80810D103 14,682 185,427 SH   SOLE   0 0 185,427
Sea Ltd COM 81141R100 470,669 2,364,577 SH   SOLE   596,995 0 1,767,582
Seres Therapeutics Inc COM 81750R102 142,678 5,823,603 SH   SOLE   4,848,596 0 975,007
Shopify Inc COM 82509L107 304,947 269,400 SH   SOLE   113,739 0 155,661
Smartsheet Inc COM 83200N103 22,725 327,974 SH   SOLE   0 0 327,974
Snap Inc COM 83304A106 228,117 4,555,968 SH   SOLE   0 0 4,555,968
Southern Copper Corp COM 84265V105 1,982 30,438 SH   SOLE   30,438 0 0
Spirit AeroSystems Holdings In COM 848574109 347 8,883 SH   SOLE   0 0 8,883
Splunk Inc COM 848637104 223,511 1,315,623 SH   SOLE   510,588 0 805,035
Spotify Technology SA COM L8681T102 334,645 1,063,514 SH   SOLE   732,627 0 330,887
Square Inc COM 852234103 927,149 4,260,013 SH   SOLE   2,033,780 0 2,226,233
SSR Mining Inc COM 784730103 2,482 123,408 SH   SOLE   123,408 0 0
Steel Dynamics Inc COM 858119100 3,199 86,776 SH   SOLE   86,776 0 0
Stratasys Ltd COM M85548101 86,034 4,152,236 SH   SOLE   4,123,959 0 28,277
Suncor Energy Inc COM 867224107 3,183 189,666 SH   SOLE   185,413 0 4,253
Synopsys Inc COM 871607107 90,220 348,017 SH   SOLE   311,285 0 36,732
Syros Pharmaceuticals Inc COM 87184Q107 47,545 4,381,992 SH   SOLE   3,385,301 0 996,691
Taiwan Semiconductor Manufactu COM 874039100 313,952 2,879,241 SH   SOLE   1,153,224 0 1,726,017
TechnipFMC PLC COM G87110105 1,641 174,581 SH   SOLE   171,467 0 3,114
Teck Resources Ltd COM 878742204 2,998 165,201 SH   SOLE   165,201 0 0
Teladoc Health Inc COM 87918A105 564,700 2,824,067 SH   SOLE   1,839,808 0 984,259
Teledyne Technologies Inc COM 879360105 170 433 SH   SOLE   0 0 433
Teradyne Inc COM 880770102 11,833 98,698 SH   SOLE   0 0 98,698
Tesla Inc COM 88160R101 879,718 1,246,642 SH   SOLE   1,167,587 0 79,055
Thermo Fisher Scientific Inc COM 883556102 11,144 23,925 SH   SOLE   0 0 23,925
TOTAL SE COM 89151E109 8,167 194,863 SH   SOLE   194,863 0 0
Trimble Inc COM 896239100 35,567 532,681 SH   SOLE   0 0 532,681
Twilio Inc COM 90138F102 450,783 1,331,709 SH   SOLE   539,201 0 792,508
Twist Bioscience Corp COM 90184D100 260,017 1,840,306 SH   SOLE   1,446,874 0 393,432
Union Pacific Corp COM 907818108 809 3,887 SH   SOLE   3,887 0 0
United Parcel Service Inc COM 911312106 8,092 48,054 SH   SOLE   0 0 48,054
Unity Software Inc COM 91332U101 189,924 1,237,531 SH   SOLE   694,135 0 543,396
Univar Solutions Inc COM 91336L107 2,149 113,021 SH   SOLE   113,021 0 0
Vale SA COM 91912E105 6,472 386,144 SH   SOLE   386,144 0 0
Valero Energy Corp COM 91913Y100 1,260 22,276 SH   SOLE   22,276 0 0
Veeva Systems Inc COM 922475108 17,360 63,766 SH   SOLE   0 0 63,766
Veracyte Inc COM 92337F107 160,134 3,272,038 SH   SOLE   2,845,771 0 426,267
Verisk Analytics Inc COM 92345Y106 44,004 211,975 SH   SOLE   0 0 211,975
Vertex Pharmaceuticals Inc COM 92532F100 21,140 89,449 SH   SOLE   0 0 89,449
Virgin Galactic Holdings Inc COM 92766K106 13,897 585,624 SH   SOLE   0 0 585,624
Walt Disney Co/The COM 254687106 66,302 365,946 SH   SOLE   0 0 365,946
Weyerhaeuser Co COM 962166104 4,354 129,864 SH   SOLE   129,864 0 0
Williams Cos Inc/The COM 969457100 1,370 68,327 SH   SOLE   68,327 0 0
Workday Inc COM 98138H101 179,170 747,758 SH   SOLE   337,168 0 410,590
Workhorse Group Inc COM 98138J206 9,269 468,624 SH   SOLE   0 0 468,624
Xilinx Inc COM 983919101 8,909 62,839 SH   SOLE   0 0 62,839
Xylem Inc/NY COM 98419M100 1,593 15,652 SH   SOLE   15,652 0 0
Zendesk Inc COM 98936J101 24,301 169,796 SH   SOLE   0 0 169,796
Zillow Group Inc COM 98954M200 499,904 3,851,340 SH   SOLE   1,923,455 0 1,927,885
Zoom Video Communications Inc COM 98980L101 156,363 463,545 SH   SOLE   347,746 0 115,799